Becoming Free, Remaining Free: Manumission and Enslavement in New Orleans, 1846-1862

Fragile Freedom Lawsuits illuminate struggle to maintain liberty Legal historian Judith Kelleher Schafer\u27s book compliments other recent and important studies of manumission and freedom in the antebellum South. Schafer\u27s work, like Stephen Whitman and Christopher Phillips study...

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Are We to Be a Nation?: The Making of the Constitution

The Constitution of the United States is the product of a revolution in political thought as momentous as the winning of American independence. This profusely illustrated volume is a magnificent tribute to the oldest surviving charter of a federal republic. In a felicitous blend of words and pictures, Richard B. Bernstein retells the entire story of this revolution: the problems under the Articles of Confederation; the intense, often vituperative debate between Americans and Europeans over the brave new republican experiment; the arguing, reasoning, and reconciliation of interests before, during, and after the Federal Convention in 1787; the often bitter struggle for ratification in the thirteen states and the critical importance of The Federalist in the accompanying propaganda war; the beginnings of government under the Constitution; and the states’ adoption of the Bill of Rights. The delegates to the Federal Convention were the foremost men of their states and regions—bookish but not reclusive, activist but not undisciplined, principled but not rigid. Bernstein’s colorful description of the intellectual and political ferment they first created and then controlled brings to life their heroic effort. Along with these lost chapters of our history, he shows how experiments in government were a critical part of Americans’ attempts to define their identity as a nation and a people. The Constitution was the result of no miracle; the outcome was never foreordained. A blend of theory and practicality, it was to be understood by all, not just by experts, and was no talisman against evils or unyielding to new experiences. As it bound up the founding generation, it was to be a guide to their successors. Illuminating his discussion—and our understanding—of the Constitution is a huge array of rare, in some cases unique, documents assembled by The New York Public Library for its exhibition commemorating the bicentennial of the Constitution.https://digitalcommons.nyls.edu/fac_books/1096/thumbnail.jp

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease