Herbal Dietary Supplements: Safety, Efficacy, and Use by Breast Cancer Survivors

Gemstone Team IMAC (Integrative Medicine and Cancer)Herbal dietary supplements (HDS) are widely used in complementary, alternative, and integrative medicine, but data on attitudes, behavior, safety, and efficacy are lacking. Using mixed methods, we administered an online survey to >1,000 breast cancer survivors to investigate HDS practices and perceptions and performed in vitro studies assessing the efficacy and toxicity of actein, a bioactive component of the HDS black cohosh (Actaea racemosa). Among cancer survivors, curcumin, flaxseed, and green tea were reported as the most frequently used HDS. Many subjects increased HDS intake after diagnosis and sought web-based information on HDS. In human breast cancer (MCF-7) and liver (HepG2/C3A) cell lines, actein had anti-proliferative and anti-estrogenic effects and did not exhibit hepatotoxicity or affect the action of tamoxifen and raloxifene

MOESM2 of Optimization of yeast-based production of medicinal protoberberine alkaloids

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Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2

The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mammalian cells