110 research outputs found
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
- Author
- Allende
- Allende
- Ammit
- Bandhuvula
- Bandhuvula
- Brinkmann
- Brinkmann
- Caiying Guo
- Chiba
- Cohen
- Cyster
- Deutschman
- Dong-Soon Im
- Grigorova
- Gräler
- Hanyaloglu
- Hla
- Hla
- Ishii
- Jo
- Kabashima
- Kamal M. Khanna
- Khanna
- Kitano
- Ledgerwood
- Lee
- Leo Lefrancois
- Liu
- Liu
- Lo
- Mamdouh
- Mandala
- Marchese
- Massberg
- Matloubian
- Mechtcheriakova
- Muller
- Myat Lin Oo
- Oo
- Pan
- Pham
- Rivera
- Rosen
- Sachpatzidis
- Sanchez
- Schwab
- Schwab
- Sebzda
- Shobha Thangada
- Singer
- Sinha
- Timothy Hla
- Victoria A. Blaho
- Vroon
- Walzer
- Watterson
- Wei
- Weninger
- Yamanaka
- Zemann
- Publication venue
- The Rockefeller University Press
- Publication date
- Field of study
The sphingosine 1-phosphate receptor 1 (S1P1) promotes lymphocyte egress from lymphoid organs. Previous work showed that agonist-induced internalization of this G protein–coupled receptor correlates with inhibition of lymphocyte egress and results in lymphopenia. However, it is unclear if S1P1 internalization is necessary for this effect. We characterize a knockin mouse (S1p1rS5A/S5A) in which the C-terminal serine-rich S1P1 motif, which is important for S1P1 internalization but dispensable for S1P1 signaling, is mutated. T cells expressing the mutant S1P1 showed delayed S1P1 internalization and defective desensitization after agonist stimulation. Mutant mice exhibited significantly delayed lymphopenia after S1P1 agonist administration or disruption of the vascular S1P gradient. Adoptive transfer experiments demonstrated that mutant S1P1 expression in lymphocytes, rather than endothelial cells, facilitated this delay in lymphopenia. Thus, cell-surface residency of S1P1 on T cells is a primary determinant of lymphocyte egress kinetics in vivo
Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon
- Author
- A Calcabrini
- A Senthilkumar
- AC Williams
- AK Rowe
- B Pitasawat
- B Walther
- C Lambros
- Chantal Menut
- CS Macedo De
- D Ngnokam
- Eugenie Aimée Madiesse Kemgne
- F Munoz-Martinez
- F Tchoumbougnang
- Fabrice Fekam Boyom
- FF Boyom
- FF Boyom
- GF Santoro
- IC Moura
- J Addae-Kyereme
- J Hutchinson
- Jean Marie Bessiere
- Jiri Gut
- K Kaur
- OO Abiodun
- PA Cornwell
- Paul Henri Amvam Zollo
- Philip Jon Rosenthal
- R Cedillo-Rivera
- Vincent Ngouana
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
In a search for alternative treatment for malaria, plant-derived essential oils extracted from the stem barks and leaves of Cleistopholis patens and Uvariastrum pierreanum (Annonaceae) were evaluated in vitro for antiplasmodial activity against the W2 strain of Plasmodium falciparum. The oils were obtained from 500 g each of stem barks and leaves, respectively, by hydrodistillation, using a Clevenger-type apparatus with the following yields: 0.23% and 0.19% for C. patens and 0.1% and 0.3% for U. pierreanum (w/w relative to dried material weight). Analysis of 10% (v/v) oil in hexane by gas chromatography and mass spectrometry identified only terpenoids in the oils, with over 81% sesquiterpene