Uncompromising Positions: Reiterations of Misogyny Embedded in Lesbian and Feminist Communities' Framing of Lesbian Femme Identities

Queer femmes in 1950s bar cultures were often not viewed as "real lesbians;" radical feminism condemned femmes as trying to please patriarchy. This paper investigates ways such views regarding femmes reiterate misogynist notions of female bodies. It places femme narratives challenging such conceptualizations as contesting counter-cultural reiterations of misogyny. Résumé Les femmes queer dans la culture des bars des années 50 souvent n’étaient pas vues comme de "vraies lesbiennes", le féminisme radical condamnait les femmes queer disant qu’elles essayaient de plaire à la patriarchie. Cet article étudie les façons dont ce genre de vues au sujet de femmes réitère les notions misogynes sur le corps féminin. Il place les narrations su les femmes en mettant endéfice genre de conceptualisation comme contestant les réitérations contre-culturelles de la misogynie

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways

Contagion and Antidote: Changing Locations of "Risk" in BC Public School's Discourse on Disability

This paper examines discourses of disability in British Columbia’s public schools over the past century. I begin with overviewing gendered, racialized, able- norms that delineated who was deemed eligible for citizenship in the foundation of BC schools. From historical analysis, I move to examining current discourse regarding disability inclusion in public schools. This analysis focuses on a presentation by Vancouver School Board Autism and Inclusion consultants who, while arguing the importance of inclusion of students with disabilities in mainstream classrooms, did do so with the goal of eradicating student difference. I draw from critical disability studies scholars that afford possibilities for public educational institutions to further depart from exclusionary pasts.Education, Faculty ofEducational Studies (EDST), Department ofUnreviewedGraduat

"Is it still a boy?" : hetero/gender normativity in Kindergarten

This study examines everyday practices (talk, play, curriculum) in Kindergarten that works with and against hetero/gender normativity. To conduct this research, I spent three months in a Kindergarten classroom in a Vancouver public school. In addition to conducting everyday observations, I facilitated focus groups with students and interviews with educators based on their experiences planning and taking part in curriculum for Valentine’s Day, Anti-Bullying/Pink Shirt Day, and Mother’s Day. This combination of data illustrated ways hetero/gender norms become institutionally routinized in Kindergarten regardless of progressive district school policies and the occasional special events that discourage homophobic bullying. Of critical importance to my analysis are discrepancies between discourse about what children are (e.g., innocent, masculine, feminine) and what children do within their play and social interactions. Such discourses neutralize heterosexuality and gender conformity as asexual, and hyper-sexualize queer and transgender subjectivities, rendering them “inappropriate” in Kindergarten. My research suggests that this normalizes the gender and sexual status quo while othering children who may not fit within these limited parameters. This dissertation contributes to educational and critical childhood studies that seek to understand the routes by which queer and transgender students are isolated and ostracized within public school social life.Arts, Faculty ofGender, Race, Sexuality and Social Justice, Institute forGraduat

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways