Features of modelling dynamics for heating processes of cylindrical cast iron products in gas ovens

The process of heating the billets of rolling mills from cast iron in gas heating ovens (both in covalent and casting floors) has clear requirements for temperature heating regimes. Compliance with the requirements of technology is possible with the use of automatic control devices. Programmable logic controllers are commonly used as a temperature control device. Correct operation of automation is possible because of a definite model of the heating process dynamics

FEATURES OF MODELLING DYNAMICS FOR HEATING PROCESSES OF CYLINDRICAL CAST IRON PRODUCTS IN GAS OVENS

The process of heating the billets of rolling mills from cast iron in gas heating ovens (both in covalent and casting floors) has clear requirements for temperature heating regimes. Compliance with the requirements of technology is possible with the use of automatic control devices. Programmable logic controllers are commonly used as a temperature control device. Correct operation of automation is possible because of a definite model of the heating process dynamics

Ribonuclease binase apoptotic signature in leukemic Kasumi-1 cells

Cytotoxic exogenous RNases triggering apoptotic response in malignant cells have potential as anticancer drugs; surprisingly, detailed characterization of the RNase-induced apoptosis has not been conducted so far. Here we show that a cytotoxic RNase from Bacillus intermedius (binase) induces extrinsic and intrinsic apoptotic pathways in leukemic Kasumi-1 cells. The experiments were performed using TaqMan Array Human Apoptosis 96-well Plate for gene expression analysis, and flow cytometry. Cytometric studies demonstrated dissipation of the mitochondrial membrane potential, opening of mitochondrial permeability transition pores, activation of caspases, increase of intracellular Ca 2+ and decrease of reactive oxygen species levels. We found that expression of 62 apoptotic genes is up-regulated, including 16 genes that are highly up-regulated, and only one gene was found to be down-regulated. The highest, 16 fold increase of the expression level was observed for TNF gene. Highly up-regulated genes also include the non-canonical NF-κB signaling pathway and inflammatory caspases 1,4. The obtained results suggest that binase induces evolutionary acquired cellular response to a microbial agent and triggers unusual apoptosis pathway. © 2013 Elsevier Masson SAS. All rights reserved

Extracorporeal Membrane Oxygenation for Graft Dysfunction Early After Heart Transplantation: A Systematic Review and Meta-analysis

Introduction: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a prevailing option for the management of severe early graft dysfunction. This systematic review and individual patient data (IPD) meta-analysis aims to evaluate (1) mortality, (2) rates of major complications, (3) prognostic factors, and (4) the effect of different VA-ECMO strategies on outcomes in adult heart transplant (HT) recipients supported with VA-ECMO. Methods and Results: We conducted a systematic search and included studies of adults (≥18 years) who received VA-ECMO during their index hospitalization after HT and reported on mortality at any timepoint. We pooled data using random effects models. To identify prognostic factors, we analysed IPD using mixed effects logistic regression. We assessed the certainty in the evidence using the GRADE framework. We included 49 observational studies of 1477 patients who received VA-ECMO after HT, of which 15 studies provided IPD for 448 patients. There were no differences in mortality estimates between IPD and non-IPD studies. The short-term (30-day/in-hospital) mortality estimate was 33% (moderate certainty, 95% confidence interval [CI] 28%–39%) and 1-year mortality estimate 50% (moderate certainty, 95% CI 43%–57%). Recipient age (odds ratio 1.02, 95% CI 1.01–1.04) and prior sternotomy (OR 1.57, 95% CI 0.99–2.49) are associated with increased short-term mortality. There is low certainty evidence that early intraoperative cannulation and peripheral cannulation reduce the risk of short-term death. Conclusions: One-third of patients who receive VA-ECMO for early graft dysfunction do not survive 30 days or to hospital discharge, and one-half do not survive to 1 year after HT. Improving outcomes will require ongoing research focused on optimizing VA-ECMO strategies and care in the first year after HT

A summary of new predictive high frequency thermo-vibrational models in porous media

In this chapter, we consider the effect of mechanical vibration on the onset of convection in porous media. The porous media is saturated either by a pure fluid or by a binary mixture. The importance of transport model on stability diagrams are presented and discussed. The stability threshold for the Darcy-Brinkman case in the RaTc-R and kc-R diagrams are presented (where RaTc, kc and R are the critical Rayleigh number, the critical wave number and the vibration parameters respectively). It is shown that there is a significant deviation from the Darcy model. In the thermo-solutal case with the Soret effect, the influence of vibration on the reduction of multi-cellular convection is emphasized. A new analytical relation for obtaining the threshold of mono-cellular convection is derived. This relation shows how the separation factor Ψ is related to controlling parameters of the problem, Ψ = f (R, ε*, Le) when the wave number k -> 0. The importance of vibrational parameter definition is highlighted and it is shown how, by using a proper definition for vibrational parameter, we may obtain compact relationship. It is also shown how this result may be used to increase components separation

Возможности коррекции микробиоты ротоглотки и кишечника у детей природными средствами на основе экстрактов растений

The widespread use of antibacterial drugs for the treatment of respiratory diseases causes antimicrobial resistance in opportunistic microorganisms, which leads to the chronic forms of respiratory diseases and contributes to the risk of repeated respiratory infections. One of the new therapeutic solutions is the use of multicomponent water-soluble plant extracts. The goal of this study was to evaluate the antibacterial efficacy of the extracts of multicomponent herbal remedies versus the synthetic antiseptic for the treatment of the oropharyngeal and gut opportunistic microflora in children with chronic tonsillitis.In a retrospective study, we compared the effectiveness of the plant extract Tonzinal (experimental group, 100 patients) versus the Miramistin antiseptic agent (control group, 40 patients) for the treatment of chronic tonsillitis in children 5 to 15 years old using various treatment regimens.The oropharyngeal microbiocenosis was investigated by the bacteriological analysis of smears from the posterior wall of the pharynx and tonsils. Bacterial strains were isolated by inoculation on liquid agar media with the subsequent identification of Staphylococcus aureus, Streptococcus pyogenes, Candida spp., Moraxela cataralis, and Mycoplasma pneumonie according to the morphological and biochemical characteristics. For the bacteriological analysis of gut microbiocenosis, Staphylococcus aureus, Streptococcus spp., Candida spp., Klebsiella spp., Clostridiums spp., and Proteus spp. were isolated from the fecal filtrate and then identified by the same methods. The occurrence rate of microorganisms in patients of the experimental and control groups was compared before and after the 10-day course of therapy.A statistically significant decrease in the occurrence rate of Staphylococcus aureus (from 25% to 0%, p<0.01) and Candida spp. (from 18% to 0%, p<0.01) in the oropharynx of patients in the experimental group and from 20% to 7.5% and from 5% to 0% (p<0.05), respectively, in the control group was observed. A statistically significant decrease in the occurrence rate of Streptococcus pyogenes was only observed in the experimental group (from 30% to 0%, p<0.01). Treatment with Tonzinal or Miramistin did not lead to the statistically significant changes in the occurrence rate of opportunistic microorganisms in the gut microflora of the patients in both groups. Therefore, we have shown a higher antimicrobial efficacy of Tonzinal versus the Miramistin antiseptic for the treatment of the oropharyngeal opportunistic microorganisms in children with chronic tonsillitis.Широкое применение антибактериальных препаратов для лечения респираторных заболеваний формирует резистентность к антибиотикам у условно-патогенных микроорганизмов, что влечет за собой хронические формы респираторных заболеваний и способствует риску повторных респираторных инфекций. Одним из новых терапевтических решений может быть применение многокомпонентных фитопрепаратов в виде водорастворимых экстрактов. Цель данного исследования – оценить эффективность антибактериального действия экстрактов многокомпонентных фитопрепаратов на условно-патогенную микрофлору ротоглотки и  кишечника у детей с диагнозом «хронический тонзиллит» по  сравнению с синтетическим антисептиком.В ретроспективном исследовании мы провели сравнение фитопрепарата «Тонзинал» (опытная группа, 100 человек) с антисептическим средством «Мирамистин» (группа контроля, 40 человек), определяя эффективность различных схем лечения хронического тонзиллита у детей в возрасте от 5 до 15 лет. Микробиоценоз ротоглотки исследовали с помощью бактериологического анализа мазков с задней стенки глотки и миндалин. Штаммы микроорганизмов выделяли методом посева на жидкие агаризованные среды с последующей идентификацией Staphylococcus aureus, Streptococcus pyogenes, Candida spp., Moraxela cataralis, Mycoplasma pneumonie по морфологическим и биохимическим признакам. Для проведения бактериологического анализа микробиоценоза кишечника штаммы условно-патогенных микроорганизмов выделяли из копрофильтрата аналогичным способом и идентифицировали Staphylococcus aureus, Streptococcus spp., Candida spp., Klebsiella spp., Clostridiums spp., Proteus spp. Сравнивали частоту встречаемости микроорганизмов, имеющих показатели интенсивности обсемененности более 104  КОЕ/г, в опытной группе и группе контроля до начала лечения и после 10‑дневного курса терапии.После 10‑дневного курса терапии в  ротоглотке наблюдали статистически значимое снижение частоты встречаемости Staphylococcus aureus и Candida spp. в опытной группе с 25% до 0% и с 18% до 0% соответственно (p<0.01) и в группе контроля с 20% до 7.5% и с 5% до 0% соответственно (p<0.01). Частота встречаемости Streptococcus pyogenes статистически значимо снизилась только в опытной группе (с 30% до 0%, p<0.01). При исследовании кишечной микрофлоры статистически значимых изменений частоты встречаемости исследуемых бактерий в опытной группе и группе контроля после применения препаратов не выявлено. Таким образом, мы показали более высокую антимикробную эффективность «Тонзинала» в отношении условно-патогенных микроорганизмов ротоглотки по сравнению с антисептиком «Мирамистин» при хроническом тонзиллите у детей

