Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer’s disease

Background Increasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer’s disease (AD). Methods We measured hippocampal volume and deformation-based shape differences in 22 patients with svPPA compared with 99 patients with AD and 92 controls. Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeT-Brain) was used on MRI images obtained at the diagnostic visit. Results Comparable left and right hippocampal atrophy were observed in svPPA and AD. Deformation-based shape analysis showed a common pattern of morphological deformation in svPPA and AD compared with controls. More specifically, both svPPA and AD showed inward deformations in the dorsal surface of the hippocampus, from head to tail on the left side, and more limited to the anterior portion of the body in the right hemisphere. These results also pointed out that both diseases are characterized by a lateral displacement of the central part (body) of the hippocampus. Discussion Our study provides critical new evidence of hippocampal morphological changes in svPPA, similar to those found in AD. These findings highlight the importance of considering morphological hippocampal changes as part of the anatomical profile of patients with svPPA

A Proposed Model

Rocha-Penedo, R., Cruz-Jesus, F., & Oliveira, T. (2021). Opposite Outcomes of Social Media Use: A Proposed Model. In S. K. Sharma, Y. K. Dwivedi, B. Metri, & N. P. Rana (Eds.), Re-imagining Diffusion and Adoption of Information Technology and Systems: A Continuing Conversation - IFIP WG 8.6 International Conference on Transfer and Diffusion of IT, TDIT 2020, Proceedings (pp. 524-537). (IFIP Advances in Information and Communication Technology; Vol. 618). Springer. https://doi.org/10.1007/978-3-030-64861-9_46Social media are probably one of the most influential and disruptive technology of the present times. It is ubiquitous and has the capability to influence virtually every aspect of one’s life while, at the same time, also influence the way firms and public organizations operate and communicate with individuals. Although there is a plethora of studies in the IS literature focused on SM adoption and outcomes, studies hypothesizing positive and negative outcomes together are scarce. We propose a comprehensive research model to shed light on SM positive and negative outcomes, and how these affect one’s happiness. We also explore how personality traits can influence these relationships.authorsversionpublishe

Ants impact the energy reserves of natural enemies through the shared honeydew exploitation

[EN] Ants, as well as many species of parasitoids and predators, rely on sugar-richfoodssuchashoneydewtofulfilltheirenergeticneeds.Thus,antsandnatural enemies may interact through the shared honeydew exploitation. 2.Ant-exclusionexperimentswereperformedinacitrusorchardtotestthehypothesis that ants may impact the energy reserves of predators and parasitoids through the competitionforhoneydew.Throughtheuseofhigh-performanceliquidchromatography (HPLC)thelevelofantactivitywiththeenergyreservesandfeedinghistoryofindividual specimens collected in the field during representative days of spring, summer, and autumn were related. 3. Out of 145 Aphytis chrysomphali Mercet parasitoids captured in the field, 65% were classified as sugar-fed and 24.7% as honeydew-fed. In summer, when ant activity peaked,therewasasignificant negativecorrelationbetweenthelevelofantactivityand the total sugar content and honeydew feeding incidence by A.chrysomphali. Out of 47 individuals of the predator Chrysoperla carnea sensu lato (Stephens), captured in the field, 55.3% were classified as sugar-fed. We found a significant negative effect of the level of ant activity on the sugar-feeding incidence by C.carneain spring. 4.Thepresentstudyprovidesevidencethatantscaninterferewiththeenergyreserves of natural enemies. This interaction may be widespread in various ecosystems with important consequences for the arthropod community composition and with practical implicationsforbiologicalcontrolgiventhatabsenceofsugarfeedingisdetrimentalfor thefitness of many species of predatorsand parasitoidsDr Jerome Casas is greatly acknowledged for valuable comments on earlier versions of the manuscript and Dr Petr Duelli for providing help with the Chrysoperla identifications. We also thank Dr Cristina Navarro Campos and Dr Aleixandre Beltra for their help in the field samplings and for stimulating discussions, Barbara Rodriguez for help in the laboratory analyses and the reviewers for their helpful comments. This work was supported by the project (RTA2010-00012-C02-02) assigned to F. G. M from the Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA), Spain and the project (BIO2013-48779-C4-1-R) from Spanish Ministry of Science and Innovation and COST action CM1303 on Systems Biocatalysis.Calabuig Gomar, A.; Tena Barreda, A.; Wäkers, FL.; Lucia Fernandez-Arrojo; Plou, FJ.; García Mari, F.; Pekas, A. (2015). Ants impact the energy reserves of natural enemies through the shared honeydew exploitation. Ecological Entomology. 40:687-695. https://doi.org/10.1111/een.12237S68769540Avidov, Z., Balshin, M., & Gerson, U. (1970). Studies onAphytis coheni, a parasite of the California red scale,Aonidiella aurantii in Israel. Entomophaga, 15(2), 191-207. doi:10.1007/bf02371871Bartlett, B. R. (1961). The Influence of Ants Upon Parasites, Predators, and Scale Insects1. Annals of the Entomological Society of America, 54(4), 543-551. doi:10.1093/aesa/54.4.543Bascompte, J., Jordano, P., & Olesen, J. M. (2006). Asymmetric Coevolutionary Networks Facilitate Biodiversity Maintenance. Science, 312(5772), 431-433. doi:10.1126/science.1123412Blüthgen, N., E. Stork, N., & Fiedler, K. (2004). Bottom-up control and co-occurrence in complex communities: honeydew and nectar determine a rainforest ant mosaic. Oikos, 106(2), 344-358. doi:10.1111/j.0030-1299.2004.12687.xCalabuig, A., Garcia-Marí, F., & Pekas, A. (2013). Ants affect the infestation levels but not the parasitism of honeydew and non-honeydew producing pests in citrus. Bulletin of Entomological Research, 104(4), 405-417. doi:10.1017/s0007485313000564Campbell, M. M. (1976). Colonisation of Aphytis melinus DeBach (Hymenoptera, Aphelinidae) in Aonidiella aurantii (Mask.) (Hemiptera, Coccidae) on citrus in South Australia. Bulletin of Entomological Research, 65(4), 659-668. doi:10.1017/s0007485300006350Carroll, C. R., & Janzen, D. H. (1973). Ecology of Foraging by Ants. Annual Review of Ecology and Systematics, 4(1), 231-257. doi:10.1146/annurev.es.04.110173.001311Cerdá, X., Palacios, R., & Retana, J. (2009). Ant Community Structure in Citrus Orchards in the Mediterranean Basin: Impoverishment as a Consequence of Habitat Homogeneity. Environmental Entomology, 38(2), 317-324. doi:10.1603/022.038.0203DUELLI, P. (1980). Adaptive dispersal and appetitive flight in the green lacewing, Chrysopa cornea. Ecological Entomology, 5(3), 213-220. doi:10.1111/j.1365-2311.1980.tb01144.xDuelli, P. (1980). Preovipository migration flights in the green lacewing, Chrysopa carnea (Planipennia, Chrysopidae). Behavioral Ecology and Sociobiology, 7(3), 239-246. doi:10.1007/bf00299370Eubanks, M. D., & Finke, D. L. (2014). Interaction webs in agroecosystems: beyond who eats whom. Current Opinion in Insect Science, 2, 1-6. doi:10.1016/j.cois.2014.06.005Faria, C. A., Wäckers, F. L., & Turlings, T. C. J. (2008). The nutritional value of aphid honeydew for non-aphid parasitoids. Basic and Applied Ecology, 9(3), 286-297. doi:10.1016/j.baae.2007.02.001Finney, G. L. (1948). Culturing Chrysopa californica and Obtaining Eggs for Field Distribution. Journal of Economic Entomology, 41(5), 719-721. doi:10.1093/jee/41.5.719HEIMPEL, G. E., & COLLIER, T. R. (1996). THE EVOLUTION OF HOST-FEEDING BEHAVIOUR IN INSECT PARASITOIDS. Biological Reviews, 71(3), 373-400. doi:10.1111/j.1469-185x.1996.tb01279.xHeimpel, G. E., Rosenheim, J. A., & Mangel, M. (1997). Predation on adult Aphytis parasitoids in the field. Oecologia, 110(3), 346-352. doi:10.1007/s004420050168Heimpel, G. E., Rosenheim, J. A., & Kattari, D. (1997). Adult feeding and lifetime reproductive success in the parasitoid Aphytis melinus. Entomologia Experimentalis et Applicata, 83(3), 305-315. doi:10.1046/j.1570-7458.1997.00185.xHOGERVORST, P. A. M., WÄCKERS, F. L., & ROMEIS, J. (2007). Detecting nutritional state and food source use in field-collected insects that synthesize honeydew oligosaccharides. Functional Ecology, 21(5), 936-946. doi:10.1111/j.1365-2435.2007.01297.xHölldobler, B., & Wilson, E. O. (1990). The Ants. doi:10.1007/978-3-662-10306-7Holway, D. A., Lach, L., Suarez, A. V., Tsutsui, N. D., & Case, T. J. (2002). The Causes and Consequences of Ant Invasions. Annual Review of Ecology and Systematics, 33(1), 181-233. doi:10.1146/annurev.ecolsys.33.010802.150444James, D. G., Stevens, M. M., O’Malley, K. J., & Faulder, R. J. (1999). Ant Foraging Reduces the Abundance of Beneficial and Incidental Arthropods in Citrus Canopies. Biological Control, 14(2), 121-126. doi:10.1006/bcon.1998.0678JERVIS, M. A., & KIDD, N. A. C. (1986). HOST-FEEDING STRATEGIES IN HYMENOPTERAN PARASITOIDS. Biological Reviews, 61(4), 395-434. doi:10.1111/j.1469-185x.1986.tb00660.xJervis, M. A., Kidd, N. A. C., Fitton, M. G., Huddleston, T., & Dawah, H. A. (1993). Flower-visiting by hymenopteran parasitoids. Journal of Natural History, 27(1), 67-105. doi:10.1080/00222939300770051Kaplan, I., & Eubanks, M. D. (2005). APHIDS ALTER THE COMMUNITY-WIDE IMPACT OF FIRE ANTS. Ecology, 86(6), 1640-1649. doi:10.1890/04-0016Lach, L. (2007). Argentine ants displace floral arthropods in a biodiversity hotspot. Diversity and Distributions, 14(2), 281-290. doi:10.1111/j.1472-4642.2007.00410.xLaverty, T. M., & Plowright, R. C. (1985). Competition between hummingbirds and bumble bees for nectar in flowers of Impatiens biflora. Oecologia, 66(1), 25-32. doi:10.1007/bf00378548LeVan, K. E., Hung, K.