595 research outputs found
Ecosystem approach to harvesting in the Arctic : walking the tightrope between exploitation and conservation in the Barents Sea
Funidng: This study was supported by the Changing Arctic Ocean project MiMeMo (NE/R012679/1) jointly funded by the UKRI Natural Environment Research Council (NERC) and the German Federal Ministry of Education and Research (BMBF/03F0801A). Brierley was also supported by ArcticPRIZE (NE/P005721/1).Projecting the consequences of warming and sea-ice loss for Arctic marine food web and fisheries is challenging due to the intricate relationships between biology and ice. We used StrathE2EPolar, an end-to-end (microbes-to-megafauna) food web model incorporating ice-dependencies to simulate climate-fisheries interactions in the Barents Sea. The model was driven by output from the NEMO-MEDUSA earth system model, assuming RCP 8.5 atmospheric forcing. The Barents Sea was projected to be > 95% ice-free all year-round by the 2040s compared to > 50% in the 2010s, and approximately 2 °C warmer. Fisheries management reference points (FMSY and BMSY) for demersal fish (cod, haddock) were projected to increase by around 6%, indicating higher productivity. However, planktivorous fish (capelin, herring) reference points were projected to decrease by 15%, and upper trophic levels (birds, mammals) were strongly sensitive to planktivorous fish harvesting. The results indicate difficult trade-offs ahead, between harvesting and conservation of ecosystem structure and function.Publisher PDFPeer reviewe
How is climate change affecting marine life in the Arctic?
Rising temperature is melting the ice that covers the Arctic Ocean, allowing sunlight into waters that have been dark for thousands of years. Previously barren ice-covered regions are being transformed into productive seas. Here we explain how computer modelling can be used to predict how this transformation will affect the food web that connects plankton to fish and top-predators like whales and polar bears. Images of starving polar bears have become symbolic of the effects of warming climate. Melting of the sea-ice is expected to reduce the bears’ ability to hunt for seals. However, at the same time, the food web upon which they depend is becoming more productive, so it is not completely clear what the eventual outcome will be for the bears. Computer models help us to understand these systems and inform policy decisions on the management of newly available Arctic resources
Crew Exploration Vehicle Ascent Abort Overview
One of the primary design drivers for NASA's Crew Exploration Vehicle (CEV) is to ensure crew safety. Aborts during the critical ascent flight phase require the design and operation of CEV systems to escape from the Crew Launch Vehicle and return the crew safely to the Earth. To accomplish this requirement of continuous abort coverage, CEV ascent abort modes are being designed and analyzed to accommodate the velocity, altitude, atmospheric, and vehicle configuration changes that occur during ascent. The analysis involves an evaluation of the feasibility and survivability of each abort mode and an assessment of the abort mode coverage. These studies and design trades are being conducted so that more informed decisions can be made regarding the vehicle abort requirements, design, and operation. This paper presents an overview of the CEV, driving requirements for abort scenarios, and an overview of current ascent abort modes. Example analysis results are then discussed. Finally, future areas for abort analysis are addressed
EXPERIMENTAL STUDIES OF MITIGATION MATERIALS FOR BLAST INDUCED TBI
The objective of this experimental study is to compare the effects of various materials obstructing the flow of a blast wave and the ability of the given material to reduce the damage caused by the blast. Several methods of energy transfer in blast wave flows are known or expected including: material interfaces with impedance mismatches, density changes in a given material, internal shearing, and particle fracture. The theory applied to this research is that the greatest energy transfer within the obstructing material will yield the greatest mitigation effects to the blast. Sample configurations of foam were varied to introduce material interfaces and filler materials with varying densities and impedances (liquids and powders). The samples were loaded according to a small scale blast produced by an explosive driven shock tube housing gram-range charges. The transmitted blast profiles were analyzed for variations in impulse characteristics and frequency components as compared to standard free field profiles. The results showed a rounding effect of the transmitted blast profile for all samples with the effects of the low density fillers surpassing all others tested.United States. Office of Naval Research (N00014-08-1-0261
Particle size effect on strength, failure and shock behavior in Polytetrafluoroethylene-Al-W granular composites
The variation of metallic particle size and sample porosity significantly
alters the dynamic mechanical properties of high density granular composites
processed using a cold isostatically pressed mixture of polytetrafluoroethylene
(PTFE), aluminum (Al) and tungsten (W) powders. Quasi-static and dynamic
experiments are performed with identical constituent mass fractions with
variations in the size of the W particles and pressing conditions. The
relatively weak polymer matrix allows the strength and fracture modes of this
material to be governed by the granular type behavior of agglomerated metal
particles. A higher ultimate compressive strength was observed in relatively
high porosity samples with small W particles compared to those with coarse W
particles in all experiments. Mesoscale granular force chains comprised of the
metallic particles explain this unusual phenomenon as observed in a hydrocode
simulation of a drop-weight test. Macrocracks forming below the critical
failure strain for the matrix and unusual behavior due to a competition between
densification and fracture in dynamic tests of porous samples were also
observed. Shock loading of this granular composite resulted in higher fraction
of total internal energy deposition in the soft PTFE matrix, specifically
thermal energy, which can be tailored by the W particle size distribution.Comment: 35 pages, 13 figure
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MoonLITE programmatic and technological update
MoonLITE is a proposed four penetrator lunar mission. Following a US/UK working group assessment, a science assessment and the first UK impact trials, a full mission-level phase A study has begun. A technological and programmatic update of the mission is given
Complex chromosome 17p rearrangements associated with low-copy repeats in two patients with congenital anomalies
