Assessing lithological uncertainty in dikes: Simulating construction history and its implications for flood safety assessment

Dikes often have a long history of reinforcement, with each reinforcement adding new material resulting in a heterogeneous dike. As data on the dike internal heterogeneity is sparse, it is generally overlooked in the stability assessment of dikes. We present an object-based and process-based model simulating dike construction history on archeological dike cross, yielding similar patterns of heterogeneity as observed in real dikes, and apply it in a dike safety assessment. Model predictions improve when being based on more accurate statistics of dike buildup, or when being conditioned to ground truth data. When incorporated in a dike stability assessment, multiple model runs can be coupled to hydrological simulations and dike slope stability calculations, resulting in a probabilistic stability assessment considering internal dike heterogeneity. While high-resolution observations are still sparse, good model accuracies can be reached by combining regional information on dike buildup with local point observations and this model provides a parsimonious basis to include information of internal dike heterogeneity in safety assessments

Hyper-resolution PCR-GLOBWB: opportunities and challenges from refining model spatial resolution to 1km over the European continent

The quest for hydrological hyper-resolution modelling has been on-going for more than a decade. While global hydrological models (GHMs) have seen a reduction in grid size, they have thus far never been consistently applied at a hyper-resolution (<Combining double low line1km) at the large scale. Here, we present the first application of the GHM PCR-GLOBWB at 1km over Europe. We thoroughly evaluated simulated discharge, evaporation, soil moisture, and terrestrial water storage anomalies against long-term observations and subsequently compared results with the established 10 and 50km resolutions of PCR-GLOBWB. Subsequently, we could assess the added value of this first hyper-resolution version of PCR-GLOBWB and assess the scale dependencies of model and forcing resolution. Eventually, these insights can help us in understanding the current challenges and opportunities from hyper-resolution models and in formulating the model and data requirements for future improvements. We found that, for most variables, epistemic uncertainty is still large, and issues with scale commensurability exist with respect to the long-term yet coarse observations used. Merely for simulated discharge, we can confidently state that model output at hyper-resolution improves over coarser resolutions due to better representation of the river network at 1km. However, currently available observations are not yet widely available at hyper-resolution or lack a sufficiently long time series, which makes it difficult to assess the performance of the model for other variables at hyper-resolution. Here, additional model validation efforts are needed. On the model side, hyper-resolution applications require careful revisiting of model parameterization and possibly the implementation of more physical processes to be able to resemble the dynamics and spatial heterogeneity at 1km. With this first application of PCR-GLOBWB at 1km, we contribute to meeting the grand challenge of hyper-resolution modelling. Even though the model was only assessed at the continental scale, valuable insights could be gained which have global validity. As such, it should be seen as a modest milestone on a longer journey towards locally relevant model output. This, however, requires a community effort from domain experts, model developers, research software engineers, and data providers

GLOFRIM v1.0 - A globally applicable computational framework for integrated hydrological-hydrodynamic modelling

We here present GLOFRIM, a globally applicable computational framework for integrated hydrological-hydrodynamic modelling. GLOFRIM facilitates spatially explicit coupling of hydrodynamic and hydrologic models and caters for an ensemble of models to be coupled. It currently encompasses the global hydrological model PCR-GLOBWB as well as the hydrodynamic models Delft3D Flexible Mesh (DFM; solving the full shallow-water equations and allowing for spatially flexible meshing) and LISFLOOD-FP (LFP; solving the local inertia equations and running on regular grids). The main advantages of the framework are its open and free access, its global applicability, its versatility, and its extensibility with other hydrological or hydrodynamic models. Before applying GLOFRIM to an actual test case, we benchmarked both DFM and LFP for a synthetic test case. Results show that for sub-critical flow conditions, discharge response to the same input signal is near-identical for both models, which agrees with previous studies. We subsequently applied the framework to the Amazon River basin to not only test the framework thoroughly, but also to perform a first-ever benchmark of flexible and regular grids on a large-scale. Both DFM and LFP produce comparable results in terms of simulated discharge with LFP exhibiting slightly higher accuracy as expressed by a Kling-Gupta efficiency of 0.82 compared to 0.76 for DFM. However, benchmarking inundation extent between DFM and LFP over the entire study area, a critical success index of 0.46 was obtained, indicating that the models disagree as often as they agree. Differences between models in both simulated discharge and inundation extent are to a large extent attributable to the gridding techniques employed. In fact, the results show that both the numerical scheme of the inundation model and the gridding technique can contribute to deviations in simulated inundation extent as we control for model forcing and boundary conditions. This study shows that the presented computational framework is robust and widely applicable. GLOFRIM is designed as open access and easily extendable, and thus we hope that other large-scale hydrological and hydrodynamic models will be added. Eventually, more locally relevant processes would be captured and more robust model inter-comparison, benchmarking, and ensemble simulations of flood hazard on a large scale would be allowed for

Detection of HER2 amplification in breast carcinomas: comparison of multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH) combined with automated spot counting

