7 research outputs found
Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study
- Author
- Abdellaoui D. M.
- Al Khedr D. A.
- Ameli D. R.
- Anxionnat P. R.
- Armspach P. J.
- Audoin Bertrand
- Audoin P. B.
- Ayache D. S.
- Ayrignac D. X.
- Ayrignac X.
- Bannier Elise
- Barillot D. C.
- Beltran D. S.
- Bensa D. C.
- Bereau D. M.
- Berger D. E.
- Berry P. I.
- Berthe C.
- Biotti D.
- Boncoeur-Martel D. M.
- Bonhomme D. G.
- Bonneville P. F.
- Bottin D. L.
- Bourre Bertrand
- Bourre D. B.
- Boutet D. C.
- Brassat D.
- Brassat P. D.
- Brisset J. C.
- Brochet Bruno
- Brochet P. B.
- Brunel H.
- Cabre P. P.
- Callier C.
- Camdessanche P. J.
- Camus-Jacqmin D. M.
- Cappe C.
- Carra-Dalliere D. C.
- Casey D. R.
- Casez D. O.
- Castelnovo D. G.
- Castex C.
- Cervenansky Frédéric
- Chamard-Witkowski D. L.
- Chatagner V.
- Ciron D. J.
- Ciron Jonathan
- Clanet P. M.
- Clavelou P. P.
- Cobo-Calvo A.
- Cohen D. M.
- Cohen M.
- Collongues D. N.
- Collongues N.
- Commovick O.
- Constans D. J.
- Cotton F.
- Cotton P. F.
- Coustans M.
- Coze S.
- Creange P. A.
- Dardel D. P.
- de Seze J.
- de Seze P. J.
- Debard N.
- Debouverie Marc
- Debouverie P. M.
- Deburghraeve? D. V.
- Defer P. G.
- Derache D. N.
- Derache N.
- Deruelle F.
- Desal D. H.
- Deschamps R.
- Desille-Dugast M.
- Dewas C.
- Di Lelio B.
- Diallo S. S.
- Diop Kane M.
- Dousset P. V.
- Droulon K.
- Dufay N.
- Dulau C.
- Dumont E.
- Durand-Dubief D. F.
- Durand-Dubief F.
- Edan P. G.
- Fagniez D. O.
- Ferre D. J.
- Fiard G.
- Fontaine P. B.
- Frangoulis D. B.
- Fromont D. A.
- Galanaud P. D.
- Galli P.
- Gallot G.
- Gele P.
- Gerardin D. E.
- Giannesini D. C.
- Girard Nicolas
- Gonin D. S.
- Gout D. O.
- Grand D. S.
- Guennnoc D. A.
- Guillemin P. F.
- Guillevin D. R.
- Guttmann P. C.
- Hautecoeur P. P.
- Heinzlef D. O.
- Henry D. C.
- Jousset N.
- Kasonde D. I.
- Kounkou K. K.
- Krainik D. A.
- Kremer D. S.
- Laage D. C.
- Labauge P. P.
- Labeyrie D. C.
- Laplaud David,
- Laplaud P. D.
- Le Page D. E.
- Le Port D.
- Lebranchu P.
- Lebrun-Frenay Christine
- Lebrun-Frenay D. C.
- Lefaucheur D. R.
- Lehmann P.
- Lehmann S.
- Leray D. E.
- Lescieux E.
- Lifticariu D. C.
- Lommazi S.
- Lubetzki P. C.
- Magy P. L.
- Maillard D. E.
- Maillart E.
- Maltete D. D.
- Marignier D. R.
- Marignier R.
- Mathey D. G.
- Mathey G.
- Maze D. M.
- Menjot de Champfleur Nicolas
- Meunier G.
- Michel D. L.
- Michel L.
- Moisset D. X.
- Mondot D. L.
- Montcuquet Alexis
- Montcuquet D. A.
- Moreau P. T.
- Moreau Thibault
- Muraz R.
- Neau P. J.
- Nicol M.
- Nifle D. C.
- Oesterle D. H.
- Olaiz D. J.
- Ouallet D. J.
- Papeix C.
- Papeix D. C.
- Patry D. I.
- Peaureaux-Averseng D. D.
- Pelletier Jean
- Pelletier P. J.
- Pico P. F.
- Pierot D. L.
- Pinna F.
- Pottier D. C.
- Protin A.
- Pyatigorskaya D. N.
- Rabois E.
- Ranjeva P. J.
- Rebeix I.
- Rico-Lamy D. A.
- Ricolfi D. F.
- Roch D. J.
- Rollot F.
- Ruet D. A.
- Ruiz A.
- Sampaio M.
- Sappey-Marinier D. D.
- Savatovsky D. J.
- Sehaki S.
- Servan D. J.
- Slesari D. I.
- Stankoff P. B.
- Taithe D. F.
- Tanguy D. J.
- Thouvenot Eric
- Thouvenot P. E.
- Tilikete C.
- Tourbah Ayman
- Tourbah P. A.
- Tourdias D. T.
- Vaillant D. M.
- Vermersch P. P.
- Vimont C.
- Visneux V.
- Vukusic P. S.
- Vukusic S.
- Wiertlewski D. S.
- Zephir D. H.
- Zephir H.
- Ziegler A.
- Zorila D. C.
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/05/2018
- Field of study
International audienc
Aquatic community structure as sentinel of recent environmental changes unraveled from lake sedimentary records from the Atacama Desert, Chile
- Author
- A Aránguiz-Acuña
- A Aránguiz-Acuña
- A Aránguiz-Acuña
- A Correa-Metrio
- A Gómez
- A Maldonado
- A Pell
- A Poulícbreve
- A Sáez
- AL Bobst
- AP Ariani
- AP Roberts
- B Ritter
- B Zolitschka
- C Ortega
- C Rosenzweig
- D Hering
- DGA
- DH Urrego
- DJ Dunlop
- EC Rodrigues-Bartozek
- EG Bellinger
- EM Gayo
- F Lamy
- F Lamy
- FG Blanchet
- FP Díaz
- G Petterson
- G Vargas
- H Hirst
- H Pizarro
- HG Pollard
- HS Marcial
- I Pizarro
- I Salas
- J Antonovics
- J Herkovits
- J Houston
- J Oksanen
- J Quade
- J Tapia
- J-BW Stuut
- JA Naranjo
- JB Korosi
- JL Betancourt
- JL Diederich
- JS Pigati
- K Krammer
- K Krammer
- K Ziervogel
- KA Smith
- KD Bennett
- L Orsini
- L Romero
- L Tauxe
- L Tauxe
- M Cantonatti
- M Cerda
- M Grosjean
- M Ramírez
- M Rojas
- MA Rogalski
- MA Rogalski
- MB Abbott
- ME Evans
- MM Salvarredy-Aranguren
- MO Hill
- O López-Sandoval
- OECD: Eutrophication of Waters
- P Appleby
- P Goldstein
- P Guilizzoni
- P Kasprzak
- P Legendre
- P Legendre
- P Turko
- P Šmilauer
- PB Hamilton
- R Adrian
- R Cerveny
- R Rico-Martínez
- R Tolloti
- RD DeLaune
- RH Sillitoe
- S Salminen
- T Dittmar
- T Jordan
- T Jordan
- W Keller
- Y Liu
- Y Shaked
- Y Tao
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Silver nanoparticles impact phototrophic biofilm communities to a considerably higher degree than ionic silver
- Author
- A Frattini
- A Ivask
- A Maynard
- A Oukarroum
- A Paule
- A Paule
- A Schultz
- AG González
- AG González
- AG González
- AJ Miao
- Alexandre Lamy
- AM Badawy El
- AR Flegal
- Aridane G. González
- AV Kachynski
- B Nowack
- BP Barnett
- C Carlson
- C Chen
- C-N Lok
- CM Niemeyer
- CO Dimkpa
- D Borrok
- E Navarro
- E Navarro
- ED Hullebusch van
- ET Hwang
- G Oberdörster
- H Boston
- H Hillebrand
- H Utermöhl
- HT Ratte
- I Capek
- I Sondi
- J Fabrega
- J Fabrega
- J Ha
- J Liu
- J Perelaer
- JB Fein
- Jean-Luc Rols
- JL Barriada
- JL Garland
- JN Murdock
- Joséphine Leflaive
- JR Morones
- JW Costerton
- K Kalishwaralal
- L Ranjard
- M Cardinale
- M González-Dávila
- M Rico
- MA Radzig
- MM Fisher
- MN Moore
- N Gou
- NS Wigginton
- Oleg S. Pokrovsky
- OS Pokrovsky
- OS Pokrovsky
- Q Feng
- RE Martinez
- S Kittler
- S Mohanty
- S Pal
- S Pavasupree
- SA Sañudo-Wilhelmy
- Stéphane Mombo
- TJ Battin
- W He
- W Tungittiplakorn
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Neuraxial analgesia is not associated with an increased risk of post-partum relapses in MS
- Author
- Adeleine P.
