Efficiency versus Effectiveness: The Teacher Versus the Computer in Classroom Education

This study presented the following hypothesis: H1 There is a significant difference in the performance of Business Computer Application students who are taught Word Processing by packaged tutorial software and Business Computer Application students who are taught Word Processing by teacher-assisted method as measured by Word Processing Unit Test

Overcoming hesitancy to submit manuscripts for peer review

Publishing completed research is essential for knowledge dissemination and career advancement, yet many academics experience submission anxiety. Reasons include fear of rejection, imposter syndrome, and perfectionism. This commentary reviews drivers of submission hesitancy and outlines evidence-based strategies to empower manuscript submission. Consequences of delays are detrimental for individual productivity and scientific progress. Indicators of unhelpful rumination during endless revisions include excessive time re-reviewing background literature or endlessly analyzing data. Plagiarism angst can also stall submission. Strategies to promote manuscript submission include setting readiness checklists and timeline goals, seeking mentor perspectives on drafts, forming peer writing groups for accountability, understanding text reuse conventions, viewing peer input as collaborative, and reframing rejection as an expected part of review. While incentives must be reformed, mindset shifts can initiate positive norms amid existing pressures. Scientists have a responsibility to disseminate timely research and can implement techniques to do so

Preparing First-Time Leaders for an Urban Public School District: An Action Research Study of a Collaborative District-University Partnership

This article reports the results for the first cycle of an action research study about a district-university partnership. Two district facilitators and two university facilitators co-constructed a principal preparation program for an innercity school district to help prepare the next generation of building leaders. Twenty-two students participated in the 15-month nontraditional program. The study found that in preparing first-time school leaders, the most helpful experiences were those that developed self-understanding and readiness for the role change. New instructional techniques and the full-time residency facilitated this learning. It also found that the partnership, though providing new and exciting opportunities to deviate from the traditional preparation model, needed further development

Functional Network Development During the First Year: Relative Sequence and Socioeconomic Correlations

The first postnatal year is characterized by the most dramatic functional network development of the human lifespan. Yet, the relative sequence of the maturation of different networks and the impact of socioeconomic status (SES) on their development during this critical period remains poorly characterized. Leveraging a large, normally developing infant sample with multiple longitudinal resting-state functional magnetic resonance imaging scans during the first year (N = 65, scanned every 3 months), we aimed to delineate the relative maturation sequence of 9 key brain functional networks and examine their SES correlations. Our results revealed a maturation sequence from primary sensorimotor/auditory to visual to attention/default-mode, and finally to executive control networks. Network-specific critical growth periods were also identified. Finally, marginally significant positive SES–brain correlations were observed at 6 months of age for both the sensorimotor and default-mode networks, indicating interesting SES effects on functional brain maturation. To the best of our knowledge, this is the first study delineating detailed longitudinal growth trajectories of all major functional networks during the first year of life and their SES correlations. Insights from this study not only improve our understanding of early brain development, but may also inform the critical periods for SES expression during infancy

A proposal for further developing fatigue-related post COVID-19 health states for burden of disease studies

Previous efforts to estimate the burden of fatigue-related symptoms due to long COVID have a very high threshold for inclusion of cases, relative to the proposed definition from the World Health Organization. In practice this means that milder cases, that may be occurring very frequently, are not included in estimates of the burden of long COVID which will result in underestimation. A more comprehensive approach to modelling the disease burden from long COVID, in relation to fatigue, can ensure that we do not only focus on what is easiest to measure; which risks losing focus of less severe health states that may be more difficult to measure but are occurring very frequently. Our proposed approach provides a means to better understand the scale of challenge from long COVID, for consideration when preventative and mitigative action is being planned

Feminist everyday political economy : space, time and violence

It goes without saying that feminist International Political Economy (IPE) is concerned in one way or another with the everyday – conceptualized as both a site of political struggle and a site within which social relations are (re)produced and governed. Given the long-standing grounding of feminist research in everyday gendered experiences, many would ask: Why do we need an explicit feminist theorization of the everyday? After all, notions of everyday life and everyday political struggle infuse feminist analysis. This paper seeks to interrogate the concept of the everyday – questioning prevalent understandings of the everyday and asking whether there is analytical and conceptual utility to be gained in articulating a specifically feminist understanding of it. We argue that a feminist political economy of the everyday can be developed in ways that push theorizations of social reproduction in new directions. We suggest that one way to do this is through the recognition that social reproduction is the everyday alongside a three-part theorization of space, time and violence (STV). It is an approach that we feel can play an important role in keeping IPE honest – that is, one that recognizes how important gendered structures of everyday power and agency are to the conduct of everyday life within global capitalism

Maintenance Cognitive Stimulation Therapy: An Economic Evaluation Within a Randomized Controlled Trial

