3,932 research outputs found
On the heating of source of the Orion KL hot core
We present images of the J=10-9 rotational lines of HC3N in the vibrationally
excited levels 1v7, 1v6 and 1v5 of the hot core (HC) in Orion KL. The images
show that the spatial distribution and the size emission from the 1v7 and 1v5
levels are different. While the J=10-9 1v7 line has a size of 4''x 6'' and
peaks 1.1'' NE of the 3 mm continuum peak, the J=10--9 1v5 line emission is
unresolved (<3'') and peaks 1.3'' south of the 3 mm peak. This is a clear
indication that the HC is composed of condensations with very different
temperatures (170 K for the 1v7 peak and K for the 1v5 peak). The
temperature derived from the 1v7 and 1v5 lines increases with the projected
distance to the suspected main heating source I. Projection effects along the
line of sight could explain the temperature gradient as produced by source I.
However, the large luminosity required for source I, >5 10^5 Lsolar, to explain
the 1v5 line suggests that external heating by this source may not dominate the
heating of the HC. Simple model calculations of the vibrationally excited
emission indicate that the HC can be internally heated by a source with a
luminosity of 10^5 Lsolar, located 1.2'' SW of the 1v5 line peak (1.8'' south
of source I). We also report the first detection of high-velocity gas from
vibrationally excited HC3N emission. Based on excitation arguments we conclude
that the main heating source is also driving the molecular outflow. We
speculate that all the data presented in this letter and the IR images are
consistent with a young massive protostar embedded in an edge-on disk.Comment: 13 pages, 3 figures, To be published in Ap.J. Letter
Magneto-caloric effect in the pseudo-binary intermetallic YPrFe17 compound
We have synthesized the intermetallic YPrFe17 compound by arc-melting. X-ray
and neutron powder diffraction show that the crystal structure is rhombohedral
with View the MathML source space group (Th2Zn17-type). The investigated
compound exhibits a broad isothermal magnetic entropy change {\Delta}SM(T)
associated with the ferro-to-paramagnetic phase transition (TC \approx 290 K).
The |{\Delta}SM| (\approx 2.3 J kg-1 K-1) and the relative cooling power
(\approx 100 J kg-1) have been calculated for applied magnetic field changes up
to 1.5 T. A single master curve for {\Delta}SM under different values of the
magnetic field change can be obtained by a rescaling of the temperature axis.
The results are compared and discussed in terms of the magneto-caloric effect
in the isostructural R2Fe17 (R = Y, Pr and Nd) binary intermetallic alloys.Comment: Preprint, 5 pages (postprint), 4 figures, regular pape
ISO observations toward the reflection nebula NGC 7023: A nonequilibrium ortho- to para-H2 ratio
We have observed the S(0), S(1), S(2), S(3), S(4) and S(5) rotational lines
of molecular hydrogen (H2) towards the peak of the photodissociation region
(PDR) associated with the reflection nebula NGC 7023. The observed H2 line
ratios show that they arise in warm gas with kinetic temperatures ~300 - 700 K.
However, the data cannot be fitted by an ortho- to para- (OTP) ratio of 3. An
OTP ratio in the range ~1.5 - 2 is necessary to explain our observations. This
is the first detection of a non-equilibrium OTP ratio measured from the H2
pure-rotational lines in a PDR. The existence of a dynamical PDR is discussed
as the most likely explanation for this low OTP ratio.Comment: 4 pages, 3 figure
Human myeloid dendritic cells treated with supernatants of rotavirus infected Caco-2 cells induce a poor Th1 response
Q3Q2154-161We have previously shown that human myeloid dendritic cells treated with purified rotavirus induce an allogenic Th1 response. To determine if rotavirus in the context of an intestinal microenvironment modulates the function of dendritic cells, we treated these cells with supernatants from non-infected or infected Caco-2 cells and studied their capacity to promote Th1 or Th2 responses. Dendritic cells treated with supernatants from rotavirus-infected Caco-2 cells promoted a significantly lower Th1 response, in comparison with those treated with purified rotavirus. We wanted to establish if TGF-beta 1, induced, or TSLP, not induced, during rotavirus infection, could mediate this effect. Neutralization of TGF-beta but not TSLP in the supernatant prior to treatment of dendritic cells increased their capacity to promote a Th1 response. The results suggest that the TGF-beta 1 induced by rotavirus could be an immune evasion mechanism, and may partially explain the poor rotavirus-specific T cell response we have previously evidenced. (C) 2011 Elsevier Inc. All rights reserved
N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer reviewe
Activity/inactivity circadian rhythm shows high similarities between young obesity-induced rats and old rats
The objective of the present study was to compare differences between elderly rats and young obesity-induced rats in their activity/inactivity circadian rhythm. The investigation was motivated by the differences reported previously for the circadian rhythms of both obese and elderly humans (and other animals), and those of healthy, young or mature individuals. Three groups of rats were formed: a young control group which was fed a standard chow for rodents; a young obesity-induced group which was fed a high-fat diet for four months; and an elderly control group with rats aged 2.5 years that was fed a standard chow for rodents. Activity/inactivity data were registered through actimetry using infrared actimeter systems in each cage to detect activity. Data were logged on a computer and chronobiological analysis were performed. The results showed diurnal activity (sleep time), nocturnal activity (awake time), amplitude, acrophase, and interdaily stability to be similar between the young obesity-induced group and the elderly control group, but different in the young control group. We have concluded that obesity leads to a chronodisruption status in the body similar to the circadian rhythm degradation observed in the elderly
Mid-J CO emission from the Orion BN/KL explosive outflow
High spatial resolution low-J 12CO observations have shown that the
wide-angle outflow seen in the Orion BN/KL region correlates with the famous H2
fingers. Recently, high-resolution large-scale mappings of mid- and higher-J CO
emissions have been reported toward the Orion molecular cloud 1 core region
using the APEX telescope. Therefore, it is of interest to investigate this
outflow in the higher-J 12CO emission, which is likely excited by shocks. The
observations were carried out using the dual-color heterodyne array CHAMP+ on
the APEX telescope. The images of the Orion BN/KL region were obtained in the
12CO J=6-5 and J=7-6 transitions with angular resolutions of 8.6 and 7.4
arcsec, respectively. The results show a good agreement between our higher-J
12CO emission and SMA low-J 12CO data, which indicates that this wide-angle
outflow in Orion BN/KL is likely the result of an explosive event that is
related to the runaway objects from a dynamically decayed multiple system. From
our observations, we estimate that the kinetic energy of this explosive outflow
is about 1-2x10^47 erg. In addition, a scenario has been proposed where part of
the outflow is decelerated and absorbed in the cloud to explain the lack of CO
bullets in the southern part of BN/KL, which in turn induces the methanol
masers seen in this region.Comment: 5 pages, 4 figure
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