99 research outputs found
Study of microRNAs-21/221 as potential breast cancer biomarkers in Egyptian women
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/01/2016
- Field of study
microRNAs (miRNAs) play an important role in cancer prognosis. They are small molecules, approximately 17–25 nucleotides in length, and their high stability in human serum supports their use as novel diagnostic biomarkers of cancer and other pathological conditions. In this study, we analyzed the expression patterns of miR-21 and miR-221 in the serum from a total of 100 Egyptian female subjects with breast cancer, fibroadenoma, and healthy control subjects. Using microarray-based expression profiling followed by real-time polymerase chain reaction validation, we compared the levels of the two circulating miRNAs in the serum of patients with breast cancer (n = 50), fibroadenoma (n = 25), and healthy controls (n = 25). The miRNA SNORD68 was chosen as the housekeeping endogenous control. We found that the serum levels of miR-21 and miR-221 were significantly overexpressed in breast cancer patients compared to normal controls and fibroadenoma patients. Receiver Operating Characteristic (ROC) curve analysis revealed that miR-21 has greater potential in discriminating between breast cancer patients and the control group, while miR-221 has greater potential in discriminating between breast cancer and fibroadenoma patients. Classification models using k-Nearest Neighbor (kNN), Naïve Bayes (NB), and Random Forests (RF) were developed using expression levels of both miR-21 and miR-221. Best classification performance was achieved by NB Classification models, reaching 91% of correct classification. Furthermore, relative miR-221 expression was associated with histological tumor grades. Therefore, it may be concluded that both miR-21 and miR-221 can be used to differentiate between breast cancer patients and healthy controls, but that the diagnostic accuracy of serum miR-21 is superior to miR-221 for breast cancer prediction. miR-221 has more diagnostic power in discriminating between breast cancer and fibroadenoma patients. The overexpression of miR-221 has been associated with the breast cancer grade. We also demonstrated that the combined expression of miR-21 and miR-221can be successfully applied as breast cancer biomarkers
Increased myeloperoxidase activity as an indicator of neutrophil-induced inflammation and sepsis in neonates
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 31/05/2016
- Field of study
Background: MPO is an enzyme that contains heme secreted by phagocytic cells after the respiratory burst system activation. MPO is expressed mainly by neutrophils and monocytes in small quantities and it is very important to determine further process of hydrogen peroxide.Objective: to evaluate neutrophils activation and the MPO enzyme activity in plasma as an indicator of sepsis as well as sepsis severity in neonates with sepsis with correlation to their clinical and laboratory findings.Methods: were classified into 2 groups: sepsis group: included 45 neonates with gestational ages 28-40 weeks with sepsis, 15 of them had been subjected to follow up samples, control group: included 30 neonates proved to be free of sepsis. All neonates were subjected to history taking, clinical examination and measurement of plasma MPO enzyme.Results: this study revealed that MPO activity and neutrophil cell count are increased in sepsis group compared to the non-septic neonates. The ROC curve showed that the best cut off for MPO in prediction of septic patients and mortality was found >54 mu/ml and >83 mu/ml respectively. There was positive correlation between MPO enzyme activity and the total leukocyte count and neutrophil count. By following up some of sepsis group neonates there was significant decrease in MPO activity goes along with improvement in clinical state of neonates with sepsis. MPO enzyme activity was found to be low in septic shock patients who also have pancytopenia compared to septic patients without shock.Conclusion: plasma MPO enzyme proved to be a good marker of sepsis in neonates, with a good prognostic value in severe cases.Keywords: MPO, inflammatory response, neonates, sepsi
Cell-Type Specific Roles for PTEN in Establishing a Functional Retinal Architecture
- Author
- Publication venue
- Publication date
- 01/01/2012
- Field of study
BACKGROUND: The retina has a unique three-dimensional architecture, the precise organization of which allows for complete sampling of the visual field. Along the radial or apicobasal axis, retinal neurons and their dendritic and axonal arbors are segregated into layers, while perpendicular to this axis, in the tangential plane, four of the six neuronal types form patterned cellular arrays, or mosaics. Currently, the molecular cues that control retinal cell positioning are not well-understood, especially those that operate in the tangential plane. Here we investigated the role of the PTEN phosphatase in establishing a functional retinal architecture. METHODOLOGY/PRINCIPAL FINDINGS: In the developing retina, PTEN was localized preferentially to ganglion, amacrine and horizontal cells, whose somata are distributed in mosaic patterns in the tangential plane. Generation of a retina-specific Pten knock-out resulted in retinal ganglion, amacrine and horizontal cell hypertrophy, and expansion of the inner plexiform layer. The spacing of Pten mutant mosaic populations was also aberrant, as were the arborization and fasciculation patterns of their processes, displaying cell type-specific defects in the radial and tangential dimensions. Irregular oscillatory potentials were also observed in Pten mutant electroretinograms, indicative of asynchronous amacrine cell firing. Furthermore, while Pten mutant RGC axons targeted appropriate brain regions, optokinetic spatial acuity was reduced in Pten mutant animals. Finally, while some features of the Pten mutant retina appeared similar to those reported in Dscam-mutant mice, PTEN expression and activity were normal in the absence of Dscam. CONCLUSIONS/SIGNIFICANCE: We conclude that Pten regulates somal positioning and neurite arborization patterns of a subset of retinal cells that form mosaics, likely functioning independently of Dscam, at least during the embryonic period. Our findings thus reveal an unexpected level of cellular specificity for the multi-purpose phosphatase, and identify Pten as an integral component of a novel cell positioning pathway in the retina
BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways
- Author
- Abdalah Mohamed
- Abdallah Kishk
- Abdullah Samy
- Adel Abdelkhalek
- Ahmed Hamed Arisha
- Ahmed Hamed Arisha
- Ahmed Said
- Asma Alanazi
- Asma Alanazi
- Ateya Khafaga
- Eman Said Amer
- Emil Tîrziu
- Eyad Sarhan
- Hamdy Yehia
- Hisham Mohamed
- Hussein Abdellatif
- Hussein Abdellatif
- Iulia Maria Bucur
- Judy Wael
- Kerolos Wagdy
- Linda Saweres
- Maria Hanna
- Mohamed Reda
- Mohammed Alassiri
- Mohammed Alassiri
- Mohammed Alassiri
- Nourelden Dwidar
- Rama Ahmed
- Rawan Eltahan
- Rowina Elgarhy
- Sara Elkomy
- Tarek Khamis
- Tarek Ragab
- Youliana Shaker
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/11/2023
- Field of study
Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a promising option to mitigate several diabetic complications.Methods: In this study, we evaluated the therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) in a rat model of STZ-induced DN. After the confirmation of diabetes, rats were treated with BM-MSCs and sacrificed at week 12 after treatment.Results: Our results showed that STZ-induced DN rats had extensive histopathological changes, significant upregulation in mRNA expression of renal apoptotic markers, ER stress markers, inflammatory markers, fibronectin, and intermediate filament proteins, and reduction of positive immunostaining of PCNA and elevated P53 in kidney tissue compared to the control group. BM-MSC therapy significantly improved renal histopathological changes, reduced renal apoptosis, ER stress, inflammation, and intermediate filament proteins, as well as increased positive immunostaining of PCNA and reduced P53 in renal tissue compared to the STZ-induced DN group.Conclusion: In conclusion, our study indicates that BM-MSCs may have therapeutic potential for the treatment of DN and provide important insights into their potential use as a novel therapeutic approach for DN
Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study
- Author
- A Abdullah
- A Al-Serri
- A Ali
- A Muthumala
- A Ulu
- AA Settin
- AM Sarry El-Din
- B Afsar
- CU Chae
- D Schleinitz
- DN Meroufel
- EM Al-Harbi
- F Galletti
- GH Goossens
- HA Sliem
- HN Chmaisse
- I Arfa
- K Masuo
- KK Alharbi
- M Akra-Ismail
- M Keskin
- MA Abolfotouh
- MA El-Hazmi
- N Zawilla
- Nancy M. Ahmed
- Nancy N. Shahin
- NS Kalupahana
- Olfat G. Shaker
- P Deurenberg
- PM Frossard
- RA Ramadan
- S Mehri
- S Mehri
- T Baroudi
- Tarek K. Motawi
- TG Pickering
- WA Zarouk
- WHO
- YB Saab
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
- Alamoudi U
- Albeladi B
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alfarsi MA
- Alghamdi B
- Alghamdi M
- Algohary O
- Alhabli I
- Alhendy M
- Ali A
- Ali A
- Ali H
- Ali SS
- Alimi Q
- Aljiffry M
- Aljohani E
- Aljohani S
- Alkammash A
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnawam E
- Alnuqaydan SA
- Alomar IN
- Alqahtani E
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Altaf A
- Altamimi A
- Althwainy A
- Altoe F
- Altwigry AM
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alwafai MG
- Aly AK
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzayat T
- Amandito R
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin J
- Ammar M
- Ammar MS
- Amreia M
- Anandkumar D
- Anderson D
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- Andres Garcia-Marin J
- Ansaloni L
- Antar S
- Anthoulakis C
- Anwar AW
- Anwer W
- Anyanwu L-J
- Aql S
- Arachchi PP
- Arachchige LAJJ
- Aranzabal Durand SY
- Araujo R
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arnaud AP
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- Arroyo Basto CA
- Arulampalam T
- Asal M
- Asele FA
- Ashraf SF
- Ashton A
- Assouto PA
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- Attallah NA
- Attard M
- Attia AM
- Aung KP
- Austraite A
- Awuku-Asabre J
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- Ayandipo OO
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- Azmitia Mendizabal CA
- Azodo IA
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- Badwi NM
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- Baldacchino M
- Balila RMH
- Balkan AZA
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- Barnacle J
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- Barrionuevo Ojeda RR
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- Beyene R
- Bezerra Morais PA
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- Bharj IS
- Bhat S
- Bhattacharya S
- Bhopal KF
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- Bjorklund I
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- Boal M
- Boddy A
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- Boshnaq M
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- Bradulskis S
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- Browning DRL
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- Camilleri-Brennan JF
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- Cengiz Y
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- Chapman A
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- Chen CY
- Chen JHC
- Chenn R
- Chew LS
- Chhabra S
- Chidambaram S
- Chiu S
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- Chong BFHK
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- Clements JM
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- Contreras Merida SM
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- Contreras Vergara AL
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- Dawnay G
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- dos Santos DV
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- Drake TM
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- Dwydar A
- Ebdewi H
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- Eisner L
- El Ashal G
- El Deen KN
- El Gendy A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Hamouly AS
- El-Kashef H
- El-Ma'doul AS
- El-Rabaa S
- El-Shahat NS
- El-Sheemy H
- Elabdin HZ
- Elashmawy M
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbatahgy A
- Elbermawy M
- Eldamaty L
- Elebute O
- Elena G
- Elfeki H
- Elfil M
- Elfouly N
- Elfouly Y
- Elgebaly A
- Elgendy FI
- Elhendawy AOA
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkhadrawi M
- Elkholy A
- Elkolaly SS
- Elkorashy AM
- Elmelegy R
- Elnemr AE
- Elsawahly DME
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elshaer K
- Elshaer M
- Elshafay AE
- Elshanwany S
- Elsheikh S
- Elsherbiny AS
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Escobar EG
- Estupinian S
- Etchill E
- Etman M
- Eysa A
- Eyssartier E
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- Fadel A
- Fahiem A
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fakher R
- Farah A
- Faraz A
- Farhad M
- Farinella E
- Farooq T
- Farquharson A
- Fattah AA
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- Fawzy A
- Felipe CO
- Fergusson S
- Fergusson SJ
- Fermani C
- Fernandez-Bueno F
- Fievet L
- Findlay-Cooper K
- Firdouse M
- Fitzgerald JEF
- Forno W
- Fouad A
- Fouad D
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- Fraga GP
- Francois-Coridon H
- Freitas AV
- Frisk B
- Fujii F
- Furqan MM
- Gadhvi V
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- Vlachogiorgos A
- Wagener M
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- Yallop L
- Yaseen T
- Yaseen TM
- Yavuz MA
- Yee J
- Yeo LS
- Yeung ENW
- Yong CO
- Youssef D
- Youssef H
- Youssif JH
- Zachariades D-C
- Zakir M
- Zalabia MF
- Zamarin K
- Zani A
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zhang Z
- Zheng F
- Zidan H
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- Zil-E-Ali A
- Zilinskas J
- Zilinskiene R
- Zimmermann EF
- Zuber M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey
- Author
- Abbas Ahmed Hosam Eldin Hasan
- Abbas Ghanem
- Abbas Hazem
- Abbatini Francesca
- Abdalbakheet Duaa
- Abdallah Emad
- Abdelazim Tarek
- Abdelaziz Nabil Yassin Tammam
- Abdelglil Momen
- Abdelhalim Ahmed
- Abdelhalim Mostafa Mohammed
- Abdelhamid Ahmed
- Abdelhamid Mohamed Sayed
- Abdelkhalik Morsi Mohamed Morsi
- Abdellatif Ahmed
- Abdelmageed Mohammed Elkassaby
- Abdelmaksoud Mohamed
- Abdelmohsen Ahmed
- Abdelmomen Ahmed Ezzat Elghrieb
- Abdelmoneim Ibrahim Tharwat Mohamed
- Abdelmonem Mohamed Ahmed
- Abdelmotaleb Hussien Ali
- Abdelrafee Ahmed
- Abdelrasheed Sayed
- Abdelsayed Emad Fahim
- Abdo Nael
- Abdulatef Shehab Ahmed Ali
- Abdullah Alqahtani Ali
- Abdulrahman Chadi
- Abdur-Rahman Lukman
- Abduraboh Abdullah Fayez
- Abed Ali Ibrahim Eldawy
- Abiodun Azeez Lateef
- Abiyere Henry
- Aboelmagid Hamdy Haggag Ebrahim
- Abolnasr Khaled Samir
- Abosi-Appeadu Kessewa
- Abouelnagah Galal
- Abozeid Ahmad Mahmoud
- Abozeid Mahmoud
- Abualkhair Wael
- Abualnaja Yousra
- Abualsel Abdulmenem
- Abuosba Abdelrahman
- Abusalem Osama
- Abusiam Wael
- Abutalib Raid Abdullah
- Abuzeid Mohamed Mostafa
- Addari Giulio
- Adebowale Yusuf
- Adejumo Adeyinka
- Adel Mohammed
- Adeoluwa Ojajuni
- Adeyeye Ademola
- Adly Ramy Magdy
- Adorisio Ottavio
- Agbonrofo Peter
- Agrawal Abhishek
- Ahmad Farooq
- Ahmad Misbahu Haruna
- Ahmad Mustafa
- Ahmad Sufian
- Ahmad Suhaib
- Ahmed Abeer Abdul Hameed
- Ahmed Arooj
- Ahmed Emad Ali
- Ahmed Hassan
- Ahmed Mohamed
- Ahmed Mostafa Mahmoud
- Aitali Abdelmounaim
- Akeel Nouf
- Akhtar Khalid
- Akin Furkan Atakan
- Akinmade Akinola
- Al Eisa Abdulmohsen
- Al Hassn Ibrahim
- Al Naeb Mohamed
- Al Turki Neamat Ahmed Ali
- Al-Bahrani Ahmed
- Al-Kubati Waheeb
- Al-Masari Hayder Makki
- Al-Sadery Humood
- Alaa Mohammed
- Alabbas Haytham
- Alafghani Haitham
- Alarabi Rayan
- Alawadhi Abdulbari Mohammed
- Alawady Mohammed
- Alawfi Homoud
- Alazzam Saleh
- Albadry Ali Almahdy Ali
- Albahooth Khalid
- Albalawi Ibrahim Altedlawi
- Albeshri Khalid A.
- Aleksandr Ogoreltsev
- Alfalah Haitham
- Algatanesh Nassib
- Alghamdi Faisal Saleh
- Alghamdi Saleh
- Alghuliga Abdullah
- Alhamdany Arkan Shubber
- Alharbi Abdulhamid
- Alhazmi Barrag
- Alhazmi Waleed
- Alhedaithy Alhanouf
- Alhendawey Moaaz
- Alhussaini Mohammed Khalid
- Alhussien Fade Ahmed
- Ali Ali Sayed
- Ali Bandar Idrees A.
- Ali Doaa
- Ali Mahmoud
- Ali Mohamed Anwar Abdel Razik
- Ali Muhammad Zulfiqar
- Ali Shabeer
- Ali Syed Muhammad
- Aliyu Yakubu
- Aljathlany Yousef
- Aljawhari Adel Ali
- Alkhalegy Ayman
- Alkhayat Ali
- Alkhayat Mohammed Amer
- Allaeys Mathias
- Almaghrabi Alhassan Hesham
- Almasri Mahmoud
- Almulhim Abdulrhman
- Alnabarawi Mahmoud
- Alnahas Yousef
- Alnashar Ahmed
- Alnoqaidan Emad
- Alomieri Adil
- Alotaibi Abdullah
- Alotaibi Abdulrahman
- Alotaibi Abdulrahman
- Alowairdhi Tumadher
- Alqarni Ahmed
- Alqasaby Abdallah
- Alqudaihi Heba
- Alrashidi Yousef
- Alsallum Ofays
- Alsawat Salem
- Alshabi Yaser Ahmad
- Alshehari Mohammed Mohammed Hasan
- Alshukr Sarah
- Alsuwaimel Munir A.
- Althobaiti Majid
- Althumali Abdullah
- Altomare Donato F.
- Alvarez Gallesio José Maria
- Alwan Ahmed
- Alwusaibie Ahmed
- Alyami Mohammad
- Alzahrani Khalid H.
- Alzahrani Saud
- Alzamanan Mahdi
- Alzamel Heythem
- Amal Benzakour
- Amary Mohamed Mokhtar
- Amen Mohamed Mohsen
- Amer Nasser Mohammed
- Amir Mohammed
- Amr Wesam
- Andrea Chierici
- Andrea Police
- Andriola Valeria
- Angrisani Marco
- Angulo Victor Manuel Pinto
- Antonio D’Alessandro
- Anwer Mariyah
- Aoun Rany
- Arbutina Dragana
- Archid Rami
- Aremu Isiaka
- Argenio Giulio
- Arnold Marion
- Arnouse Mohamed Mohamed Hamdy
- Asar Khalid Mohammad Ibrahim
- Ashimov Erkin
- Ashraf Tamer
- Asif Muhammad
- Aslam Mohammad
- Ateeb Mujammad
- Atef Gehad
- Atici Semra Demirli
- Attia Ahmed Mohamed
- Ayoub Larissa
- Azer Mina
- Aziz Mina
- Aziz Muhammad Akram Abdul
- Ba Mamadou
- Bacher Annica
- Bafaraj Ahmed
- Bagaglini Giulia
- Balla Andrea
- Barbary Hesham
- Barberis Andrea
- Barbon Carlotta
- Basendowah Mohammed
- Bashah Moataz M.
- Bashir Umar
- Bashlachev Andrey
- Bassuni Majid
- Bàmbina Fabrizio
- Bellato Vittoria
- Belli Andrea
- Bensaad Ahmed
- Berchtold Valeria
- Bernante Paolo
- Bertels Laurie
- Beshir Hatem
- Bhatt Nikita
- Bogdan Stoica
- Bonci Eduard-Alexandru
- Borasi Andrea
- Botros Ibram
- Botteri Emanuele
- Bouchrika Amal
- Boukorou Garyfallia
- Brahmachari Swagata
- Bruzzaniti Placido
- Calik Bulent
- Calvo Mikel Prieto
- Campagnaro Tommaso
- Campanelli Michela
- Campennì Paola
- Canfora Alfonso
- Capizzi Vita
- Carrano Francesco Maria
- Castaldi Antonio
- Cavallaro Giuseppe
- Chacón Mario Franco
- Charalabopoulos Alexandros
- Cherfa Harieche Abdennour Abderahim
- Chiarella Vito
- Chipaila Jackson
- Cianci Pasquale
- Cillara Nicola
- Cirillo Bruno
- Ciubotaru Cezar
- Colás-Ruiz Enrique
- Colleoni Ramiro
- Colombo Francesco
- Coniglio Denise
- Costanzo Federico
- Cuk Vladica
- Curtis Nathan
- Dagorno Claire
- Daibes Adel Goda Hussein
- Danilov Michail
- Dare Julius Kolajo
- Daudi Irfan
- Davies Justin
- Dawdi Salahaldeen
- De Falco Nadia
- De Fatico GSerena
- De La Hermosa Alicia Ruiz
- De Lucia Francesca
- De Sousa Xavier
- Del Muslim Ka
- Demeester Steve
- Depuydt Martijn
- Dere Ümit Akın
- Derinov Aleksandr
- Di Bartolomeo Alessandro
- Di Carlo Sara
- Di Lorenzo Nicola
- Di Martino Marcello
- Di Saverio Salomone
- Diamantopoulou Angela
- Díaz Andrés Vega
- Díaz Jeancarlos J. Trujillo
- Doerner Johannes
- Dogjani Agron
- Don Cristine
- Duran Erik Efrain Sosa
- Durayb Norah
- Dursun Ayberk
- Dziakova Jana
- Echevarria Miguel Jose Pinto
- Edassy Mohammed El
- Efetov Sergey
- Eke Grace
- El-Hussuna Alaa
- El-Wakeel Ayman
- Elalfy Khaled
- Elbahrawy Aly
- Elbatal Amira Alsayed Abdelhai
- Eldeeb Ahmed
- Eldemery Mohamed
- Eldesouki Mohammed Nabil
- Eldesouky Omnia
- Eleshra Ahmed
- Elfeki Hossam
- Elgaly Maher Elesawi Kamel
- Elgamal Hesham
- Elganash Abdelazim
- Elgazar Amr
- Elgazar Elsayed Aly
- Elgendy Hesham
- Elghadban Hosam
- Elhafez Raheem El-Gohary Abd
- Elhattab Ahmad
- Elhawary Ahmed Adel
- Elkafoury Ahmed
- Elkased Ahmed Farag
- Elkatt Mahmoud Mohamed
- Elkhouly Ahmed G.