- Aguilar M
- Aladro Benito Y.
- Allaire C.
- Alpérovitch A.
- Amato M. P.
- Androdias G.
- Arbizu T.
- Arzua-Mouronte D.
- Athéa N.
- Aufauvre D.
- Baron J. C.
- Bates D.
- Baulieu E. E.
- Belair C.
- Belaïsch-Allard J.
- Benoit T.
- Berger E.
- Berger Eric
- Biron A.
- Blondiau M.
- Boggild M.
- Boissel J. P.
- Bonakim Dib W.
- Bone I.
- Bonneviot G.
- Borgel F.
- Boulay C.
- Bourrin J. C.
- Bracoud L.
- Brassat D.
- Brassat David
- Brunet P.
- Burguera J. A.
- Büschsenschutz D.
- Carton H.
- Carton H.
- Casey Romain
- Castelnovo G.
- Castelnovo Giovanni
- Cavazzuti M.
- Chauplannaz G.
- Chauplannaz G.
- Citterio A.
- Clanet M.
- Clavelou P.
- Clavelou Pierre
- Clerc C.
- Clerico Marinella
- Collongues N.
- Comi G.
- Conard J.
- Confavreux C.
- Confavreux C.
- Confavreux C.
- Confavreux C.
- Cornette M.
- Cornu C.
- Cornu C.
- Correia de Sa J.
- Cortinovis-Tourniaire P.
- Cortinovis-Tourniaire P.
- Cotton F.
- Coustans M.
- Couvreur G.
- Dat S.
- De Andres de Frutos C.
- De Sèze J.
- De Sèze Jérôme
- Debouverie M.
- Debouverie Marc
- Deburghraeve V.
- Delestre F.
- Delisse B.
- Derache N.
- Devoize J. L.
- Dumas R.
- Durand G.
- Durand-Dubief F.
- Durand-Dubief Françoise
- Durelli L.
- Durelli Luca
- D’Amico E.
- d’Archangues C.
- d’Hooghe M. B.
- d’Hooghe M. B.
- D’Hooghe Marie Béatrice
- Edan G.
- Edan G.
- El-Etr M.
- El-Etr M.
- Fernandez O.
- Ferrier A.
- Ffrench P.
- Filippi M.
- Fioretti C.
- Flachenecker P.
- Frequin S.
- Gambi D.
- Geens K. M. J.
- Geffner Sclarky D.
- Gerdelat-Mas A.
- Ghezzi A.
- Gibert I.
- Gil R.
- Goas J. Y.
- Gonsette R.
- Gregory R. P.
- Grimaud J.
- Grimaud J.
- Grimaud J.
- Gromaire-Fayolle N.
- Guennoc A. M.
- Guillaume D.
- Guy N.
- Haas J.
- Hansen H. J.
- Hartung H. P.
- Hartung H. P.
- Hautecoeur P.
- Hautecoeur P.
- Hautecoeur Patrick
- Hawkins S.
- Hedreville M. A.
- Heinzlef O.
- Heinzlef Olivier
- Heltberg A.
- Henry P.
- Hernandez J. J.
- Hinzelin G.
- Hommes O.
- Hommes O.
- Hours M.
- Howell S. J. L.
- Huber S.
- Hutchinson M.
- Hutchinson M.
- Hutchinson M.
- Hutchinson Michael
- Huttin B.
- Inglese M.
- Ionescu I.
- Ionescu I.
- Ionescu I.
- Ionescu Iuliana
- Janssens J.
- Johnson M.
- Jongen P.
- Kappos L.
- Kolleger H.
- Kölmel H. W.
- Lanctin-Garcia C.
- Laplaud D. A.
- Laplaud David-Axel
- Latombe D.
- Lau G.
- Lauxerois M.
- Lavie Caroline
- Le Page Emmanuelle
- Lebrun-Frenay C.
- Lebrun-Frenay Christine
- Leche J.
- Lechner-Scott J.
- Lepage E.
- Loche D.
- Lyon-Caen O.
- Madigand M.
- Madinier G.
- Mancardi G. L.
- Marignier R.
- Marignier Romain
- Martinelli V.
- Mauch E.
- Mazingue A.
- Medaer R.
- Meucci G.
- Miller D. H.
- Minier D.
- Mol L.
- Moreau T.
- Moreau T.
- Moreau T.
- Moreau Thibault
- Moroianu C.
- Motti L.
- Ménard J.