Abstract. In this study the detection of HER2 gene amplification was evaluated using Fluorescence In Situ Hybridization (FISH; PathVysion) in comparison with Multiplex Ligation-dependent Probe Amplification (MLPA), a PCR based technique. These two methods were evaluated on a series of 46 formalin fixed paraffin embedded breast carcinomas, previously tested for protein overexpression by HercepTest (grouped into Hercep 1+, 2+ and 3+). HER2 gene amplification (ratio 2.0) by FISH was found in 9/10, 10/30 and 0/6 in IHC 3+, 2+ and 1+/0 cases, respectively. Digitalized automated spot counting performed with recently developed CW4000 CytoFISH software was 100% concordant with manual FISH scoring. Using MLPA 18/46 samples showed a clear HER2 amplification. Comparing MLPA and IHC showed the same results as for FISH and IHC. All but one FISH positive cases (18/19) were confirmed by MLPA for the presence of the gene amplification. The overall concordance of detection of Her2 gene amplification by FISH and MLPA was 98% (45/46). Furthermore, both the level of amplification and equivocal results correlated well between both methods. In conclusion, MLPA is a reliable and reproducible technique and can be used as an either alternative or additional test to determine HER2 status in breast carcinomas

Ground water and climate change

As the world’s largest distributed store of fresh water, ground water plays a central part in sustaining ecosystems and enabling human adaptation to climate variability and change. The strategic importance of ground water for global water and food security will probably intensify under climate change as more frequent and intense climate extremes (droughts and floods) increase variability in precipitation, soil moisture and surface water. Here we critically review recent research assessing the impacts of climate on ground water through natural and human-induced processes as well as through groundwater-driven feedbacks on the climate system. Furthermore, we examine the possible opportunities and challenges of using and sustaining groundwater resources in climate adaptation strategies, and highlight the lack of groundwater observations, which, at present, limits our understanding of the dynamic relationship between ground water and climate

TOWARD GLOBAL DROUGHT EARLY WARNING CAPABILITY: Expanding International Cooperation for the Development of a Framework for Monitoring and Forecasting

The need for a global drought early warning framework. Drought has had a significant impact on civilization throughout history in terms of reductions in agricultural productivity, potable water supply, and economic activity, and in extreme cases this has led to famine. Every continent has semiarid areas, which are especially vulnerable to drought. The Intergovernmental Panel on Climate Change has noted that average annual river runoff and water availability are projected to decrease by 10%–13% over some dry and semiarid regions in mid and low latitudes, increasing the frequency, intensity, and duration of drought, along with its associated impacts. The sheer magnitude of the problem demands efforts to reduce vulnerability to drought by moving away from the reactive, crisis management approach of the past toward a more proactive, risk management approach that is centered on reducing vulnerability to drought as much as possible while providing early warning of evolving drought conditions and possible impacts. Many countries, unfortunately, do not have adequate resources to provide early warning, but require outside support to provide the necessary early warning information for risk management. Furthermore, in an interconnected world, the need for information on a global scale is crucial for understanding the prospect of declines in agricultural productivity and associated impacts on food prices, food security, and potential for civil conflict

A global water resources ensemble of hydrological models: the eartH2Observe Tier-1 dataset

The dataset presented here consists of an ensemble of 10 global hydrological and land surface models for the period 1979–2012 using a reanalysis-based meteorological forcing dataset (0.5° resolution). The current dataset serves as a state of the art in current global hydrological modelling and as a benchmark for further improvements in the coming years. A signal-to-noise ratio analysis revealed low inter-model agreement over (i) snow-dominated regions and (ii) tropical rainforest and monsoon areas. The large uncertainty of precipitation in the tropics is not reflected in the ensemble runoff. Verification of the results against benchmark datasets for evapotranspiration, snow cover, snow water equivalent, soil moisture anomaly and total water storage anomaly using the tools from The International Land Model Benchmarking Project (ILAMB) showed overall useful model performance, while the ensemble mean generally outperformed the single model estimates. The results also show that there is currently no single best model for all variables and that model performance is spatially variable. In our unconstrained model runs the ensemble mean of total runoff into the ocean was 46 268 km3 yr−1 (334 kg m−2 yr−1), while the ensemble mean of total evaporation was 537 kg m−2 yr−1. All data are made available openly through a Water Cycle Integrator portal (WCI, wci.earth2observe.eu), and via a direct http and ftp download. The portal follows the protocols of the open geospatial consortium such as OPeNDAP, WCS and WMS. The DOI for the data is https://doi.org/10.1016/10.5281/zenodo.167070

Twenty-three unsolved problems in hydrology (UPH) – a community perspective

This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through on-line media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focussed on process-based understanding of hydrological variability and causality at all space and time scales. Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come

The Influence of Grain Size Distribution on the Hydraulic Gradient for Initiating Backward Erosion

Backward erosion by piping is one of the processes that threaten the stability of river embankments in the Netherlands. During high river stages, groundwater flow velocities underneath the embankment increase as a result of the steepened hydraulic gradient. If a single outflow point exists or forms, the concentrated flow can entrain soil particles, leading to the formation of a subsurface pipe. The processes controlling this phenomenon are still relatively unknown due to their limited occurrence and because piping is a subsurface phenomenon. To study the initiation of piping, we performed laboratory experiments in which we induced water flow through a porous medium with a vertically orientated outflow point. In these experiments, we explicitly considered grain size variations, thus adding to the existing database of experiments. Our experiments showed that the vertical velocity needed for the initiation of particle transport can be described well by Stokes’ law using the median grain size. We combine this with a novel method to relate bulk hydraulic conductivity to the grain size distribution. This shows that knowledge of the grain size distribution and the location of the outflow point are sufficient to estimate the hydraulic gradient needed to initiate pipe formation in the experiment box