"Und was macht man dann damit?" Slavistinnen und Slavisten im Beruf

Die Broschüre gibt anhand von Interviews mit Alumni bzw. Alumnae v.a. der Bamberger Slavistik Auskunft über Berufswege und Optionen, vermittelt Erfahrungen im Berufseinstieg und gibt wertvolle Hinweise für die Studierenden des Faches

Tagungsband zum 4. BIH-Treffen 2019: Interdisziplinäre Forschung - Chancen und Herausforderungen: Fachtagung für wissenschaftlich Beschäftigte und Nachwuchskräfte an Bauingenieur-Institutionen deutscher Hochschulen

Forschung und Wissenschaft sind wichtige Standbeine einer modernen Hochschule. Sie stellen eine Grundlage für die primäre Aufgabe der Hochschulen dar, die praxisnahe und berufsbefähigende Lehre auf dem aktuellen Stand der Technik und Wissenschaft. Mittlerweile widmen sich auch die Hochschulen der Ausbildung von wissenschaftlichem Nachwuchs. Prosperierende Forschungsarbeit ist dafür ein unverzichtbarer Bestandteil. Der Leitgedanke „Interdisziplinäre Forschung – Chancen und Herausforderungen“ des BIH-Treffens 2019 soll zum fachübergreifenden Austausch von Know-how in Forschungs- und Lehrmethoden anregen. Eine große Bandbreite an Fachbeiträgen bietet spannende Einblicke in die Arbeit der Kolleginnen und Kollegen in den unterschiedlichen Fachbereichen des Bauwesens der zahlreichen deutschen Hochschulen. Dazu gehören Beiträge zu modernen Messmethoden in der Geotechnik und dem Bahnbau ebenso wie Forschungsergebnisse aus dem konstruktiven Ingenieurbau, der Baukonstruktion, der Haustechnik und der Verkehrsplanung und nicht zuletzt Erfahrungen zu interdisziplinären Lehrmethoden.:Einfluss der Nachverdichtung granularer Böden auf die Phasengeschwindigkeiten von Rayleighwellen Sommerliche Überhitzung in Wohngebäuden – Baukonstruktive und haustechnische Anpassungsmaßnahmen Die „Hochschulweite Interdisziplinäre Projektwoche (HIP)“ an der TH Köln – andere Welten kennenlernen! Forschungsprojekt „Duale Radlösung“ – Wahlfreie Führung als Mittel der Radverkehrslösung Zwang in Hochbaudecken aus Stahlbeton (Kooperative Promotion) Robustheit und Vulnerabilität der Wasserstraßeninfrastruktur Vergleichbarkeit der Messsysteme an Zug- und Biegeproben aus den Werkstoffen Stahl und Holz Entwicklung einer Messmethodik zur Bestimmung der Schienenbewegung unter dem rollenden RadResearch and science are important mainstay of a modern university. They provide a basis for the primary task of the universities, the practical and occupational teaching on the current state of technology and science. In the meantime, the universities are also dedicating themselves to the training of junior scientists. Prospering research is an indispensable part of this. The guiding idea 'Interdisciplinary Research - Opportunities and Challenges' of the BIH meeting 2019 is intended to stimulate the interdisciplinary exchange of expertise in research and teaching methods. A wide range of specialist contributions provides exciting insights into the work of colleagues in the various specialized fields of civil engineering at numerous German universities. This includes papers to modern measuring methods in geotechnical engineering and railway construction, as well as research results from structural engineering, building construction, building technology and traffic planning, and last but not least, experience in interdisciplinary teaching methods.:Einfluss der Nachverdichtung granularer Böden auf die Phasengeschwindigkeiten von Rayleighwellen Sommerliche Überhitzung in Wohngebäuden – Baukonstruktive und haustechnische Anpassungsmaßnahmen Die „Hochschulweite Interdisziplinäre Projektwoche (HIP)“ an der TH Köln – andere Welten kennenlernen! Forschungsprojekt „Duale Radlösung“ – Wahlfreie Führung als Mittel der Radverkehrslösung Zwang in Hochbaudecken aus Stahlbeton (Kooperative Promotion) Robustheit und Vulnerabilität der Wasserstraßeninfrastruktur Vergleichbarkeit der Messsysteme an Zug- und Biegeproben aus den Werkstoffen Stahl und Holz Entwicklung einer Messmethodik zur Bestimmung der Schienenbewegung unter dem rollenden Ra

