Development and testing of a mouse simulated space flight model

The development and testing of a mouse model for simulating some aspects of weightlessness that occur during space flight, and the carrying out of immunological flight experiments on animals was discussed. The mouse model is an antiorthostatic, hypokinetic, hypodynamic suspension model similar to the one used with rats. It is shown that this murine model yield similar results to the rat model of antiorthostatic suspension for simulating some aspects of weightlessness. It is also shown that mice suspended in this model have decreased interferon-alpha/beta production as compared to control, nonsuspended mice or to orthostatically suspended mice. It is suggested that the conditions occuring during space flight could possibly affect interferon production. The regulatory role of interferon in nonviral diseases is demonstrated including several bacterial and protozoan infections indicating the great significance of interferon in resistance to many types of infectious diseases

The inner dark matter distribution of the Cosmic Horseshoe (J1148+1930) with gravitational lensing and dynamics

We present a detailed analysis of the inner mass structure of the Cosmic Horseshoe (J1148+1930) strong gravitational lens system observed with the Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3). In addition to the spectacular Einstein ring, this systems shows a radial arc. We obtained the redshift of the radial arc counter image $z_\text{s,r} = 1.961 \pm 0.001$ from Gemini observations. To disentangle the dark and luminous matter, we consider three different profiles for the dark matter distribution: a power-law profile, the NFW, and a generalized version of the NFW profile. For the luminous matter distribution, we base it on the observed light distribution that is fitted with three components: a point mass for the central light component resembling an active galactic nucleus, and the remaining two extended light components scaled by a constant M/L. To constrain the model further, we include published velocity dispersion measurements of the lens galaxy and perform a self-consistent lensing and axisymmetric Jeans dynamical modeling. Our model fits well to the observations including the radial arc, independent of the dark matter profile. Depending on the dark matter profile, we get a dark matter fraction between 60 % and 70 %. With our composite mass model we find that the radial arc helps to constrain the inner dark matter distribution of the Cosmic Hoseshoe independently of the dark matter profile.Comment: 19 pages, 14 figures, 8 tables, submitted to A&

Experiment K-6-23. Effect of spaceflight on levels and function of immune cells

Two different immunology experiments were performed on samples received from rats flown on Cosmos 1887. In the first experiment, rat bone marrow cells were examined in Moscow for their response to colony stimulating factor-M. In the second experiment, rat spleen and bone marrow cells were stained in Moscow with a variety of antibodies directed against cell surface antigenic markers. These cells were preserved and shipped to the United States where they were subjected to analysis on a flow cytometer. The results of the studies indicate that bone marrow cells from flown rats showed a decreased response to colony stimulating factor than did bone marrow cells from control rats. There was a higher percentage of spleen cells from flown rats staining positively for pan-T-cell, suppressor-T-cell and innate interleukin-2 receptor antigens than from control animals. In addition, a higher percentage of cells that appeared to be part of the myelogenous population of bone marrow cells from flown rats stained positively for surface immunoglobulin than did equivalent cells from control rats

Direct measurement of the magnification produced by galaxy clusters as gravitational lenses

Context. Weak lensing is one of the most readily available diagnostic tools to measure the total density profiles of distant clusters of galaxies. Unfortunately, it suffers from the well-known mass-sheet degeneracy, so that weak lensing analyses cannot lead to fully reliable determinations of the total mass of the clusters. One possible way to set the relevant scale of the density profile would be to make a direct measurement of the magnification produced by the clusters as gravitational lenses; in the past, this objective has been addressed in a number of ways, but with no significant success. Aims. We revisit a suggestion made a few years ago for this general purpose, based on the use of the fundamental plane as a standard rod for early-type galaxies. Here we move one step further, beyond the simple outline of the idea given earlier, and quantify some statistical properties of this innovative diagnostic tool, with the final goal of identifying clear guidelines for a future observational test of concrete cases, which turns out to be well within the current instrument capabilities. Methods. The study is carried out by discussing the statistical properties of fundamental plane measurements for a sample of early-type source galaxies behind a massive cluster, for which a weak lensing analysis is assumed to be available. Some general results are first obtained analytically and then tested and extended by means of dedicated simulations. Results. We proceed with determining the optimal way of using fundamental plane measurements to determine the mass scale of a given cluster, which we find to be the study of a sample of early-type galaxies behind the cluster distributed approximately uniformly on the sky. We discuss the role of the redshift distribution of the source galaxies, in relation to the redshift of the lensing cluster and to the limitations of fundamental plane measurements. Simple simulations are carried out for clusters with intrinsic properties similar to those of the Coma cluster. We also show that, within a realistic cosmological scenario, substructures do not contribute much to the magnification signal that we are looking for, but add only a modest amount of scatter. Conclusions. We find that for a massive cluster (M-200 > 10(15) M-circle dot) located at redshift 0.3 +/- 0.1, a set of about 20 fundamental plane measurements, combined with a robust weak lensing analysis, should be able to lead to a mass determination with a precision of 20% or better

