Heritage Matters- January 2007

INSIDE THIS ISSUE Conferences upcoming, p. 10 Grant applications, p. 11 Internships, p. 3 National Register listings, p. 5 Tribal Preservation Officer list, p. 9 CONTENTS NPS ACTIVITIES, pages 2-4 Inupiaq Heritage in Northwestern Alaska, p. 2 Cultural Resources Diversity Internship Program, p. 3 Historic Trees, the National Park Service, and History, p. 3 STATE INITIATIVES, pages 5-8 National Register Nominations, p. 5 • Ridge Trail Historic District, Walsh and Pembina Counties, North Dakota • Emery Hall, Wilberforce University, Green County, Ohio • Ponca Agency, Boyd County, Nebraska • Ohio Theatre, Toledo, Ohio • Hydaburg Totem Park, Hydaburg, Alaska • Sunrise Mine Historic District, eastern Wyoming • Pilsen Historic District, Chicago, Illinois TRIBAL INITIATIVES, pages 8-9 NAGPRA Develops New Outreach Initiatives, p. 8 Current THPO Listings, p. 9 CONFERENCES, ANNOUNCEMENTS, AND EVENTS, pages 10-11 Conferences, p. 10 Vernacular Architectural Forum Annual Meeting in Savannah, p. 10 Organization of American Historians Annual Meeting in Minneapolis, p. 10 US/ICOMOS International Symposium on Heritage Tourism in San Francisco, p. 10 Arkansas Historical Association Conference in Little Rock, p. 10 American Association of Museums Annual Meeting in Chicago, p. 11 National Trust for Historic Preservation National Preservation Conference in St. Paul, p. 11 Announcements, p. 11 Preserve America Grant Applications, p. 11 Save America’s Treasures Grant Applications, p. 11 Events, p. 11 Preservation-related Commemorations, p. 1

Heritage Matters- January 2007

INSIDE THIS ISSUE Conferences upcoming, p. 10 Grant applications, p. 11 Internships, p. 3 National Register listings, p. 5 Tribal Preservation Officer list, p. 9 CONTENTS NPS ACTIVITIES, pages 2-4 Inupiaq Heritage in Northwestern Alaska, p. 2 Cultural Resources Diversity Internship Program, p. 3 Historic Trees, the National Park Service, and History, p. 3 STATE INITIATIVES, pages 5-8 National Register Nominations, p. 5 • Ridge Trail Historic District, Walsh and Pembina Counties, North Dakota • Emery Hall, Wilberforce University, Green County, Ohio • Ponca Agency, Boyd County, Nebraska • Ohio Theatre, Toledo, Ohio • Hydaburg Totem Park, Hydaburg, Alaska • Sunrise Mine Historic District, eastern Wyoming • Pilsen Historic District, Chicago, Illinois TRIBAL INITIATIVES, pages 8-9 NAGPRA Develops New Outreach Initiatives, p. 8 Current THPO Listings, p. 9 CONFERENCES, ANNOUNCEMENTS, AND EVENTS, pages 10-11 Conferences, p. 10 Vernacular Architectural Forum Annual Meeting in Savannah, p. 10 Organization of American Historians Annual Meeting in Minneapolis, p. 10 US/ICOMOS International Symposium on Heritage Tourism in San Francisco, p. 10 Arkansas Historical Association Conference in Little Rock, p. 10 American Association of Museums Annual Meeting in Chicago, p. 11 National Trust for Historic Preservation National Preservation Conference in St. Paul, p. 11 Announcements, p. 11 Preserve America Grant Applications, p. 11 Save America’s Treasures Grant Applications, p. 11 Events, p. 11 Preservation-related Commemorations, p. 1

Heritage Matters- July 2005

INSIDE THIS ISSUE Conferences upcoming, p. 17 National Historic Landmark designations, p. 3 National Register nominations, p. 8 Publication of note, p. 18 CONTENTS NPS ACTIVITIES, pages 1–5 Cultures of a Country, p. 1 National Historic Landmarks designated, p. 3 Preserve and Play Conference, p. 4 PARTNERS’ ACTIVITIES, pages 6–7 Seminar, Public Meaning of Archeological Heritage, p. 6 AAM Annual Meeting 2005 report, p. 7 STATE ACTIVITIES, pages 8-15 National Register Nominations, p. 8 • Pascua Cultural Center, Tucson, Arizona • Town Doctor’s House and Site, Southold, New York • Louis J. Bailey Branch Library—Gary International Institute, Gary, Indiana • Our Savior’s Scandinavian Lutheran Church, Kenaston, North Dakota • B’nai Jacob Synagogue, Ottumna, Iowa • Whitepath and Fly Smith Gravesite, Hopkinsville, Kentucky • Winnemucca Hotel, Humboldt County, Nevada • Government Boarding School at Lac de Flambeau, Wisconsin • Ivey Delph Apartments, New York City • Edificio Patio Español, San Juan, Puerto Rico POINT OF VIEW, page 16 The Original Mason-Dixon Line, p. 16 CONFERENCES AND NOTICES, pages 17–19 Conferences, p. 17 • Multicultural Days: An International Perspective Conference, St. Catherines, Ontario, Canada • 5th International Conference on Diversity in Organizations, Communities and Nations, Bejing, China • 2005 Pecos Conference, White Rock, New Mexico • Graduate Association for African-American History at the University of Memphis, Memphis, Tennessee • SACRPH Biennial Conference, Coral Gables, Florida • American Studies Association Annual Conference, Washington, DC • Call for Papers: Mid-Atlantic Popular/American Culture Association Annual Conference, New Brunswick, New Jersey • Call for Papers: Association for Museum History Annual Conference, Washington, DC Notices, p. 18 Asian Reflections on the American Landscape Available Assistance Needed for Untold Stories and Unsung Heroes in the Making of the National Park

