Los vasco-navarros ante la España, y ante los otros españoles : tres capítulos y un epílogo

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Atribución del pie de imp.: Palau, 282267Signaturizado numéricament

Procesadores de bajo coste y su aplicación en la docencia de Ingeniería de Computadores

La Informática evoluciona a gran velocidad y es necesario actualizar con frecuencia los recursos de aprendizaje para mantener el interés de los estudiantes. En la actualidad, hay una gran diversidad de plataformas de cómputo de bajo coste que son utilizadas como recursos en los estudios de Informática. Raspberry Pi y algunos modelos de Arduino (como Arduino Due), ambas basadas en procesadores ARM, son ejemplos representativos de este tipo de plataformas. Las arquitecturas ARM son ejemplos de procesadores RISC que actualmente gozan de gran popularidad por su buena relación entre potencia computacional, consumo y coste. De hecho, constituyen el núcleo de muchos de los teléfonos móviles y sistemas empotrados actuales. Al estar tan cerca de los estudiantes, el uso de este tipo de recursos en el aula representa una oportunidad para: (1) motivar a los alumnos de Bachillerato y Educación Secundaria para estudiar el Grado de Informática y (2) potenciar el interés de los alumnos de Grado de Informática por la Ingeniería de Computadores. Existe una serie de eventos consolidados que tienen una gran difusión social. En ellos, se muestran vistosos ejemplos de aplicación y funcionamiento de este tipo de plataformas. En este trabajo se describen el conjunto de sistemas interactivos y basados en plataformas computacionales de bajo coste que se han desarrollado para ser utilizadas en este tipo de eventos. De acuerdo con nuestra experiencia de participación, creemos que están sirviendo para despertar el interés del alumno de secundaria por la Informática en general, y más específicamente por la Ingeniería de Computadores. Por otra parte, un porcentaje de los alumnos que cursan el Grado de Ingeniería Informática no está interesado en el análisis de los componentes hardware y de su organización para construir un computador moderno. Piensan que la asignatura de Arquitectura de Computadores del Grado en Ingeniería Informática está lejos de su futura actividad profesional. En este contexto, nos planteamos seleccionar ARM como arquitectura de referencia para desarrollar los contenidos de la asignatura de Arquitectura de Computadores. Creemos que esta decisión mejora el interés del alumno por dos motivos: (1) el objeto de estudio se usa en multitud de plataformas muy cotidianas para el alumno y (2) es posible diseñar las actividades prácticas de las asignaturas basadas en elementos reales y no únicamente virtuales. Este trabajo muestra las distintas actividades tanto a nivel teórico como práctico que se plantean al alumno en el marco de la asignatura Arquitectura de Computadores.Computer Science is advancing rapidly and it is necessary to keep the educational resources up to date in order to keep the interest of students. Nowadays, there is a wide variety of low-cost computing platforms that are used as educational resources in the Computer Science degree. Raspberry Pi and some models of Arduino (such as Arduino Due), which are both based on ARM processors, are representative examples of this kind of platforms. ARM architectures are instances of RISC processors which nowadays have reached an important popularity due to their good relation between performance, consumption and cost. In fact, they constitute the core of numerous current mobile phones and embedded systems. Considering their proximity to the students, the use of this kind of resources in the classroom is an opportunity to: (1) encourage the high schools pupils to study the Computer Science degree and (2) to increase the interest of the students for the Computer Engineering. There are several consolidated informational events of great social outreach in which different examples of application of this kind of platforms are shown. In this work, the set of interactive systems designed to be used in this kind of events is described. According to our experience, we think that they arouse the interest of high schools pupils for the Computer Science in general, and, more specifically, for the Computer Engineering. Furthermore, a percentage of the students of the Computer Science degree is not interested in the analysis of hardware components and the architecture of modern computers. They think that the subject of Computer Architecture of the Computer Science Degree is far from his/her future career. In this context, we will select ARM as a reference architecture where the contents of the subject Computer Architecture will be developed on. We think this might improve the motivation of the students mainly for two reasons: (1) the object of study is being used in a lot of modern platforms; and (2) it is possible to design the practical activities of the subjects using real platforms and not only virtual ones. This work shows the activities proposed to the students in the context of the subject Computer Architecture, considering both practical and theoretical approaches

Weighing the Solar Axion

Axion helioscopes search for solar axions and axion-like particles via inverse Primakoff conversion in strong laboratory magnets pointed at the Sun. While helioscopes can always measure the axion coupling to photons, the conversion signal is independent of the mass for axions lighter than around 0.02 eV. Masses above this value on the other hand have suppressed signals due to axion-photon oscillations which destroy the coherence of the conversion along the magnet. However, the spectral oscillations present in the axion conversion signal between these two regimes are highly dependent on the axion mass. We show that these oscillations are observable given realistic energy resolutions and can be used to determine the axion mass to within percent level accuracies. Using projections for the upcoming helioscope IAXO, we demonstrate that $>3\sigma$ sensitivity to a non-zero axion mass is possible between $3 \times 10^{-3}$ and $10^{-1}$ eV for both the Primakoff and axion-electron solar fluxes.Comment: 13 pages, 7 figures, matches published version, code available at http://cajohare.github.io/IAXOmas

Exploring structure–activity relationships in photodynamic therapy anticancer agents based on Ir(III)-COUPY conjugates

Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under hypoxic conditions remain to be developed. Herein, we took the advantageous properties of COUPY fluorophores and cyclometalated Ir(III) complexes to develop novel PDT agents based on Ir(III)-COUPY conjugates with the aim of exploring structure–activity relationships. The structural modifications carried out within the coumarin scaffold had a strong impact on the photophysical properties and cellular uptake of the conjugates. All Ir(III)-COUPY conjugates exhibited high phototoxicity under green light irradiation, which was attributed to the photogeneration of ROS, while remaining non-toxic in the dark. Among them, two hit conjugates showed excellent phototherapeutic indexes in cisplatin-resistant A2780cis cancer cells, both in normoxia and in hypoxia, suggesting that photoactive therapy approaches based on the conjugation of far-red/NIR-emitting COUPY dyes and transition metal complexes could effectively tackle in vitro acquired resistance to cisplatin

SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain

Objectives To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix and to determine the impact of maternal SARS-CoV-2 infection on the presence, concentration and persistence of specific SARS-CoV-2 antibodies. Design and patients This is a prospective, multicentre longitudinal study (April-December 2020) in 60 mothers with SARS-CoV-2 infection and/or who have recovered from COVID-19. A control group of 13 women before the pandemic were also included. Setting Seven health centres from different provinces in Spain. Main outcome measures Presence of SARS-CoV-2 RNA in breast milk, targeting the N1 region of the nucleocapsid gene and the envelope (E) gene; presence and levels of SARS-CoV-2-specific immunoglobulins (Igs)-IgA, IgG and IgM-in breast milk samples from patients with COVID-19. Results All breast milk samples showed negative results for presence of SARS-CoV-2 RNA. We observed high intraindividual and interindividual variability in the antibody response to the receptor-binding domain of the SARS-CoV-2 spike protein for each of the three isotypes IgA, IgM and IgG. Main Protease (MPro) domain antibodies were also detected in milk. 82.9% (58 of 70) of milk samples were positive for at least one of the three antibody isotypes, with 52.9% of these positive for all three Igs. Positivity rate for IgA was relatively stable over time (65.2%-87.5%), whereas it raised continuously for IgG (from 47.8% for the first 10 days to 87.5% from day 41 up to day 206 post-PCR confirmation). Conclusions Our study confirms the safety of breast feeding and highlights the relevance of virus-specific SARS-CoV-2 antibody transfer. This study provides crucial data to support official breastfeeding recommendations based on scientific evidence. ARS-CoV-2 antibodies but not RNA are found in breast milk from COVID-19 infected mothers

Iniciativa basada en Kahoot para motivar a los alumnos de Arquitectura de Computadores

Debido al auge de la formación universitaria en remoto, es común que las clases magistrales teóricas deriven en un monólogo del profesor con baja participación del alumnado. Existe una escasa utilización, de las herramientas disponibles para participar en la clase: mensajería instantánea, micrófono o funciones de “levantar la mano”. Esta situación se agrava aún más cuando el ratio de alumnos es alto y, por tanto, es más complicada la comunicación con todos ellos, así como saber si están asimilando los conceptos. En este trabajo se describe la experiencia docente en la asignatura de Arquitectura de Computadores de incorporar una herramienta de aprendizaje móvil electrónico (M-learning), concretamente, Kahoot. Esta herramienta permite que el profesor plantee actividades participativas en el aula para reforzar el aprendizaje y aumentar la participación de los alumnos. Se ha realizado un estudio para determinar si el uso de Kahoot ha estimulado el aprendizaje de la asignatura de Arquitectura de Computadores y si ha mejorado la nota global final del alumnado.Due to the rise of remote university training, it is common for theoretical lectures to result in a monologue by the professor with low student participation. There is little use of the tools available to participate in the class: instant messaging, microphone or ’raise your hand’ functions. This situation is even worse when the ratio of students is high and, therefore, it is more complicated to communicate with all of them, as well as to know if they are assimilating the concepts. This paper describes the teaching experience in the Computer Architecture course of incorporating a mobile e-learning tool (M-learning), specifically, Kahoot. This tool allows the teacher to propose participatory activities in the classroom to reinforce learning and increase student participation. A study has been carried out to determine whether the use of Kahoot has stimulated the learning of the Computer Architecture subject and whether it has improved the students’ final overall grade

Search for the Higgs boson in events with missing transverse energy and b quark jets produced in proton-antiproton collisions at s**(1/2)=1.96 TeV

We search for the standard model Higgs boson produced in association with an electroweak vector boson in events with no identified charged leptons, large imbalance in transverse momentum, and two jets where at least one contains a secondary vertex consistent with the decay of b hadrons. We use ~1 fb-1 integrated luminosity of proton-antiproton collisions at s**(1/2)=1.96 TeV recorded by the CDF II experiment at the Tevatron. We find 268 (16) single (double) b-tagged candidate events, where 248 +/- 43 (14.4 +/- 2.7) are expected from standard model background processes. We place 95% confidence level upper limits on the Higgs boson production cross section for several Higgs boson masses ranging from 110 GeV/c2 to 140 GeV/c2. For a mass of 115 GeV/c2 the observed (expected) limit is 20.4 (14.2) times the standard model prediction.Comment: 8 pages, 2 figures, submitted to Phys. Rev. Let