-L. J., McCann, K. R., Ludka, J. T., & Holway, D. A. (2013). Floral visitation by the Argentine ant reduces pollinator visitation and seed set in the coast barrel cactus, Ferocactus viridescens. Oecologia, 174(1), 163-171. doi:10.1007/s00442-013-2739-zTeresa Martinez-Ferrer, M., Grafton-Cardwell, E. E., & Shorey, H. H. (2003). Disruption of parasitism of the California red scale (Homoptera: Diaspididae) by three ant species (Hymenoptera: Formicidae). Biological Control, 26(3), 279-286. doi:10.1016/s1049-9644(02)00158-5McEwen, P. K., Clow, S., Jervis, M. A., & Kidd, N. A. C. (1993). Alteration in searching behaviour of adult female green lacewingsChrysoperla carnea (Neur.: Chrysopidae) following contact with honeydew of the black scaleSaissetia oleae (Hom.: Coccidae) and solutions containing acidhydrolysed L-tryptophan. Entomophaga, 38(3), 347-354. doi:10.1007/bf02374452Miller, T. E. (1994). Direct and Indirect Species Interactions in an Early Old-Field Plant Community. The American Naturalist, 143(6), 1007-1025. doi:10.1086/285646Moreno, D. S., Haney, P. B., & Luck, R. F. (1987). Chlorpyrifos and Diazinon as Barriers to Argentine Ant (Hymenoptera: Formicidae) Foraging on Citrus Trees1. Journal of Economic Entomology, 80(1), 208-214. doi:10.1093/jee/80.1.208Ohgushi, T. (2008). Herbivore‐induced indirect interaction webs on terrestrial plants: the importance of non‐trophic, indirect, and facilitative interactions. Entomologia Experimentalis et Applicata, 128(1), 217-229. doi:10.1111/j.1570-7458.2008.00705.xOLSON, D. M., & WÄCKERS, F. L. (2006). Management of field margins to maximize multiple ecological services. Journal of Applied Ecology, 44(1), 13-21. doi:10.1111/j.1365-2664.2006.01241.xPace, M. L., Cole, J. J., Carpenter, S. R., & Kitchell, J. F. (1999). Trophic cascades revealed in diverse ecosystems. Trends in Ecology & Evolution, 14(12), 483-488. doi:10.1016/s0169-5347(99)01723-1Pekas, A., Aguilar, A., Tena, A., & Garcia-Marí, F. (2010). Influence of host size on parasitism by Aphytis chrysomphali and A. melinus (Hymenoptera: Aphelinidae) in Mediterranean populations of California red scale Aonidiella aurantii (Hemiptera: Diaspididae). Biological Control, 55(2), 132-140. doi:10.1016/j.biocontrol.2010.07.010Pekas, A., Tena, A., Aguilar, A., & Garcia-Marí, F. (2010). Effect of Mediterranean Ants (Hymenoptera: Formicidae) on California Red Scale (Hemiptera: Diaspididae) Populations in Citrus Orchards. Environmental Entomology, 39(3), 827-834. doi:10.1603/en09207Pekas, A., Tena, A., Aguilar, A., & Garcia-Marí, F. (2010). Spatio-temporal patterns and interactions with honeydew-producing Hemiptera of ants in a Mediterranean citrus orchard. Agricultural and Forest Entomology, 13(1), 89-97. doi:10.1111/j.1461-9563.2010.00501.xRosen, D., & DeBach, P. (1979). Species of Aphytis of the World. doi:10.1007/978-94-009-9603-8Rosumek, F. B., Silveira, F. A. O., de S. Neves, F., de U. Barbosa, N. P., Diniz, L., Oki, Y., … Cornelissen, T. (2009). Ants on plants: a meta-analysis of the role of ants as plant biotic defenses. Oecologia, 160(3), 537-549. doi:10.1007/s00442-009-1309-xRudgers, J. A., & Gardener, M. C. (2004). EXTRAFLORAL NECTAR AS A RESOURCE MEDIATING MULTISPECIES INTERACTIONS. Ecology, 85(6), 1495-1502. doi:10.1890/03-0391Sheldon, J. K., & MacLeod, E. G. (1971). Studies on the Biology of the Chrysopidae II. The Feeding Behavior of the Adult of Chrysopa carnea (Neuroptera). Psyche: A Journal of Entomology, 78(2), 107-121. doi:10.1155/1971/505909Stelzl, M., & Devetak, D. (1999). Neuroptera in agricultural ecosystems. Agriculture, Ecosystems & Environment, 74(1-3), 305-321. doi:10.1016/s0167-8809(99)00040-7STEPPUHN, A., & WACKERS, F. L. (2004). HPLC sugar analysis reveals the nutritional state and the feeding history of parasitoids. Functional Ecology, 18(6), 812-819. doi:10.1111/j.0269-8463.2004.00920.xStyrsky, J. D., & Eubanks, M. D. (2006). Ecological consequences of interactions between ants and honeydew-producing insects. Proceedings of the Royal Society B: Biological Sciences, 274(1607), 151-164. doi:10.1098/rspb.2006.3701Tena, A., Hoddle, C. D., & Hoddle, M. S. (2013). Competition between honeydew producers in an ant–hemipteran interaction may enhance biological control of an invasive pest. Bulletin of Entomological Research, 103(6), 714-723. doi:10.1017/s000748531300045xTena, A., Llácer, E., & Urbaneja, A. (2013). Biological control of a non-honeydew producer mediated by a distinct hierarchy of honeydew quality. Biological Control, 67(2), 117-122. doi:10.1016/j.biocontrol.2013.07.018TENA, A., PEKAS, A., WÄCKERS, F. L., & URBANEJA, A. (2013). Energy reserves of parasitoids depend on honeydew from non-hosts. Ecological Entomology, 38(3), 278-289. doi:10.1111/een.12018Tena, A., Pekas, A., Cano, D., Wäckers, F. L., & Urbaneja, A. (2015). Sugar provisioning maximizes the biocontrol service of parasitoids. Journal of Applied Ecology, 52(3), 795-804. doi:10.1111/1365-2664.12426Völkl, W., Woodring, J., Fischer, M., Lorenz, M. W., & Hoffmann, K. H. (1999). Ant-aphid mutualisms: the impact of honeydew production and honeydew sugar composition on ant preferences. Oecologia, 118(4), 483-491. doi:10.1007/s004420050751Wackers, F. L. (2000). Do oligosaccharides reduce the suitability of honeydew for predators and parasitoids? A further facet to the function of insect-synthesized honeydew sugars. Oikos, 90(1), 197-201. doi:10.1034/j.1600-0706.2000.900124.xWäckers, F. L. (2001). A comparison of nectar- and honeydew sugars with respect to their utilization by the hymenopteran parasitoid Cotesia glomerata. Journal of Insect Physiology, 47(9), 1077-1084. doi:10.1016/s0022-1910(01)00088-9Wäckers, F. L. (2005). Suitability of (extra-)floral nectar, pollen, and honeydew as insect food sources. Plant-Provided Food for Carnivorous Insects, 17-74. doi:10.1017/cbo9780511542220.003Wäckers, F. L., van Rijn, P. C. J., & Heimpel, G. E. (2008). Honeydew as a food source for natural enemies: Making the best of a bad meal? Biological Control, 45(2), 176-184. doi:10.1016/j.biocontrol.2008.01.007Wade, M. R., Zalucki, M. P., Wratten, S. D., & Robinson, K. A. (2008). Conservation biological control of arthropods using artificial food sprays: Current status and future challenges. Biological Control, 45(2), 185-199. doi:10.1016/j.biocontrol.2007.10.024Way, M. J. (1963). Mutualism Between Ants and Honeydew-Producing Homoptera. Annual Review of Entomology, 8(1), 307-344. doi:10.1146/annurev.en.08.010163.001515Wilder, S. M., Barnum, T. R., Holway, D. A., Suarez, A. V., & Eubanks, M. D. (2012). Introduced fire ants can exclude native ants from critical mutualist-provided resources. Oecologia, 172(1), 197-205. doi:10.1007/s00442-012-2477-7YOO, H. J. S., KIZNER, M. C., & HOLWAY, D. A. (2013). Ecological effects of multi-species, ant-hemipteran mutualisms in citrus. Ecological Entomology, 38(5), 505-514. doi:10.1111/een.12042ZAPPALA, L., CAMPOLO, O., GRANDE, S. B., SARACENO, F., BIONDI, A., SISCARO, G., & PALMERI, V. (2012). Dispersal of Aphytis melinus (Hymenoptera: Aphelinidae) after augmentative releases in citrus orchards. European Journal of Entomology, 109(4), 561-568. doi:10.14411/eje.2012.070Zoebelein, G. (2009). Der Honigtau als Nahrung der Insekten: Teil I. Zeitschrift für Angewandte Entomologie, 38(4), 369-416. doi:10.1111/j.1439-0418.1956.tb01612.

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