Background Cognitive Stimulation Therapy (CST) is effective and cost-effective for people with mild-to-moderate dementia when delivered biweekly over 7 weeks. Aims To examine whether longer-term (maintenance) CST is cost-effective when added to usual care. Methods Cost-effectiveness analysis within multicenter, single-blind, pragmatic randomized controlled trial; subgroup analysis for people taking acetylcholinesterase inhibitors (ACHEIs). A total of 236 participants with mild-to-moderate dementia received CST for 7 weeks. They were randomized to either weekly maintenance CST added to usual care or usual care alone for 24 weeks. Results Although outcome gains were modest over 6 months, maintenance CST appeared cost-effective when looking at self-rated quality of life as primary outcome, and cognition (MMSE) and proxy-rated quality-adjusted life years as secondary outcomes. CST in combination with ACHEIs offered cost-effectiveness gains when outcome was measured as cognition. Conclusions Continuation of CST is likely to be cost-effective for people with mild-to-moderate dementia

Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomal formulation in patients with solid tumours

Background: This phase 1 study examined the safety, tolerability, pharmacokinetics and preliminary efficacy of eribulin-liposomal formulation (eribulin-LF) in patients with advanced solid tumours. Methods:\ud Eligible patients with ECOG PS 0–1 were treated with eribulin-LF either on day 1 every 21 days (Schedule 1), or on days 1 and 15 every 28 days (Schedule 2). Doses ranged from 1.0 to 3.5 mg/m2, with dose escalation in a 3 + 3 design. The dose-expansion phase evaluated eribulin-LF in select tumour types. Primary objectives: maximum tolerated dose (MTD) and the recommended dose/schedule of eribulin-LF. Results: Totally, 58 patients were enroled (median age = 62 years). The MTD was 1.4 mg/m2 (Schedule 1) or 1.5 mg/m2 (Schedule 2), the latter dose selected for the dose-expansion phase. Dose-limiting toxicity (DLTs) in Schedule 1: hypophosphatemia and increased transaminase levels. DLTs in Schedule 2: stomatitis, increased alanine aminotransferase, neutropenia and febrile neutropenia. The pharmacokinetic profile of eribulin-LF showed a similar half-life to that of eribulin (~30 h), but with a 5-fold greater maximum serum concentration and a 40-fold greater area-under-the-curve. Eribulin-LF demonstrated clinical activity with approximately 10% of patients in both schedules achieving partial responses. Conclusions: Eribulin-LF was well tolerated with a favourable pharmacokinetic profile. Preliminary evidence of clinical activity in solid tumours was observed

Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity

BACKGROUND: Biallelic variants in OGDHL, encoding part of the α-ketoglutarate dehydrogenase complex, have been associated with highly heterogeneous neurological and neurodevelopmental disorders. However, the validity of this association remains to be confirmed. A second OGDHL patient cohort was recruited to carefully assess the gene-disease relationship. METHODS: Using an unbiased genotype-first approach, we screened large, multiethnic aggregated sequencing datasets worldwide for biallelic OGDHL variants. We used CRISPR/Cas9 to generate zebrafish knockouts of ogdhl, ogdh paralogs, and dhtkd1 to investigate functional relationships and impact during development. Functional complementation with patient variant transcripts was conducted to systematically assess protein functionality as a readout for pathogenicity. RESULTS: A cohort of 14 individuals from 12 unrelated families exhibited highly variable clinical phenotypes, with the majority of them presenting at least one additional variant, potentially accounting for a blended phenotype and complicating phenotypic understanding. We also uncovered extreme clinical heterogeneity and high allele frequencies, occasionally incompatible with a fully penetrant recessive disorder. Human cDNA of previously described and new variants were tested in an ogdhl zebrafish knockout model, adding functional evidence for variant reclassification. We disclosed evidence of hypomorphic alleles as well as a loss-of-function variant without deleterious effects in zebrafish variant testing also showing discordant familial segregation, challenging the relationship of OGDHL as a conventional Mendelian gene. Going further, we uncovered evidence for a complex compensatory relationship among OGDH, OGDHL, and DHTKD1 isoenzymes that are associated with neurodevelopmental disorders and exhibit complex transcriptional compensation patterns with partial functional redundancy. CONCLUSIONS: Based on the results of genetic, clinical, and functional studies, we formed three hypotheses in which to frame observations: biallelic OGDHL variants lead to a highly variable monogenic disorder, variants in OGDHL are following a complex pattern of inheritance, or they may not be causative at all. Our study further highlights the continuing challenges of assessing the validity of reported disease-gene associations and effects of variants identified in these genes. This is particularly more complicated in making genetic diagnoses based on identification of variants in genes presenting a highly heterogenous phenotype such as "OGDHL-related disorders"