Untersuchung und Eindämmung eines SARS-CoV-2-Alpha-Ausbruchs in einer Pflegeeinrichtung im Landkreis Dithmarschen, Juni 2021

Bewohnende und Personal in Pflegeeinrichtungen gehören zu den Personengruppen, die ab dem 27.12.2020 in Deutschland priorisiert die COVID-19-Impfung erhielten. Diese zeigte eine gute Wirksamkeit hinsichtlich des Schutzes vor Infektionen mit der Alpha-Variante und eine sehr hohe Wirksamkeit vor schweren Krankheitsverläufen. In einer Pflegeeinrichtung im Landkreis Dithmarschen kam es zwischen dem 01.04. und 23.06.2021 dennoch zu einem SARS-CoV-2-Ausbruch, bei dem eine hohe Anzahl vollständig geimpfter Personen infiziert wurde und teilweise schwer erkrankte oder verstarb. Beschrieben werden zum einen die Methoden, die bei der Ausbruchsuntersuchung im Pflegeheim angewandt wurden, und zum anderen die Maßnahmen, die schlussendlich zur Ausbruchseindämmung beitrugen.Peer Reviewe

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain

Reactive oxygen species (ROS) produced in the mitochondrial respiratory chain (RC) are primary signals that modulate cellular adaptation to environment, and are also destructive factors that damage cells under the conditions of hypoxia/reoxygenation relevant for various systemic diseases or transplantation. The important role of ROS in cell survival requires detailed investigation of mechanism and determinants of ROS production. To perform such an investigation we extended our rule-based model of complex III in order to account for electron transport in the whole RC coupled to proton translocation, transmembrane electrochemical potential generation, TCA cycle reactions, and substrate transport to mitochondria. It fits respiratory electron fluxes measured in rat brain mitochondria fueled by succinate or pyruvate and malate, and the dynamics of NAD+ reduction by reverse electron transport from succinate through complex I. The fitting of measured characteristics gave an insight into the mechanism of underlying processes governing the formation of free radicals that can transfer an unpaired electron to oxygen-producing superoxide and thus can initiate the generation of ROS. Our analysis revealed an association of ROS production with levels of specific radicals of individual electron transporters and their combinations in species of complexes I and III. It was found that the phenomenon of bistability, revealed previously as a property of complex III, remains valid for the whole RC. The conditions for switching to a state with a high content of free radicals in complex III were predicted based on theoretical analysis and were confirmed experimentally. These findings provide a new insight into the mechanisms of ROS production in RC

Is the meiofauna a good indicator for climate change and anthropogenic impacts?

Our planet is changing, and one of the most pressing challenges facing the scientific community revolves around understanding how ecological communities respond to global changes. From coastal to deep-sea ecosystems, ecologists are exploring new areas of research to find model organisms that help predict the future of life on our planet. Among the different categories of organisms, meiofauna offer several advantages for the study of marine benthic ecosystems. This paper reviews the advances in the study of meiofauna with regard to climate change and anthropogenic impacts. Four taxonomic groups are valuable for predicting global changes: foraminifers (especially calcareous forms), nematodes, copepods and ostracods. Environmental variables are fundamental in the interpretation of meiofaunal patterns and multistressor experiments are more informative than single stressor ones, revealing complex ecological and biological interactions. Global change has a general negative effect on meiofauna, with important consequences on benthic food webs. However, some meiofaunal species can be favoured by the extreme conditions induced by global change, as they can exhibit remarkable physiological adaptations. This review highlights the need to incorporate studies on taxonomy, genetics and function of meiofaunal taxa into global change impact research

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Regulatory T cells (T(reg) cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of T(reg) cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3' untranslated region. Release of SATB1 from the control of Foxp3 in T(reg) cells caused loss of suppressive function, establishment of transcriptional T(eff) cell programs and induction of T(eff) cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining T(reg) cell functionality.Marc Beyer... Timothy Sadlon...Simon C Barry... et al

Sound sketch procedure for auralization of the interior sound of a high speed train

Godkänd; 2012; 20140929 (orjo

Screen use, sleep duration, daytime somnolence, and academic failure in schoolaged adolescents

Abstract In this study, we examined the relationship between screen time use, sleep characteristics, daytime somnolence, and academic performance in school-aged adolescents. We surveyed 1,257 12- to 18-year-old adolescents attending 52 schools in urban or suburban areas of Argentina. We recorded the daily exposure to various screen-based activities, including video- and online-gaming, social media, TV or streaming. Screen time and device type in the hour before bedtime, sleep patterns during weekdays and weekends, somnolence (Pediatric Daytime Sleepiness Scale score), and grades in language and mathematics were also assessed. Structural Equation Modelling was used to identify a path connecting the latent variables. Results are expressed as standardized regression weights (srw). Missing data were present in 393 subjects, and thus the final sample consisted of 864 complete responses. Daytime somnolence (i.e., PDSS score � 15) was observed in 614 participants (71%), and academic failure (i.e., grades < 7/10) in 352 of them (41%). Time spent using video gaming consoles was negatively associated with sleep duration (srw = -0.22, p<0.01) and positively connected with daytime somnolence (srw = 0.11, p<0.01). Use of mobile devices was associated with lower academic performance (srw = -0.11, p<0.01). Sleep duration was inversely related to daytime somnolence (srw = -0.27, p<0.01), which was in turn negatively associated with academic performance (srw = -0.18, p<0.05). Bedtime computer use did not influence any outcome. In summary, among adolescents, screen use adversely affected nighttime sleep, daytime somnolence, and academic performance. These findings call for the implementation of educational public campaigns aimed at promoting healthy sleep and reducing screen exposure among adolescents

Clinical presentation and outcomes of the first patients with COVID-19 in Argentina: Results of 207079 cases from a national database.

BackgroundThere is limited evidence on the clinical characteristics of SARS-CoV-2 infection in Latin America. We present findings from a nationwide study in Argentina.Research questionWhat is disease severity measures and risk factors are associated with admission to an intensive care unit and mortality?Study design and methodsData were extracted from the COVID-19 database of the Integrated Argentina Health Information System, encompassing the period of March 3rd to October 2nd, 2020, using a standardized case report form that included information on contact history, clinical signs and symptoms, and clinical diagnosis. Information was collected at the initial site of care and follow-up conducted through calls by the regional healthcare authorities. A confirmed case of COVID-19 was defined as having a positive result through sequencing or real-time reverse-transcriptase polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swab specimens.ResultsRT-PCR testing was positive in 738,776 cases. Complete datasets were available for analysis in 207,079 cases. Mean age was 42.9±18.8 years, 50.0% were males. Frequent co-existing conditions included hypertension (19.2%), diabetes (9.7%), asthma (6.1%) and obesity (5.2%). Most common symptoms included fever (58.5%), cough (58.0%), headache (45.4%), and sore throat (42.1%). Death or ICU admission were independently associated with older age, male, coma, dyspnea or tachypnea, and seizures, with underlying co-morbidities such as immunodeficiency, chronic renal failure, and liver disease showing the strongest effects.InterpretationMost cases of COVID-19 diagnosed in Argentina were mild and had a favorable outcome, but fatality rates were relatively elevated. Risk factors for adverse outcome included older age, male sex, coma and seizures, and the concurrent presence of several morbidities. These data may be useful for healthcare providers and healthcare policy makers of low-middle income and Latin American countries to guide decisions toward optimized care during the pandemic