53 research outputs found

    The relationship between medical innovation and health expenditures

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    Onur Başer (MEF Author)Objectives: It is widely accepted that medical innovation includes many costly activities, and that it is a key driver of rising health care expenditures. Understanding the relationship between medical innovation and health care expenditures is critical for health policy makers to effectively make resource allocation decisions. This study seeks to investigate the relationship between medical innovation and health care expenditures. Methods: We assessed data from the World Intellectual Property Organization and World Bank statistics for the year 2014, which included data from 72 countries. The number of patent publications in the categories of medical technology, biotechnology, and pharmaceuticals were included as medical innovation indicators; public heath, health care costs per capita, and total health care costs (percentage of gross domestic product [GDP]) were included as indicators of health care-related expenditures. A canonic correlation analysis (CCA) was performed to examine the degree of association between the sets of medical innovation and health care expenditure variables. Results: Study results indicate that there is a strong positive correlation between medical innovation and health care expenditure variables (rc= 0.68, p<0.001). Conclusions: In light of this study, health policy makers should manage the relationship between medical innovation and health care expenditures with a focus on accessibility. Improved communication channels in the social system, increased international cooperation, and the determination of a proper balance between the benefits and costs of innovation may help to continue improving medical innovation and enhance health care accessibility. We hope that the study results offer an increased awareness of the relationship and balance between innovation and expenditure, and will help to create an improved health system.WOS:000396606300046Science Citation Index Expanded - Social Sciences Citation IndexQ1Meeting AbstractUluslararası işbirliği ile yapılmayan - HAYIRKasım2016YÖK - 2016-1

    Dentofacial Morphology in Third Molar Agenesis

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    Objective:In the literature, some studies show a relation between tooth agenesis and craniofacial morphology, whereas other authors conclude that dental agenesis exerts little influence on dent facial structures. The objective of this study was to determine the existence of any relation between bilateral agenesis of the maxillary and/or mandibular third molars and the anteroposterior dimensions and vertical growth pattern of the jaws.Subjects and Methods:Sixty-eight subjects between the ages of 13 and 17 years with bilateral agenesis of maxillary third molars (group I, n=37), bilateral agenesis of the mandibular third molars (group II, n=19), and agenesis of all third molars (group III, n=12) as well as 33 subjects without third molar agenesis (group IV) were selected from the radiology archive. A before and after treatment orthopantomograph and the pretreatment cephalometric radiograph of the subjects were used. Several angular and linear parameters representing the anteroposterior dimensions and vertical growth pattern of the jaws were measured on cephalometric radiographs. The data were analyzed by Kolmogorov-Smirnov test, analysis of variance for 1 factor, and independent-samples t test. Statistical significance was set at p,0.05.Results:When the agenesis groups (groups I, II, and III) were compared with the control group, it was found that all parameters representing the anteroposterior dimensions of both jaws (A-Ptm, CoA, ANS-PNS, CoB, CoGn, CoPog, and ABRB) were significantly smaller in all agenesis groups (p,0.05). The parameters reflecting the vertical growth pattern did not represent any difference among the groups (p.0.05).Conclusion:In subjects with bilateral or total third molar agenesis, the anteroposterior dimensions of both jaws were smaller in comparison with subjects without tooth agenesis. Vertical growth pattern of the jaws did not differ among the groups

    Unravelling Guest Dynamics in Crystalline Molecular Organics Using 2 H Solid-State NMR and Molecular Dynamics Simulation

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    2H solid-state NMR and atomistic molecular dynamics (MD) simulations are used to understand the disorder of guest solvent molecules in two cocrystal solvates of the pharmaceutical furosemide. Traditional approaches to interpreting the NMR data fail to provide a coherent model of molecular behavior and indeed give misleading kinetic data. In contrast, the direct prediction of the NMR properties from MD simulation trajectories allows the NMR data to be correctly interpreted in terms of combined jump-type and libration-type motions. Time-independent component analysis of the MD trajectories provides additional insights, particularly for motions that are invisible to NMR. This allows a coherent picture of the dynamics of molecules restricted in molecular-sized cavities to be determined

    Unravelling guest dynamics in crystalline molecular organics using 2H solid-state NMR and molecular dynamics simulation

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    2H solid-state NMR and atomistic molecular dynamics (MD) simulations are used to understand the disorder of guest solvent molecules in two cocrystal solvates of the pharmaceutical furosemide. Traditional approaches to interpreting the NMR data fail to provide a coherent model of molecular behavior and indeed give misleading kinetic data. In contrast, the direct prediction of the NMR properties from MD simulation trajectories allows the NMR data to be correctly interpreted in terms of combined jump-type and libration-type motions. Time-independent component analysis of the MD trajectories provides additional insights, particularly for motions that are invisible to NMR. This allows a coherent picture of the dynamics of molecules restricted in molecular-sized cavities to be determined

    Genomic insights into the origin of farming in the ancient Near East

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    We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000 and 1,400 BC, from Natufian hunter–gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a ‘Basal Eurasian’ lineage that had little if any Neanderthal admixture and that separated from other non-African lineages before their separation from each other. The first farmers of the southern Levant (Israel and Jordan) and Zagros Mountains (Iran) were strongly genetically differentiated, and each descended from local hunter–gatherers. By the time of the Bronze Age, these two populations and Anatolian-related farmers had mixed with each other and with the hunter–gatherers of Europe to greatly reduce genetic differentiation. The impact of the Near Eastern farmers extended beyond the Near East: farmers related to those of Anatolia spread westward into Europe; farmers related to those of the Levant spread southward into East Africa; farmers related to those of Iran spread northward into the Eurasian steppe; and people related to both the early farmers of Iran and to the pastoralists of the Eurasian steppe spread eastward into South Asia

    Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

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    Comparison of two different IMRT planning techniques in the treatment of nasopharyngeal carcinoma Effect on parotid gland radiation doses

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    To compare the effect of two different intensity-modulated radiation therapy (IMRT) planning techniques on parotid gland doses in patients with nasopharyngeal carcinoma (NPC)
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