739 research outputs found
Tenecteplase for the treatment of acute ischemic stroke: a review of completed and ongoing randomized controlled trials
Alteplase has been the mainstay of thrombolytic treatment since the National Institutes of Neurological Disorders and
Stroke trial was published in 1995. Over recent years, several trials have investigated alternative thrombolytic agents.
Tenecteplase, a genetically engineered mutant tissue plasminogen activator, has a longer half-life, allowing single intravenous
bolus administration without infusion, is more fibrin specific, produces less systemic depletion of circulating
fibrinogen, and is more resistant to plasminogen activator inhibitor compared to alteplase. Tenecteplase is established as
the first-line intravenous thrombolytic drug for myocardial infarction, where it has been shown to achieve comparable
reperfusion with reduced risk of systemic bleeding in comparison to alteplase. We review the literature on tenecteplase
for the treatment of acute ischemic stroke, with a focus on the major completed and ongoing trials. Overall, tenecteplase
shows promise for treatment of acute ischemic stroke, both in populations currently eligible for alteplase and also in
groups not currently treated with thrombolysis
Search for Higgs bosons decaying to tautau pairs in ppbar collisions at sqrt(s) = 1.96 TeV
We present a search for the production of neutral Higgs bosons decaying into
tautau pairs in ppbar collisions at a center-of-mass energy of 1.96 TeV. The
data, corresponding to an integrated luminosity of 5.4 fb-1, were collected by
the D0 experiment at the Fermilab Tevatron Collider. We set upper limits at the
95% C.L. on the product of production cross section and branching ratio for a
scalar resonance decaying into tautau pairs, and we then interpret these limits
as limits on the production of Higgs bosons in the minimal supersymmetric
standard model (MSSM) and as constraints in the MSSM parameter space.Comment: 7 pages, 5 figures, submitted to PL
Measurement of three-jet differential cross sections d sigma-3jet / d M-3jet in p anti-p collisions at sqrt(s)=1.96 TeV
We present the first measurement of the inclusive three-jet differential
cross section as a function of the invariant mass of the three jets with the
largest transverse momenta in an event in p anti-p collisions at sqrt(s) = 1.96
TeV. The measurement is made in different rapidity regions and for different
jet transverse momentum requirements and is based on a data set corresponding
to an integrated luminosity of 0.7 fb^{-1} collected with the D0 detector at
the Fermilab Tevatron Collider. The results are used to test the three-jet
matrix elements in perturbative QCD calculations at next-to-leading order in
the strong coupling constant. The data allow discrimination between
parametrizations of the parton distribution functions of the proton.Comment: 10 pages, 4 figures, 2 tables, submitted to Phys. Lett. B, corrected
chi2 values for NNPD
Measurements of inclusive W+jets production rates as a function of jet transverse momentum in ppbar collisions at sqrt{s}=1.96 TeV
This Letter describes measurements of inclusive W (--> e nu) + n jet cross
sections (n = 1-4), presented as total inclusive cross sections and
differentially in the nth jet transverse momentum. The measurements are made
using data corresponding to an integrated luminosity of 4.2 fb-1 collected by
the D0 detector at the Fermilab Tevatron Collider, and achieve considerably
smaller uncertainties on W +jets production cross sections than previous
measurements. The measurements are compared to next-to-leading order
perturbative QCD (pQCD) calculations in the n =1-3 jet multiplicity bins and to
leading order pQCD calculations in the 4-jet bin. The measurements are
generally in agreement with pQCD predictions, although certain regions of phase
space are identified where the calculations could be improved
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Measurement of spin correlation in ttbar production using dilepton final states
We measure the correlation between the spin of the top quark and the spin of
the anti-top quark in (ttbar -> W+ W- b bbar -> l+ nu b l- nubar bbar) final
states produced in ppbar collisions at a center of mass energy sqrt(s)=1.96
TeV, where l is an electron or muon. The data correspond to an integrated
luminosity of 5.4 fb-1 and were collected with the D0 detector at the Fermilab
Tevatron collider. The correlation is extracted from the angles of the two
leptons in the t and tbar rest frames, yielding a correlation strength C=
0.10^{+0.45}_{-0.45}, in agreement with the NLO QCD prediction within two
standard deviations, but also in agreement with the no correlation hypothesis.Comment: 10 pages, 3 figures, submitted to PL
Search for single top quarks in the tau+jets channel using 4.8 fb of collision data
We present the first direct search for single top quark production using tau
leptons. The search is based on 4.8 fb of integrated luminosity
collected in collisions at =1.96 TeV with the D0 detector
at the Fermilab Tevatron Collider. We select events with a final state
including an isolated tau lepton, missing transverse energy, two or three jets,
one or two of them tagged. We use a multivariate technique to discriminate
signal from background. The number of events observed in data in this final
state is consistent with the signal plus background expectation. We set in the
tau+jets channel an upper limit on the single top quark cross section of
\TauLimObs pb at the 95% C.L. This measurement allows a gain of 4% in expected
sensitivity for the observation of single top production when combining it with
electron+jets and muon+jets channels already published by the D0 collaboration
with 2.3 fb of data. We measure a combined cross section of
\SuperCombineXSall pb, which is the most precise measurement to date.Comment: 12 pages, 5 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Measurement of the ttbar production cross section using dilepton events in ppbar collisions
We present a measurement of the ttbar production cross section sigma(ttbar)
in ppbar collisions at sqrt{s} = 1.96 TeV using 5.4 fb-1 of integrated
luminosity collected with the D0 detector. We consider final states with at
least two jets and two leptons (ee, emu, mumu), and events with one jet for the
the emu final state as well. The measured cross section is sigma(ttbar)= 7.36
+0.90-0.79 (stat + syst) pb. This result combined with the cross section
measurement in the lepton + jets final state yields sigma(ttbar)=7.56
+0.63-0.56 (stat + syst) pb, which agrees with the standard model expectation.
The relative precision of 8% of this measurement is comparable to the latest
theoretical calculations.Comment: 9 pages, published in Phys. Lett.
b-Jet Identification in the D0 Experiment
Algorithms distinguishing jets originating from b quarks from other jet
flavors are important tools in the physics program of the D0 experiment at the
Fermilab Tevatron p-pbar collider. This article describes the methods that have
been used to identify b-quark jets, exploiting in particular the long lifetimes
of b-flavored hadrons, and the calibration of the performance of these
algorithms based on collider data.Comment: submitted to Nuclear Instruments and Methods in Physics Research
- …