One-year post-graduate course curriculum

The central objective of the European project TRUST is to deliver co-produced knowledge to support Transitions to the Urban Water Services of Tomorrow, enabling communities to achieve a sustainable, low-carbon water future without compromising service quality. TRUST delivered research driven innovations in governance, modelling concepts, technologies, decision support tools, and novel approaches to integrated water, energy, and infrastructure asset management. These innovations have been demonstrated by the implementation of the most promising interventions in the urban water system of the nine different participating city pilot regions. TRUST outcomes are incorporated into planning guidelines and decision support tools, and through dissemination of the knowledge generated to a broad stakeholder community including water utilities, water authorities, technology and service providers, and academics. Among others, the results from the TRUST project can be presented through university courses; i.e. the subject of this deliverable. Given the importance of post-graduate education, a curriculum for a one-year postgraduate course on sustainable management of urban water cycle services (UWCS) is prepared. The aim of the curriculum is to provide a reference that may be adapted or adopted by any European university or network of universities. Although the curriculum and courses presented are hypothetical, for the descriptions actual course contents of several European universities are used. TRUST deliverables are presented as course reading.Schalkwijk, B.; Frijns, J.; Saegrov, S.; Alegre, H. (2015). One-year post-graduate course curriculum: Sustainable Management of Urban Water Cycle Services. http://hdl.handle.net/10251/5363

Urban water system metabolism assessment using WaterMet2 model

12th International Conference on Computing and Control for the Water Industry, CCWI2013, 2013-09-06, 2013-09-09, Perugia, ItalyThis paper presents a new "WaterMet2" model for integrated modelling of an urban water system (UWS). The model is able to quantify the principal water flows and other main fluxes in the UWS. The UWS in WaterMet2 is characterised using four different spatial scales (indoor area, local area, subcatchment and system area) and a daily temporal resolution. The main subsystems in WaterMet2 include water supply, water demand, wastewater and cyclic water recovery. The WaterMet2 is demonstrated here through modelling of the urban water system of Oslo city in Norway. Given a fast population growth, WaterMet2 analyses a range of alternative intervention strategies including 'business as usual', addition of new water resources, increased rehabilitation rates and water demand schemes to improve the performance of the Oslo UWS. The resulting five intervention strategies were compared with respect to some major UWS performance profiles quantified by the WaterMet2 model and expert's opinions. The results demonstrate how an integrated modelling approach can assist planners in defining a better intervention strategy in the future.This work was carried out as part of the ‘TRansition to Urban water Services of Tomorrow’ (TRUST) project. The authors wish to acknowledge the European Commission for funding TRUST project in the 7th Framework Programme under Grant Agreement No. 265122

The impact of culture and sociological and psychological issues on Muslim patients with breast cancer in Pakistan

This is a non-final version of an article published in final form in Cancer Nursing, 32(4), 2009. The final published article is available from the link below.Breast cancer is the most common form of cancer in Muslim women in Pakistan. The impact of the initial diagnosis, culture, religion, and psychosocial and psychological aspects of the disease is not well established. This qualitative study examined the experience and coping strategies used by patients with breast cancer in relation to its impact on their physical, mental health, religious, and family issues. Thirty patients with breast cancer were interviewed. Data were analyzed using thematic analysis. The patient's experience of breast cancer focused on the range of emotions felt throughout the illness trajectory, the importance of religion and family support on coping strategies used to manage the adverse effects of chemotherapy, and also the financial concerns. This is the first study to examine Pakistani Muslim women's views on the lived experience of breast cancer. This article provides clarification of the voiced experiences of women with breast cancer. The data not only highlight the role of religion and family support as essential coping strategies but also emphasize the issues of isolation, aggression, and anger as common responses to chemotherapy. Unique features of this study are women's need to seek spiritual support for their illness and the overriding innate characteristic of maternal responsibility. These cultural features require further analysis and research

Dissecting the loci underlying maturation timing in Atlantic salmon using haplotype and multi-SNP based association methods

Characterizing the role of different mutational effect sizes in the evolution of fitness-related traits has been a major goal in evolutionary biology for a century. Such characterization in a diversity of systems, both model and non-model, will help to understand the genetic processes underlying fitness variation. However, well-characterized genetic architectures of such traits in wild populations remain uncommon. In this study, we used haplotype-based and multi-SNP Bayesian association methods with sequencing data for 313 individuals from wild populations to test the mutational composition of known candidate regions for sea age at maturation in Atlantic salmon (Salmo salar). We detected an association at five loci out of 116 candidates previously identified in an aquaculture strain with maturation timing in wild Atlantic salmon. We found that at four of these five loci, variation explained by the locus was predominantly driven by a single SNP suggesting the genetic architecture of this trait includes multiple loci with simple, non-clustered alleles and a locus with potentially more complex alleles. This highlights the diversity of genetic architectures that can exist for fitness-related traits. Furthermore, this study provides a useful multi-SNP framework for future work using sequencing data to characterize genetic variation underlying phenotypes in wild populations.Peer reviewe

The lived experience of head and neck cancer patients receiving curative radiotherapy: A systematic review and meta‐ethnography

Objective: This review aims to explore, appraise, and synthesise the existing evidence of the meaning that head and neck cancer (HNC) patients assign to the experience of receiving curative radiotherapy. Methods: Qualitative evidence synthesis was undertaken using meta‐ethnography. Published literature was identified using 7 databases: AMED, ASSIA, CINAHL, EMBASE, MEDLINE, PubMed, and PsycINFO. Databases were searched from January 2005 to April 2017. The strategy was supplemented by grey literature and citation searches. Results: Out of 1403 titles, 57 abstracts and 35 full texts were screened. Ultimately, 8 studies were eligible for inclusion. The evidence base was moderate to strong in quality. Most of the studies showed that HNC patients undergoing radiotherapy have unmet needs. Four related concepts were identified: the disruption to life that the disease and radiotherapy treatment cause, patients' feelings of isolation, the need for patients to make sense of their situation, and the waiting and uncertainty that radiotherapy creates. Conclusions: The current literature suggests that both HNC and radiotherapy cause disruption in patients' lives. Radiotherapy causes many unpleasant side effects, and in this difficult treatment period, HNC patients feel isolated, uncertain, and in need of coping strategies. Therapeutic radiographers are ideally placed to offer a supportive relationship. By having a deeper understanding of patients' lived experience, radiographers may form stronger relationships and more effectively help patients through their radiotherapy

Plasticity in response to feed availability - does feeding regime influence the relative growth performance of domesticated, wild and hybrid Atlantic salmon Salmo salar parr?

