Compensatory component of PRP-technology and knee-joint osteoarthrosis of dogs

Input: Osteoarthrosis belongs to heterogenous group of diseases with similar morphological and clinical implications that leads to the cartilage and subchondral bone lesion, as well as lesion of other joint components (synovium, ligaments, capsule and periarticular muscles) (patent RU 2117997, 2240602, 2240603, 22464304, 22464305, 2271139, 2271140, 2303436, 2323694, 2323695) . Aim of research – to develop treatment technology of animals with aseptic osteoarthrosis by applying thrombocyte rich plasma. Objectives: The objects of the study were dogs with knee-joint osteoarthrosis of I-III level. Every animal was older than 6 years old, with a live weight ≥30 kg. Methods: clinical, X-ray research, endoscopy. Results: A week later after the autoplasma re-introduction, positive dynamics in all the animals was observed. In particular, lameness decreased, volume of the affected limb muscles recovered a little. At the end of therapy lameness disappeared in all animals virtually, but in some animals it was appeared after loading. Regain mobility joint crepitus disappeared. Joint mobility was recovered, crepitation disappeared. At the end of the treatment, control radiography of affected limbs showed a positive dynamics, consist in unevenness reducing of the articular surface, size of osteophytes reducing, osteosclerosis percent reduction. In the time of re-arthroscopy at the end of treatment some positive dynamics had observed; chondromalacia of I stage was marked, edema and hyperemia of synovial villi reduction, no generalized synovitis, no pulping of partial anterior cruciate ligament in particular. Discussion: Leanness, joint rigidity reduction in all animals by the end of the treatment course proves the presence of anti-inflammatory, regenerative effect of thrombocyte-rich plasma. Chondroprotective effect of platelet-derived growth factor cause reduction of edema of the synovial membrane and cartilage chondromalacia reduction, and reduction in the size of the cartilage defects observed during arthroscopic visualization. Lack of side effects and complications indicate high availability and safety of the method, in comparison with the standard treatment methods of animal osteoarthritis

Gastric cancer with multiple metastases in pregnancy: a case report

The mortality rate in gastric cancer during pregnancy is very high, which dictates the need to research and improve the methods of early diagnosis of malignancies, as well as studying the pathogenesis of malignant tumors in pregnant women. We report a lethal case of gastric cancer in a pregnant woman. The findings of the autopsy, histological, histochemical and immunohistochemical examinations verified gastric signet ring cells carcinoma with multiple metastases and infiltration of the placental intervillous space. The possible pathogenesis of cancer with changes in the hormonal background occurring in pregnant women is discussed. Understanding the endocrine mechanisms of carcinoma pathogenesis will be useful for developing new therapies for gastric cancer

A PMT-Block test bench

The front-end electronics of the ATLAS hadronic calorimeter (Tile Cal) is housed in a unit, called {\it PMT-Block}. The PMT-Block is a compact instrument comprising a light mixer, a PMT together with its divider and a {\it 3-in-1} card, which provides shaping, amplification and integration for the signals. This instrument needs to be qualified before being assembled on the detector. A PMT-Block test bench has been developed for this purpose. This test bench is a system which allows fast, albeit accurate enough, measurements of the main properties of a complete PMT-Block. The system, both hardware and software, and the protocol used for the PMT-Blocks characterisation are described in detail in this report. The results obtained in the test of about 10000 PMT-Blocks needed for the instrumentation of the ATLAS (LHC-CERN) hadronic Tile Calorimeter are also reported.Comment: 23 pages, 10 figure

Treatment of children with chemical burns of esophagus with various etiology

Background. At present continuous growth of pathology after chemical burns of the esophagus (CBE) in children is observed. The lack of uniform statistical information about this pathology in domestic and foreign literature considerably complicates studying of that nosology. The purpose of the present study is optimization of treatment techniques in children with chemical burns of the esophagus with various etiology and generalization of our own experience of treatment in this contingent of patients.Material and methods. We have analyzed treatment techniques in 147 children with CBE with various etiology and severity for last decade. The general method of diagnosis was esophagogastroscopy performed within the first day of hospitalization. Endoscopic examination showed following stages of CBE: I stage in 36 patients, II stage in 67 cases and 44 patients had III stage.Results. In children with I stage CBE erosive inflammatory process was controlled by conservative therapy in 10–14 days. This cohort of patients from 3–4 day of disease was considered outpatient. Patients with II stage CBE erosive inflammatory changes were treated by complex therapy on 21–23 day. There were surgical complications observed.    Patients with III stage CBE referred in most severe condition. Length of conservative treatment for erosive  inflammatory process was 1 month. In this group of patients we observed complications in 24 cases (16.3%) and bougienage was performed according to different techniques. Duration of bougienage varied from 3 to 24 months. Later on all children were observed out-patiently according to the place of residence.Conclusions. Performed therapy should be complex and differentiated regarding the severity of trauma. Complex treatment technique designed in our hospital is quite efficient and could be recommended for clinical application. All children suffered from CBE are to be followed up refularly. Preventive medical check-up should include endoscopic examination, once every three months to avoid possible esophageal stenosis development. Preventive treatment for esophagitis is mandatory during the period of preventive medical check-up

Hadron Energy Reconstruction for the ATLAS Calorimetry in the Framework of the Non-parametrical Method

This paper discusses hadron energy reconstruction for the ATLAS barrel prototype combined calorimeter (consisting of a lead-liquid argon electromagnetic part and an iron-scintillator hadronic part) in the framework of the non-parametrical method. The non-parametrical method utilizes only the known $e/h$ ratios and the electron calibration constants and does not require the determination of any parameters by a minimization technique. Thus, this technique lends itself to an easy use in a first level trigger. The reconstructed mean values of the hadron energies are within $\pm 1$ of the true values and the fractional energy resolution is $[(58\pm3)/\sqrt{E}+(2.5\pm0.3)$. The value of the $e/h$ ratio obtained for the electromagnetic compartment of the combined calorimeter is $1.74\pm0.04$ and agrees with the prediction that $e/h > 1.7$ for this electromagnetic calorimeter. Results of a study of the longitudinal hadronic shower development are also presented. The data have been taken in the H8 beam line of the CERN SPS using pions of energies from 10 to 300 GeV.Comment: 33 pages, 13 figures, Will be published in NIM

Evaluation morphological changes in temporo-mandibular joints with experimental animals in the process of modeling fibrous ankylosis and the impact of transkranial electric stimulation on them

The results of morphological changes in temporomandibular joint (TMJ) with 30 experimental animals in the process of modeling fibrous ankylosis are given in the article. The analysis of the results obtained has shown the positive impact of transkranial electric stimulation (TES-therapy) which reduced the destructive processes in bone tissue of mandibular head and mandibular fossa thus accelerating the process of their restructuring and the promotion of osteogenesis process compared to the fabrics of TMJ with experimental animals to whom the TES-therapy has not been applied

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal