261 research outputs found
The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth
- Author
- Publication venue
- 'Nature Research Society'
- Publication date
- Field of study
\ua9 The Author(s) 2024.Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (LM), which are trafficked from the bacterium to the host via unknown mechanisms. Arabinomannan is thought to be a capsular derivative of these molecules, lacking a lipid anchor. However, the mechanism by which this material is generated has yet to be elucidated. Here, we describe the identification of a glycoside hydrolase family 76 enzyme that we term LamH (Rv0365c in Mycobacterium tuberculosis) which specifically cleaves α−1,6-mannoside linkages within LM and LAM, driving its export to the capsule releasing its phosphatidyl-myo-inositol mannoside lipid anchor. Unexpectedly, we found that the catalytic activity of this enzyme is important for efficient exit from stationary phase cultures, potentially implicating arabinomannan as a signal for growth phase transition. Finally, we demonstrate that LamH is important for M. tuberculosis survival in macrophages
Promises and Perils of New Global Governance: A Case of the G20
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- Common_Framework_For_The_Supervision_Of_Internationally_Active_Insurance_Groups
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- See Dana Brakman Reiser
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
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- Zobernig G
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- zur Nedden M
- Zychacek V
- Publication venue
- Publication date
- 01/01/2008
- Field of study
A detailed study is presented of the expected performance of the ATLAS
detector. The reconstruction of tracks, leptons, photons, missing energy and
jets is investigated, together with the performance of b-tagging and the
trigger. The physics potential for a variety of interesting physics processes,
within the Standard Model and beyond, is examined. The study comprises a series
of notes based on simulations of the detector and physics processes, with
particular emphasis given to the data expected from the first years of
operation of the LHC at CERN
Measurement of the production cross section for W-bosons in association with jets in pp collisions at s=7 TeV with the ATLAS detector
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- Aad G.
- Abbott B.
- Abdallah J.
- Abdelalim A. A.
- Abdesselam A.
- Abdinov O.
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- Publication venue
- Publication date
- 01/01/2011
- Field of study
This Letter reports on a first measurement of the inclusive W + jets cross section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC, with the ATLAS detector. Cross sections, in both the electron and muon decay modes of the W-boson, are presented as a function of jet multiplicity and of the transverse momentum of the leading and next-to-leading jets in the event. Measurements are also presented of the ratio of cross sections sigma (W + >= n)/sigma(W + >= n - 1) for inclusive jet multiplicities n = 1-4. The results, based on an integrated luminosity of 1.3 pb(-1), have been corrected for all known detector effects and are quoted in a limited and well-defined range of jet and lepton kinematics. The measured cross sections are compared to particle-level predictions based on perturbative QCD. Next-to-leading order calculations, studied here for n <= 2, are found in good agreement with the data. Leading-order multiparton event generators, normalized to the NNLO total cross section, describe the data well for all measured jet multiplicitie
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Sport, genetics and the `natural athlete': The resurgence of racial science
- Author
- Bale John
- Barker Martin
- Benedict Ruth
- Blake Andrew
- Bouchard Claude
- Boulay Marcel R.
- Bourdieu Pierre
- Bourdieu Pierre
- BRETT ST LOUIS
- Brohm Jean-Marie
- Burfoot Amby
- Burfoot Amby
- Burkitt Ian
- Cashmore Ellis E.
- Cuvier Georges Léopold
- Dennis Carina
- Duncan Margaret Carlisle
- Edwards Harry
- Entine Jon
- Feyerabend Paul
- Fleming Scott
- Gilroy Paul
- Gobineau Arthur de
- Goldberg David Theo
- Gould Stephen Jay
- Haraway Donna
- Hargreaves Jennifer
- Hargreaves John
- Herrnstein Richard J.
- Hoberman John
- International Human Genome Sequencing Consortium
- Jones Steve
- Knox Robert
- Kohn Marek
- Kuhn Thomas
- Locke John
- Maguire Joseph
- Malina Robert M.
- Miles Robert
- Monaco James
- Popper Karl
- Rose Steven
- Rose Steven
- Samson Jacques
- Sands R.R.
