On high-order iterative schemes for the matrix pth root avoiding the use of inverses

This paper is devoted to the approximation of matrix pth roots. We present and analyze a family of algorithms free of inverses. The method is a combination of two families of iterative methods. The first one gives an approximation of the matrix inverse. The second family computes, using the first method, an approximation of the matrix pth root. We analyze the computational cost and the convergence of this family of methods. Finally, we introduce several numerical examples in order to check the performance of this combination of schemes. We conclude that the method without inverse emerges as a good alternative since a similar numerical behavior with smaller computational cost is obtained.The research of the authors S.A. and S.B. was funded in part by Programa de Apoyo a la investigación de la Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia 20928/PI/18 and by PID2019-108336GB-100 (MINECO/FEDER). The research of the author M.Á.H.-V. was supported in part by Spanish MCINN PGC2018-095896-B-C21. The research of the author Á.A.M. was funded in part by Programa de Apoyo a la investigación de la Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia 20928/PI/18 and by Spanish MCINN PGC2018-095896-B-C21

Comparative Analysis of Thermal Behavior in Different Seasons in Building Heritage: Case Study of the Royal Hospital of Granada

The present investigation carries out a thermal evaluation of two rooms located in the Royal Hospital of Granada (Rector’s Office). This is a heritage building where have been done studies that allow the as-sessment of possible improvements in future interventions that guarantee improvement in en-ergy and regulatory compliance are decisive. This article presents for the first time, through energy simulation, the behavior of two rooms in two temporal periods, thermally extreme (summer and winter) and with opposite orientations. This has allowed the potential benefits to be considered in real climate conditions. The results demonstrate and quantify that considering the location, orientation, arrangement of openings, and inclusion of transition zones between the exterior and the interior, an improvement in thermal comfort is obtained. The southwesterly orientation is favorable in the winter period and the northeasterly orientation in the summer period. It is also confirmed that the arrangement of thick masonry walls responds adequately in climates with high thermal amplitudes, favoring the mitigation of extreme conditions. It is concluded by stating that the orientation and the construction components are the main responsible factors for the thermal capacity in this type of building. In this context, the use of non-destructive study methods offers valuable scientific support through the results obtained.University of Granada and the Vicerrectorado de Investi- gación y Transferencia, with the project PP2022.PP.2

Marco para parsing predictivo interactivo aplicado a la lengua castellana

El marco teórico de Parsing Predictivo Interactivo (IPP) permite construir sistemas de anotación sintáctica interactivos. Los anotadores humanos pueden utilizar estos sistemas de ayuda para crear árboles sintácticos con muy poco esfuerzo (en comparación con el trabajo requerido para corregir manualmente árboles obtenidos a partir de un analizador sintáctico completamente automático). En este artículo se presenta la adaptación a la lengua castellana del marco IPP y su herramienta de anotación IPP-Ann, usando modelos obtenidos a partir del UAM Spanish Treebank. Hemos llevado a cabo experimentación simulando al usuario para obtener métricas de evaluación objetivas para nuestro sistema. Estos resultados muestran que el marco IPP aplicado al UAM Spanish Treebank se traduce en una importante cantidad de esfuerzo ahorrado, comparable con el obtenido al aplicar el marco IPP para analizar la lengua inglesa mediante el Penn Treebank.The Interactive Predictive Parsing (IPP) framework allows us the construction of interactive tree annotation systems. These can help human annotators in creating error-free parse trees with little effort (compared to manually post-editing the trees obtained from a completely automatic parser). In this paper we adapt the IPP framework and the IPP-Ann annotation tool for parse of the Spanish language, by using models obtained from the UAM Spanish Treebank. We performed user simulation experimentation and obtained objective evaluation metrics. The results establish that the IPP framework over the UAM Treebank shows important amounts of user effort reduction, comparable to the gains obtained when applying IPP to the English language on the Penn Treebank.Work supported by the EC (FEDER, FSE), the Spanish Government and Generalitat Valenciana (MICINN, ”Plan E”, under grants MIPRCV ”Consolider Ingenio 2010” CSD2007-00018, MIT-TRAL TIN2009-14633-C03-01, ALMPR Prometeo/2009/014 and FPU AP2006-01363)

Desarrollo de un método abreviado para la determinación cuantitativa de ácidos grasos en leche con especial énfasis en los ácidos grasos de cadena larga

