Alien Registration- Brube, Rosanna (Fort Fairfield, Aroostook County)

https://digitalmaine.com/alien_docs/35925/thumbnail.jp

Decolonising museum cultures: an artist and a geographer in collaboration

There is much published research and strategic rhetoric on decolonising the discipline, the academy, and institutions of social and cultural importance. However, very little literature examines the stepping stones in the process of materially challenging, changing, and decolonising institutions themselves. This paper emerges as an outline of axes or episodes of dialogue in a collaborative journey between the artist Rosanna Raymond and myself, since 2005. We outline the issues encountered: some of these are intrinsically the legacies of imperial museology and the paradigms through which we evaluate and exhibit the cultures of racialised “others.” The episodes act as a means of understanding the politics and ways of decolonising that are possible. The collaboration enables the potential for interdisciplinary “ways of seeing” that counter colonial frameworks. The paper unravels the effect of imperial accounts of “other” cultures at museums, explored here through “Maori” and “Polynesian” curatorial practices and representations at the museum

Rosanna Raymond’s SaVAge K’lub at the eighth Asia Pacific Triennial of Contemporary Art

This visual essay is based on a conversation in June 2016 between artist Rosanna Raymond and academic Karen Jacobs on Raymond’s art work, The SaVAge K’lub, with which she contributed to the eighth Asia Pacific Triennial of Contemporary Art. While this artwork challenges a variety of stereotypical misrepresentations of Pacific people and their arts, it unexpectedly appeared to reinforce certain perceptions too

Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy

Missense variants in RNA-binding proteins (RBPs) underlie a spectrum of disease phenotypes, including amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy. Here, we present ten independent families with a severe, progressive muscular dystrophy, reminiscent of oculopharyngeal muscular dystrophy (OPMD) but of much earlier onset, caused by heterozygous frameshift variants in the RBP hnRNPA2/B1. All disease-causing frameshift mutations abolish the native stop codon and extend the reading frame, creating novel transcripts that escape nonsense-mediated decay and are translated to produce hnRNPA2/B1 protein with the same neomorphic C-terminal sequence. In contrast to previously reported disease-causing missense variants in HNRNPA2B1, these frameshift variants do not increase the propensity of hnRNPA2 protein to fibrillize. Rather, the frameshift variants have reduced affinity for the nuclear import receptor karyopherin β2, resulting in cytoplasmic accumulation of hnRNPA2 protein in cells and in animal models that recapitulate the human pathology. Thus, we expand the phenotypes associated with HNRNPA2B1 to include an early-onset form of OPMD caused by frameshift variants that alter its nucleocytoplasmic transport dynamics

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Twisted

FABRA-KEI-SKIN, 2004. Photography: Kerry Brown; Digital manipulation: Matt Barron; Conception, drawings, body adornment: Rosanna Raymond. Tapa cloths courtesy of Liverpool Museum collections.Rosanna Raymond is a performance/ installation/body adornment artist and writer. A New Zealand-born Pacific Islander of Samoan descent, she is currently living and working in London with her family. A founding member of the acclaimed Pacific Sisters performance art collective in New Zealand. A ‘Tusitala’ or storyteller at heart, Raymond’s work takes a variety of forms ranging from installation works to spoken word to body adornment, with pieces held in gallery, museum and private collections around the world. She has forged a role over the past fifteen years as a producer and commentator on contemporary urban Pacific Island culture, fusing traditional practises with modern innovations and techniques. Raymond specialises in customising the images with her own drawings that tell stories of the work

One eye on the tusk

Tiare Tito: Te Aupouri/NgaPuhi/Ngati Wharetoa/ Rarotonga. Neck piece of coconut disk Tupe seed. TUSKS AND FEVERS, 2006. Photography: Kerry Brown; conception, drawings, body adornment: Rosanna Raymond.Rosanna Raymond is a performance/ installation/body adornment artist and writer. A New Zealand-born Pacific Islander of Samoan descent, she is currently living and working in London with her family. A founding member of the acclaimed Pacific Sisters performance art collective in New Zealand. A ‘Tusitala’ or storyteller at heart, Raymond’s work takes a variety of forms ranging from installation works to spoken word to body adornment, with pieces held in gallery, museum and private collections around the world. She has forged a role over the past fifteen years as a producer and commentator on contemporary urban Pacific Island culture, fusing traditional practises with modern innovations and techniques. Raymond specialises in customising the images with her own drawings that tell stories of the work