Growth of farmed, wild and F1 hybrid Atlantic salmon parr, Salmo salar, was investigated under three contrasting feeding regimes in order to understand how varying levels of food availability affects relative growth. Treatments consisted of standard hatchery feeding (ad libitum), access to feed for 4h every day, and access to feed for 24h on three alternate days weekly. Mortality was low in all treatments, and food availability had no effect on survival of all groups. The offspring of farmed S. salar significantly outgrew the wild S. salar, while hybrids displayed intermediate growth. Furthermore, the relative growth differences between the farmed and wild S. salar did not change across feeding treatments, indicating a similar plasticity in response to feed availability. Although undertaken in a hatchery setting, these results suggest that food availability may not be the sole driver behind the observed reduced growth differences found between farmed and wild fishes under natural conditions

The structural variation landscape in 492 Atlantic salmon genomes

Structural variants (SVs) are a major source of genetic and phenotypic variation, but remain challenging to accurately type and are hence poorly characterized in most species. We present an approach for reliable SV discovery in non-model species using whole genome sequencing and report 15,483 high-confidence SVs in 492 Atlantic salmon (Salmo salar L.) sampled from a broad phylogeographic distribution. These SVs recover population genetic structure with high resolution, include an active DNA transposon, widely affect functional features, and overlap more duplicated genes retained from an ancestral salmonid autotetraploidization event than expected. Changes in SV allele frequency between wild and farmed fish indicate polygenic selection on behavioural traits during domestication, targeting brain-expressed synaptic networks linked to neurological disorders in humans. This study offers novel insights into the role of SVs in genome evolution and the genetic architecture of domestication traits, along with resources supporting reliable SV discovery in non-model species.Peer reviewe

Basin-scale phenology and effects of climate variability on global timing of initial seaward migration of Atlantic salmon (Salmo salar)

Migrations between different habitats are key events in the lives of many organisms. Such movements involve annually recurring travel over long distances usually triggered by seasonal changes in the environment. Often, the migration is associated with travel to or from reproduction areas to regions of growth. Young anadromous Atlantic salmon (Salmo salar) emigrate from freshwater nursery areas during spring and early summer to feed and grow in the North Atlantic Ocean. The transition from the freshwater (parr') stage to the migratory stage where they descend streams and enter salt water (smolt') is characterized by morphological, physiological and behavioural changes where the timing of this parr-smolt transition is cued by photoperiod and water temperature. Environmental conditions in the freshwater habitat control the downstream migration and contribute to within- and among-river variation in migratory timing. Moreover, the timing of the freshwater emigration has likely evolved to meet environmental conditions in the ocean as these affect growth and survival of the post-smolts. Using generalized additive mixed-effects modelling, we analysed spatio-temporal variations in the dates of downstream smolt migration in 67 rivers throughout the North Atlantic during the last five decades and found that migrations were earlier in populations in the east than the west. After accounting for this spatial effect, the initiation of the downstream migration among rivers was positively associated with freshwater temperatures, up to about 10 degrees C and levelling off at higher values, and with sea-surface temperatures. Earlier migration occurred when river discharge levels were low but increasing. On average, the initiation of the smolt seaward migration has occurred 2.5days earlier per decade throughout the basin of the North Atlantic. This shift in phenology matches changes in air, river, and ocean temperatures, suggesting that Atlantic salmon emigration is responding to the current global climate changes

Intervention concepts for energy saving, recovery and generation from the urban water system

There are numerous options for energy measures in the water sector ranging from water conservation and process efficiency improvements to new technologies and redesigning water systems. Next to energy efficiency improvements, there is a need for new concepts in which water is viewed as a carrier of energy. Municipal wastewater is a potential source of chemical energy, i.e. organic carbon that can be recovered as biogas in sludge digestion. Even more so, domestic (waste)water is a source of thermal energy. And in areas with altitude differences, installing micro-hydro technologies in water distribution systems can convert energy from the pressure and flow into electricity. This report presents intervention concepts for energy saving, recovery and generation from the urban water system. Summarised, the main outcomes of research undertaken at 9 case studies are: i) Algarve and Alcoy water supply system: by performing an energy audit, the most energy efficient operating scheme can be determined. ii) Oslo and Amsterdam water cycle: the thermal energy recovery potential from wastewater is large, and it is in particular feasible if coupled to aquifer thermal energy storage systems. iii) Schiphol and Athens wastewater treatment: the energy generation at wastewater treatment plants through biogas can be enhanced by co-digestion and thermophilic digestion. iv) Lanhirano, Athens and Algare water supply system: in a water distribution system, water and energy can be saved by integrating pressure and energy management., i.e. by installing micro-turbines.Frijns, J.; Monteiro, A.; De Graaff, M.; Carriço, N.; Covas, D.; Cabrera Marcet, E.; Lausund, E.... (2014). Intervention concepts for energy saving, recovery and generation from the urban water system. http://hdl.handle.net/10251/4662