The Stellar Initial Mass Function in Early-Type Galaxies From Absorption Line Spectroscopy. II. Results

The spectral absorption lines in early-type galaxies contain a wealth of information regarding the detailed abundance pattern, star formation history, and stellar initial mass function (IMF) of the underlying stellar population. Using our new population synthesis model that accounts for the effect of variable abundance ratios of 11 elements, we analyze very high quality absorption line spectra of 38 early-type galaxies and the nuclear bulge of M31. These data extend to 1um and they therefore include the IMF-sensitive spectral features NaI, CaII, and FeH at 0.82um, 0.86um and 0.99um, respectively. The models fit the data well, with typical rms residuals ~1%. Strong constraints on the IMF and therefore the stellar mass-to-light ratio, (M/L)_stars, are derived for individual galaxies. We find that the IMF becomes increasingly bottom-heavy with increasing velocity dispersion and [Mg/Fe]. At the lowest dispersions and [Mg/Fe] values the derived IMF is consistent with the Milky Way IMF, while at the highest dispersions and [Mg/Fe] values the derived IMF contains more low-mass stars (is more bottom-heavy) than even a Salpeter IMF. Our best-fit (M/L)_stars values do not exceed dynamically-based M/L values. We also apply our models to stacked spectra of four metal-rich globular clusters in M31 and find an (M/L)_stars that implies fewer low-mass stars than a Milky Way IMF, again agreeing with dynamical constraints. We discuss other possible explanations for the observed trends and conclude that variation in the IMF is the simplest and most plausible.Comment: 16 pages, 13 figures, ApJ accepte

The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development

The Drosophila single-minded and trachealess bHLH-PAS genes control transcription and development of the CNS midline cell lineage and tracheal tubules, respectively. We show that Single-minded and Trachealess activate transcription by forming dimers with the Drosophila Tango protein that is an orthologue of the mammalian Arnt protein. Both cell culture and in vivo studies show that a DNA enhancer element acts as a binding site for both Single-minded::Tango and Trachealess::Tango heterodimers and functions in controlling CNS midline and tracheal transcription. Isolation and analysis of tango mutants reveal CNS midline and tracheal defects, and gene dosage studies demonstrate in vivo interactions between single-minded::tango and trachealess::tango. These experiments support the existence of an evolutionarily conserved, functionally diverse bHLH-PAS protein regulatory system

The merger-driven evolution of massive early-type galaxies

Galaxie

H0LiCOW X: Spectroscopic/imaging survey and galaxy-group identification around the strong gravitational lens system WFI2033-4723

