QUASI-RECURRENT WEYL SPACES

In this work we define Quasi-Recurrent Weyl spaces and examine the hypersurfaces of them

Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery.

The European Union-funded E-PILEPSY network aims to improve awareness of, and accessibility to, epilepsy surgery across Europe. In this study we assessed current clinical practices in epilepsy monitoring units (EMUs) in the participating centers. A 60-item web-based survey was distributed to 25 centers (27 EMUs) of the E-PILEPSY network across 22 European countries. The questionnaire was designed to evaluate the characteristics of EMUs, including organizational aspects, admission, and observation of patients, procedures performed, safety issues, cost, and reimbursement. Complete responses were received from all (100%) EMUs surveyed. Continuous observation of patients was performed in 22 (81%) EMUs during regular working hours, and in 17 EMUs (63%) outside of regular working hours. Fifteen (56%) EMUs requested a signed informed consent before admission. All EMUs performed tapering/withdrawal of antiepileptic drugs, 14 (52%) prior to admission to an EMU. Specific protocols on antiepileptic drugs (AED) tapering were available in four (15%) EMUs. Standardized Operating Procedures (SOP) for the treatment of seizure clusters and status epilepticus were available in 16 (59%). Safety measures implemented by EMUs were: alarm seizure buttons in 21 (78%), restricted patient's ambulation in 19 (70%), guard rails in 16 (59%), and specially designated bathrooms in 7 (26%). Average costs for one inpatient day in EMU ranged between 100 and 2200 Euros. This study shows a considerable diversity in the organization and practice patterns across European epilepsy monitoring units. The collected data may contribute to the development and implementation of evidence-based recommended practices in LTM services across Europe

Ultra-Rare Genetic Variation in the Epilepsies : A Whole-Exome Sequencing Study of 17,606 Individuals

Sequencing-based studies have identified novel risk genes associated with severe epilepsies and revealed an excess of rare deleterious variation in less-severe forms of epilepsy. To identify the shared and distinct ultra-rare genetic risk factors for different types of epilepsies, we performed a whole-exome sequencing (WES) analysis of 9,170 epilepsy-affected individuals and 8,436 controls of European ancestry. We focused on three phenotypic groups: severe developmental and epileptic encephalopathies (DEEs), genetic generalized epilepsy (GGE), and non-acquired focal epilepsy (NAFE). We observed that compared to controls, individuals with any type of epilepsy carried an excess of ultra-rare, deleterious variants in constrained genes and in genes previously associated with epilepsy; we saw the strongest enrichment in individuals with DEEs and the least strong in individuals with NAFE. Moreover, we found that inhibitory GABA(A) receptor genes were enriched for missense variants across all three classes of epilepsy, whereas no enrichment was seen in excitatory receptor genes. The larger gene groups for the GABAergic pathway or cation channels also showed a significant mutational burden in DEEs and GGE. Although no single gene surpassed exome-wide significance among individuals with GGE or NAFE, highly constrained genes and genes encoding ion channels were among the lead associations; such genes included CACNAIG, EEF1A2, and GABRG2 for GGE and LGI1, TRIM3, and GABRG2 for NAFE. Our study, the largest epilepsy WES study to date, confirms a convergence in the genetics of severe and less-severe epilepsies associated with ultra-rare coding variation, and it highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology.Peer reviewe

Advances in reforming and partial oxidation of hydrocarbons for hydrogen production and fuel cell applications

One of the most attractive routes for the production of hydrogen or syngas for use in fuel cell applications is the reforming and partial oxidation of hydrocarbons. The use of hydrocarbons in high temperature fuel cells is achieved through either external or internal reforming. Reforming and partial oxidation catalysis to convert hydrocarbons to hydrogen rich syngas plays an important role in fuel processing technology. The current research in the area of reforming and partial oxidation of methane, methanol and ethanol includes catalysts for reforming and oxidation, methods of catalyst synthesis, and the effective utilization of fuel for both external and internal reforming processes. In this paper the recent progress in these areas of research is reviewed along with the reforming of liquid hydrocarbons, from this an overview of the current best performing catalysts for the reforming and partial oxidizing of hydrocarbons for hydrogen production is summarized

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants explain between 39.6% and 90% of genetic risk for GGE and its subtypes. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analyses of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current antiseizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment

Determination of Antimicrobial Activity of Root Extract in Sartoria hedysaroides

Bu çalışmada Konya’dan toplanan ve endemik bir bitki olan Sartoria hedysaroides’in aseton, etanol ve metanol ekstrelerinin üç farklı konsantrasyonu (50, 100, 150 μg/plak) kullanılarak, antimikrobiyal aktivitelerinin belirlenmesi amaçlanmıştır. Çalışma disk difüzyon yöntemi kullanılarak Escherichia coli (ATCC 25992), Enterecoccus fecalis (ATCC 29212), Bacillus subtilis (NRS-744), Bacillus cereus (ATCC 11778), Pseudomonas aeruginosa, Proteus vulgaris, Micrococcus luteus, Listeria monocytogenes (ATCC 7644), Klebsiella pneumoniae, Yersinia enterecolitica mikroorganizmaları üzerinde denenmiştir. Genel olarak elde edilen zon çapları konsantrasyonun artmasına bağlı olarak artmış olmakla birlikte pozitif kontrol olarak kullanılan amikasin’in oluşturduğu zon çapına ulaşamamıştır. Bulgularımıza göre S. hedysaroides ekstrelerinin bazı Gram (+) ve (-) bakterilere karşı düşük antimikrobiyal aktivite gösterdiği belirlenmiştir.In this study, extracts of Sartoria hedysaroides which was endemic for Konya were prepared with acetone, ethanol and methanol and antimicrobial activities of these extracts were examined on test microorgansims as follows: Escherichia coli (ATCC 25992), Enterecoccus fecalis (ATCC 29212), Klebsiella pneumoniae, Bacillus subtilis (NRS-744), Proteus vulgaris, Micrococcus luteus, Listeria monocytogenes (ATCC 7644), Pseudomonas aeruginosa, Bacillus cereus (ATCC 11778), Yersinia enterecolitica by disc diffusion methods. It was concluded that the inhibition zones increased due to concentration of extracts but none of the microorganisms didn’t reached values of positive control. As a results of study, we have found that S. hedysaroides revealed low antimicrobial activity against some Gram (+) and (-) bacteria

Determination of Antimicrobial Activity of Root Extract in Sartoria hedysaroides

Bu çalışmada Konya’dan toplanan ve endemik bir bitki olan Sartoria hedysaroides’in aseton, etanol ve metanol ekstrelerinin üç farklı konsantrasyonu (50, 100, 150 μg/plak) kullanılarak, antimikrobiyal aktivitelerinin belirlenmesi amaçlanmıştır. Çalışma disk difüzyon yöntemi kullanılarak Escherichia coli (ATCC 25992), Enterecoccus fecalis (ATCC 29212), Bacillus subtilis (NRS-744), Bacillus cereus (ATCC 11778), Pseudomonas aeruginosa, Proteus vulgaris, Micrococcus luteus, Listeria monocytogenes (ATCC 7644), Klebsiella pneumoniae, Yersinia enterecolitica mikroorganizmaları üzerinde denenmiştir. Genel olarak elde edilen zon çapları konsantrasyonun artmasına bağlı olarak artmış olmakla birlikte pozitif kontrol olarak kullanılan amikasin’in oluşturduğu zon çapına ulaşamamıştır. Bulgularımıza göre S. hedysaroides ekstrelerinin bazı Gram (+) ve (-) bakterilere karşı düşük antimikrobiyal aktivite gösterdiği belirlenmiştir.In this study, extracts of Sartoria hedysaroides which was endemic for Konya were prepared with acetone, ethanol and methanol and antimicrobial activities of these extracts were examined on test microorgansims as follows: Escherichia coli (ATCC 25992), Enterecoccus fecalis (ATCC 29212), Klebsiella pneumoniae, Bacillus subtilis (NRS-744), Proteus vulgaris, Micrococcus luteus, Listeria monocytogenes (ATCC 7644), Pseudomonas aeruginosa, Bacillus cereus (ATCC 11778), Yersinia enterecolitica by disc diffusion methods. It was concluded that the inhibition zones increased due to concentration of extracts but none of the microorganisms didn’t reached values of positive control. As a results of study, we have found that S. hedysaroides revealed low antimicrobial activity against some Gram (+) and (-) bacteria