Prediction of Tool Recipe Runtimes in Semiconductor Manufacturing

To improve throughput, due date adherence, or tool usage in semiconductor manufacturing, it is crucial to model the duration of individual processes such as coating, diffusion, or etching. Equipped with such data, production planning can develop dispatch schemes and schedules for optimized material routing. However, just a few tools indicate how long a process will take. Many variables affect the runtime of tool recipes that are used to realize processes. These variables include wafer processing mode, historical context, batch size, and job handling. In this thesis, a model that allows inferring tool recipe runtimes with adequate accuracy shall be developed. Firstly, predictive models shall be built for selected tools with known runtime behavior to establish a baseline for the methodology. Tools will be selected to cover a broad spectrum of processing modalities. The main predictors will be revealed using variable importance analysis. Furthermore, the analysis shall reveal under which conditions recipe runtime modeling is most accurate. Secondly, a generic approach shall be created to model recipe runtime. By accounting for tool, process, and material context, methods would be investigated from feature selection and automatic model selection. Finally, a pipeline for data cleansing, feature engineering, model building, and metrics will be developed using historical data from a wide range of factory data sources. Finally, a scheme to operationalize the findings shall be outlined. In particular, this requires establishing model serving to enable consumption in applications such as dispatching or operator interfaces

Radical Islamic Democracy

Can democracy be at once radical and Islamic? In this paper I argue that it can. My argument is based on a comparison and contrast of certain aspects in the social-political thought of two contemporary authors: Axel Honneth who defends a particular conception of radical democracy, and Rached al-Ghannouchi who defends a particular conception of the Islamic state. I begin with Honneth’s early articulation of his model of radical democracy as reflexive cooperation, which he presents as an alternative that reconciles Arendtian republicanism and Habermasian proceduralism while avoiding their weaknesses. I also refer to his more mature conception of democracy by way of highlighting his understanding of democracy as a process of constituting civil society. This is significant for the purposes of this paper since it forms the most important link between Honneth’s radical democracy and Ghannouchi’s Islamic model of political rule. I then introduce Ghannouchi’s theoretical account of the Islamic state with a focus on his conception of shura (consultation) in order to bring to the fore both the similarities and dissimilarities with Honneth’s theory of democracy. By this point I will have identified Islamic resources for a conception of democracy that, like Honneth’s democracy as reflexive cooperation, shares with proceduralism an instrumental view of democratic procedures, and with republicanism a strong connection between the pre-political social level and politics. Next, I ask whether this conception of radical Islamic democracy can square its dual commitment to pluralism and Islamic unity. Again, I draw on Ghannouchi’s thought to respond to the challenge, doing so in a way that brings out the agonistic dimension in radical Islamic democracy. I conclude by making explicit how radical Islamic democracy carves out a conceptual space in which proceduralist, republican and agonistic features are combined

The virtuous arguer as a virtuous sequencer

In this paper we draw on the munazara tradition to intervene in the debate on whether argument assessment should be agent- or act-based. We introduce and deploy the notion of sequencing - the ordering of the antagonist's critical moves - to make explicit an ambiguity between the agent and the act of arguing. We show that sequencing is a component of argumentation that inextricably involves the procedure as well as the agent and, therefore, its assessment cannot be adequately undertaken if either agent- or act-based norms are ignored or demoted. We present our intervention through a challenge that virtue argumentation needs to address for it to be considered an alternative to existing theories of argument assessment (Section 2). We then briefly introduce munazara and focus on its notion of sequencing to explicate the interdependence between the agent and the procedure (Section 3). Next, we address the challenge by offering an account of the virtuous arguer as a virtuous sequencer (Section 4). In conclusion, we reflect on the implications of sequencing on virtue argumentation and the norms of argumentation

ANN for Parkinson’s Disease Prediction

Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Doctors do not know what causes it and finds difficulty in early diagnosing the presence of Parkinson’s disease. An artificial neural network system with back propagation algorithm is presented in this paper for helping doctors in identifying PD. Previous research with regards to predict the presence of the PD has shown accuracy rates up to 93% [1]; however, accuracy of prediction for small classes is reduced. The proposed design of the neural network system causes a significant increase of robustness. It is also has shown that networks recognition rates reached 100%

