Characterizing Alpine peatlands from drones: a case study

Alpine peatlands occur in alpine, sub-alpine and mountain regions of the world and can be frequently found on the Alps as well as on the Andes, on the Tibetan Plateau, on the Australian Alps and in other regions of the world. Italian Alps host a large number of relatively small bogs and fens that can be found on gently sloping surfaces or in small valleys created by past glaciers. The high precipitation-low temperature climatic regime ensures large water availability to these ecosystems. The uniqueness and importance of peatlands in the Alpine territory is strongly linked to the countless ecosystem services that they provide, including their ability of sequestering and stocking carbon, providing habitat for flora and fauna including endangered species, supporting important biological diversity, being reservoir of high-quality freshwater during warm and dry seasons, and having the role of paleo-climate archives. Despite their importance, the peatlands of the Alps are still poorly studied and incompletely mapped, probably because they are relatively small and difficult to access. The use of remote sensing techniques provides a possible solution, allowing extending local measurements to wider areas in a fast and cost-effective way. Our hypothesis is that the spatial distribution of different plant associations as well as the spatial variability of vegetation biomass may provide important information for mapping the spatial distribution of peat properties, thus making remote sensing an effective method for peatland studies. In this work, we present the results obtained by using data collected by Unmanned Aerial Vehicles (UAVs) on the Val di Ciampo alpine peatland (Province of Belluno, northeast Italy) in July 2021. LiDAR data, hyperspectral data and aerial digital photos were simultaneously collected on an area of 88.000 m2. Field observations and measurements were performed in the same period, providing georeferenced ground information on vegetation and peat characteristics. Peat and vegetation samples were collected and analyzed in the lab. For each vegetation association we measured the height of plants and determined their above- and below-ground biomass based on 20 above-ground and 15 below-ground samples. As for the peat, we measured the peat thickness and determined the bulk density and the organic carbon content of 46 samples. Our results show that some of the correlations found between the parameters that characterize different vegetation associations can be used to calibrate the data collected by UAVs and extend the results from point locations to the entire peatland. For example, we found that the aboveground biomass is significantly correlated (r = 0.81, p < 0.001) to the local average vegetation height, therefore both LiDAR data and the Digital Surface Model (DSM) extracted from the photos can be used to estimate and map the vegetation aboveground biomass. The correlation between the surface microtopography and the aboveground biomass will also be presented, as well as other correlations between vegetation patterns and peat depth and properties. The significance of combining UAVs multi-sensor data with field observations for the characterization of Alpine peatlands will be discussed

EARLY IMPACT PROCEDURES FOR FLOOD EVENTSFEBRUARY 2007 MOZAMBIQUE FLOOD

Satellite images and GIS procedures are key elements for emergency management, especially in case of events hitting developing countries, more vulnerable to calamities and less prepared to face them. This article aims to show the procedure applied for the pro-duction of a cartography of flooded areas during the early impact phase; these activities are developed within ITHACA, centre of excellence, in charge of giving technological support to the WFP (World Food Programme), the biggest agency of the UN. The flood in Mozambique, occurred in January 2007, is illustrated as an example of events management

Effect of the number of daily distributions of solid feed on veal calves' health status, behaviour, and alterations of rumen and abomasa

The research aimed at evaluating the effect of three versus two daily distributions of solid feed on veal calves' health, behaviour, and rumen and abomasal mucosa alterations with the rationale that three distributions might improve calves' health and welfare. The study was carried out in two veal calf farms that provided different amounts of solid feed (farm A 200 kg DM/calf; farm B 150 kg DM/calf) during the fattening in addition to liquid milk-replacer. It involved 342 calves in farm A and 108 calves in farm B. The change from two to three solid feed distributions/day started for half calves/farm after the third month of fattening when farm A was feeding 800 g and farm B 600 g DM/calf/day. Health status, blood haemoglobin, and behaviour were assessed on farm at different times. Calves' carcass weight was recorded and rumens and abomasa were inspected post mortem. Increasing solid feed distributions did not improve calves' health but it reduced non-nutritive oral behaviours (4.8 versus 3.2 ± 0.4% for two and three distributions/day, respectively) by prolonging the time spent eating solid feed. Carcass weight was similar between treatments. Three daily solid feed distributions did not reduce the prevalence of rumen mucosa hyperkeratinisation and abomasal alterations, worsening the frequency of rumen plaques. As the partition of daily dose of solid feed in three distributions is more time and labour consuming, its benefits addressing only the reduction of non-nutritive oral behaviours seem not sufficient to justify the routinely adoption of this practice by veal producers

