O1-4 Validation of questions to assess the mode of commuting to/from school for children according to their parents: the PACO study

Background The active commuting to school behaviour is an opportunity to increase the physical activity levels. The most frequent used tool to assess the mode of commuting to school is self-reporting by children or by their parents. However, there is a lack of information about the validity between both, children and parents. So, the purpose is to validate the questions of mode of commuting to go and come back from school of children according to their parents'. Method A total of 611 parents (mean age: 43.28±6.25 years old) and their children (mean age: 11.44±2.77 years old) from Granada (Spain) completed a family (mode of commuting of children reported by parents as part of the Family PACO questionnaire) and a student questionnaire validated (Chillon et al., 2017) (mode and frequency of commuting to and from school questionnaire), respectively, in two measurement points. The questions from the ‘Family PACO questionnaire' are: “How does your child usually go to school?” and “How does your child usually come back?”; and the questions from the ‘mode and frequency of commuting to and from school questionnaire' are: “How do you usually go to school?” and “How do you usually go from school?”. The validation between parents and childreńs questions was analysed using Kappa and Spearman correlation coefficients. The results of the kappa are considered as: poor agreement (0-0.20), acceptable agreement (0.21-0.40), moderate agreement (0.41-0.60), substantial agreement / good (0.61-0.80) and almost perfect / very good agreement (0.81-1.00) (Landis & Koch, 1977). The Spearman correlations coefficients were interpreted as low (> 0.30), moderate (0.30-0.50), and high (> 0.50) (Van Dyck, Cardon, Deforche, & De Bourdeaudhuij, 2015). Results The validity of questions from both questionnaires about mode of commuting presented high coefficients of validation (Kappa coefficient; 0.865 to school and 0.839 from school and Spearman correlation; rho=0.882 to school and rho=0.860 from school). Conclusion The questions about the mode of commuting to/from school from the ‘Family PACO questionnaire’ are valid method. Therefore, the use of the questions would be recommended to assess children's mode of commuting

High-frequency stratigraphic architecture of a 3rd order depositional sequence in the coastal margin setting of Iberian Basin (Segovia Province, Spain)

En este trabajo se analiza la arquitectura estratigráfica detallada y la ciclicidad interna de la secuencia deposicional de 3er orden del Turoniense Superior – Coniaciense Basal en el margen costero de la Cuenca Ibérica (Provincia de Segovia), dentro de sucesiones predominantemente terrígenas con algunas intercalaciones carbonatadas de plataforma somera. La correlación de 16 columnas estratigráficas a lo largo de un perfil perpendicular al margen costero ha permitido identificar cuatro conjuntos de parasecuencias (4º orden) y 10 parasecuencias (5º orden), cuyo espesor y continuidad lateral varían en función de relaciones de onlap y toplap de las parasecuencias inferiores y superiores respectivamente, dentro de cada conjunto mayor (4º orden). Asimismo, dentro de las parasecuencias de 5º orden, se han identificado hasta dos parasecuencias de orden mayor (6º orden), cuyo reconocimiento está supeditado a los términos carbonatados de las sucesiones sedimentarias. En el trabajo se analiza la compleja superposición de cortejos sedimentarios que genera un patrón de apilamiento deposicional en el que coexisten tres rangos de secuencias de alta frecuencia (4º, 5º y 6º orden), aclarando las relaciones entre las facies terrígenas y carbonatadas en este margen costero, así como las diferentes tendencias sedimentarias que se reconstruyen en función de la escala de observación.The cyclicity and the stratigraphic architecture of the Upper Turonian-Lower Coniacian 3rd-order sequence have been analysed in the coastal margin of the Iberian Basin (north of the Central System, province of Segovia). This sequence is composed of coastal terrigenous sediments with some shallow shelf carbonate intercalations. The 3rd-order sequence is composed of several ranges of high-frequency superimposed parasequences. Each of the four parasequence sets (4th-order), can be divided into up to three parasequences (5th-order), which in turn are composed of two minor parasequences (6th-order), recognized only in the carbonate sediments of the sedimentary succession. Thickness and lateral extent of the parasequence sets depend on the number of their internal parasequences. Parasequences and minor parasequences thins and pinch out landwards with onlap and toplap relationships regarding the basal and top parasequence set and parasequence boundaries. The presence in the sedimentary record of 4th- 5th- and 6th-order parasequences originates a complex overlap of Systems Tracts; and thus, depending on the observation scale, different sedimentary trends can be recognized. At a detailed scale, the presence of these Systems Tracts allows to clarify the terrigenous and carbonate facies relationships. Although both facies have been formed in a single depositional episode, they were deposited in different stages of the episode. Siliciclastic facies represent the Shelf Margin Wedge/Transgressive Systems Tracts, being supplied to the Basin during a relative sea level lowstand and located at the coastal margin; later, during the subsequent transgression, they are reworked. On the other hand, carbonate sediments were deposited basinwards, during relative sea level highstands (Highstand System Tract). This depositional model explains the scarce presence of mixed facies. Two other different sedimentary trends are recognized in the entire sequence. First, the thinning upwards trend of parasequence sets, which is related with the overall regressive trend in the upper part of the sequence (due to accommodation loss). Secondly, the progressive upwards decrease of siliciclastic deposits and a correlative increase in carbonate sediments in the parasequence sets, which suggests the existence of a longer transgressive trend (2nd-order), which continues in the overlying Coniacian sequence.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEMadrid (Comunidad Autónoma)Universidad de Alcalá de Henarespu

Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage

The role of uric acid levels in the cardiovascular continuum is not clear. Our objective is to analyze the prevalence of hyperuricemia (HU) and its association with cardiovascular risk factors (CVRF), subclinical target organ damage (sTOD), and cardiovascular diseases (CVD). We evaluated the prevalence of HU in 6.927 patients included in the baseline visit of the IBERICAN study. HU was defined as uric acid levels above 6 mg/dL in women, and 7 mg/dL in men. Using adjusted logistic regression models, the odds ratios were estimated according to CVRF, sTOD, and CVD. The prevalence of HU was 16.3%. The risk of HU was higher in patients with pathological glomerular filtration rate (aOR: 2.92), heart failure (HF) (aOR: 1.91), abdominal obesity (aOR: 1.80), hypertension (HTN) (aOR: 1.65), use of thiazides (aOR: 1.54), left ventricular hypertrophy (LVH) (aOR: 1.36), atrial fibrillation (AFIB) (aOR: 1.29), and albuminuria (aOR: 1.27). On the other hand, being female (aOR: 0.82) showed a reduced risk. The prevalence of HU was higher in men, in patients presenting CVRF such as HTN and abdominal obesity, and with co-existence of LVH, atrial fibrillation (AFIB), HF, and any form of kidney injury. These associations raise the possibility that HU forms part of the early stages of the cardiovascular continuum. This may influence its management in Primary Healthcare because the presence of HU could mean an increased CV risk in the patients

Heterozygous Arrhythmogenic Cardiomyopathy-desmoplakin Mutation Carriers Exhibit a Subclinical Cutaneous Phenotype with Cell Membrane Disruption and Lack of Intercellular Adhesion

Genetic variants that result in truncation in desmoplakin (DSP) are a known cause of arrhythmogenic cardiomyopathy (AC). In homozygous carriers, the combined involvement of skin and heart muscle is well defined, however, this is not the case in heterozygous carriers. The aim of this work is to describe cutaneous findings and analyze the molecular and ultrastructural cutaneous changes in this group of patients. Four women and eight men with a mean age of 48 ± 14 years were included. Eight met definitive criteria for AC, one was borderline and three were silent carriers. No relevant macroscopic changes in skin and hair were detected. However, significantly lower skin temperature (29.56 vs. 30.97 ◦C, p = 0.036) and higher transepidermal water loss (TEWL) (37.62 vs. 23.95 g m 2 h 1, p = 0.028) were observed compared to sex- and age-matched controls. Histopathology of the skin biopsy showed widening of intercellular spaces and acantholysis of keratinocytes in the spinous layer. Immunohistochemistry showed a strongly reduced expression of DSP in all samples. Trichogram showed regular nodules (thickening) compatible with pseudomonilethrix. Therefore, regardless of cardiac involvement, heterozygous patients with truncation-type variants in DSP have lower skin temperature and higher TEWL, constant microscopic skin involvement with specific patterns and pseudomonilethrix in the trichogram.Andalusian Society of Cardiology with a “beca de Investigación general