A new and simple method was developed for the extraction and derivatization of fatty acid (FA) in milk. Lipid extraction of milk was carried out in H2SO4/methanol. Methylation was performed for 2 h at 60°C, and FA methyl esters were recovered for chromatographic analysis by the addition of hexane. The method parameters were optimized and the simple method was compared to the official reference procedure for the extraction and methylation of FAs in milk samples. For most of the 24 FAs determined, similar or significantly higher recoveries were obtained by the simple method than by the conventional method. The simple method allows processing a high number of samples, at the same time, minimizing the sample manipulation and, consequently, the sample loss and contamination. In conclusion, the proposed method is simple, rapid, low cost, and achieves good resultsUn nuevo método abreviado se desarrolló para la extracción y derivatización de ácidos grasos en leche. La extracción de los lípidos de la leche se llevó a cabo en H2SO4/metanol. La metilación se realizó a 60°C durante 2 h y los ésteres metílicos de los ácidos grasos fueron recuperados para el análisis cromatográfico mediante la adición de hexano. Los parámetros del método fueron optimizados y el método abreviado fue comparado con el método de referencia para la determinación de ácidos grasos en leche. En la mayor parte de los 24 ácidos grasos analizados, el método abreviado mostró recuperaciones similares o mejores que el método convencional. El método simple permite procesar un alto número de muestras al mismo tiempo, minimizando la manipulación de la muestra y consecuentemente la pérdida de la misma y su contaminación. En conclusión, el método propuesto es simple, rápido, económico y logra buenos resultadosThe authors thank Consellería do Medio Rural (FEADER 2008/32 and FEADER 2008/33) and Dirección Xeral de Investigación Desenvolvemento e Innovación (Xunta de Galicia, Lucas Labrada program) for financial supportS

Production of spinach in intensive Mediterranean horticultural systems can be sustained by organic-based fertilizers without yield penalties and withlow environmental impacts

Agricultural production of leafy vegetables in Mediterranean countries aims to achieve high yields without elevated nitrate contents in the edible parts. This implies an adjusted nutrient management, especially of nitrogen (N), in irrigated horticultural systems under semiarid conditions. These horticultural systems are highly relevant in SE Spain from an economic perspective. However, the management of N fertilizer, generally applied in large amounts (150–250 kg N ha−1 in a split application), could trigger losses of reactive N to the environment. The use of novel fertilizers may fulfill the nitrogen requirements of the crop, but should also help to decrease the environmental impacts of production, thus achieving carbon-neutral horticultural systems through (e.g.) enhancement of carbon (C) stocks and greenhouse gases (GHG) emission abatement. In this experiment, eight different fertilizing scenarios at a normalized N application rate of 150 kg N ha−1 were assessed in terms of crop yields, nutrients uptake, C stocking capacity, and yield-scaled GHG emissions. Inorganic NPK fertilizers, digestates, biosolids, composts, and vermicomposts were included among this set of fertilizers. Our results show that organic-based stabilized materials, especially composts, lowered the NO3 − concentration in spinach leaves, in comparison to organic raw materials and synthetic fertilizers. They also produced yields similar to those of slow-release synthetic fertilizers, but with a significant increase in soil organic C 61 days after application. In general, N2O emissions were positively affected by the treatments. Nevertheless, direct N2O emissions were generally low (the highest emission factor, 0.13, being for the biosolid treatment) due to the combined mitigating effect of both the edapho-climatic conditions and the management practices. In general, cumulative CO2 emissions were high in all organic scenarios compared to the control treatment (299 kg C-CO2 ha−1), the highest values being observed in the treatment with biosolid (589 kg C-CO2 ha−1), probably due to differences in the labile organic C contents. In conclusion, some of the organic-based treatments showed multiple positive effects: on crop quality (i.e. leaf N content), crop yields, and GHG mitigation potential. Based on our results, the use of these materials represents an optimized N fertilizer strategy to help achieve a circular economy, by closing nutrient loops and decreasing the environmental impacts of horticultural production systems in semiarid regions of southern Europ

The History of the El Niño - Southern Oscillation according to lacustrine and marine sediments

El gran impacte que El Niño — Oscil·lació del Sud (ENSO) té en la nostra societat industrialitzada ha esperonat la comunitat científica d'arreu a entendre quins són els mecanismes físics que el controlen, així com clarificar quina ha estat la seva història. El registre sedimentari de sensors naturals, com els llacs o la mar, ha permès reconstruir la història de l'ENSO. En aquest article, els autors donen una visió sintètica de la història d'aquest fenomen climàtic al llarg dels darrers quatre milions d'anys.The large impact of the El Niño – Southern Oscillation (ENSO) in our industrial society has spurred the scientific community to understand the physical processes that trigger this climate phenomenum and to elucidate its history. The sedimentary record of natural sensors, such as lakes and seas, was used to reconstruct the history of the ENSO and to obtain a comprehensive history of this climate phenomenon throughout the last 4 million years