- Todorov Tzvetan
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/2003
- Field of study
This article explores the ethical implications of recent discussions that naturalize the relationship between race, the body and sport within the frame of genetic science. Many suggestions of a racially distributed genetic basis for athletic ability and performance are strategically posited as a resounding critique of the `politically correct' meta-narratives of established sociological and anthropological forms of explanation that emphasize the social and cultural construction of race. I argue that this use of genetic science in order to describe and explain common-sense impressions of racial physiology and sporting ability is founded on erroneous premises of objectivity and disinterest, and inflates the analytical efficacy of scientific truth claims. I suggest that assertions of a value-free science of racial athletic ability reify race as inherited permanent biological characteristics that produce social hierarchies and are more characteristic of a longer history of `racial science'
The multi-dimensional character of wisdom
- Author
- A Bergsma
- A Giddens
- Aristotle
- Aristotle
- Australian Medical Association
- Australian Public Service Commission
- B Flyvbjerg
- B Head
- B McKenna
- B McKenna
- BJ Avolio
- BM Benedict
- C Mickler
- CD Ryff
- CD Ryff
- CD Ryff
- CL Keyes
- CP Long
- D Rooney
- DM Rousseau
- EM Barker
- GJ Hughes
- I Berlin
- J Bigelow
- J Dunne
- J Eflin
- J Kekes
- J Korff
- J Whittaker
- JA Greene
- JD Webster
- JD Webster
- JD Webster
- JE Mathieu
- JL Horn
- JS Eccles
- JS Lansing
- L-C Malan
- M Ardelt
- M Ardelt
- M Foucault
- M Foucault
- M Foucault
- M Nussbaum
- M Polanyi
- MC Bligh
- MG Edwards
- MJ Limas
- MP Kriger
- N Pearson
- N Pearson
- N Sherman
- NW Biggart
- P Bourdieu
- PB Baltes
- PB Baltes
- PB Baltes
- PM Podsakoff
- R Axelrod
- R House
- RC Miner
- RH Frank
- RJ Sternberg
- RJ Sternberg
- RJ Sternberg
- RJ Sternberg
- RJ Sternberg
- RJ Sternberg
- RJ Sternberg
- SC Brown
- ST Hannah
- SWJ Kozlowski
- UM Staudinger
- VP Clayton
- W Indick
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Caspase-Dependent Inhibition of Mousepox Replication by gzmB
- Author
- A Mullbacher
- A Mullbacher
- A Mullbacher
- A Mullbacher
- A Müllbacher
- A Postigo
- AH Wyllie
- Arno Müllbacher
- Aulikki Koskinen
- B Turk
- BA Callus
- CA Benedict
- CT Pham
- D Kagi
- D Kagi
- DC Tscharke
- DJ Brick
- DJ Pickup
- E Rouvier
- Eva Ma Gálvez
- F Fenner
- G Bossi
- Georg Häcker
- I Voskoboinik
- J Lieberman
- J Pardo
- J Pardo
- J Pardo
- J Pardo
- J Pardo
- J Tschopp
- JA Trapani
- JE Chipuk
- JH Russell
- JL Macen
- JM Adams
- Julián Pardo
- L Riera
- M Aoyagi
- M Dobbelstein
- M Krzyzowska
- M Obeid
- M Regner
- M Tewari
- Mario Lobigs
- Markus M. Simon
- Matthias Regner
- MC Wei
- ME van den Broek
- MF van den Broek
- MJ Smyth
- MM Simon
- MM Simon
- N Chen
- P Boya
- P Li
- P Martin
- PA Revell
- PG Ashton-Rickardt
- R Wallich
- RA Pereira
- RV Blanden
- SA Lakhani
- SF Fischer
- SJ Gardai
- SJ Turner
- SS Metkar
- ST Wasilenko
- Y Wang
- Publication venue
- Public Library of Science
- Publication date
- 19/10/2009
- Field of study
BACKGROUND: Ectromelia virus is a natural mouse pathogen, causing mousepox. The cytotoxic T (Tc) cell granule serine-protease, granzyme B, is important for its control, but the underlying mechanism is unknown. Using ex vivo virus immune Tc cells, we have previously shown that granzyme B is able to activate several independent pro-apoptotic pathways, including those mediated by Bid/Bak/Bax and caspases-3/-7, in target cells pulsed with Tc cell determinants. METHODS AND FINDINGS: Here we analysed the physiological relevance of those pro-apoptotic pathways in ectromelia infection, by incubating ectromelia-immune ex vivo Tc cells from granzyme A deficient (GzmB(+) Tc cells) or granzyme A and granzyme B deficient (GzmAxB(-/-) Tc cell) mice with ectromelia-infected target cells. We found that gzmB-induced apoptosis was totally blocked in ectromelia infected or peptide pulsed cells lacking caspases-3/-7. However ectromelia inhibited only partially apoptosis in cells deficient for Bid/Bak/Bax and not at all when both pathways were operative suggesting that the virus is able to interfere with apoptosis induced by gzmB in case not all pathways are activated. Importantly, inhibition of viral replication in vitro, as seen with wild type cells, was not affected by the lack of Bid/Bak/Bax but was significantly reduced in caspase-3/-7-deficient cells. Both caspase dependent processes were strictly dependent on gzmB, since Tc cells, lacking both gzms, neither induced apoptosis nor reduced viral titers. SIGNIFICANCE: Out findings present the first evidence on the biological importance of the independent gzmB-inducible pro-apoptotic pathways in a physiological relevant virus infection model
HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
- Author
- A Antinori
- A Benton
- A Gongvatana
- A Nath
- AK Njamnshi
- AK Njamnshi
- AL Piatt
- Alfred K Njamnshi
- AT Beck
- BM Ances
- C Montavon
- Callixte T Kuate
- CDC
- CJ Golden
- CL Carey
- D Rieu
- D Wechsler
- D Wechsler
- DB Clifford
- DJ Moore
- DM Gronwall
- Donald R Franklin
- Dora M Njamnshi
- Dora Mbanya
- E Masliah
- E Masliah
- EJ Kongnyuy
- Emilienne Nchindap
- F Gonzalez-Scarano
- FA Konings
- FE Odiase
- Fidele Binam
- G Awuba JaM
- G van Marle
- GD Kanmogne
- Georgette D Kanmogne
- H Klove
- IP Everall
- J Brandt
- JA Gladsjo
- JA Joska
- JD Gupta
- JJ Manly
- John A McCutchan
- Julius Y Fonsah
- K Robertson
- KR Robertson
- L Boisse
- LA Cysique
- LF D'Elia
- Lucette A Cysique
- M Alirezaei
- M Cherner
- M Maj
- M Zhang
- MC Diehr
- MH Wong
- N Ndembi
- N Ruffieux
- N Sacktor
- NA DeFilippis
- RH Benedict
- RJ Ellis
- RJ Ellis
- RK Heaton
- RK Heaton
- RK Heaton
- Robert K Heaton
- Roland Doh
- Ronald J Ellis
- RS Durvasula
- Sabine Eta
- SK Kongs
- SP Woods
- SP Woods
- ST Burda
- UNAIDS
- Y Persidsky
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>The disease burden of human immunodeficiency virus (HIV) - acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults.</p> <p>Methods</p> <p>We used a battery of 19 NP measures in a cross-sectional study with 44 HIV+ adults and 44 demographically matched HIV- controls, to explore the validity of these NP measures in Cameroon, and evaluate the effect of viral infection on seven cognitive ability domains.</p> <p>Results</p> <p>In this pilot study, the global mean z-score on the NP battery showed worse overall cognition in the HIV+ individuals. Significantly lower performance was seen in the HIV+ sample on tests of executive function, speed of information processing, working memory, and psychomotor speed. HIV+ participants with AIDS performed worse than those with less advanced HIV disease.</p> <p>Conclusions</p> <p>Similar to findings in Western cohorts, our results in Cameroon suggest that HIV infection, particularly in advanced stages, is associated with worse performance on standardized, Western neurocognitive tests. The tests used here appear to be promising for studying NeuroAIDS in sub-Saharan Africa.</p
Intranasal Treatment of Central Nervous System Dysfunction in Humans
- Author
- A Bohringer
- AJ Guastella
- AJ Guastella
- B Fruehwald-Schultes
- BJ Balin
- BK Alldredge
- BR Olson
- C Benedict
- C Benedict
- C Benedict
- C Benedict
- C Benedict
- C Benedict
- C Benedict
- C Bitter
- C Schulz
- CA Pedersen
- Christian Benedict
- CL Graff
- Colin D. Chapman
- CT Velthoven van
- D Kerr
- D Simeon
- DF Swaab
- DP Wermling
- E MacDonald
- E Shemesh
- G Domes
- GJ Haan de
- GJ Morton
- H Ashton
- H Baker
- H Schmidt
- HB Schiöth
- HB Schiöth
- Helgi B. Schiöth
- J Born
- J Halaas
- J Lochhead
- J MacVicar
- JD Sinden
- JJ Ramsey
- K Kristensson
- L Danielyan
- L Danielyan
- LR Hanson
- LR Hanson
- Lusine Danielyan
- M Brüne
- M Guthoff
- M Hallschmid
- M Hallschmid
- M Holsti
- M Kosfeld
- MA Reger
- MA Reger
- MA Reger
- Manfred Hallschmid
- MW Schwartz
- N Joyce
- N Nonaka
- NM Sorge van
- O Lindvall
- P Bossolasco
- P McGonigle
- PC Baier
- PC Baier
- PY Jeannet
- R Adolphs
- R Arletti
- RA Nathan
- RA Scranton
- RD Broadwell
- RG Thorne
- RG Thorne
- RG Thorne
- RG Thorne
- S Bassin
- S Craft
- S Craft
- S Fliedner
- SA Deadwyler
- SB Cassidy
- SC Woods
- ST Charlton
- Suzanne Craft
- SV Dhuria
- SV Dhuria
- SV Dhuria
- T Fişgin
- T Pang
- TM Robertson
- TR Wolfe
- V Jogani
- W Kern
- WA Banks
- WA Banks
- WE Lindup
- WH Frey II
- William H. Frey
- XQ Chen
- Y Jiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …