LASTİK AGREGALI BETONLARDA ELASTİSİTE MODÜLÜNÜN DENEYSEL VE TEORİK OLARAK İNCELENMESİ

Bu çalışmada, atık lastiklerden beton içinde kullanmak amacıyla ince ve iri lastik agregalar üretilmiştir. Bu lastik agregalar normal agrega ile sırasıyla % 5, 10, 15 ve 20 oranlarında hacimsel olarak yer değiştirilmek suretiyle lastik agregalı betonlar elde edilmiştir. Üretilen lastik agregalı betonların fiziksel ve mekanik özellikleri belirlenmiştir. Eğilmede çekme deneylerinin yapılabilmesi için 100x100x500 mm ebatlarında kiriş numuneler hazırlanmıştır. Bu numuneler eğilmede çekme deneylerine tabi tutularak deney esnasında kirişlerin orta noktalarından elde edilen sehim miktarları ölçülmüştür. Bu sehim miktarlarından faydalanarak üretilen lastik agregalı betonların elastisite modülleri belirlenmiştir. Ayrıca, üretilen lastik agregalı betonların elastisite modülleri çeşitli ülkelerin standartlarında önerilen ampirik formüllerle de hesaplanmıştır. Deneysel olarak belirlenen elastisite modülleri ile ampirik formüllerle hesaplanan elastisite modülleri arasındaki ilişki belirlenmeye çalışılmıştır. Sonuç olarak, betondaki lastik miktarı arttıkça deneysel verilerle hesaplanan elastisite modülleri ile ampirik formüllerle hesaplanan elastisite modülleri arasındaki ilişkinin azaldığı belirlenmiştir. Ancak, Amerika Beton Enstitüsü (ACI) tarafından önerilen formül ile deneysel olarak hesaplanan elastisite modülü arasında oldukça yüksek bir ilişki olduğu görülmüştür

Common polymorphisms of growth hormone: Growth hormone receptor axis in Turkish children with short stature

Objective: A single-nucleotide polymorphism of the growth hormone 1 gene, GH1IVS4+90A>T (rs2665802), associated with short stature and a polymorphism of the growth hormone receptor gene, exon 3 deleted variant, associated with increased responsiveness to growth hormone have been reported previously. We aimed to investigate the frequency of both polymorphisms and their correlation to height in Turkish short children. Also, we aimed to evaluate the effect of exon 3 deleted variant on response to 1-year growth hormone therapy. Materials and Methods: Children with idiopathic isolated growth hormone deficiency (n = 39) and with idiopathic short stature (n = 10) and 50 control subjects were evaluated for anthropo-metric parameters, annual growth velocity, and annual height gain. Growth hormone receptor gene polymorphisms were analyzed via multiplex polymerase chain reaction; growth hormone 1 gene polymorphism was analyzed via polymerase chain reaction and single-strand confor-mation polymorphism techniques. Results: The frequency of genotypes carrying the “A” allele was not significantly higher in the idiopathic isolated growth hormone deficiency group than in the idiopathic short stature and control groups (P = .03 for each). The exon 3 deleted variant genotype was significantly lower in the idiopathic short stature group compared to the control group (P = .01). There was no effect of exon 3 deleted variant, on response to the first-year growth hormone therapy. Conclusion: In Turkish population, no correlation was found between the “A” allele of GH1IVS4+90A>T polymorphism and idiopathic isolated growth hormone deficiency and short stature, and a significant negative correlation was found between exon 3 deleted variant and idiopathic short stature and short stature. Exon 3 deleted variant has no effect on response to growth hormone treatment.Istanbul Universit

A Comparative Study of Multiparametric MRI Sequences in Measuring Prostate Cancer Index Lesion Volume

Objectives: To compare the effectiveness of individual multiparametric prostate MRI (mpMRI) sequences—T2W, diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC), and dynamic contrast-enhanced (DCE)—in assessing prostate cancer (PCa) index lesion volume using whole-mount pathology as the ground-truth; to assess the impact of an endorectal coil (ERC) on the measurements. Materials and Methods: We retrospectively enrolled 72 PCa patients who underwent 3T mpMRI with (n = 39) or without (n = 33) an ERC. A pathologist drew the index lesion borders on whole-mount pathology using planimetry (whole-mountvol). A radiologist drew the borders of the index lesion on each mpMRI sequence—T2Wvol, DWIvol, ADCvol, and DCEvol. Additionally, we calculated the maximum index lesion volume for each patient (maxMRIvol). The correlation and differences between mpMRI and whole-mount pathology in measuring the index lesion volume and the impact of an ERC were investigated. Results: The median T2Wvol, DWIvol, ADCvol, DCEvol, and maxMRIvol were 0.68 cm3, 0.97 cm3, 0.98 cm3, 0.82 cm3, and 1.13 cm3. There were good positive correlations between whole-mountvol and mpMRI sequences. However, all mpMRI-derived volumes underestimated the median whole-mountvol volume of 1.97 cm3 (P ≤ 0.001), with T2Wvol having the largest volumetric underestimation while DWIvol and ADCvol having the smallest. The mean relative index lesion volume underestimations of maxMRIvol were 39.16% ± 32.58% and 7.65% ± 51.91% with and without an ERC (P = 0.002). Conclusion: T2Wvol, DWIvol, ADCvol, DCEvol, and maxMRIvol substantially underestimate PCa index lesion volume compared with whole-mount pathology, with T2Wvol having the largest volume underestimation. Additionally, using an ERC exacerbates the volume underestimation

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised

Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus

EXPERIMENTAL AND THEORETICAL STUDY OF MODULUS OF ELASTICITY ON RUBBERIZED CONCRETE

Emiroglu, Mehmet/0000-0002-0214-4986WOS: 000273608400010In this study, fine and coarse rubber aggregates were produced for using in concrete. Rubber filled concretes have been produced by replacing the normal aggregates with rubber aggregates (5%, 10%, 15% and 20%) by volume respectively. Physical and mechanical properties of the produced rubber filled concretes have been determined. Beam specimens with 100 x 100 x 500 mm were prepared for the three point bending tests. The three point bending tests have conducted on these beam specimens and deflection amount of the beams during the test have been measured. By using the deflection values elasticity modulus of the produced specimens have been determined. Also, the elasticity modulus of the specimens has been calculated by using empirical equations which were proposed from some countries' standards. It was tried to determine that the relationship between the experimental results and empirical equation results for elasticity modulus. As a result, it is determined that while increasing rubber content in the concrete the relationship between experimental results and empirical equation results for elasticity modulus were decreased. However, it is observed that there was a high correlation between experimental results and empirical equation proposed by American Concrete Institute (ACI) for elasticity modulus