Genome comparison of erythromycin resistant campylobacter from Turkeys identifies hosts and pathways for horizontal spread of erm(B) genes

Los patógenos en el género Campylobacter son la causa más común de gastroenteritis bacteriana transmitida por los alimentos. La campilobacteriosis, causada principalmente por Campylobacter jejuni y Campylobacter coli, se transmite a los humanos mediante alimentos de origen animal, especialmente aves de corral. En cuanto a muchos patógenos, la resistencia antimicrobiana en Campylobacter está aumentando a un ritmo alarmante. La prescripción de eritromicina es el tratamiento de elección para los casos clínicos que requieren terapia antimicrobiana, pero esto se ve comprometido por la movilidad del gen de resistencia a la eritromicina erm (B) entre las cepas. Aquí, evaluamos la resistencia a seis antimicrobianos en 170 aislados de Campylobacter (133 C. coli y 37 C. jejuni) de pavos. Los aislados resistentes a la eritromicina (n = 85; 81 C. coli y 4 C. jejuni) se examinaron en busca de la presencia del gen erm (B), que no se ha identificado previamente en aislamientos de pavos. Se secuenciaron los genomas de dos aislamientos positivos de C. coli y en ambos aislamientos el gen erm (B) se agrupó con determinantes de resistencia contra aminoglucósidos más tetraciclina, incluidos aad9, aadE, aph (2 ") - IIIa, aph (3 ') - IIIa , y genes tet (O). El análisis genómico comparativo identificó secuencias erm (B) idénticas entre Campylobacter de pavos, Streptococcus suis de cerdos y Enterococcus faecium y Clostridium difficile de humanos. Esto es consistente con múltiples eventos de transferencia horizontal entre diferentes especies de bacterias que colonizan pavos. Este ejemplo destaca el potencial de diseminación de la resistencia antimicrobiana a través de los límites de las especies bacterianas que pueden comprometer su efectividad en la terapia antimicrobiana.Pathogens in the genus Campylobacter are the most common cause of food-borne bacterial gastro-enteritis. Campylobacteriosis, caused principally by Campylobacter jejuni and Campylobacter coli, is transmitted to humans by food of animal origin, especially poultry. As for many pathogens, antimicrobial resistance in Campylobacter is increasing at an alarming rate. Erythromycin prescription is the treatment of choice for clinical cases requiring antimicrobial therapy but this is compromised by mobility of the erythromycin resistance gene erm(B) between strains. Here, we evaluate resistance to six antimicrobials in 170 Campylobacter isolates (133 C. coli and 37 C. jejuni) from turkeys. Erythromycin resistant isolates (n = 85; 81 C. coli and 4 C. jejuni) were screened for the presence of the erm(B) gene, that has not previously been identified in isolates from turkeys. The genomes of two positive C. coli isolates were sequenced and in both isolates the erm(B) gene clustered with resistance determinants against aminoglycosides plus tetracycline, including aad9, aadE, aph(2″)-IIIa, aph(3′)-IIIa, and tet(O) genes. Comparative genomic analysis identified identical erm(B) sequences among Campylobacter from turkeys, Streptococcus suis from pigs and Enterococcus faecium and Clostridium difficile from humans. This is consistent with multiple horizontal transfer events among different bacterial species colonizing turkeys. This example highlights the potential for dissemination of antimicrobial resistance across bacterial species boundaries which may compromise their effectiveness in antimicrobial therapy.• Ministerio de Ciencia e Innovación. Ayudas AGL2009-07550, AGL2012-39028 • Ministerio de Agricultura, Alimentación y Medio Ambiente. Ayuda 2014/000223 • Comunidad Autónoma de Madrid. Ayudas S2009 / AGR-1489; S2013 / ABI-2747 • Ministerio de Economía y Competitividad de España. Ayuda AGL2012-39028 • Ministerio de Economía y Competitividad. Beca BES-2013-065003, para Diego Flórez Cuadrado • Consejo de Investigación Médica. Ayuda MR / L015080 / 1, para Samuel K. SheppardpeerReviewe