Galaxies and galaxy groups located along the line of sight towards gravitationally lensed quasars produce high-order perturbations of the gravitational potential at the lens position. When these perturbation are too large, they can induce a systematic error on $H_0$ of a few-percent if the lens system is used for cosmological inference and the perturbers are not explicitly accounted for in the lens model. In this work, we present a detailed characterization of the environment of the lens system WFI2033-4723 ($z_{\rm src} = 1.662$, $z_{\rm lens}$ = 0.6575), one of the core targets of the H0LICOW project for which we present cosmological inferences in a companion paper (Rusu et al. 2019). We use the Gemini and ESO-Very Large telescopes to measure the spectroscopic redshifts of the brightest galaxies towards the lens, and use the ESO-MUSE integral field spectrograph to measure the velocity-dispersion of the lens ($\sigma_{\rm {los}}= 250^{+15}_{-21}$ km/s) and of several nearby galaxies. In addition, we measure photometric redshifts and stellar masses of all galaxies down to $i < 23$ mag, mainly based on Dark Energy Survey imaging (DR1). Our new catalog, complemented with literature data, more than doubles the number of known galaxy spectroscopic redshifts in the direct vicinity of the lens, expanding to 116 (64) the number of spectroscopic redshifts for galaxies separated by less than 3 arcmin (2 arcmin) from the lens. Using the flexion-shift as a measure of the amplitude of the gravitational perturbation, we identify 2 galaxy groups and 3 galaxies that require specific attention in the lens models. The ESO MUSE data enable us to measure the velocity-dispersions of three of these galaxies. These results are essential for the cosmological inference analysis presented in Rusu et al. (2019).Comment: Matches the version accepted for publication by MNRAS. Note that this paper previously appeared as H0LICOW X

The Lick AGN Monitoring Project 2011: Reverberation Mapping of Markarian 50

The Lick AGN Monitoring Project 2011 observing campaign was carried out over the course of 11 weeks in Spring 2011. Here we present the first results from this program, a measurement of the broad-line reverberation lag in the Seyfert 1 galaxy Mrk 50. Combining our data with supplemental observations obtained prior to the start of the main observing campaign, our dataset covers a total duration of 4.5 months. During this time, Mrk 50 was highly variable, exhibiting a maximum variability amplitude of a factor of 4 in the U-band continuum and a factor of 2 in the H-beta line. Using standard cross-correlation techniques, we find that H-beta and H-gamma lag the V-band continuum by tau_cen = 10.64(-0.93,+0.82) and 8.43(-1.28,+1.30) days, respectively, while the lag of He II 4686 is unresolved. The H-beta line exhibits a symmetric velocity-resolved reverberation signature with shorter lags in the high-velocity wings than in the line core, consistent with an origin in a broad-line region dominated by orbital motion rather than infall or outflow. Assuming a virial normalization factor of f=5.25, the virial estimate of the black hole mass is (3.2+-0.5)*10^7 solar masses. These observations demonstrate that Mrk 50 is among the most promising nearby active galaxies for detailed investigations of broad-line region structure and dynamics.Comment: Accepted for publication in ApJ Letters. 6 pages, 4 figure

The Sloan Digital Sky Survey Quasar Lens Search. VI. Constraints on Dark Energy and the Evolution of Massive Galaxies

We present a statistical analysis of the final lens sample from the Sloan Digital Sky Survey Quasar Lens Search (SQLS). The number distribution of a complete subsample of 19 lensed quasars selected from 50,836 source quasars is compared with theoretical expectations, with particular attention to the selection function. Assuming that the velocity function of galaxies does not evolve with redshift, the SQLS sample constrains the cosmological constant to \Omega_\Lambda=0.79^{+0.06}_{-0.07}(stat.)^{+0.06}_{-0.06}(syst.) for a flat universe. The dark energy equation of state is found to be consistent with w=-1 when the SQLS is combined with constraints from baryon acoustic oscillation (BAO) measurements or results from the Wilkinson Microwave Anisotropy Probe (WMAP). We also obtain simultaneous constraints on cosmological parameters and redshift evolution of the galaxy velocity function, finding no evidence for redshift evolution at z<1 in any combinations of constraints. For instance, number density evolution quantified as \nu_n=d\ln\phi_*/d\ln(1+z) and the velocity dispersion evolution \nu_\sigma=d\ln\sigma_*/d\ln(1+z) are constrained to \nu_n=1.06^{+1.36}_{-1.39}(stat.)^{+0.33}_{-0.64}(syst.) and \nu_\sigma=-0.05^{+0.19}_{-0.16}(stat.)^{+0.03}_{-0.03}(syst.) respectively when the SQLS result is combined with BAO and WMAP for flat models with a cosmological constant. We find that a significant amount of dark energy is preferred even after fully marginalizing over the galaxy evolution parameters. Thus the statistics of lensed quasars robustly confirm the accelerated cosmic expansion.Comment: 44 pages, 12 figures, 4 tables, accepted for publication in A