1,059 research outputs found
Cellular Models for River Networks
A cellular model introduced for the evolution of the fluvial landscape is
revisited using extensive numerical and scaling analyses. The basic network
shapes and their recurrence especially in the aggregation structure are then
addressed. The roles of boundary and initial conditions are carefully analyzed
as well as the key effect of quenched disorder embedded in random pinning of
the landscape surface. It is found that the above features strongly affect the
scaling behavior of key morphological quantities. In particular, we conclude
that randomly pinned regions (whose structural disorder bears much physical
meaning mimicking uneven landscape-forming rainfall events, geological
diversity or heterogeneity in surficial properties like vegetation, soil cover
or type) play a key role for the robust emergence of aggregation patterns
bearing much resemblance to real river networks.Comment: 7 pages, revtex style, 14 figure
Latest results on Jovian disk X-rays from XMM-Newton
We present the results of a spectral study of the soft X-ray emission
(0.2-2.5 keV) from low-latitude (`disk') regions of Jupiter. The data were
obtained during two observing campaigns with XMM-Newton in April and November
2003. While the level of the emission remained approximately the same between
April and the first half of the November observation, the second part of the
latter shows an enhancement by about 40% in the 0.2-2.5 keV flux. A very
similar, and apparently correlated increase, in time and scale, was observed in
the solar X-ray and EUV flux.
The months of October and November 2003 saw a period of particularly intense
solar activity, which appears reflected in the behaviour of the soft X-rays
from Jupiter's disk. The X-ray spectra, from the XMM-Newton EPIC CCD cameras,
are all well fitted by a coronal model with temperatures in the range 0.4-0.5
keV, with additional line emission from Mg XI (1.35 keV) and Si XIII (1.86
keV): these are characteristic lines of solar X-ray spectra at maximum activity
and during flares.
The XMM-Newton observations lend further support to the theory that Jupiter's
disk X-ray emission is controlled by the Sun, and may be produced in large part
by scattering, elastic and fluorescent, of solar X-rays in the upper atmosphere
of the planet.Comment: 17 pages, 7 figures, accepted for publication in a special issue of
Planetary and Space Scienc
Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia
We previously reported linkage of schizophrenia and schizoaffective disorder to 13q32–34 in the European descent Afrikaner population
from South Africa. The nature of genetic variation underlying linkage peaks in psychiatric disorders remains largely unknown and both
rare and common variants may be contributing. Here, we examine the contribution of common variants located under the 13q32–34
linkage region. We used densely spaced SNPs to fine map the linkage peak region using both a discovery sample of 415 families and a
meta-analysis incorporating two additional replication family samples. In a second phase of the study, we use one family-based data set
with 237 families and independent case–control data sets for fine mapping of the common variant association signal using HapMap SNPs.
We report a significant association with a genetic variant (rs9583277) within the gene encoding for the myosin heavy-chain Myr 8
(MYO16), which has been implicated in neuronal phosphoinositide 3-kinase signaling. Follow-up analysis of HapMap variation within
MYO16 in a second set of Afrikaner families and additional case–control data sets of European descent highlighted a region across introns
2–6 as the most likely region to harbor common MYO16 risk variants. Expression analysis revealed a significant increase in the level of
MYO16 expression in the brains of schizophrenia patients. Our results suggest that common variation within MYO16 may contribute to
the genetic liability to schizophrenia.National Institute of Mental Health (NIMH) Grant MH061399, the Lieber Center for Schizophrenia Research at Columbia University, Gray Matters Fellowship and NARSAD Young Investigator Award.http://www.nature.com/npphb201
Effects of phosphorus and drought stresses on dry matter and phosphorus allocation in wheat
First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.
Nivolumab has been associated with longer overall survival than docetaxel among patients with previously treated non-small-cell lung cancer (NSCLC). In an open-label phase 3 trial, we compared first-line nivolumab with chemotherapy in patients with programmed death ligand 1 (PD-L1)-positive NSCLC.
We randomly assigned, in a 1:1 ratio, patients with untreated stage IV or recurrent NSCLC and a PD-L1 tumor-expression level of 1% or more to receive nivolumab (administered intravenously at a dose of 3 mg per kilogram of body weight once every 2 weeks) or platinum-based chemotherapy (administered once every 3 weeks for up to six cycles). Patients receiving chemotherapy could cross over to receive nivolumab at the time of disease progression. The primary end point was progression-free survival, as assessed by means of blinded independent central review, among patients with a PD-L1 expression level of 5% or more.
Among the 423 patients with a PD-L1 expression level of 5% or more, the median progression-free survival was 4.2 months with nivolumab versus 5.9 months with chemotherapy (hazard ratio for disease progression or death, 1.15; 95% confidence interval [CI], 0.91 to 1.45; P=0.25), and the median overall survival was 14.4 months versus 13.2 months (hazard ratio for death, 1.02; 95% CI, 0.80 to 1.30). A total of 128 of 212 patients (60%) in the chemotherapy group received nivolumab as subsequent therapy. Treatment-related adverse events of any grade occurred in 71% of the patients who received nivolumab and in 92% of those who received chemotherapy. Treatment-related adverse events of grade 3 or 4 occurred in 18% of the patients who received nivolumab and in 51% of those who received chemotherapy.
Nivolumab was not associated with significantly longer progression-free survival than chemotherapy among patients with previously untreated stage IV or recurrent NSCLC with a PD-L1 expression level of 5% or more. Overall survival was similar between groups. Nivolumab had a favorable safety profile, as compared with chemotherapy, with no new or unexpected safety signals. (Funded by Bristol-Myers Squibb and others; CheckMate 026 ClinicalTrials.gov number, NCT02041533 .)
Measurement of the Branching Fraction for B->eta' K and Search for B->eta'pi+
We report measurements for two-body charmless B decays with an eta' meson in
the final state. Using 11.1X10^6 BBbar pairs collected with the Belle detector,
we find BF(B^+ ->eta'K^+)=(79^+12_-11 +-9)x10^-6 and BF(B^0 ->
eta'K^0)=(55^+19_-16 +-8)x10^-6, where the first and second errors are
statistical and systematic, respectively. No signal is observed in the mode B^+
-> eta' pi^+, and we set a 90% confidence level upper limit of BF(B^+->
eta'pi^+) eta'K^+- decays is
investigated and a limit at 90% confidence level of -0.20<Acp<0.32 is obtained.Comment: Submitted to Physics Letters
Atmospheric effects on extensive air showers observed with the Surface Detector of the Pierre Auger Observatory
Atmospheric parameters, such as pressure (P), temperature (T) and density,
affect the development of extensive air showers initiated by energetic cosmic
rays. We have studied the impact of atmospheric variations on extensive air
showers by means of the surface detector of the Pierre Auger Observatory. The
rate of events shows a ~10% seasonal modulation and ~2% diurnal one. We find
that the observed behaviour is explained by a model including the effects
associated with the variations of pressure and density. The former affects the
longitudinal development of air showers while the latter influences the Moliere
radius and hence the lateral distribution of the shower particles. The model is
validated with full simulations of extensive air showers using atmospheric
profiles measured at the site of the Pierre Auger Observatory.Comment: 24 pages, 9 figures, accepted for publication in Astroparticle
Physic
The exposure of the hybrid detector of the Pierre Auger Observatory
The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays.
It consists of a surface array to measure secondary particles at ground level
and a fluorescence detector to measure the development of air showers in the
atmosphere above the array. The "hybrid" detection mode combines the
information from the two subsystems. We describe the determination of the
hybrid exposure for events observed by the fluorescence telescopes in
coincidence with at least one water-Cherenkov detector of the surface array. A
detailed knowledge of the time dependence of the detection operations is
crucial for an accurate evaluation of the exposure. We discuss the relevance of
monitoring data collected during operations, such as the status of the
fluorescence detector, background light and atmospheric conditions, that are
used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic
Determination of |Vcb| using the semileptonic decay \bar{B}^0 --> D^{*+}e^-\bar{\nu}
We present a measurement of the Cabibbo-Kobayashi-Maskawa (CKM) matrix
element |Vcb| using a 10.2 fb^{-1} data sample recorded at the \Upsilon(4S)
resonance with the Belle detector at the KEKB asymmetric e^+e^- storage ring.
By extrapolating the differential decay width of the \bar{B}^0 -->
D^{*+}e^-\bar{\nu} decay to the kinematic limit at which the D^{*+} is at rest
with respect to the \bar{B}^0, we extract the product of |Vcb| with the
normalization of the decay form factor F(1), |Vcb |F(1)=
(3.54+/-0.19+/-0.18)x10^{-2}, where the first error is statistical and the
second is systematic. A value of |Vcb| = (3.88+/-0.21+/-0.20+/-0.19)x10^{-2} is
obtained using a theoretical calculation of F(1), where the third error is due
to the theoretical uncertainty in the value of F(1). The branching fraction
B(\bar{B}^0 --> D^{*+}e^-\bar{\nu}) is measured to be
(4.59+/-0.23+/-0.40)x10^{-2}.Comment: 20 pages, 6 figures, elsart.cls, submitted to PL
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