Case Study in Refractory Non-Hodgkin's Lymphoma: Successful Treatment with Plerixafor

The present case study describes our experience in treating a young woman diagnosed with a relapsing case of diffuse large cell lymphoma, who was heavily pre-treated with chemotherapy and radiotherapy. Our only chance to improve her survival was by using high-dose chemotherapy, followed by peripheral stem cell rescue. Unfortunately, in this patient, collecting sufficient stem cells for bone marrow transplantation proved to be very difficult since she had already been heavily treated with chemotherapy and radiotherapy. Currently, granulocyte colony-stimulating factor (G-CSF) alone or G-CSF plus chemotherapy are the most commonly used treatments for stem cell mobilization. However, 5–30% of patients do not respond to these agents. Plerixafor is a new hematopoietic stem cell-mobilizing drug that antagonizes the binding of chemokine stromal cell-derived factor-1α to CXC chemokine receptor 4. It is indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma [Kessans et al.: Pharmacotherapy 2010;30:485–492; Jantunen: Expert Opin Biol Ther 2011;11:1241–1248]. Based on our findings, we consider plerixafor to be a very efficient and practical solution to mobilize and collect stem cells among all patients in such a situation, enabling us to proceed to autologous bone marrow transplantation and peripheral stem cell rescue in order to improve the patients’ overall survival

Hydrogels and Dentin-Pulp Complex Regeneration: From the Benchtop to Clinical Translation

Dentin-pulp complex is a term which refers to the dental pulp (DP) surrounded by dentin along its peripheries. Dentin and dental pulp are highly specialized tissues, which can be affected by various insults, primarily by dental caries. Regeneration of the dentin-pulp complex is of paramount importance to regain tooth vitality. The regenerative endodontic procedure (REP) is a relatively current approach, which aims to regenerate the dentin-pulp complex through stimulating the differentiation of resident or transplanted stem/progenitor cells. Hydrogel-based scaffolds are a unique category of three dimensional polymeric networks with high water content. They are hydrophilic, biocompatible, with tunable degradation patterns and mechanical properties, in addition to the ability to be loaded with various bioactive molecules. Furthermore, hydrogels have a considerable degree of flexibility and elasticity, mimicking the cell extracellular matrix (ECM), particularly that of the DP. The current review presents how for dentin-pulp complex regeneration, the application of injectable hydrogels combined with stem/progenitor cells could represent a promising approach. According to the source of the polymeric chain forming the hydrogel, they can be classified into natural, synthetic or hybrid hydrogels, combining natural and synthetic ones. Natural polymers are bioactive, highly biocompatible, and biodegradable by naturally occurring enzymes or via hydrolysis. On the other hand, synthetic polymers offer tunable mechanical properties, thermostability and durability as compared to natural hydrogels. Hybrid hydrogels combine the benefits of synthetic and natural polymers. Hydrogels can be biofunctionalized with cell-binding sequences as arginine-glycine-aspartic acid (RGD), can be used for local delivery of bioactive molecules and cellularized with stem cells for dentin-pulp regeneration. Formulating a hydrogel scaffold material fulfilling the required criteria in regenerative endodontics is still an area of active research, which shows promising potential for replacing conventional endodontic treatments in the near future

Extending the Decision-Making Capabilities in Remanufacturing Service Contracts by Using Symbiotic Simulation

Remanufacturing is a critical enabler of a resource efficient manufacturing industry that has long been associated with high value products. Over time, the commercial relationship between customers and service providers has been made through the fulfilment of rights and obligations under remanufacturing service contracts. Nonetheless, financial analysis to evaluate the contract terms and conditions are becoming increasingly difficult to conduct due to complex decision problems inherent in remanufacturing systems. In order to achieve better and safer decision-making to shape the business strategies, remanufacturers often employ computer-based simulation tools to assess contractual obligations and customers’ needs. This paper discusses the roles of a symbiotic simulation system (SSS) in supporting decision-making in remanufacturing systems. An industrial case study of power transformer remanufacturing illustrates how SSS can support contract remanufacturers in managing service contracts planning and execution. By linking the simulation model to the physical system, it has been demonstrated that the capabilities of the remanufacturers to make critical decisions throughout the entire service contract period can be extended