Recent molecular cytogenetic data have shown that the constitution of complex chromosome rearrangements (CCRs) may be more complicated than previously thought. The complicated nature of these rearrangements challenges the accurate delineation of the chromosomal breakpoints and mechanisms involved. Here, we report a molecular cytogenetic analysis of two patients with congenital anomalies and unbalanced de novo CCRs involving chromosome 17p using high-resolution array-based comparative genomic hybridization (array CGH) and fluorescent in situ hybridization (FISH). In the first patient, a 4-month-old boy with developmental delay, hypotonia, growth retardation, coronal synostosis, mild hypertelorism, and bilateral club feet, we found a duplication of the Charcot-Marie–Tooth disease type 1A and Smith-Magenis syndrome (SMS) chromosome regions, inverted insertion of the Miller-Dieker lissencephaly syndrome region into the SMS region, and two microdeletions including a terminal deletion of 17p. The latter, together with a duplication of 21q22.3-qter detected by array CGH, are likely the unbalanced product of a translocation t(17;21)(p13.3;q22.3). In the second patient, an 8-year-old girl with mental retardation, short stature, microcephaly and mild dysmorphic features, we identified four submicroscopic interspersed 17p duplications. All 17 breakpoints were examined in detail by FISH analysis. We found that four of the breakpoints mapped within known low-copy repeats (LCRs), including LCR17pA, middle SMS-REP/LCR17pB block, and LCR17pC. Our findings suggest that the LCR burden in proximal 17p may have stimulated the formation of these CCRs and, thus, that genome architectural features such as LCRs may have been instrumental in the generation of these CCRs
Antarctic pack ice algal distribution: Floe-scale spatial variability and predictability from physical parameters
©2017. Commonwealth of Australia. Antarctic pack ice serves as habitat for microalgae which contribute to Southern Ocean primary production and serve as important food source for pelagic herbivores. Ice algal biomass is highly patchy and remains severely undersampled by classical methods such as spatially restricted ice coring surveys. Here we provide an unprecedented view of ice algal biomass distribution, mapped (as chlorophyll a) in a 100 m by 100 m area of a Weddell Sea pack ice floe, using under-ice irradiance measurements taken with an instrumented remotely operated vehicle. We identified significant correlations (p < 0.001) between algal biomass and concomitant in situ surface measurements of snow depth, ice thickness, and estimated sea ice freeboard levels using a statistical model. The model's explanatory power (r2 = 0.30) indicates that these parameters alone may provide a first basis for spatial prediction of ice algal biomass, but parameterization of additional determinants is needed to inform more robust upscaling efforts
Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation
Myeloid and plasmacytoid dendritic cells (mDCs, pDC) are crucial to the immune system, detecting microorganisms and linking the innate and adaptive immunity. pDC are present in small quantities in tissues that are in contact with the external environment; mainly the skin, the inner lining of the nose, lungs, stomach and intestines. They produce large amounts of IFN-α after stimulation and are pivotal for the induction of antiviral responses. Chronic obstructive pulmonary disease (COPD) patients are known to be more susceptible to viral infections. We have demonstrated that exposure of mDC to cigarette smoke extract (CSE) leads to the release of chemokines, however, not much is known about the role of pDC in COPD. In this study, we addressed several key questions with respect to the mechanism of action of CSE on human pDC in an in vitro model. Human pDCs were isolated from normal healthy volunteers and subjected to fresh CSE and the levels of IL-8, TNF-α, IP-10, IL-6, IL-1, IL-12 and IL-10 and IFN-α were studied by both ELISA and real time PCR methods. We observed that CSE augmented the production of IL-8 and suppressed the release of TNF-α, IL-6 and IFN-α. Moreover, CSE suppressed PI3K/Akt signalling in pDC. In conclusion, our data indicate that CSE has both the potential to diminish anti-viral immunity by downregulating the release of IFN-α and other pro-inflammatory cytokines while, at the same time, augmenting the pathogenesis of COPD via an IL-8 induced recruitment of neutrophils
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Disaggregation of SMOS soil moisture over West Africa using the Temperature and Vegetation Dryness Index based on SEVIRI land surface parameters
The overarching objective of this study was to produce a disaggregated SMOS Soil Moisture (SM) product using land surface parameters from a geostationary satellite in a region covering a diverse range of ecosystem types. SEVIRI data at 15 minute temporal resolution were used to derive the Temperature and Vegetation Dryness Index (TVDI) that served as SM proxy within the disaggregation process. West Africa (3 N, 26 W; 28 N, 26 E) was selected as a case study as it presents both an important North-South climate gradient and a diverse range of ecosystem types. The main challenge was to set up a methodology applicable over a large area that overcomes the constraints of SMOS (low spatial resolution) and TVDI (requires similar atmospheric forcing and triangular shape formed when plotting morning rise temperature versus fraction of vegetation cover) in order to produce a 0.05 degree resolution disaggregated SMOS SM product at sub-continental scale. Consistent cloud cover appeared as one of the main constraints for deriving TVDI, especially during the rainy season and in the southern parts of the region and a large adjustment window (105x105 SEVIRI pixels) was therefore deemed necessary. Both the original and the disaggregated SMOS SM products described well the seasonal dynamics observed at six locations of in situ observations. However, there was an overestimation in both products for sites in the humid southern regions; most likely caused by the presence of forest. Both TVDI and the associated disaggregated SM product was found to be highly sensitive to algorithm input parameters; especially of conditions of high fraction of vegetation cover. Additionally, seasonal dynamics in TVDI did not follow the seasonal patters of SM. Still, its spatial heterogeneity was found to be a good proxy for disaggregating SMOS SM data; main river networks and spatial patterns of SM extremes (i.e. droughts and floods) not seen in the original SMOS SM product were revealed in the disaggregated SM product for a test case of July-September 2012. The disaggregation methodology thereby successfully increased the spatial resolution of SMOS SM, with potential application for local drought/flood monitoring of importance for the livelihood of the population of West Africa
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