- Elmesery Mohamed
- Elmetwally Ashraf S.
- Elmoghazy Mohamed Ibrahim
- Elnaghi Hisham
- Elnakash Ahmed Mostafa
- Elnemr Islam
- Elnour Ahmed Abd Elbaset Elsayed Abu
- Elrefai Mohamad
- Elsaied Adham
- Elsanhoury Kareem
- Elsanosi Abdelrhman Azhari Mohammed
- Elsayed Mohamed Abdelmoneim
- Elsayed Mohamed Ahmed Abdelhalim Ahmed
- Elseberbihy John Rezk Hanna
- Elshaer Ahmed Mohammed
- Elshazli Mostafa
- Elsheik Ahmad
- Elsheik Ahmed
- Elsherbiny Osama
- Elshikh Essam
- Elsorogy Mohamed
- Elvira Tartaglia
- Elzayady Hany M.
- Elzayat Ibrahim
- Elzeftawy Shady Ahmed
- Emile Sameh Hany
- Enad Farazdaq
- Epifani Angelo Gabriele
- Eral Burak
- Ezz Ahmed
- Fadel Bashir A.
- Fahiem Andrew
- Fakhr Ibrahim
- Falaschi Federica
- Familiari Pietro
- Farag Mohamed
- Farid Ahmed Mohammed
- Farid Mohamed
- Farouk Mohamed
- Farouk Nehal
- Fathy Mohammad
- Fatima Tauseef
- Fawzy Ahmed
- Faye Papa Mamadou
- Fayed Mohamed Abdelaziz Mohamed Abdalla M
- Fazli Mohammad Rafi
- Felix Marcos José Serrato
- Ferrara Francesco
- Ferrario Luca
- Ferri Lorenzo
- Fieturi Nura Ahmed
- Fikry Mohamed
- Fiore Antonio
- Flores Manuel SSalas
- Foppa Caterina
- Fouad Amgad
- Franceschilli Marzia
- Fransvea Pietro
- Frasson Matteo
- Frauenfelder Claire
- Frazzetta Giuseppe
- Freitas Carla
- Frigerio Isabella
- Frontali Alice
- Gaarour Osama
- Gabr Mohamed A.
- Gad Hamada
- Galala Ahmed
- Gallo Gaetano
- Gamal Ehab
- Gamal Sameh
- Ganau Mario
- Garino Mauro
- Garmanovs Tatiana
- Garoufalia Zoe
- Garreffa Emanuele
- Gazia Carlo
- Gehwolf Philipp
- Gendy Samuel Elkess Morcos
- George Ihediwa
- Ghabisha Saif Ali
- Ghafoor Tariq
- Ghanem Ahmed
- Gharbia Mohamed
- Ghazala Mohamed Jomma
- Ghonim Mostafa
- Ghunaim Mohammed
- Giani Alessandro
- Giardino Alessandro
- Giarratano Gabriella
- Giuffrida Maria Carmela
- Giugliano Marco
- Golea Smain
- Gomez Caroina Gonzalez
- Gondal Zafar
- Gonzales Erick Ivan Huaman
- Gorin David
- Gots Alexander
- Grappelli Virgilio Michael Ambrosi
- Guaitoli Eleonora
- Guerci Claudio
- Guerrero José Eaazim Flores
- Guida Anna
- Gulcu Baris
- Gurung Binay
- Haddad Feras
- Hadi Sabah Anwar
- Hamdi Salah
- Hamed Esmael Ali
- Hamed Hosam
- Hamed Mohamed Korayem Fattouh
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- Uggeri Fabio
- Uraiqat Ahmad
- Uranitsch Stefan
- Uslu Gülberk
- Valente Marina
- Valery Nekoval
- Van Daele Elke
- Van Praet Charles
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- Vanommeslaeghe Hanne
- Varma Gopala Pillay
- Vázquez-Melero Alba
- Vella Ivan
- Veltri Marco
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- Vikrantmr Sharma
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- Vishwakarma Kushagra
- Vosloo Susan
- W Njoroge P.