hydrocarbons in C. patens extracts and U. pierreanum stem bark oil, while the leaf oil from the latter species was found to contain a majority of monoterpenes. For C. patens, the major components were α-copaene, δ-cadinene, and germacrene D for the stem bark oil and β-caryophyllene, germacrene D, and germacrene B for the leaf oil. The stem bark oil of U. pierreanum was found to contain mainly β-bisabolene and α-bisabolol, while α- and β-pinenes were more abundant in the leaf extract. Concentrations of oils obtained by diluting 1-mg/mL stock solutions were tested against P. falciparum in culture. The oils were active, with IC50 values of 9.19 and 15.19 μg/mL for the stem bark and leaf oils, respectively, of C. patens and 6.08 and 13.96 μg/mL, respectively, for those from U. pierreanum. These results indicate that essential oils may offer a promising alternative for the development of new antimalarials
Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study
- Author
- Adil A
- Agarwal A
- Aigner F
- Akowuah E
- Albertsmeiers M
- Argus L
- Arnaud A
- Ataide G
- Baiocchi G
- Batista S
- Benson RA
- Bhangu A
- Boccalatte L
- Brar A
- Brouk P
- Buarque I
- Calvache J
- Caruana EJ
- Chaudhry D
- Chetty G
- Christensen P
- Cox D
- Dajti I
- Dawson BE
- Edwards J
- El-Hussuna A
- Emile SH
- Fiore M
- Forlani S
- Gallo G
- Ghosh D
- Gjata A
- Glasbey JC
- Gohar M
- Gradinariu G
- Grecinos G
- Gujjuri RR
- Hadzibegovic AD
- Hailu DS
- Hossain K
- Jones CS
- Kamarajah SK
- Kauppila J
- Keatley JM
- Kembuan G
- Khatri C
- Khosravi M
- Klat J
- Kopjar T
- Kronberger I
- Laukkarinen J
- Lawani I
- Lawday S
- Lederhuber H
- Li E
- Lincango E
- Loffler M
- Lorena MA
- Mann H
- Marson EJ
- Martin J
- Mclean KA
- Mengesha MG
- Mersich T
- Metallidis S
- Mihanovic J
- Modolo MM
- Mohan HM
- Mozafari M
- Murphy GJ
- Nepogodiev D
- Novysedlak R
- Olivos M
- Oo AY
- Pata F
- Patel AJ
- Pellino G
- Perez Rivera CJ
- Picciochi M
- Pockney P
- Ridley B
- Rogers LJ
- Sanders J
- Siaw-Acheampong K
- Simoes JF
- Slavchev M
- Tabiri S
- Tamiru H
- Taylor EH
- Tiwari A
- Townend P
- Trout IM
- Tsoulfas G
- Tyson N
- Vaja R
- VanRamshorst G
- Venn ML
- Wettstein D
- Wilkin RJ
- Zmora O
- Publication venue
- Publication date
- 01/08/2021
- Field of study
Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality
- Author
- Abdalkader M
- Acampa M
- Adami A
- Adebayo TT
- Ahmad S
- Al Hashmi AM
- Alexiev F
- Araújo AP
- Arsovska AA
- Asif KS
- Aykac O
- Ayo-Martin O
- Baek JH
- Bajrami A
- Banerjee S
- Barrientos Guerra JD
- Bello AH
- Below K
- Bernava G
- Bessa F
- Biller J
- Blasco J
- Bolognese M
- Bonnet T
- Boskamp S
- Brady M
- Brola W
- Carrera E
- Castro P
- Charidimou A
- Chebl A
- Chen HS
- Chen M
- Chen Y
- Chieh CY
- Churojana A
- Ciopleias B
- Colasurdo M
- Conforto AB
- Cora EA
- Cruz-Culebras A
- Czap A
- Czlonkowska A
- Dao VP
- de Havenon AH
- de la Cruz Fernández B
- de Oliveira Neves L
- De Raedt S
- de Sousa DA
- Demeestere J
- Dharmadhikari S
- Dimitriade A
- Dippel D
- Dirren E
- Dorobek M
- Drenck N
- Duong HQ
- Dušek P
- Dy JSH
- Dębiec A
- Enzinger C
- Escartín López J
- Eskey CJ
- Falup-Pecurariu C
- Farhoudi M
- Farooqui M
- Fernández Ferro JC
- Ferreira P
- Feske SK
- Fibrich P
- Field TS
- Fonseca L
- Fujita K
- Fukuda H
- García Sánchez MJ
- Gattringer T
- Ghoreishi A
- Gongora-Rivera F
- Goyal N
- Grimmett KB
- Guillán Rodríguez M
- Guzik AK
- Hamid MA
- Haring J
- Hashemilar M
- Haussen DC
- Hernandez-Fernandez F
- Hidalgo RCT
- Hlaváčová H
- Hovingh M
- Hrabanovska E
- Huded V
- Hussain SI
- Imamura H
- Infante-Valenzuela A
- Inoa V
- Jancar N
- Jillela D
- John S
- Jurák L
- Kadlčíková J
- Kalpachki R
- Kan PT
- Karapanayiotides T
- Kargiotis O
- Karlinski MA
- Karpowicz I
- Kelly ME
- Khatri R
- Khoury NN
- Kiley NL
- Klein P
- Klečka L
- Kolikonda MK
- Kosuke M
- Koutroulou I
- Kovář M
- Krastev G
- Krishnan K
- Kristoffersen ES
- Kwan J
- Labuz-Roszak BM
- Lameirinhas da Silva I
- Lara S
- Lasek-Bal A
- Le HV
- Lee JS
- Lee SB
- Lemmens R
- Lenthall R
- Lereis VP
- Lesaine E
- Li G
- Ligot N
- Linfante I
- Lo H
- Longoni M
- Loochtan AI
- Lopez CD
- Lycan S
- Ma A
- Maali L
- Machi P
- Male SS
- Mansour OY
- Martinez-Marino M
- Marto JP
- Martíns RT
- Masoud HE
- Matsumaru Y
- Mbroh J
- Michel P
- Mikulik R
- Min J
- Mohamed GA
- Mohammaden M
- Mohammadzadeh N
- Moniche F
- Montaner J
- Mora Cuervo DL
- Nagel S
- Nagendra S
- Nahab F
- Nalleballe K
- Neumann J
- Nguyen TN
- Nogueira RG
- Nunes AP
- Ohara N
- Omran SS
- Orgeta-Gutierrez S
- Ornello R
- Palaiodimou L
- Paloušková H
- Peeling L
- Perez-Sanchez S
- Pham TN
- Pikula A
- Pinho E Melo T
- Poli S
- Prajapati C
- Punter M
- Qureshi MM
- Radaideh Y
- Rahal F
- Rahman A
- Ramakrishnan P
- Rashid U
- Rayo-Taranto B
- Rebello LC
- Reiner P
- Reiser M
- Renieri L
- Rocha M
- Rodrigues M
- Rodriguez-Kadota L
- Rodríguez Fernández C
- Rodríguez-Vázquez A
- Rohan V
- Rojas-Soto DM
- Roje Bedekovic M
- Romoli M
- Rosenkranz M
- Rouanet F
- Ruland S
- Sabben C
- Sabetay SI
- Sacco S
- Sadeghi Hokmabadi E
- Sakaguchi M
- Sakai K
- Sakai N
- Sakelarova T
- Salmaggi A
- Sangalli D
- Sani AF
- Santiago IB
- Sathya A
- Scozzari D.
- Sedova P
- Senadim S
- Seo KD
- Sheth SA
- Shindo S
- Siegler JE
- Sienkiewicz-Jarosz H
- Silva ML
- Simpkins AN
- Skoda O
- Sobh K
- Sobolewski P
- Sohn SI
- Sonoda K
- Starosciak AK
- Staszewski J
- Strambo D
- Strbian D
- Sugiura Y
- Sundseth A
- Sunmonu TA
- Suryadevara NC
- SVIN COVID-19 Global COVID Stroke Registry
- Sylaja PN
- Takenobu Y
- Tarlov NE
- Taylor RA
- Tenora D
- Thomalla G
- Ton MD
- Toyoda K
- Tran AD
- Tsivgoulis G
- Uwatoko T
- van Dam-Nolen DHK
- Vanacker P
- Vandervorst F
- Vences MÁ
- Venketasubramanian N
- Voetsch B
- Wahab KW
- Wan Yahya WNN
- Wan Zaidi WA
- Wiącek M
- Wu TY
- Yaghi S
- Yalung PM
- Yamagami H
- Yamamoto N
- Yamamoto R
- Yang S
- Yazawa Y
- Yoshimoto T
- Zaidat OO
- Zhang L
- Zhang L
- Zielinska-Turek J
- Zini A
- Özdemir AÖ
- Čabal M
- Šimůnek L
- Škorňa M
- Šrámek M
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background and purpose: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year.
Methods: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020).
Results: There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths.
