The Naas Motorway Bypass - A Cost Benefit Analysis. Quarterly Economic Commentary Special Article, January 1984

The paper examines the Naas Motorway Bypass which cost £16m at 1983 prices. Twelve thousand vehicles a day using the bypass save over 10 minutes between 8 am and 8 pm and 6 minutes at other times. Five thousand vehicles a day using the present route through Naas also benefit by saving 4 minutes due to reduced congestion in the town. In addition to time savings, the bypass reduces accidents and fuel costs. Ninety-one per cent of the benefits accrue in time savings. The internal rate of return on the project is estimated at 20.51 per cent, assuming 2 per cent annual traffic and income growth. The sensitivity tests of the results show that even with zero growth in incomes and traffic for twenty years, a high proportion of leisure time savings with zero value and no increase in the value of fuel savings the project would have an internal rate of return which meets the test discount rate used by the Department of Finance. The environmental aspects of the bypass are positive in terms of noise and smoke and lead pollution reduction. The impact on farm severence and natural amenities on the motorway route has been mitigated by several design features of the bypass

Indigenous Resiliency Project Participatory Action Research Component: A report on the Research Training and Development Workshop, Townsville, February 2008

The Indigenous Resiliency Project proposes to build capacity in Indigenous communities in Australia, New Zealand and Canada to conduct investigations into the factors that may support Indigenous people in responding toblood borne viral (BBV) and sexually transmitted infections (STI). The goal of this international project is to identify strategies related to resiliency that can be incorporated into public health and clinical practice. The Australian arm of the Indigenous Resiliency Project focuses on young adults (aged 16 to 25 years) in urban settings. It employs a range of research methods to gain an understanding of the factors thatmight be strengthened to better protect young Aboriginal and Torres Strait Islander people against BBV and STI. The project has four components, the third being the Participatory Action Research (PAR) project. The PAR has four aims: 1. Build the capacity of Aboriginal Community Controlled Health Services in Participatory Action Research practice. 2. Identify, assess and enhance selected BBV/STI resilience capability of Aboriginal and Torres Strait Islander populations in the study sites. 3. Inform on opportunities to decrease the risk of BBV/STI transmission in these populations. 4. Provide information for local and area health service planning for Aboriginal and Torres Strait Islander BBV/STI prevention. The PAR project is running in three sites: the Townsville Aboriginal and Islander Health Service (TAIHS), Derbarl Yerrigan Medical Service in Perth (DY), and the Aboriginal Medical Service in Redfern (AMS). In each health service, a site research team works together with a research team from the National Centre in HIV Epidemiology and Clinical Research (NCHECR) to develop the project locally. Each site is using the following framework: Phase I: Develop protocols, identifypriority population, and obtain ethics. Phase II: Research training and development workshop. Phase III: Fieldwork – recruitment, observation, and data collection. Phase IV: Focus groups. Phase V: Analysis and dissemination of findings. This report describes the first two phases of the PAR project at the TIAHS.the International Collaborative Indigenous Health Research Program (ICIHRP

Ariel - Volume 8 Number 2

Executive Editor James W. Lockard , Jr. Issue Editor Doug Hiller Business Manager Neeraj K. Kanwal University News Richard J. Perry World News Doug Hiller Opinions Elizabeth A. McGuire Features Patrick P. Sokas Sports Desk Shahab S. Minassian Managing Editor Edward H. Jasper Managing Associate Brenda Peterson Photography Editor Robert D. Lehman, Jr. Graphics Christine M. Kuhnl

The advent of the Anthropocene in Australasia.

As early as the late 19th Century, several scientists had suggested that humans were starting to influence the physical environment of planet Earth (e.g. Marsh, 1864; Stoppani, 1873; Arrhenius, 1896; Chamberlain, 1897). This idea was resurrected and expanded in 2000 by Paul Crutzen, a Nobel Prize-winning chemist, and the late Eugene Stoermer, a professor of biology specialising in diatoms, who suggested that we had left the Holocene and entered the “Anthropocene” (Crutzen and Stoermer, 2000). As summarised by Steffen et al. (2011) and Wolfe et al. (2013), these iconoclastic scientists were referring to the Anthropocene as the interval of demonstrable human alteration of global biogeochemical cycles, beginning subtly in the late 18th Century following James Watt’s invention of the coal-fired steam engine, and accelerating markedly in the mid-20th Century (termed “The Great Acceleration”). Thus Crutzen and Stoermer (2000) argued that the Anthropocene should be an epoch, and for a starting date at the beginning of the Industrial Revolution (Monastersky, 2015)

Tracking an exotic raw material: Aboriginal movement through the Blue Mountains, Sydney, NSW during the Terminal Pleistocene

A compliance-based excavation on Parramatta River (western Sydney) found evidence of a brief visitation by Aboriginal people during the terminal Pleistocene (c.14 ka), from which an exotic raw material–medium-grained porphyroblastic andalusite-cordierite hornfels–was recovered. This raw material is rare in the region, only found in the Megalong Valley situated some 75 km west of the site in Parramatta, and separated from the site by the Blue Mountains–a 40 km wide, 1 km high dissected sandstone upland. Historical observations and geological evidence suggest that the Coxs River, which runs through the upland, formed the probable connection between the two locales. The formation of the site at c.14 ka, along with our broader understanding of the region, suggests that the upland was only explored after the Last Glacial Maximum (LGM) and that the Great Dividing Range may have formed a significant barrier to early peopling of Sahul. Further, a delay between the end of the LGM and the exploration of the region implies populations were severely affected by the event and required considerable time to recover. The coincident timing of rapid sea-level rise from Meltwater Phase Pulse 1A and an increased supply of moisture associated with the Antarctic Climate Reversal at the time of many site initiations may have been factors in the upland and south west slopes visitation. Finally, the movement of the unusual hornfels artefact provides a coarse indication of the ranging territory for hunter-gatherers living in a temperate region (c. 8,000 km2) at this time. This is probably a lower estimate but begins to provide a quantitative value with which to begin to ratify the increasing divergence between archaeological and genomic studies in their definitions of mobility, sedentism and regional nomadism

AMPK:a target for drugs and natural products with effects on both diabetes and cancer

The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy that appears to have arisen at an early stage during eukaryotic evolution. In 2001 it was shown to be activated by metformin, currently the major drug for treatment for type 2 diabetes. Although the known metabolic effects of AMPK activation are consistent with the idea that it mediates some of the therapeutic benefits of metformin, as discussed below it now appears unlikely that AMPK is the sole target of the drug. AMPK is also activated by several natural plant products derived from traditional medicines, and the mechanisms by which they activate AMPK are discussed. One of these is salicylate, probably the oldest medicinal agent known to humankind. The salicylate prodrug salsalate has been shown to improve metabolic parameters in subjects with insulin resistance and prediabetes, and whether this might be mediated in part by AMPK is discussed. Interestingly, there is evidence that both metformin and aspirin provide some protection against development of cancer in humans, and whether AMPK might be involved in these effects is also discussed

Trends in prevalence, mortality, and morbidity associated with high systolic blood pressure in Brazil from 1990 to 2017 : estimates from the “Global Burden of Disease 2017” (GBD 2017) study

Background: Hypertension remains the leading risk factor for cardiovascular disease (CVD) worldwide, and its impact in Brazil should be assessed in order to better address the issue. We aimed to describe trends in prevalence and burden of disease attributable to high systolic blood pressure (HSBP) among Brazilians ≥ 25 years old according to sex and federal units (FU) using the Global Burden of Disease (GBD) 2017 estimates. Methods: We used the comparative risk assessment developed for the GBD study to estimate trends in attributable deaths and disability-adjusted life-years (DALY), by sex, and FU for HSBP from 1990 to 2017. This study included 14 HSBP-outcome pairs. HSBP was defined as ≥ 140 mmHg for prevalence estimates, and a theoretical minimum risk exposure level (TMREL) of 110–115 mmHg was considered for disease burden. We estimated the portion of deaths and DALYs attributed to HSBP. We also explored the drivers of trends in HSBP burden, as well as the correlation between disease burden and sociodemographic development index (SDI). Results: In Brazil, the prevalence of HSBP is 18.9% (95% uncertainty intervals [UI] 18.5–19.3%), with an annual 0.4% increase rate, while age-standardized death rates attributable to HSBP decreased from 189.2 (95%UI 168.5–209.2) deaths to 104.8 (95%UI 94.9–114.4) deaths per 100,000 from 1990 to 2017. In spite of that, the total number of deaths attributable to HSBP increased 53.4% and HSBP raised from 3rd to 1st position, as the leading risk factor for deaths during the period. Regarding total DALYs, HSBP raised from 4th in 1990 to 2nd cause in 2017. The main driver of change of HSBP burden is population aging. Across FUs, the reduction in the age-standardized death rates attributable to HSBP correlated with higher SDI. Conclusions: While HSBP prevalence shows an increasing trend, age-standardized death and DALY rates are decreasing in Brazil, probably as results of successful public policies for CVD secondary prevention and control, but suboptimal control of its determinants. Reduction was more significant in FUs with higher SDI, suggesting that the effect of health policies was heterogeneous. Moreover, HSBP has become the main risk factor for death in Brazil, mainly due to population aging

The BLAST View of the Star Forming Region in Aquila (ell=45deg,b=0deg)

We have carried out the first general submillimeter analysis of the field towards GRSMC 45.46+0.05, a massive star forming region in Aquila. The deconvolved 6 deg^2 (3\degree X 2\degree) maps provided by BLAST in 2005 at 250, 350, and 500 micron were used to perform a preliminary characterization of the clump population previously investigated in the infrared, radio, and molecular maps. Interferometric CORNISH data at 4.8 GHz have also been used to characterize the Ultracompact HII regions (UCHIIRs) within the main clumps. By means of the BLAST maps we have produced an initial census of the submillimeter structures that will be observed by Herschel, several of which are known Infrared Dark Clouds (IRDCs). Our spectral energy distributions of the main clumps in the field, located at ~7 kpc, reveal an active population with temperatures of T~35-40 K and masses of ~10^3 Msun for a dust emissivity index beta=1.5. The clump evolutionary stages range from evolved sources, with extended HII regions and prominent IR stellar population, to massive young stellar objects, prior to the formation of an UCHIIR.The CORNISH data have revealed the details of the stellar content and structure of the UCHIIRs. In most cases, the ionizing stars corresponding to the brightest radio detections are capable of accounting for the clump bolometric luminosity, in most cases powered by embedded OB stellar clusters