- Waleed Aasma
- Wali Zubair
- Waqar Shahzad Hussain
- Warusavitarne Janindra
- Waseem Talat
- Wexner Steven
- Wuraola Funmilola Olanike
- Yacir El Alami
- Yakar Fatih
- Yanaga Katsuhiko
- Yassin Nouf
- Yassine Wassim Abou
- Yeşilyurt Değercan
- Yildiz Alp
- Yousef Yousef Mohamed
- Youssef Mohamed
- Youssef Youssef Abdel Aziz
- Yves Van Nieuwenhove
- Zafar Noman
- Zahra Tarek
- Zaidi Mariam
- Zaieem Mohammad
- Zakaria Hazem M.
- Zakharenko Alexander
- Zancana Giuseppa
- Zentar Aziz
- Zese Monica
- Zewar Karem Shahin Mohamed
- Zidan Ahmed Azmy
- Zigiotto Daniele
- Zubayraeva Albina
- Zuhdy Mohammad
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020
Global economic burden of unmet surgical need for appendicitis
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- Wiborg J.
- Widiastini T. A.
- Wild J. R. L.
- Williams O.
- Wilson L.
- Wilson M.
- Witherspoon P.
- Wogensen F.
- Woin E.
- Wold T. B.
- Wolf B.
- Wondimu S.
- Wondoh P.
- Wong C. S.
- Wong C. Y.
- Wong H. Y.
- Wood G.
- Woodward H.
- Worku M.
- Worku T.
- Wredberg C.
- Wright N. J.
- Xerri T.
- Yahaya M. T.
- Yakubu M.
- Yam S. Y.
- Yang J.
- Yaseen T.
- Yaseen T. M.
- Yavuz M. A.
- Ye J.
- Yeang L. J.
- Yeo L. S.
- Yeung M. H. A.
- Yifieyeh A.
- Yip C.
- Yip S. B. S.
- Ymeri S.
- Yoganathan P.
- Yong C. O.
- Yong G. L.
- Youssef D.
- Youssef H.
- Youssef M.
- Youssif J. H.
- Yuksek M. A.
- Yusufali T.
- Zaa'treh R.
- Zachariades D. -C.
- Zadoroznas A.
- Zahran D.
- Zakaria E.
- Zakaria M.
- Zakaria Y.
- Zaki A.
- Zalabia M. F.
- Zamarin K.
- Zammit S.
- Zampitis N.
- Zani A.
- Zanini N.
- Zapata F.
- Zarb C.
- Zardab A.
- Zegarra S.
- Zerihun A. B.
- Zhang Z.
- Zheng F.
- Zidan H.
- Zidan M.
- Ziff O.
- Zil-E-Ali A.
- Zilinskas J.
- Zilinskiene R.
- Ziubryte G.
- Zohair A.
- Zuber M.
- Zulkifli A.
- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
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- Abbasy J
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- Abd El Hameed OS
- Abd El Hamid N
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- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
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- Abdel-Kader SM
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- Elazoul M
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- Elbatahgy A
- Elbe P
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- Elbisomy KH
- Eldafrawy M
- Eldamaty L
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- Elena G
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- Elfiky M
- Elfil M
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- Elfouly Y
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- Elhalawany E
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- Elhelbawy MS
- Elhendawy A
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- Elhusseiny AAE
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- Elkady F
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- Elkhadrawi M
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- Elsemelawy R
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- Elsherbiny AS
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- Elzahed N
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- Elzowawi F
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- Eng C
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- Espin-Basany E
- Espinoza F
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- Feidantsis T
- Felipe CO
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- Mostafa M
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- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
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- A Yacoub M.
- A. Adam M.
- A. Nassar M.
- A. Nemer A.
- Aahlin E. K.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
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