Conclusions: During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
- Author
- Abbadie F
- Achkar A
- Ackroyd A
- Adamczyk A
- Adarraga Cansino Md
- Addala A
- Adnet F
- Agarwal G
- Ageno W
- Agnelli G
- Agnelli G
- Al Ahmad W
- Al-Refaie F
- Alexandra Jf
- Alikhan R
- Allameddine A
- Altarriba Es
- Amado Fernández C
- Amitrano M
- Amore M
- Angelini E
- Antignani Pl
- Aquilanti S
- Aranda Blazquez R
- Arden C
- Arellano Rodrigo E
- Armengou Arxe A
- Arone A
- Asaro G
- Attanzio Mt
- Attinasi V
- Austin A
- Axthelm C
- Axthelm P
- Bakhai A
- Balbarini A
- Ballaz Quincoces A
- Banfi E
- Banyai M
- Barcellona D
- Barillari G
- Bartolini C
- Barton T
- Bartone M
- Bauersachs R
- Bauersachs R
- Beato Pérez Jl
- Bedate Díaz P
- Belhassane A
- Bellanuova I
- Bellisi M
- Bellizzi A
- Benaroya B
- Bergmann K
- Berremili T
- Beschorner U
- Bianchi M
- Bianchini G
- Binias Kh
- Birr V
- Blanco-Molina Ma
- Boari B
- Body R
- Bonnin C
- Boral M
- Bortoluzzi C
- Bosler F
- Bramlage P
- Bratsch H
- Brauer G
- Bresin Durand Mg
- Brisot D
- Brodmann M
- Brousse C
- Brucoli C
- Burghard S
- Calandra G
- Calvo Mijares N
- Camporese G
- Canafoglia L
- Cancellieri E
- Cannavacciuolo F
- Caprioli C
- Carlizza A
- Carnovali M
- Carrasco Expósito M
- Carrasco Mas A
- Carugati A
- Casarsa C
- Castellote Mc
- Castrodeza Sanz R
- Catalini R
- Cavazza S
- Cayman C
- Cazaubon M
- Cañas Alcántara I
- Cenci C
- Ceresa F
- Cereto Castro F
- Chacko J
- Champion O
- Chandra D
- Chanut M
- Charters F
- Chevalet P
- Church A
- Ciampa A
- Ciarambino T
- Cillari E
- Cisneros de la Fuente E
- Clemente M
- Clements J
- Clifford P
- Cohen At
- Connault J
- Constans J
- Conti F
- Cordeanu M
- Cosmi B
- Couturaud F
- Cox D
- Crouch M
- Crowther M
- D'Alessandro A
- D'Angelo A
- D'Antoni S
- Davies E
- Davies M
- de Ancos Aracil C
- De Bartolomeo G
- De Campora P
- de Daborenea González Md
- De Dedker L
- De Franciscis S
- De Gaudenzi E
- de la Fuente Aguado J
- De La Fuente T
- de las Revillas Fa
- De Santis F
- De Tommaso I
- Decoulx E
- del Carmen Fernández-Capitán M
- del Toro Cervera J
- Delgado Bregel Jl
- Delpin S
- Demann C
- Demmig A
- Derrien B
- Di Francesco L
- Di Maggio R
- Di Micco P
- Di Michele D
- Di Minno G
- Di Nisio M
- Di Salvo M
- Diamand Jm
- Diard A
- Dimitri S
- Donadio F
- Douadi Y
- Drebes A
- Dres P
- Dupas S
- Durant C
- Díez Fernández F
- D’Avino M
- Eberhad Rieker E
- Eberlein U
- Edhery S
- Eischer L
- Elias Hernández T
- Emter E
- Enea I
- Enger F
- Eschenburg J
- Eschenburg Ju
- Ewad H
- Fabbian F
- Falanga A
- Falvo N
- Farcas Taralunga C
- Felis S
- Fernández Iglesias A
- Ferrari E
- Ferri Bataler R
- Fiore V
- Fontanella A
- Forkmann L
- Franco E
- Frank J
- Frank U
- Franklin S
- Frausini G
- Freischmidt H
- Fritsche I
- Fronk Em
- Fuorlo M
- Gaillard C
- Gallerani M
- Gamberini S
- Garcia Ma
- García García Jm
- García Loizaga A
- García-Bragado Dalmau F
- Garrigues D
- Gassauer M
- George J
- Gerofke H
- Ghirarduzzi A
- Ghizzi G
- Gianniello F
- Gibbs C
- Gillet Jl
- Giordana P
- Girke F
- Gitt Ak
- Giudice G
- Goebels Mc
- Goh T
- González Porras Jr
- González Lg
- Grange C
- Grare F
- Grenot Mc
- Grün-Himmelmann K
- Guarnera G
- Guercini F
- Guggenbichler S
- Guil García M
- Gupta S
- Gutierrez Ja
- Hadj Henni A
- Hartmann K
- Heilberger P
- Heinsius A
- Held M
- Herman G
- Hernando López E
- Herold J
- Hertrich F
- Heuser S
- Hidden-Henic V
- Hirschl M
- Holmes J
- Holtea D
- Hommel H
- Hottin D
- Härtel D
- Hütte G
- Imbert B
- Imberti D
- Iosub Di
- Iozzi E
- Irvine N
- Jackson-Voyzey E
- Jacquinandi V
- Jakob D
- Jara Palomares L
- Jaras Mj
- Jeanneret C
- Jiménez Castro D
- Jiménez-Rodríguez Madridejos R
- Jones N
- Joya Seijo D
- Jungandreas K
- Jurus C
- Jörg Gr
- Kalka C
- Kallat A
- Karcher J
- Karl-Wollweber S
- Keilhau Da
- Kerr P
- Kesteven P
- Kittel K
- Knittel M
- Knolinski T
- Kopplin U
- Kroschel U
- Kröger K
- Kubicek–Hofmann C
- Köhler C
- Körner I
- La Forgia S
- La Regina M
- Lacoste A
- Lacut K
- Laeis P
- Landolfi R
- Laroche Jp
- Lecumberri R
- Lench T
- Leschke M
- Lester W
- Lewis M
- Lluís Padierna M
- Lodigiani C
- Lorenzo Hernández A
- Lowe G
- Lutz A
- López Castellanos Gt
- López Jiménez L
- López Gt
- López-Sáez Jb
- Lübbert G
- Madridano Cobo O
- Mainez Saiz C
- Mancuso G
- Manfredini R
- Manzano Espinosa L
- Marchena Yglesias Pj
- Marconi L
- Marcucci R
- Marencke Gh
- Margheriti R
- Marongiu S
- Marra A
- Marrocco F
- Martin M
- Martinelli I
- Martín del Pozo M
- Martínez N
- Masotti L
- Mazollier C
- McCormack T
- McCoye A
- McGrane F
- Mearelli F
- Mearns B
- Melibovsky L
- Mersel T
- Milesi V
- Millón Caño Ja
- Miserey G
- Mismetti P
- Modeliar Remond Ss
- Mommi V
- Monreal Bosch M
- Monreal M
- Montagna Es
- Monte Secades R
- Mora Luján Jm
- Moral Moral P
- Moreno Flores A
- Moriarty A
- Morretti T
- Morris W
- Mortensen K
- Mos L
- Moysidis T
- Mugno F
- Muñoz Rodríguez Fj
- Narayanan M
- Nedey C
- Nelles H
- Nestler K
- Neumeister A
- Nieto Rodríguez Ja
- Nitti C
- Nou M
- Núñez Fernández Mj
- Oettler W
- Olivieri O
- Oncala Sibajas E
- Onesta M
- Oo N
- Orlandini F
- Ortiz de Saracho J
- Ott I
- Otto A
- Ouvry P
- Pagliara V
- Paiella L
- Pala P
- Palasciano G
- Palla A
- Paoletti O
- Paolucci G
- Parisi R
- Parra Caballero P
- Pasca S
- Pasin M
- Pasligh M
- Patanè F
- Pedrajas Navas Jm
- Pennacchioni M
- Pepe C
- Pernod G
- Pertermann A
- Perticone F
- Peter Marschang P
- Peuch B
- Pfister R
- Piccinni Gc
- Pichot O
- Pierri F
- Piloquet Fx
- Pindur P
- Pinto A
- Piovella F
- Pivetti G
- Pizzini Am
- Placentino M
- Poli D
- Pons Martín del Campo I
- Porreca E
- Portillo Sánchez J
- Poulain V
- Pourhassan S
- Predel D
- Prisco D
- Pudollek T
- Pérez Rus G
- Quere I
- Quezada Loaiza A
- Quintavalla R
- Ramthor M
- Rancan E
- Ray P
- Reed M
- Reimer D
- Rennebaum C
- Reppel M
- Reynaldo P
- Ria L
- Richter R
- Rief P
- Riera Mestre A
- Rifai A
- Rivera Gallego A
- Rodríguez Beltrán Em
- Roldán Schilling V
- Romero Pizarro Y
- Roncero Lázaro A
- Rose P
- Rossetto V
- Rothenbücher G
- Rothhagen B
- Rovinelli M
- Roy Pm
- Rubino P
- Rudolff S
- Ruiz J
- Rupoli S
- Russo V
- Saby Jc
- Saccullo G
- Sada S
- Saja K
- Sala G
- Salmi R
- Salvi A
- Samaden A
- San Román Terán Cm
- Sangiuolo R
- Santalla Valle Ea
- Santini C
- Schafnitzl W
- Schellong S
- Schenone A
- Schiller M
- Schlosser A
- Schmeink P
- Schmeink T
- Schmidt J
- Schnabl S
- Schneider H
- Schnupp S
- Schulze M
- Schäfer A
- Schön N
- Sciacqua A
- Sechtem U
- Sedl S
- Serra R
- Severino S
- Sevestre Ma
- Signorelli Ss
- Silvestri E
- Silvestris F
- Simon F
- Simonot-Lalandec E
- Siniscalchi V
- Siragusa S
- Sivakumaran M
- Sohal M
- Sollazzo V
- Solomons G
- Sonnenschein K
- Sorvillo S
- Stachowitz J
- Staub D
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- Stoshikj S
- Strafino C
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- Sánchez Fuentes D
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- Violo C
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- von Bilderling P
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- Wittig K
- Wucherpfennig P
- Zafar A.
- Zanatta N
- Zierock P
- Zingaretti O
- Zorzi F
- zur Nieden T
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- 01/01/2017
- Field of study
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
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- Al-Mamun A
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- Al-Momani HM
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- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
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- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
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- Adelson JD
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- Umeokonkwo CD
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- Venketasubramanian N
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- Wickramasinghe ND
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- Wijeratne T
- Wilner LB
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- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
- Bazmandegan G
- Becker JS
- Bedi N
- Beghi E
- Behzadifar M
- Bejot Y
- Bekuma TTT
- Bell ML
- Bello AK
- Ben L
- Bender RG
- Bennett DA
- Bennitt FB
- Bensenor IM
- Benziger CP
- Berhe K
- Berman AE
- Bernabe E
- Bernstein RS
- Bertolacci GJ
- Bhagavathula AS
- Bhageerathy R
- Bhala N
- Bhandari D
- Bhardwaj P
- Bhat AG
- Bhattacharyya K
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- Yousefi B
- Yousefi Z
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- Yousuf AY
- Yu C
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- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
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- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
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- Zhang Z-J
- Zhao JT
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- Zheleva B
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- Zhu C
- Ziapour A
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- Zlavog BS
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Two-particle azimuthal correlations in photonuclear ultraperipheral Pb plus Pb collisions at 5.02 TeV with ATLAS
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- Zakharchuk N
- Zambito S
- Zanzi D
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zerradi S
- Zerwas D
- Zhang B
- Zhang DF
- Zhang G
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- Zhao Y
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 01/07/2021
- Field of study
Two-particle long-range azimuthal correlations are measured in photonuclear collisions using
1.7
nb
−
1
of 5.02 TeV
Pb
+
Pb
collision data collected by the ATLAS experiment at the CERN Large Hadron Collider. Candidate events are selected using a dedicated high-multiplicity photonuclear event trigger, a combination of information from the zero-degree calorimeters and forward calorimeters, and from pseudorapidity gaps constructed using calorimeter energy clusters and charged-particle tracks. Distributions of event properties are compared between data and Monte Carlo simulations of photonuclear processes. Two-particle correlation functions are formed using charged-particle tracks in the selected events, and a template-fitting method is employed to subtract the nonflow contribution to the correlation. Significant nonzero values of the second- and third-order flow coefficients are observed and presented as a function of charged-particle multiplicity and transverse momentum. The results are compared with flow coefficients obtained in proton-proton and proton-lead collisions in similar multiplicity ranges, and with theoretical expectations. The unique initial conditions present in this measurement provide a new way to probe the origin of the collective signatures previously observed only in hadronic collision
Configuration and performance of the ATLAS b-jet triggers in Run 2
- Author
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- Abbott B
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- Zhemchugov A
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/12/2021
- Field of study
Several improvements to the ATLAS triggers used to identify jets containing b-hadrons (b-jets) were implemented for data-taking during Run 2 of the Large Hadron Collider from 2016 to 2018. These changes include reconfiguring the b-jet trigger software to improve primary-vertex finding and allow more stable running in conditions with high pile-up, and the implementation of the functionality needed to run sophisticated taggers used by the offline reconstruction in an online environment. These improvements yielded an order of magnitude better light-flavour jet rejection for the same b-jet identification efficiency compared to the performance in Run 1 (2011–2012). The efficiency to identify b-jets in the trigger, and the conditional efficiency for b-jets that satisfy offline b-tagging requirements to pass the trigger are also measured. Correction factors are derived to calibrate the b-tagging efficiency in simulation to match that observed in data. The associated systematic uncertainties are substantially smaller than in previous measurements. In addition, b-jet triggers were operated for the first time during heavy-ion data-taking, using dedicated triggers that were developed to identify semileptonic b-hadron decays by selecting events with geometrically overlapping muons and jets
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