Lo tangible e intangible del diseño

1 archivo PDF (366 páginas)"El Departamento de Evaluación del Diseño, en el Tiempo de la División de Ciencias y Artes para el Diseño de la Universidad Autónoma Metropolitana, Azcapotzalco, publica este libro colectivo, donde se aborda la discusión y el análisis sobre "Lo tangible e intangible del diseño". Este libro tiene como finalidad el profundizar en distintas posiciones teóricas, metodológicas y empíricas, donde un grupo interdisciplinario de profesores investigadores del Departamento de Evaluación, desde la arquitectura, los estudios urbanos, la educación, la historia, la semiótica, el diseño de la comunicación gráfica y el industrial; buscan convergencias y discuten divergencias que puedan generar servir como referentes intelectuales y teóricos, en el diseño. Este libro es resultado del Cuarto Coloquio Departamental: Lo tangible e Intangible del Diseño. Evaluación de Objetos, Espacios, Mensajes, realizado durante el mes de septiembre del año 2004, el cual se constituyó como un espacio para el intercambio de experiencias académicas y profesionales, desde una perspectiva interdisciplinaria, centrada en la reflexión y la discusión sobre la manera de cómo se puede analizar, definir y evaluar, lo tangible y lo intangible en el diseño"

Taxonomic and Environmental Variability in the Elemental Composition and Stoichiometry of Individual Dinoflagellate and Diatom Cells from the NW Mediterranean Sea

Here we present, for the first time, the elemental concentration, including C, N and O, of single phytoplankton cells collected from the sea. Plankton elemental concentration and stoichiometry are key variables in phytoplankton ecophysiology and ocean biogeochemistry, and are used to link cells and ecosystems. However, most field studies rely on bulk techniques that overestimate carbon and nitrogen because the samples include organic matter other than plankton organisms. Here we used X-ray microanalysis (XRMA), a technique that, unlike bulk analyses, gives simultaneous quotas of C, N, O, Mg, Si, P, and S, in single-cell organisms that can be collected directly from the sea. We analysed the elemental composition of dinoflagellates and diatoms (largely Chaetoceros spp.) collected from different sites of the Catalan coast (NW Mediterranean Sea). As expected, a lower C content is found in our cells compared to historical values of cultured cells. Our results indicate that, except for Si and O in diatoms, the mass of all elements is not a constant fraction of cell volume but rather decreases with increasing cell volume. Also, diatoms are significantly less dense in all the measured elements, except Si, compared to dinoflagellates. The N:P ratio of both groups is higher than the Redfield ratio, as it is the N:P nutrient ratio in deep NW Mediterranean Sea waters (N:P = 20–23). The results suggest that the P requirement is highest for bacterioplankton, followed by dinoflagellates, and lowest for diatoms, giving them a clear ecological advantage in P-limited environments like the Mediterranean Sea. Finally, the P concentration of cells of the same genera but growing under different nutrient conditions was the same, suggesting that the P quota of these cells is at a critical level. Our results indicate that XRMA is an accurate technique to determine single cell elemental quotas and derived conversion factors used to understand and model ocean biogeochemical cycles

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Observation of the Production of Three Massive Gauge Bosons at root s=13 TeV

The first observation is reported of the combined production of three massive gauge bosons (VVV with V = W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis is based on a data sample recorded by the CMS experiment at the CERN LHC corresponding to an integrated luminosity of 137 fb(-1). The searches for individualWWW, WWZ, WZZ, and ZZZ production are performed in final states with three, four, five, and six leptons (electrons or muons), or with two same-sign leptons plus one or two jets. The observed (expected) significance of the combinedVVV production signal is 5.7 (5.9) standard deviations and the corresponding measured cross section relative to the standard model prediction is 1.02(-0.23)(+0.26). The significances of the individual WWW and WWZ production are 3.3 and 3.4 standard deviations, respectively. Measured production cross sections for the individual triboson processes are also reported