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

FAN1, a DNA structure-specific nuclease, interacts with MLH1, but the repair pathways in which this complex acts are unknown. FAN1 processes DNA interstrand crosslinks (ICLs) and FAN1 variants are modifiers of the neurodegenerative Huntington's disease (HD), presumably by regulating HD-causing CAG repeat expansions. Here, we identify specific amino acid residues in two adjacent FAN1 motifs that are critical for MLH1 binding. Disruption of the FAN1-MLH1 interaction confers cellular hypersensitivity to ICL damage and defective repair of CAG/CTG slip-outs, intermediates of repeat expansion mutations. FAN1-S126 phosphorylation, which hinders FAN1-MLH1 association, is cell cycle-regulated by cyclin-dependent kinase activity and attenuated upon ICL induction. Our data highlight the FAN1-MLH1 complex as a phosphorylation-regulated determinant of ICL response and repeat stability, opening novel paths to modify cancer and neurodegeneration

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B cell lymphoma

Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNAs (eRNAs) that can regulate transcription of target genes by means of in cis as well as in trans action. eRNAs stabilize contacts between distal genomic regions and mediate the interaction of DNA with master transcription factors. Here, we characterised an enhancer RNA, GECPAR (GErminal Center Proliferative Adapter RNA), that is specifically transcribed in normal and neoplastic germinal center B-cells from the super-enhancer of POU2AF1, a key regulatory gene of the germinal center reaction. Using diffuse large B cell lymphoma cell line models, we demonstrated the tumor suppressor activity of GECPAR, which is mediated via its transcriptional regulation of proliferation and differentiation genes, particularly MYC and the Wnt pathway

Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics

The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity in Children and Adolescents integrates and updates the previous guidelines to deliver an evidence based approach to the disease. The following areas were reviewed: (1) obesity definition and causes of secondary obesity; (2) physical and psychosocial comorbidities; (3) treatment and care settings; (4) prevention.The main novelties deriving from the Italian experience lie in the definition, screening of the cardiometabolic and hepatic risk factors and the endorsement of a staged approach to treatment. The evidence based efficacy of behavioral intervention versus pharmacological or surgical treatments is reported. Lastly, the prevention by promoting healthful diet, physical activity, sleep pattern, and environment is strongly recommended since the intrauterine phase

Contrasting styles of (U)HP rock exhumation along the Cenozoic Adria-Europe plate boundary (Western Alps, Calabria, Corsica)

Since the first discovery of ultrahigh pressure (UHP) rocks 30 years ago in the Western Alps, the mechanisms for exhumation of (U)HP terranes worldwide are still debated. In the western Mediterranean, the presently accepted model of synconvergent exhumation (e.g., the channel-flow model) is in conflict with parts of the geologic record. We synthesize regional geologic data and present alternative exhumation mechanisms that consider the role of divergence within subduction zones. These mechanisms, i.e., (i) the motion of the upper plate away from the trench and (ii) the rollback of the lower plate, are discussed in detail with particular reference to the Cenozoic Adria-Europe plate boundary, and along three different transects (Western Alps, Calabria-Sardinia, and Corsica-Northern Apennines). In the Western Alps, (U)HP rocks were exhumed from the greatest depth at the rear of the accretionary wedge during motion of the upper plate away from the trench. Exhumation was extremely fast, and associated with very low geothermal gradients. In Calabria, HP rocks were exhumed from shallower depths and at lower rates during rollback of the Adriatic plate, with repeated exhumation pulses progressively younging toward the foreland. Both mechanisms were active to create boundary divergence along the Corsica-Northern Apennines transect, where European southeastward subduction was progressively replaced along strike by Adriatic northwestward subduction. The tectonic scenario depicted for the Western Alps trench during Eocene exhumation of (U)HP rocks correlates well with present-day eastern Papua New Guinea, which is presented as a modern analog of the Paleogene Adria-Europe plate boundary

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic