Evaluation of the Private and Social Costs of an On-Farm Biodiversity Conservation Program in Western New South Wales

Native vegetation, and its associated biodiversity, are becoming scarce in Australia and therefore valued resources to society. A significant quantity of native vegetation exists on privately managed farmlands, and so these landholders can play an important role in management and conservation. They do not, however, always conserve biodiversity at a level society desires because they do not receive the appropriate market signals. Consequently, regulations and other policy measures to protect native vegetation on farms have been introduced in all jurisdictions of Australia. But these regulatory policies can impose substantial costs to landholders, and may be ineffective in the provision of biodiversity and environmental outcomes, so they need to be continually reviewed. Recently the use of Market Based Instruments (MBI's) has received considerable attention. These instruments are based on the premise that the socially optimal level of biodiversity is not being conserved due to market failures. They are used to create a market that provides both incentives and signals to farmers to produce improved levels of environmental goods and services. The Western Division of New South Wales has primarily been used for grazing sheep on native pasture, and is characterised by large properties and marginal climatic conditions. Environmental issues in the region include soil erosion, encroachment of woody weeds and the decline of the pasture and groundcover conditions. Currently less than eight per cent of the Western Division is formally managed with conservation objectives, however the Western Catchment Management Authority hopes to raise this to 25 per cent conservation by 2035. This, amongst other factors has led to an interest in MBI's as a method of increasing conservation outcomes in this region

Disaster resilience in Australia: A geographic assessment using an index of coping and adaptive capacity

This paper reports a national-scale assessment of disaster resilience, using the Australian Disaster Resilience Index. The index assesses resilience at three levels: overall capacity for disaster resilience; coping and adaptive capacity; and, eight themes of disaster resilience across social, economic and institutional domains. About 32% of Australia's population (7.6 million people) live in an area assessed as having high capacity for disaster resilience. About 52% of Australia's population (12.3 million people) live in an area assessed as having moderate capacity for disaster resilience. The remaining 16% of Australia's population (3.8 million people) live in an area assessed as having low capacity for disaster resilience. Distribution of disaster resilience in Australia is strongly influenced by a geography of remoteness. Most metropolitan and inner regional areas were assessed as having high capacity for disaster resilience. In contrast, most outer regional, remote and very remote areas were assessed as having low capacity for disaster resilience, although areas of low capacity for disaster resilience can occur in metropolitan areas. Juxtaposed onto this distribution, themes of disaster resilience highlight strengths and barriers to disaster resilience in different communities. For example, low community capital and social cohesion is a disaster resilience barrier in many metropolitan areas, but higher community capital and social cohesion in outer regional and some remote areas supports disaster resilience. The strategic intent of a shared responsibility for disaster resilience can benefit from understanding the spatial distribution of disaster resilience, so that policies and programmes can address systemic influences on disaster resilience

The Australian Natural Disaster Resilience Index: Annual project report 2017-18

Natural hazard management policy directions in Australia – and indeed internationally – are increasingly being aligned to ideas of resilience. However, the definition and conceptualization of resilience in relation to natural hazards is keenly contested within academic literature (Klein et al., 2003; Wisner et al., 2004; Boin et al., 2010; Tierney, 2014). Broadly speaking, resilience to natural hazards is the ability of individuals and communities to cope with disturbances or changes and to maintain adaptive behaviour (Maguire and Cartwright, 2008). Building resilience to natural hazards requires the capacity to cope with the event and its aftermath, as well as the capacity to learn about hazard risks, change behaviour, transform institutions and adapt to a changing environment (Maguire and Cartwright, 2008). The Australian Natural Disaster Resilience Index is a tool for assessing the resilience of communities to natural hazards at a large scale. Using a top down approach, the assessment will provide input to macro-level policy, strategic planning, community planning and community engagement activities at National, State and local government levels. First, it is a snapshot of the current state of natural hazard resilience at a national scale. Second, it is a layer of information for use in strategic policy development and planning. Third, it provides a benchmark against which to assess future change in resilience to natural hazards. Understanding resilience strengths and weaknesses will help communities, governments and organizations to build the capacities needed for living with natural hazards. Design of the Australian Natural Disaster Resilience Index The Australian Natural Disaster Resilience Index will assess resilience based on two sets of capacities – coping capacity and adaptive capacity. We have used a hierarchical structure for the Australian Natural Disaster Resilience Index. Indicators provide the data for a theme – together the indicators measure the status of the theme. We collected approximately 90 indicators across the eight coping and adaptive capacity themes. Indicators were collected at Statistical Area 2 (SA2) resolution where possible. Results of the Australian Natural Disaster Resilience Index The results and initial trends in the eight themes of the Australian Natural Disaster Resilience Index are presented below. It should be noted that these interpretations and maps are subject to further change as the State of Disaster Resilience Report is developed. What is presented here is an overview of the pattern of index values. In all maps, lower index values in brown represent lower disaster resilience and higher index values in green represent higher disaster resilience. Each of the sections is an SA2 division of the ABS

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.

OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes. PARTICPANTS AND METHODS: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented. RESULTS: A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status. CONCLUSION: This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening

Identification of a BRCA2-Specific modifier locus at 6p24 related to breast cancer risk

Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. DNA samples from 3,881 breast cancer affected and 4,330 unaffected BRCA2 mutation carriers from 47 studies belonging to the Consortium of Investigators of Modifiers of BRCA1/2 were genotyped and available for analysis. We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80-0.90, P = 3.9×10−8). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. This report identifies the first breast cancer risk locus specific to a BRCA2 mutation background. This comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers. This panel may have clinical utility for women with BRCA2 mutations weighing options for medical prevention of breast cancer

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Introduction: Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers. Methods: We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals. Results: We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk. Conclusions: This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.Peer reviewe

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Economic Analysis and Business Development of Sustainable Wildlife Enterprises trial sites

The RIRDC study (MUA-1A) found that, for a hypothetical grazing property in the rangelands of NSW, harvesting kangaroos for human consumption could cover both the capital and variable costs of the enterprise. It also drew attention to the potential economic and environmental benefits of a reduced stocking rate of domestic stock, if accompanied by measures to control total grazing pressure. A RIRDC workshop in May 2004 on the Sustainable Wildlife Enterprises Program concluded there was a need for more economic analysis and business case development for the industry proposals that emerged from that workshop. This project was proposed to progress that work