- Ouallet J. C.
- Pachai C.
- PAGANO Thomas Antonio Massimo
- Patti F.
- Patti Francesco
- Pelissier C.
- Pelletier J.
- Pelletier Jean
- Peysson S.
- Poitevin R. J.
- Polman C.
- Poser S.
- Preuss S.
- Pugeat M.
- Rauch M.
- Rees J. E.
- Reichel D.
- Reyes Yanes P.
- Rico-Lamy A.
- Rieu L.
- Riffault G.
- Rio M. E.
- Rivrain Y.
- Rollot Fabien
- Romero F.
- Roose H.
- Rossi P.
- Rouhart F.
- Roullet E.
- Rumbach L.
- Sallansonnet-Froment M.
- Schumacher M
- Setiey A.
- Simonin C.
- Sindic C. J. M.
- Sindrn E.
- Sitruk-Ware R.
- Stankoff B.
- Strausser-Fuchs S.
- Taithe F.
- Tavella A.
- Tendolkar I.
- Thompson A.
- Thouvenot E.
- Tola M. R.
- Toureille L.
- Tourniaire P.
- Tourniaire Patricia
- Tournier-Gervason C. L.
- Trojano M.
- Trojano Maria
- Van Zandycke M.
- Verceletto M.
- Viala F.
- Vion P.
- Vukusic S.
- Vukusic S.
- Vukusic S.
- Vukusic S.
- Vukusic Sandra
- Weilbach F.
- Wiertlewski S.
- Wyremblewski P.
- Yaya R.
- Zaffaroni M.
- Zaffaroni M.
- Ziegler F.
- Publication venue
- SAGE Publications
- Publication date
- 01/01/2019
- Field of study
International audienceBackground: Obstetrical analgesia remains a matter of controversy because of the fear of neurotoxicity of local anesthetics on demyelinated fibers or their potential relationship with subsequent relapses.Objective: To assess the impact of neuraxial analgesia on the risk of relapse during the first 3 months post-partum, with a focus on women who experienced relapses during pregnancy.Methods: We analyzed data of women followed-up prospectively during their pregnancies and at least 3 months post-partum, collected in the Pregnancy in Multiple Sclerosis (PRIMS) and Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis (POPARTMUS) studies between 1992-1995 and 2005-2012, respectively. The association of neuraxial analgesia with the occurrence of a post-partum relapse was estimated by logistic regression analysis.Results: A total of 389 women were included, 215 from PRIMS and 174 from POPARTMUS. In total, 156 women (40%) had neuraxial analgesia. Overall, 24% experienced a relapse during pregnancy and 25% in the 3 months post-partum. Women with a pregnancy relapse were more likely to have a post-partum relapse (odds ratio (OR) = 1.83, p = 0.02), independently of the use of neuraxial analgesia. There was no association between neuraxial analgesia and post-partum relapse (OR = 1.08, p = 0.78).Conclusion: Neuraxial analgesia was not associated with an increased risk of post-partum relapses, whatever multiple sclerosis (MS) activity during pregnancy
Neuraxial analgesia is not associated with an increased risk of post-partum relapses in MS
- Author
- A. Alpérovitch
- A. Biron
- A. Citterio
- A. Ferrier
- A. Gerdelat-Mas
- A. Ghezzi
- A. Heltberg
- A. Mazingue
- A. Rico-Lamy
- A. Setiey
- A. Tavella
- A. Thomas
- A. Thompson
- A.M. Guennoc
- B. Delisse
- B. Huttin
- B. Stankoff
- C. Allaire
- C. Belair
- C. Boulay
- C. Clerc
- C. Confavreux
- C. Confavreux
- C. Confavreux
- C. Confavreux
- C. Cornu
- C. Cornu
- C. De Andres de Frutos
- C. d’Archangues
- C. Fioretti
- C. Lanctin-Garcia
- C. Lebrun-Frenay
- C. Moroianu
- C. Pachai
- C. Pelissier
- C. Polman
- C. Simonin
- C.J.M. Sindic