Mapping the entire functionally active endometrial microbiota

STUDY QUESTION Does endometrium harbour functionally active microorganisms and whether the microbial composition differs between proliferative and mid-secretory phases? SUMMARY ANSWER Endometrium harbours functionally alive microorganisms including bacteria, viruses, archaea and fungi whose composition and metabolic functions change along the menstrual cycle. WHAT IS KNOWN ALREADY Resident microbes in the endometrium have been detected, where microbial dysfunction has been associated with reproductive health and disease. Nevertheless, the core microorganismal composition in healthy endometrium is not determined and whether the identified bacterial DNA sequences refer to alive/functionally active microbes is not clear. Furthermore, whether there are cyclical changes in the microbial composition remains an open issue. STUDY DESIGN, SIZE, DURATION RNA sequencing (RNAseq) data from 14 endometrial paired samples from healthy women, 7 samples from the mid-secretory phase and 7 samples from the consecutive proliferative phase were analysed for the microbial RNA sequences. PARTICIPANTS/MATERIALS, SETTING, METHODS The raw RNAseq data were converted into FASTQ format using SRA Toolkit. The unmapped reads to human sequences were aligned to the reference database Kraken2 and visualised with Krona software. Menstrual phase taxonomic differences were performed by R package metagenomeSeq. The functional analysis of endometrial microbiota was obtained with HUMANn2 and the comparison between menstrual phases was conducted by one-way ANOVA. Human RNAseq analysis was performed using miARma-Seq and the functional enrichment analysis was carried out using gene set enrichment analysis (GSEA; HumanCyc). The integration of metabolic pathways between host and microbes was investigated. The developed method of active microbiota mapping was validated in independent sample set. MAIN RESULTS AND THE ROLE OF CHANCE With the novel metatranscriptomic approach, we mapped the entire alive microbiota composing of >5300 microorganisms within the endometrium of healthy women. Microbes such as bacteria, fungi, viruses and archaea were identified. The validation of three independent endometrial samples from different ethnicity confirmed the findings. Significant differences in the microbial abundances in the mid-secretory vs. proliferative phases were detected with possible metabolic activity in the host-microbiota crosstalk in receptive phase endometrium, specifically in the prostanoid biosynthesis pathway and L-tryptophan metabolism. LARGE SCALE DATA The raw RNAseq data used in the current study are available at GEO GSE86491 and at BioProject PRJNA379542. LIMITATIONS, REASONS FOR CAUTION These pioneering results should be confirmed in a bigger sample size. WIDER IMPLICATIONS OF THE FINDINGS Our study confirms the presence of active microbes, bacteria, fungi, viruses and archaea in the healthy human endometrium with implications in receptive phase endometrial functions, meaning that microbial dysfunction could impair the metabolic pathways important for endometrial receptivity. The results of this study contribute to the better understanding of endometrial microbiota composition in healthy women and its possible role in endometrial functions. In addition, our novel methodological pipeline for analysing alive microbes with transcriptional and metabolic activities could serve to inspire new analysis approaches in reproductive medicine.This work is supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER): grants RYC-2016-21199 and ENDORE SAF2017-87526- R; FEDER/Junta de Andalucía-Consejería de Economía y Conocimiento: MENDO (B-CTS-500-UGR18) and by the University of Granada Plan Propio de Investigacio ́n 2016 - Excellence actions: Unit of Excellence on Exercise and Health (UCEES) (SOMM17/6107/UGR). A.S.-L. and N.M.M. are funded by the Spanish Ministry of Science, Innovation and Universities (PRE2018-0854409 and FPU19/01638). S.A. has received honoraria for lectures from Merck. The funder had no role in this study

Aplicaciones (apps), redes sociales y comunicación móvil en el campo de la Publicidad y las Relaciones Públicas

El presente trabajo es el informe final del proyecto de Innovación Docente que, con el mismo nombre, se ha llevado a cabo en el curso 2012-2013 por parte de los profesores y alumnos que aparecen en la obra.Innovación Docente, Universidad de Cádi

Adiciones y revisiones al Atlas de la flora vascular silvestre de Burgos

Se mencionan 31 táxones con citas y/o comentarios referidos a su existencia en la provincia de Burgos. De ellos 8 suponen una novedad para el catálogo provincial.Additions and revisions for the “Atlas de la flora vascular silvestre de Burgos”, IX. 31 Taxa with either quotations or remarks, related to their existence within the province of Burgos, are mentioned. 8 out of these aforementioned ones mean a novelty value for the provincial catalogue