The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: the (UK-REBOA) multicentre RCT

Background The most common cause of preventable death after injury is haemorrhage. Resuscitative endovascular balloon occlusion of the aorta is intended to provide earlier, temporary haemorrhage control, to facilitate transfer to an operating theatre or interventional radiology suite for definitive haemostasis. Objective To compare standard care plus resuscitative endovascular balloon occlusion of the aorta versus standard care in patients with exsanguinating haemorrhage in the emergency department. Design Pragmatic, multicentre, Bayesian, group-sequential, registry-enabled, open-label, parallel-group randomised controlled trial to determine the clinical and cost-effectiveness of standard care plus resuscitative endovascular balloon occlusion of the aorta, compared to standard care alone. Setting United Kingdom Major Trauma Centres. Participants Trauma patients aged 16 years or older with confirmed or suspected life-threatening torso haemorrhage deemed amenable to adjunctive treatment with resuscitative endovascular balloon occlusion of the aorta. Interventions Participants were randomly assigned 1 : 1 to: standard care, as expected in a major trauma centre standard care plus resuscitative endovascular balloon occlusion of the aorta. Main outcome measures Primary: Mortality at 90 days. Secondary: Mortality at 6 months, while in hospital, and within 24, 6 and 3 hours; need for haemorrhage control procedures, time to commencement of haemorrhage procedure, complications, length of stay (hospital and intensive care unit-free days), blood product use. Health economic: Expected United Kingdom National Health Service perspective costs, life-years and quality-adjusted life-years, modelled over a lifetime horizon. Data sources Case report forms, Trauma Audit and Research Network registry, NHS Digital (Hospital Episode Statistics and Office of National Statistics data). Results Ninety patients were enrolled: 46 were randomised to standard care plus resuscitative endovascular balloon occlusion of the aorta and 44 to standard care. Mortality at 90 days was higher in the standard care plus resuscitative endovascular balloon occlusion of the aorta group (54%) compared to the standard care group (42%). The odds ratio was 1.58 (95% credible interval 0.72 to 3.52). The posterior probability of an odds ratio > 1 (indicating increased odds of death with resuscitative endovascular balloon occlusion of the aorta) was 86.9%. The overall effect did not change when an enthusiastic prior was used or when the estimate was adjusted for baseline characteristics. For the secondary outcomes (3, 6 and 24 hours mortality), the posterior probability that standard care plus resuscitative endovascular balloon occlusion of the aorta was harmful was higher than for the primary outcome. Additional analyses to account for intercurrent events did not change the direction of the estimate for mortality at any time point. Death due to haemorrhage was more common in the standard care plus resuscitative endovascular balloon occlusion of the aorta group than in the standard care group. There were no serious adverse device effects. Resuscitative endovascular balloon occlusion of the aorta is less costly (probability 99%), due to the competing mortality risk but also substantially less effective in terms of lifetime quality-adjusted life-years (probability 91%). Limitations The size of the study reflects the relative infrequency of exsanguinating traumatic haemorrhage in the United Kingdom. There were some baseline imbalances between groups, but adjusted analyses had little effect on the estimates. Conclusions This is the first randomised trial of the addition of resuscitative endovascular balloon occlusion of the aorta to standard care in the management of exsanguinating haemorrhage. All the analyses suggest that a strategy of standard care plus resuscitative endovascular balloon occlusion of the aorta is potentially harmful. Future work The role (if any) of resuscitative endovascular balloon occlusion of the aorta in the pre-hospital setting remains unclear. Further research to clarify its potential (or not) may be required. Trial registration This trial is registered as ISRCTN16184981. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 14/199/09) and is published in full in Health Technology Assessment; Vol. 28, No. 54. See the NIHR Funding and Awards website for further award information

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112