- C.L. Tournier-Gervason
- Caroline Lavie
- Christine Lebrun-Frenay
- CNGOF
- D. Arzua-Mouronte
- D. Aufauvre
- D. Bates
- D. Brassat
- D. Büschsenschutz
- D. Gambi
- D. Geffner Sclarky
- D. Guillaume
- D. Latombe
- D. Loche
- D. Minier
- D. Reichel
- D.A. Laplaud
- D.H. Miller
- David Brassat
- David-Axel Laplaud
- E. Berger
- E. D’Amico
- E. Lepage
- E. Mauch
- E. Roullet
- E. Sindrn
- E. Thouvenot
- E.E. Baulieu
- Emmanuelle Le Page
- Eric Berger
- F. Borgel
- F. Cotton
- F. Delestre
- F. Durand-Dubief
- F. Patti
- F. Romero
- F. Rouhart
- F. Taithe
- F. Viala
- F. Weilbach
- F. Ziegler
- Fabien Rollot
- Francesco Patti
- Françoise Durand-Dubief
- G. Androdias
- G. Bonneviot
- G. Castelnovo
- G. Chauplannaz
- G. Chauplannaz
- G. Comi
- G. Couvreur
- G. Durand
- G. Edan
- G. Edan
- G. Hinzelin
- G. Lau
- G. Madinier
- G. Meucci
- G. Riffault
- G.L. Mancardi
- Giovanni Castelnovo
- H. Carton
- H. Carton
- H. Kolleger
- H. Roose
- H.J. Hansen
- H.P. Hartung
- H.P. Hartung
- H.W. Kölmel
- I. Bone
- I. Gibert
- I. Ionescu
- I. Ionescu
- I. Ionescu
- I. Tendolkar
- Iuliana Ionescu
- J. Belaïsch-Allard
- J. Conard
- J. Correia de Sa
- J. De Sèze
- J. Grimaud
- J. Grimaud
- J. Grimaud
- J. Haas
- J. Janssens
- J. Leche
- J. Lechner-Scott
- J. Ménard
- J. Pelletier
- J.A. Burguera
- J.C. Baron
- J.C. Bourrin
- J.C. Ouallet
- J.E. Rees
- J.J. Hernandez
- J.L. Devoize
- J.P. Boissel
- J.Y. Goas
- Jean Pelletier
- Jérôme De Sèze
- K.M.J. Geens
- L. Bracoud
- L. Durelli
- L. Kappos
- L. Mol
- L. Motti
- L. Rieu
- L. Rumbach
- L. Toureille
- Luca Durelli
- M Aguilar
- M Schumacher
- M. Blondiau
- M. Boggild
- M. Cavazzuti
- M. Clanet
- M. Cornette
- M. Coustans
- M. Debouverie
- M. El-Etr
- M. El-Etr
- M. Filippi
- M. Hours
- M. Hutchinson
- M. Hutchinson
- M. Hutchinson
- M. Inglese
- M. Johnson
- M. Lauxerois
- M. Madigand
- M. Pugeat
- M. Rauch
- M. Sallansonnet-Froment
- M. Trojano
- M. Van Zandycke
- M. Verceletto
- M. Zaffaroni
- M. Zaffaroni
- M.A. Hedreville
- M.B. d’Hooghe
- M.B. d’Hooghe
- M.E. Rio
- M.P. Amato
- M.R. Tola
- Marc Debouverie
- Maria Trojano
- Marie Béatrice D’Hooghe
- Marinella Clerico
- Michael Hutchinson
- N. Athéa
- N. Collongues
- N. Derache
- N. Gromaire-Fayolle
- N. Guy
- O. Fernandez
- O. Heinzlef
- O. Hommes
- O. Hommes
- O. Lyon-Caen
- Olivier Heinzlef
- P. Adeleine
- P. Brunet
- P. Clavelou
- P. Cortinovis-Tourniaire
- P. Cortinovis-Tourniaire
- P. Ffrench
- P. Flachenecker
- P. Hautecoeur
- P. Hautecoeur
- P. Henry
- P. Jongen
- P. Reyes Yanes
- P. Rossi
- P. Tourniaire
- P. Vion
- P. Wyremblewski
- Patricia Tourniaire
- Patrick Hautecoeur
- Pierre Clavelou
- R. Dumas
- R. Gil
- R. Gonsette
- R. Marignier
- R. Medaer
- R. Sitruk-Ware
- R. Yaya
- R.J. Poitevin
- R.P. Gregory
- Romain Casey
- Romain Marignier
- S. Dat
- S. Frequin
- S. Hawkins
- S. Huber
- S. Peysson
- S. Poser
- S. Preuss
- S. Strausser-Fuchs
- S. Vukusic
- S. Vukusic
- S. Vukusic
- S. Vukusic
- S. Wiertlewski
- S.J.L. Howell
- Sandra Vukusic
- T. Arbizu
- T. Benoit
- T. Moreau
- T. Moreau
- T. Moreau
- Thibault Moreau
- V. Deburghraeve
- V. Martinelli
- W. Bonakim Dib
- Y. Aladro Benito
- Y. Rivrain
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
- Author
- Aarnio K.
- Acosta Boris Raul
- Aegidius Karen
- Akutsu Tsugio
- Albiker Christian
- Alegiani Anna
- Alemseged F.
- Almendrote Miriam
- Alonso Angelika
- Althaus Katharina
- Althaus-Knaurer Katharina
- Amarenco Pierre
- Amiri Hemasse
- Anders Bettina
- Anderson C.
- Ang T.
- Aniculaesei Adriana
- Aoki Junya
- Appleton Jason
- Arakawa Shuji
- Archer M. L.
- Arenillas Juan
- Attia J.
- Back Christina
- Bailey P.
- Balabanski A.
- Barber A.
- Barber P. A.
- Bardutzky J. rgen
- Baronnet-Chauvet Flore
- Bathe-Peters Rouven
- Bayer-Karpinska Anna
- Becerra Juan L.
- Beck Christoph
- Belchí Guillamon Olga
- Bendszus Martin
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- Jungehülsing Jan
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- Kalladka Dheeraj
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- Kamiyama Kenji
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- Kanematsu Yasuhisa
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- Kar Arindam
- Kasari O.
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- Maqueda Vicky
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- Marzina Annika
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- Matsuoka Hideki
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- Tütüncü Serdar
- Ueda Toshihiro
- Uesaka Yoshikazu
- Uotani Mihoko
- Urabe Takao
- Ustrell Xavier
- Vadot Wilfried
- Vallat W.
- Vallet Anne-Evelyne
- Vallet Pauline
- van den Berg Lucie
- van den Berg Sophie
- van Eendenburg Cecile
- van Hooff Robbert-Jan
- van Sloten Isabelle
- Vanacker Peter
- Vancaester Evelien
- Vanderdonckt Patrick
- Vandermeeren Yves
- Vanhee Frederik
- Veltkamp Roland
- Vestergaard Karsten
- Viguier Alain
- Vilas Dolores
- Villringer Kersten
- Virta J.
- Voget Dieke
- von Kummer R. diger
- von Schrader J. rg
- von Weitzel Paul
- Wahlgren Nils
- Wang W. C.
- Wang Y. T.
- Warach Steven
- Warburton Elisabeth
- Wardlaw Joanna
- Watanabe Masao
- Waters M.
- Weber Claudia
- Weber J. rg
- Wegscheider Karl
- Wegscheider Mirko
- Weimar Christian
- Weinstich Karin
- Weir L.
- Weise Christopher
- Weise Gesa
- Wijeratne T.
- Willems Chris
- Williams C.
- Wilson W.
- Winder Klemens
- Wittayer Matthias
- Wolf Marc
- Wolf Martin
- Wolff Valerie
- Wollboldt Christian
- Wollenweber Frank
- Wong A. A.
- Wong K.
- Wouters Anke
- Wu Ona
- Wu T. Y.
- Wu Y. H.
- Yagita Yoshiki
- Yakushiji Yusuke
- Yalo Bertrand
- Yamamoto Haruko
- Yan B.
- Yang F. C.
- Yang Y. W.
- Yassi N.
- Yassi Nawaf
- Yasui Keizo
- Yeh H. L.
- Yeh J. H.
- Yeh S. J.
- Yen C. H.
- Yger Marion
- Yonehara Toshiro
- Yoo Albert J.
- Yoshimura Shinichi
- Yoshimura Sohei
- Younan Nadia
- Young D.
- Yperzeele Laetita
- Ysai C. L.
- Zand Ramin
- Zegarac Vesna
- Zeiner Pia
- Zhang W. W.
- Zhao H.
- Zhao L.
