COVID-19 e asma pediátrica : que interação?

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2021Introdução COVID-19 é a doença causada pelo novo coronavírus, SARS-CoV-2, considerada pandemia a 11 de Março de 2020 pela Organização Mundial de Saúde (OMS). Existe uma ampla evidência de que a população pediátrica é menos afetada pela doença apresentando geralmente sintomas leves. A asma, uma das doenças crónicas mais comuns na criança, foi considerada inicialmente fator de risco para COVID-19. No entanto, apesar das especulações, não é claro se esta pode afetar a suscetibilidade à doença ou a sua gravidade. Objetivos O objetivo deste trabalho é fornecer uma atualização sobre asma pediátrica e COVID‐19 de forma a compreender a interação entre ambas. Pretendemos verificar se a asma pediátrica condiciona um aumento da incidência da infeção ou da gravidade da COVID-19. Metodologia Realizámos uma pesquisa sistemática da literatura (PRISMA) na Medline via PubMed a 28/08/2020 com o objetivo de encontrar artigos originais que relacionassem COVID-19 e asma pediátrica. Para tal foi usada a seguinte estratégia de pesquisa: ((covid-19) AND ((child) OR (pediatrics))) AND ((allergic asthma) OR (asthma)). Os critérios de elegibilidade foram artigos originais retrospetivos e descrição de séries de casos clínicos, que descrevessem a interação entre COVID-19 e asma pediátrica. Foram excluídos artigos de revisão e de opinião. Foi ativada a funcionalidade de notificação por e-mail alertando diariamente para a inclusão de novos artigos à pesquisa. Resultados e Conclusão Na literatura revista verificou-se que o diagnóstico prévio de asma em idade pediátrica não está associado a uma maior suscetibilidade à infeção por SARS-CoV-2, nem maior gravidade de COVID-19, em comparação com crianças não asmáticas.Introduction COVID-19 is the disease caused by the new coronavirus, SARS-CoV-2, considered a pandemic on March 11, 2020 by the World Health Organization (WHO). There is a large evidence that the pediatric population is less affected by the disease, generally presenting milder symptoms. Asthma, one of the most common chronic diseases in children, was initially considered a risk factor for COVID-19. However, despite speculation, it is unclear whether this may affect the susceptibility to the disease or the severity. Objectives The objective of this work is to provide an update on pediatric asthma and COVID-19 in order to understand the interaction between both. We aim to understand if pediatric asthma leads to an increase in the incidence of the infection or in the severity of COVID-19. Methodology We conducted a systematic literature search on Medline via PubMed on 08/28/2020 in order to find original articles that related COVID-19 and pediatric asthma. For this, the following research strategy was used: ((covid-19) AND ((child) OR (pediatrics))) AND ((allergic asthma) OR (asthma)). The eligibility criteria were original retrospective articles and description of clinical case series, describing the interaction between COVID-19 and pediatric asthma. Review and opinion articles were excluded. The e-mail notification functionality was activated, alerting daily to the inclusion of new articles in the research. Results and Conclusion The literature review confirmed that previous diagnosis of allergic asthma in pediatric age is not associated with greater susceptibility to infection by SARS-CoV-2, nor with greater severity of COVID-19, compared to non-asthmatic children

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

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