Increased social anhedonia and reduced helping behaviour in young people with high depressive symptomatology

Background: Social anhedonia, the decreased enjoyment of pleasant social experiences, is associated with depression. However, whether social anhedonia in depression affects prosocial behaviours is unclear. The current study aimed to examine how high levels of depressive symptomatology in young people affect responses to usually rewarding social situations including helping behaviour. Methods: We recruited 46 females, 16 scoring high on the Beck Depression Inventory (BDI scores ≥ 20; Mage = 19; HD) and 30 scoring low (BDI ≤ 10, Mage = 20; LD). In a social emotion task (SET), participants were presented with social scenarios and asked to rate their expected emotional responses. Subsequently, participants’ helping behaviour was measured by dropping a pile of papers near them and recording their responses. Lastly, participants completed the SET again. Results: The SET at time 1 revealed that HD individuals reported significantly stronger negative (p <.001) and weaker positive (p <.05) emotional responses to social situations than LD subjects. Additionally, all participants showed a significant increase in positive responses (p <.05) on the SET between time 1 and time 2. Moreover, HD subjects were less likely to engage in actual helping behaviour than LD participants. Limitations: Limitations of the study are that only females were tested and that no psychiatric screening interview was conducted. Conclusions: Our results indicate that young females with high levels of depression symptoms expect to respond less positively to social situations and engage less in helping behaviour compared to those with low depressive symptomatology. Social anhedonia in depression may thus contribute to decreased engagement in rewarding social situations. This, in turn, may lead to social withdrawal and might maintain depression symptoms though a lack of exposure to positive social feedback

Investigating the Link Between Liking Versus Wanting Self‐Esteem and Depression in a Nationally Representative Sample of A merican Adults

The self‐esteem movement has been around since the 1970s, and may have influenced how much value people place on self‐esteem. We predicted a negative relationship between age and the amount of value placed on self‐esteem boosts. We also investigated the correlates of liking versus wanting self‐esteem boosts (and other pleasant rewards) on depression. A nationally representative sample of American adults ( N  = 867) indicated how much they liked and wanted several pleasant rewards (i.e., sex, food, alcohol, money, friendship, self‐esteem boost). They also completed a standardized measure of depressive symptoms. As expected, there was a negative relationship between age and valuing self‐esteem boosts, sex, and alcohol. People with depressive symptoms wanted self‐esteem boosts, even though they did not like them very much. Similar effects were obtained for depressive symptoms and alcohol and friendship. This is the first research to show that self‐esteem boosts are more valued among a nationally representative sample of younger A merican adults. It also is the first research to explore the association between depression and the motivation to boost self‐esteem. People with depressive symptoms want self‐esteem, and may pursue it, but this pursuit may feel unrewarding because they do not derive pleasure from it.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93721/1/jopy781.pd

Mouse psychosocial stress reduces motivation and cognitive function in operant reward tests:A model for reward pathology with effects of agomelatine

A major domain of depression is decreased motivation for reward. Translational automated tests can be applied in humans and animals to study operant reward behaviour, aetio-pathophysiology underlying deficits therein, and effects of antidepressant treatment. Three inter-related experiments were conducted to investigate depression-relevant effects of chronic psychosocial stress on operant behaviour in mice. (A) Non-manipulated mice were trained on a complex reversal learning (CRL) test with sucrose reinforcement; relative to vehicle (VEH), acute antidepressant agomelatine (AGO, 25mg/kg p.o.) increased reversals. (B) Mice underwent chronic social defeat (CSD) or control handling (CON) on days 1-15, and were administered AGO or VEH on days 10-22. In a progressive ratio schedule motivation test for sucrose on day 15, CSD mice made fewer responses; AGO tended to reverse this effect. In a CRL test on day 22, CSD mice completed fewer reversals; AGO tended to increase reversals in CSD mice associated with an adaptive increase in perseveration. (C) Mice with continuous operant access to water and saccharin solution in the home cage were exposed to CSD or CON; CSD mice made fewer responses for saccharin and water and drank less saccharin in the active period, and drank more water in the inactive period. In a separate CSD cohort, repeated AGO was without effect on these home cage operant and consummatory changes. Overall, this study demonstrates that psychosocial stress in mice leads to depression-relevant decreases in motivation and cognition in operant reward tests; partial reversal of these deficits by AGO provides evidence for predictive validity

Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression

Adolescence is a period of change that crucially increases vulnerability to depression. Studies report blunted neural responses to reward that relate to positive affect and depression symptoms in adolescents. However how these results relate to the symptom of anhedonia in adolescents is not entirely clear. Anhedonia is not a unitary construct, but is described as having different processes (e.g. wanting vs. liking) each underpinned by different neurobiological pathways. Current studies report inconsistencies in findings when trying to relate reward processing at the behavioural and neural level with symptoms. One reason for this is the lack of specificity of clinical, behavioural and neural tasks for measuring reward in depression. Links between the experience of anhedonia in adolescent depression and the behavioural and neural measures of reward could be improved with more detailed questionnaires, more detailed measurements of the components of reward for e.g. decreased motivation/effort and more ecologically valid tasks relevant to adolescents, in the MRI scanner

Upregulating the positive affect system in anxiety and depression: Outcomes of a positive activity intervention

BackgroundResearch suggests that the positive affect system may be an important yet underexplored treatment target in anxiety and depression. Existing interventions primarily target the negative affect system, yielding modest effects on measures of positive emotions and associated outcomes (e.g., psychological well-being). The objective of the present pilot study was to evaluate the efficacy of a new transdiagnostic positive activity intervention (PAI) for anxiety and depression.MethodTwenty-nine treatment-seeking individuals presenting with clinically impairing symptoms of anxiety and/or depression were randomly allocated to a 10-session protocol comprised of PAIs previously shown in nonclinical samples to improve positive thinking, emotions, and behaviors (e.g., gratitude, acts of kindness, optimism; n = 16) or a waitlist (WL) condition (n = 13). Participants were assessed at pre- and posttreatment, as well as 3- and 6-month follow-up, on measures of positive and negative affect, symptoms, and psychological well-being. ClinicalTrials.gov Identifier: NCT02330627 RESULTS: The PAI group displayed significantly larger improvements in positive affect and psychological well-being from pre- to posttreatment compared to WL. Posttreatment and follow-up scores in the PAI group were comparable to general population norms. The PAI regimen also resulted in significantly larger reductions in negative affect, as well as anxiety and depression symptoms, compared to WL. Improvements across all outcomes were large in magnitude and maintained over a 6-month follow-up period.ConclusionsTargeting the positive affect system through a multicomponent PAI regimen may be beneficial for generating improvements in positive emotions and well-being, as well as reducing negative affect and symptoms, in individuals with clinically impairing anxiety or depression