Evidence for t\bar{t}\gamma Production and Measurement of \sigma_t\bar{t}\gamma / \sigma_t\bar{t}

Using data corresponding to 6.0/fb of ppbar collisions at sqrt(s) = 1.96 TeV collected by the CDF II detector, we present a cross section measurement of top-quark pair production with an additional radiated photon. The events are selected by looking for a lepton, a photon, significant transverse momentum imbalance, large total transverse energy, and three or more jets, with at least one identified as containing a b quark. The ttbar+photon sample requires the photon to have 10 GeV or more of transverse energy, and to be in the central region. Using an event selection optimized for the ttbar+photon candidate sample we measure the production cross section of, and the ratio of cross sections of the two samples. Control samples in the dilepton+photon and lepton+photon+\met, channels are constructed to aid in decay product identification and background measurements. We observe 30 ttbar+photon candidate events compared to the standard model expectation of 26.9 +/- 3.4 events. We measure the ttbar+photon cross section to be 0.18+0.08 pb, and the ratio of the cross section of ttbar+photon to ttbar to be 0.024 +/- 0.009. Assuming no ttbar+photon production, we observe a probability of 0.0015 of the background events alone producing 30 events or more, corresponding to 3.0 standard deviations.Comment: 9 pages, 3 figure

Precision Top-Quark Mass Measurements at CDF

We present a precision measurement of the top-quark mass using the full sample of Tevatron $\sqrt{s}=1.96$ TeV proton-antiproton collisions collected by the CDF II detector, corresponding to an integrated luminosity of 8.7 $fb^{-1}$. Using a sample of $t\bar{t}$ candidate events decaying into the lepton+jets channel, we obtain distributions of the top-quark masses and the invariant mass of two jets from the $W$ boson decays from data. We then compare these distributions to templates derived from signal and background samples to extract the top-quark mass and the energy scale of the calorimeter jets with {\it in situ} calibration. The likelihood fit of the templates from signal and background events to the data yields the single most-precise measurement of the top-quark mass, \mtop = 172.85 \pm$0.71 (stat)$\pm$0.85 (syst) GeV/c^{2}.$Comment: submitted to Phys. Rev. Let

A search for resonant production of ttˉt\bar{t} pairs in $4.8\ \rm{fb}^{-1}ofintegratedluminosityof of integrated luminosity of p\bar{p}collisionsat collisions at \sqrt{s}=1.96\ \rm{TeV}$

We search for resonant production of tt pairs in 4.8 fb^{-1} integrated luminosity of ppbar collision data at sqrt{s}=1.96 TeV in the lepton+jets decay channel, where one top quark decays leptonically and the other hadronically. A matrix element reconstruction technique is used; for each event a probability density function (pdf) of the ttbar candidate invariant mass is sampled. These pdfs are used to construct a likelihood function, whereby the cross section for resonant ttbar production is estimated, given a hypothetical resonance mass and width. The data indicate no evidence of resonant production of ttbar pairs. A benchmark model of leptophobic Z \rightarrow ttbar is excluded with m_{Z'} < 900 GeV at 95% confidence level.Comment: accepted for publication in Physical Review D Sep 21, 201