HASILTANGKAPANTERIPANG(Sea cucumber) DI PERAIRANKARANGSCOTTPULAUDATUAUSTRALIA

Perairan karang Scott (Scott Reef) yang terletak disekitar Pulau Datu berada di Perairan Laut Timor – Australia khususnya di lokasi MoU Box 74. Banyak nelayan tradisional Indonesia yang berasal dari Pulau Rote Alor dan Madura menangkap teripang di kawasan tersebut sebagai mata pencahariannya secara turun temurun. Suatu penelitian merupakan kerjasama antara Pemerintah Indonesia (Badan Penelitian dan Pengembangan Kelautan dan Perikanan) dan Pemerintah Australia (Australian Fisheries Management Autority) telah dilakukan pada bulan September 2008. Sebagai bagian dari penelitian tersebut, telah dilakukan pengamatan teripang yang mencakup aspek biologi (panjang, berat, identifikasi jenis) dan aspek penangkapan (hasil tangkapan, deskripsi perahu dan alat tangkap). Hasil penelitian teridentifikasi 20 jenis teripang yang ditangkap oleh 29 unit armada tangkap yang berasal dari Pulau Rote Alor dan Madura. Terdapat 5 jenis teripang yang dominan tertangkap dan mempunyai nilai ekonomis tinggi yaitu Holothuria nobilis, Stichopus chloronutus, Bohadschia argus, Bohadschia marmorata dan Bohadschia sp. Peralatan yang digunakan adalah pancing, lampu lentera, kacamata selam, tombak, dan keranjang penampung. Scott Reef or Datu Island waters was located in Timor Sea-Australian side, namely Mou Box 74. Since many years ago fishing activities had been going by Indonesian traditional fisherman from Rote Island Alor and Madura. The main fishing activities was to collect sea cucumber (“trepang”). The research was done a collaboration between The Agency for Marine and Fisheries Research and Development (AMFRD) Ministry of Marine Affairs and Fisheries and Australian Fisheries Management Authority (AFMA) in September 2008. Length and weight measurements, species identification were conducted for biological parameters and ( total catcth, boat description and type fishing gear for fisheries aspects). There were 20 species of sea cucumbers or trepang identified. That caught by 29 units of fishing boats in Datu Island came from Rote Island, Alor and Madura. The dominant species of Holothuria nobilis, Stichopus chloronutus, Bohadschia argus,  Bohadschia marmorata and Bohadschia sp have economically importen sea cucumbers. Fishing equipments, lantern lights, goggles, spears, and basket traps were used for collection of sea cucumbers

Cryogenic Orbital Test Bed 3 (CRYOTE3) Overview and Status

CRYOTE3 is a grassroots CFM test effort with contributing government and industry partners focused on developing and testing hardware to produce needed data for model validation and implementation into flight systems

From Sacred to Scientific: Epic Religion, Spectacular Science, and Charlton Heston’s Science Fiction Cinema

This paper analyses how long-1960s cinema responded to and framed public discourses surrounding religion and science. This approach allows for a discussion that extends beyond a critical study of the scholarly debates that surround the place of religion in science during a transitional period. Charlton Heston was an epic actor who went from literally playing God in The Ten Commandments (1956) to playing “god” as a messianic scientist in The Omega Man (1971). Best known for playing Moses, Heston became an unlikely science-based cinema star during the early 1970s. He was re-imagined as a scientist, but the religiosity of his established persona was inescapable. Heston and the science-based films he starred in capitalized upon the utopian promises of real science, and also the fears of the vocal activist counterculture. Planet of the Apes (1968), Omega Man (1971), Soylent Green (1973), and other science-based films made between 1968-1977 were bleak countercultural warnings about excessive consumerism, uncontrolled science, nuclear armament, irreversible environmental damage, and eventual human extinction. In this paper I argue that Heston’s transition from biblical epic star to science-fiction anti-hero represents the way in which the role and interpretation of science changed in post-classical cinema. Despite the shift from religious epic to science-based spectacle, religion remained a faithful component of Hollywood output indicating the ongoing connection between science and religion in US culture. I will consider the transition from sacred to science-based narratives and how religion was utilised across the production process of films that commented upon scientific advances

De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Callosum, Axon, Cardiac, Ocular, and Genital Defects

International audienceCadherins constitute a family of transmembrane proteins that mediate calcium-dependent cell-cell adhesion. The extracellular domain of cadherins consists of extracellular cadherin (EC) domains, separated by calcium binding sites. The EC interacts with other cadherin molecules in cis and in trans to mechanically hold apposing cell surfaces together. CDH2 encodes N-cadherin, whose essential roles in neural development include neuronal migration and axon pathfinding. However, CDH2 has not yet been linked to a Mendelian neurodevelopmental disorder. Here, we report de novo heterozygous pathogenic variants (seven missense, two frameshift) in CDH2 in nine individuals with a syndromic neurodevelopmental disorder characterized by global developmental delay and/or intellectual disability, variable axon pathfinding defects (corpus callosum agenesis or hypoplasia, mirror movements, Duane anomaly), and ocular, cardiac, and genital anomalies. All seven missense variants (c.1057G>A [p.Asp353Asn]; c.1789G>A [p.Asp597Asn]; c.1789G>T [p.Asp597Tyr]; c.1802A>C [p.Asn601Thr]; c.1839C>G [p.Cys613Trp]; c.1880A>G [p.Asp627Gly]; c.2027A>G [p.Tyr676Cys]) result in substitution of highly conserved residues, and six of seven cluster within EC domains 4 and 5. Four of the substitutions affect the calcium-binding site in the EC4-EC5 interdomain. We show that cells expressing these variants in the EC4-EC5 domains have a defect in cell-cell adhesion; this defect includes impaired binding in trans with N-cadherin-WT expressed on apposing cells. The two frameshift variants (c.2563_2564delCT [p.Leu855Valfs∗4]; c.2564_2567dupTGTT [p.Leu856Phefs∗5]) are predicted to lead to a truncated cytoplasmic domain. Our study demonstrates that de novo heterozygous variants in CDH2 impair the adhesive activity of N-cadherin, resulting in a multisystemic developmental disorder, that could be named ACOG syndrome (agenesis of corpus callosum, axon pathfinding, cardiac, ocular, and genital defects)

Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy

Mendelian etiologies for acute encephalopathies in previously healthy children are poorly understood, with the exception of RAN binding protein 2 (RANBP2)–associated acute necrotizing encephalopathy subtype 1 (ANE1). We provide clinical, genetic, and neuroradiological evidence that biallelic variants in ribonuclease inhibitor (RNH1) confer susceptibility to a distinctive ANE subtype. This study aimed to evaluate clinical data, neuroradiological studies, genomic sequencing, and protein immunoblotting results in 8 children from 4 families who experienced acute febrile encephalopathy. All 8 healthy children became acutely encephalopathic during a viral/febrile illness and received a variety of immune modulation treatments. Long-term outcomes varied from death to severe neurologic deficits to normal outcomes. The neuroradiological findings overlapped with ANE but had distinguishing features. All affected children had biallelic predicted damaging variants in RNH1: a subset that was studied had undetectable RNH1 protein. Incomplete penetrance of the RNH1 variants was evident in 1 family. Biallelic variants in RNH1 confer susceptibility to a subtype of ANE (ANE2) in previously healthy children. Intensive immunological treatments may alter outcomes. Genomic sequencing in children with unexplained acute febrile encephalopathy can detect underlying genetic etiologies, such as RNH1, and improve outcomes in the probands and at-risk siblings