- Ziemann Ulf
- Zonneveld Thomas
- Zuber Mathieu
- Publication venue
- 'Elsevier BV'
- Publication date
- 14/11/2020
- Field of study
Background: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. Methods: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. Findings: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I 2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52–1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03–4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [<1%], adjusted OR 5·58 [1·22–25·50]; p=0·024). Interpretation: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. Funding: None
Progression of Geographic Atrophy in Age-related Macular Degeneration
- Author
- A. Christine Hoerner
- Aaron Parnes
- Aaron Weinberg
- Abraham Poulose
- Adam Berger
- Adam Gerstenblith
- Adam Smucker
- Adam Zamboni
- Adelia Castano
- Alan J. Ruby
- Alan J. Ruby
- Alan J. Ruby
- Alan Kimura
- Alan Letson
- Alan R. Margherio
- Alana Temple
- Albert M. Maguire
- Albert Sinyai
- Albert Vitale
- Alessandro Iannaccone
- Alexander J. Brucker
- Alice Henning
- Alice Lyon
- Alice T. Lyon
- Alicia Disgdiertt
- Alicia Zetina
- Alison Nowak
- Allan Hunter
- Allan Kreiger
- Allen C. Ho
- Alycia Fleming
- Alysia Cronise
- Amanda Butt
- Amanda Fec
- Amanda Milliron
- Amberly Rodriguez
- Amelia Stokely
- Amitha Domalpally
- Amitha Domalpally
- Amy Flowers
- Amy Frost
- Amy Noffke
- Anand Swaroop
- Anderson
- Andrea Czubinski
- Andrea Degillio
- Andrea Menzel
- Andreas Lauer
- Andrew Antoszyk
- Andrew Eller
- Andrew Hendrick
- Andrew Moshfeghi
- Angel Garced
- Angela Marsh
- Angela Price
- Angelia Johnson
- Angella Karow
- Angie McDowell
- Angie Wealti
- Anita Agarwal
- Ann Marie Lane
- Ann Marie Lavorna
- Ann Miller
- Ann Wasilus
- Anne Fung
- Anne Haroldsen
- Anne Lindblad
- Anthony Medina
- Antonio Capone
- AREDS2 Research Group
- Aron Gedansky
- Arthur D. Fu
- Ashaki Meeks
- Asheesh Tewari
- Ashley Davis
- Ashley Emerson
- Atul Sharma
- Babilonia Ayukawa
- Barbara A. Blodi
- Barbara Blodi
- Barbara Burger
- Barbara Campbell
- Barbara Holderreed
- Barbara Jennings
- Barbara Johnson
- Barbara McGinley
- Barbara Nardi
- Barbara Soderling
- Barbara Taylor
- Barron C. Fishburne
- Barry Taney
- Bawa Dass
- Belen Rodriguez
- Benjamin Kim
- Benjamin Nicholson
- Bernard Doft
- Beth Malpica
- Beverly Sannazzaro
- Biarnes
- Bill Nyberg
- Bird
- Blaine Cribbs
- Bob Boleman
- Bonnie Carlstrom
- Brad Terry
- Bradley Smith
- Bradley Stern
- Brandi Hardy
- Brandon Johnson
- Brandon Lujan
- Brenda Arrington
- Brian Joondeph
- Brian Kim
- Brian Lutman
- Brian Rusinek
- Brian Swan
- Brian T. Kim
- Brian VanderBeek
- Brittany Ross
- Bruce Critser
- Bruce Gilliland
- Bruce R. Garretson
- Bryan Murphy
- Buddy Skellie
- C.H. Vitha
- Caire
- Calippe
- Cameron Stone
- Cara Everhart
- Carl Regillo
- Carl W. Baker
- Carla Del Castillo
- Carolyn Pan
- Cassandra Berryman Catlett
- Cassandra Cone
- Cassandra Grzybowski
- Catherine Cukras
- Catherine Fay
- Catherine Meyerle
- Catherine Nail Carroll
- Cecile Hunt
- Cedric George
- Celeste Figliulo
- Chad Indermill
- Chakravarthy
- Charla Meyer
- Charleen Callahan
- Charlene Balfour
- Charlene Putzulo
- Charles Richards
- Charles Wycoff
- Charles Yoon
- Charlotte Rodman
- Cherie Hornsby
- Cheryl Devine
- Cheryl Milanovic
- Chirag Patel
- Chirag Shah
- Chris Dock
- Chris Morrison
- Chris S. Bergstrom
- Christina Centinaro
- Christina Gentry
- Christina Shin
- Christina Stetson
- Christina Weng
- Christopher Brady
- Christopher Lyons
- Christopher Morris
- Christy Quesada
- Chuck Hamm
- Cindy Dorenbach
- Cindy Montague
- Claudia Clow
- Claudia Evans
- Clement K. Chan
- Colin Ma
- Colleen Cebulla
- Connie Hinz
- Connie Hoang
- Connie Keller
- Cornelia Gottlieb
- Craig Greven
- Crystal Moffett
- Csaky
- Cullen Barnett
- Cullen Jones
- Cynthia Owsley
- Cynthia Toth
- Cynthia Wallace
- Cyrie Fry
- Dan Helgren
- Dana Barnett
- Dana Gabel
- Daniel Berinstein
- Daniel Castillo
- Daniel Finkelstein
- Daniel Ketner
- Daniel P. Joseph
- Danis
- Danis
- Darin Goldman
- Darmakusuma Ie
- Darryl Hayes
- David A. Quillen
- David Boyer
- David Burley
- David Cupp
- David DiLoreto
- David Emmert
- David G. Callanan
- David G. Miller
- David Griffith
- David H. Orth
- David J. Browning
- David J. Spinak
- David Johnson
- David Johnson
- David Liao
- David M. Brown
- David Miller
- David Misch
- David Reflow
- David Sarraf
- David Steinberg
- David Stines
- David V. Weinberg
- David Walsh
- Dawn Matthews
- Dawn Sutherland
- Dean Hainsworth
- Debbie Eichelberger
- Debbie Goates Gilaspia
- Debbie Jordan
- Debbie McCormick
- Debbie Oliver
- Deborah Harrison
- Deborah Phillips
- Deborah Troillett
- Debra Cantrell
- Debra Markus
- Dena McDonald
- Deneva Zamora
- Denice Barsness
- Denise Ammons
- Denise Cunningham
- Denise Gallagher
- Denise Krolnik
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- Klein
- Klein
- Klein
- Komal Desai
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- Krista Bayer
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- Kristin Lipka
- Kristina Oliver
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- Kumar Thotapally
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- Laura Holm
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- Schaal
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- Scott Anagnoste
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- Steven Lin
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- Steven Truong
- Steven Yeh
- Suber Huang
- Sue Pope
- Suk Jin Moon
- Sun
- Sunir Garg
- Sunness
- Sunness
- Sunness
- Suresh Chandra
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- Susie Chang
- Swaroop
- Sylvia Ramos
- T. Michael Nork
- Tamara Cunningham
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- Tammy Brink
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- Tammy Gasparyan
- Tammy Walker
- Tana Williams
- Tanya Alexander Snowden
- Tanya Tracy Marsh
- Tara Farmer
- Tara Raphael
- Tara Young McCannel
- Tarek S. Hassan
- Tatiana Mikheyav
- Teresa Coffey
- Teresa Slagle
- Tereza Conway
- Theresa Cain
- Theresa Goddard
- Thomas B. Connor
- Thomas Blondo
- Thomas Friberg
- Thomas G. Chu
- Thomas J. Hwang
- Thomas Link
- Thomas R. Pheasant
- Thomas S. Stevens
- Thomas W. Stone
- Tiana Gonzales
- Tiarnan D. Keenan
- Tien Pei Wong
- Tiffanie Keaton
- Tiffany Swinford
- Tim Odem
- Timothy Bennett
- Timothy Olsen
- Tina Bell
- Tina Scheufele Cleary
- Tod A. McMillan
- Todd E. Schneiderman
- Tom Treuter
- Tony Adkins
- Torsten Wiegand
- Tracey Caldwell
- Tracey Martin
- Traci Clemons
- Traci E. Clemons
- Tracy Emond
- Tracy Kaczanowski
- Tracy Murray
- Tracy Troszak
- Travis Meredith
- Trexler Topping
- Trina Nitzsche
- Uma Balasubramaniam
- Ursula Lord Bator
- Valerie Davis
- Valerie Watson
- Vanessa Bergman
- Vanessa Denny
- Vanessa Hoelscher
- Vera Dilts
- Veronica Sneed
- Vesper Williams
- Vicki Barwick
- Victoria Donaldson
- Vinad Voleti
- Virginia Therrien
- Vivian Tanner
- W. Copley McLean
- W. Scott Thompson
- W. Zachery Bridges
- Wai T. Wong
- Wai T. Wong
- Waldemar Torres
- Walter Holland
- Wanda Carrasquillo-Boyd
- Wang
- Wayne A. Solley
- Wendy McBee
- Wenhua Li
- Willia Ingram
- William Anderson
- William Deegan
- William J. Wirostko
- William J. Wood
- William Kiernan
- William Rosenthal
- William Tasman
- Yaspan
- Yehoshua
- Yehoshua
- Yehoshua
- Yehoshua
- Yesenia Ovando
- Yesmin Urias
- Yin Chen
- Yolanda Konior
- Yu
- Yu-Guang He
- Zayna Nahas
- Zbigniew Krason
- Zlatan Sadikovic
- Zohar Yehoshua
- Zuzanna Rozenbajgier
- Publication venue
- 'Elsevier BV'
- Publication date
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