Public health impact and cost effectiveness of mass vaccination with live attenuated human rotavirus vaccine (RIX4414) in India: model based analysis

Objectives To examine the public health impact of mass vaccination with live attenuated human rotavirus vaccine (RIX4414) in a birth cohort in India, and to estimate the cost effectiveness and affordability of such a programme

Ionization of the diffuse gas in galaxies: Hot low-mass evolved stars at work

We revisit the question of the ionization of the diffuse medium in late type galaxies, by studying NGC 891, the prototype of edge-on spiral galaxies. The most important challenge for the models considered so far was the observed increase of [OIII]/Hbeta, [OII]/Hbeta, and [NII]/Halpha with increasing distance to the galactic plane. We propose a scenario based on the expected population of massive OB stars and hot low-mass evolved stars (HOLMES) in this galaxy to explain this observational fact. In the framework of this scenario we construct a finely meshed grid of photoionization models. For each value of the galactic latitude z we look for the models which simultaneously fit the observed values of the [OIII]/Hbeta, [OII]/Hbeta, and [NII]/Halpha ratios. For each value of z we find a range of solutions which depends on the value of the oxygen abundance. The models which fit the observations indicate a systematic decrease of the electron density with increasing z. They become dominated by the HOLMES with increasing z only when restricting to solar oxygen abundance models, which argues that the metallicity above the galactic plane should be close to solar. They also indicate that N/O increases with increasing z.Comment: Accepted for publication in MNRA

The origin of the light distribution in spiral galaxies

We analyse a high-resolution, fully cosmological, hydrodynamical disc galaxy simulation, to study the source of the double-exponential light profiles seen in many stellar discs, and the effects of stellar radial migration upon the spatiotemporal evolution of both the disc age and metallicity distributions. We find a ‘break’ in the pure exponential stellar surface brightness profile, and trace its origin to a sharp decrease in the star formation per unit surface area, itself produced by a decrease in the gas volume density due to a warping of the gas disc. Star formation in the disc continues well beyond the break. We find that the break is more pronounced in bluer wavebands. By contrast, we find little or no break in the mass density profile. This is, in part, due to the net radial migration of stars towards the external parts of the disc. Beyond the break radius, we find that ∼60 per cent of the resident stars migrated from the inner disc, while ∼25 per cent formed in situ. Our simulated galaxy also has a minimum in the age profile at the break radius but, in disagreement with some previous studies, migration is not the main mechanism producing this shape. In our simulation, the disc metallicity gradient flattens with time, consistent with an ‘inside-out’ formation scenario. We do not find any difference in the intensity or the position of the break with inclination, suggesting that perhaps the differences found in empirical studies are driven by dust extinction

Galactic Gradients, Postbiological Evolution and the Apparent Failure of SETI

Motivated by recent developments impacting our view of Fermi's paradox (absence of extraterrestrials and their manifestations from our past light cone), we suggest a reassessment of the problem itself, as well as of strategies employed by SETI projects so far. The need for such reevaluation is fueled not only by the failure of searches thus far, but also by great advances recently made in astrophysics, astrobiology, computer science and future studies, which have remained largely ignored in SETI practice. As an example of the new approach, we consider the effects of the observed metallicity and temperature gradients in the Milky Way on the spatial distribution of hypothetical advanced extraterrestrial intelligent communities. While, obviously, properties of such communities and their sociological and technological preferences are entirely unknown, we assume that (1) they operate in agreement with the known laws of physics, and (2) that at some point they typically become motivated by a meta-principle embodying the central role of information-processing; a prototype of the latter is the recently suggested Intelligence Principle of Steven J. Dick. There are specific conclusions of practical interest to be drawn from coupling of these reasonable assumptions with the astrophysical and astrochemical structure of the Galaxy. In particular, we suggest that the outer regions of the Galactic disk are most likely locations for advanced SETI targets, and that intelligent communities will tend to migrate outward through the Galaxy as their capacities of information-processing increase, for both thermodynamical and astrochemical reasons. This can also be regarded as a possible generalization of the Galactic Habitable Zone, concept currently much investigated in astrobiology.Comment: 30 pages, 2 figure

TESS spots a mini-neptune interior to a hot saturn in the TOI-2000 system

Hot jupiters (P 60 $\mathrm{M}_\oplus$) are almost always found alone around their stars, but four out of hundreds known have inner companion planets. These rare companions allow us to constrain the hot jupiter's formation history by ruling out high-eccentricity tidal migration. Less is known about inner companions to hot Saturn-mass planets. We report here the discovery of the TOI-2000 system, which features a hot Saturn-mass planet with a smaller inner companion. The mini-neptune TOI-2000 b ($2.70 \pm 0.15 \,\mathrm{R}_\oplus$, $11.0 \pm 2.4 \,\mathrm{M}_\oplus$) is in a 3.10-day orbit, and the hot saturn TOI-2000 c ($8.14^{+0.31}_{-0.30} \,\mathrm{R}_\oplus$, $81.7^{+4.7}_{-4.6} \,\mathrm{M}_\oplus$) is in a 9.13-day orbit. Both planets transit their host star TOI-2000 (TIC 371188886, V = 10.98, TESS magnitude = 10.36), a metal-rich ([Fe/H] = $0.439^{+0.041}_{-0.043}$) G dwarf 174 pc away. TESS observed the two planets in sectors 9-11 and 36-38, and we followed up with ground-based photometry, spectroscopy, and speckle imaging. Radial velocities from CHIRON, FEROS, and HARPS allowed us to confirm both planets by direct mass measurement. In addition, we demonstrate constraining planetary and stellar parameters with MIST stellar evolutionary tracks through Hamiltonian Monte Carlo under the PyMC framework, achieving higher sampling efficiency and shorter run time compared to traditional Markov chain Monte Carlo. Having the brightest host star in the V band among similar systems, TOI-2000 b and c are superb candidates for atmospheric characterization by the JWST, which can potentially distinguish whether they formed together or TOI-2000 c swept along material during migration to form TOI-2000 b.Comment: v3 adds RV frequency analysis; 25 pages, 11 figures, 14 tables; revision submitted to MNRAS; machine-readable tables available as ancillary files; posterior samples available from Zenodo at https://doi.org/10.5281/zenodo.7683293 and source code at https://doi.org/10.5281/zenodo.798826