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions

Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images

Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups. In this study, 158 subjects (72 NC, 46 sMCI, and 40 cMCI) were selected from the Alzheimer's Disease Neuroimaging Initiative. A sparse-constrained regression model based on the l2-1-norm was introduced to reduce the feature dimensionality and retrieve essential features for the discrimination of the three groups by using a support vector machine (SVM). An optimized strategy of feature addition based on the weight of each feature was adopted for the SVM classifier in order to achieve the best classification performance. The baseline cortical features combined with the longitudinal measurements for 2 years of follow-up data yielded prominent classification results. In particular, the cortical thickness produced a classification with 98.84% accuracy, 97.5% sensitivity, and 100% specificity for the sMCI–cMCI comparison; 92.37% accuracy, 84.78% sensitivity, and 97.22% specificity for the cMCI–NC comparison; and 93.75% accuracy, 92.5% sensitivity, and 94.44% specificity for the sMCI–NC comparison. The best performances obtained by the SVM classifier using the essential features were 5–40% more than those using all of the retained features. The feasibility of the cortical features for the recognition of anatomical patterns was certified; thus, the proposed method has the potential to improve the clinical diagnosis of sub-types of MCI and predict the risk of its conversion to Alzheimer's disease

Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients

Recent developments of tau Positron Emission Tomography (PET) allows assessment of regional neurofibrillary tangles (NFTs) deposition in human brain. Among the tau PET molecular probes, 18F-AV1451 is characterized by high selectivity for pathologic tau aggregates over amyloid plaques, limited non-specific binding in white and gray matter, and confined off-target binding. The objectives of the study are (1) to quantitatively characterize regional brain tau deposition measured by 18F-AV1451 PET in cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD participants; (2) to evaluate the correlations between cerebrospinal fluid (CSF) biomarkers or Mini-Mental State Examination (MMSE) and 18F-AV1451 PET standardized uptake value ratio (SUVR); and (3) to evaluate the partial volume effects on 18F-AV1451 brain uptake.Methods: The study included total 115 participants (CN = 49, MCI = 58, and AD = 8) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Preprocessed 18F-AV1451 PET images, structural MRIs, and demographic and clinical assessments were downloaded from the ADNI database. A reblurred Van Cittertiteration method was used for voxelwise partial volume correction (PVC) on PET images. Structural MRIs were used for PET spatial normalization and region of interest (ROI) definition in standard space. The parametric images of 18F-AV1451 SUVR relative to cerebellum were calculated. The ROI SUVR measurements from PVC and non-PVC SUVR images were compared. The correlation between ROI 18F-AV1451 SUVR and the measurements of MMSE, CSF total tau (t-tau), and phosphorylated tau (p-tau) were also assessed.Results:18F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. Most regional SUVRs showed significantly higher uptake of 18F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups (p < 0.01). Although there was an increasing tendency of 18F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18F-AV1451 deposition was found between CN and MCI brains with or without PVC (p > 0.05). Declined MMSE score was observed with increasing 18F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform. CSF p-tau was positively correlated with 18F-AV1451 deposition. PVC improved the results of 18F-AV-1451 tau deposition and correlation studies in small brain regions.Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and these regions were strongly associated with cognitive impairment and CSF biomarkers. Although more deposition was observed in MCI group, the 18F-AV-1451 PET imaging could not differentiate the MCI patients from CN population. More tau deposition related to decreased MMSE score and increased level of CSF p-tau, especially in ROIs of amygdala, entorhinal cortex and parahippocampus. PVC did improve the results of tau deposition and correlation studies in small brain regions and suggest to be routinely used in 18F-AV1451 tau PET quantification

He Has Carried His Life in His Hands: The Sarasota Assassination Society of 1884

A front page headline in the New York Times in February 1885, announced: “The Bloody Work of Band of Southern Murderers . . . the notorious Sarasota Assassination Society.” The Times story reported that Alfred B. Bidwell, formerly of Buffalo, had been arrested for vigilantism in Florida: “This organization is supposed to exist for the purpose of the secret murder of political opponents, and is composed of 20 members, bound together by terrible oaths to perform the bloody work of the band and to keep its secrets inviolate. Mr. Bidwell is charged with making his store the rendezvous of the gang . . . [and] with being a party to the murder of C. E. Abbe. . . . The information received makes this assassination society one of the most atrocious organizations ever heard of. . . . The murder of one Riley several months ago . . . [is] said to be the work of the assassins. The victims are supposed to have suffered for private as well as political causes.

Heritage Matters- Spring 2009

In this Issue: Filipinos in Ellis Island Internships Provide Career Opportunities for Diverse Students New Courses on NAGPRA Available to Tribes and Museums Recent National Historic Landmark Designations Heritage Preservation Grants Allow DC Neighborhoods to Tell Their Stories National Register Nomination