Clothing The Pre-School Child

It is the early childhood that one should be so cautious to direct, guard and protect. The activities are centered almost exclusively in the home. Really it is the period of greatest physical development. Since these ideas must be kept in mind in order to secure health, this discussion is centered on the clothing of the child, and in order to be able to select the proper type of clothing one should be acquainted with the general requirements for children\u27s clothing

Twentieth Century Etiquette (Part 3)

The full title for this book is Twentieth Century Etiquette: An Up-To-Date Book for Polite Society Containing Rules for Conduct in Public, Social and Private Life, at Home and Abroad including suggestions for oriental teas, church festivals, charity socials, costume parties, bazaars, Germans, indoor games, outdoor sports, tally-ho parties, masquerades, etc., etc. also correct dress for weddings, receptions, and all other occasions designed for both men and women, young and old. This last section of the book contains chapters titled Servants, Maids and Assistants, Births and Christenings, Funerals and Mourning, Special Suggestions, Graceful Development of the Body, Unselfishness-The Key to Graciousness, The Possibilities of Women, Women in Business, Real and Fancied Wrongs, Higher Culture, The Shaping of Character, Women Beautiful, and The Language of the Hand.https://openworks.wooster.edu/motherhomeheaven/1101/thumbnail.jp

Social Culture: A Manual of Etiquette and Deportment (Part One)

The full title of this book as listed on the title page is Social Culture: An Up-to-Date Book for Polite Society Containing Rules for Conduct in Public, Social and Private Life, at Home and Abroad Including Suggestions for Oriental Teas, Church Festivals, Charity Socials, Costume Parties, Bazaars, Germans, Indoor Games, Outdoor Sports, Tally-Ho Parties, Masquerades, Etc., Etc. Also Correct Dress for Weddings, Receptions, and All Other Occasions Designed for Both Men and Women, Young and Old. It is also, Embellished with nearly half a hundred full page engravings and numerous drawings by George Speil.https://openworks.wooster.edu/motherhomeheaven/1093/thumbnail.jp

Twentieth Century Etiquette (Part 2)

The full title for this book is Twentieth Century Etiquette: An Up-To-Date Book for Polite Society Containing Rules for Conduct in Public, Social and Private Life, at Home and Abroad including suggestions for oriental teas, church festivals, charity socials, costume parties, bazaars, Germans, indoor games, outdoor sports, tally-ho parties, masquerades, etc., etc. also correct dress for weddings, receptions, and all other occasions designed for both men and women, young and old. This second section of the book includes chapters about Telephoning-Business and Social, Social Etiquette at Washington, Calling-When and How, Dinners and Luncheons, Etiquette at the Table, Receptions, Lectures, Church, Etc., Costume Parties and What to Wear, Dress-Its Attractiveness and Appropriateness, Correspondence-Business and Social, Horseback Riding and Driving, Cycling, Golf, Dancing and Games, Courtship and Its Demands, Weddings and How to Conduct Them, Anniversaries and How to Celebrate Them, and Traveling-Home and Abroad.https://openworks.wooster.edu/motherhomeheaven/1100/thumbnail.jp

Twentieth Century Etiquette (Part 1)

The full title for this book is Twentieth Century Etiquette: An Up-To-Date Book for Polite Society Containing Rules for Conduct in Public, Social and Private Life, at Home and Abroad including suggestions for oriental teas, church festivals, charity socials, costume parties, bazaars, Germans, indoor games, outdoor sports, tally-ho parties, masquerades, etc., etc. also correct dress for weddings, receptions, and all other occasions designed for both men and women, young and old. This first section of the book contains chapters entitled The Makers of Manners, The Test of the Lady and Gentleman, Importance of Social Observances, Home-The Life Immortal, Little Folks-Their Entertainment and Dress, Self-Consciousness-How to Overcome It, Introductions-Their Importance, Greeting and Leavetaking, Conversation, Etiquette of School Days, Going Into Society, Misses and Unmarried Women, What Etiquette Demands of a Gentleman, Obligations of Bachelors, and Etiquette in the Street.https://openworks.wooster.edu/motherhomeheaven/1099/thumbnail.jp

Social Culture: A Manual of Etiquette and Deportment (Part Two)

The full title of this book as listed on the title page is, Social Culture: An Up-to-Date Book for Polite Society Containing Rules for Conduct in Public, Social and Private Life, at Home and Abroad Including Suggestions for Oriental Teas, Church Festivals, Charity Socials, Costume Parties, Bazaars, Germans, Indoor Games, Outdoor Sports, Tally-Ho Parties, Masquerades, Etc., Etc. Also Correct Dress for Weddings, Receptions, and All Other Occasions Designed for Both Men and Women, Young and Old. It is also, Embellished with nearly half a hundred full page engravings and numerous drawings by George Speil.https://openworks.wooster.edu/motherhomeheaven/1094/thumbnail.jp

A New Clevosaurid from the Triassic (Carnian) of Brazil and the Rise of Sphenodontians in Gondwana

The early evolution of lepidosaurs is marked by an extremely scarce fossil record during the Triassic. Importantly, most Triassic lepidosaur specimens are represented by disarticulated individuals from high energy accretion deposits in Laurasia, thus greatly hampering our understanding of the initial stages of lepidosaur evolution. Here, we describe the fragmentary remains of an associated skull and mandible of Clevosaurus hadroprodon sp. nov., a new taxon of sphenodontian lepidosaur from the Late Triassic (Carnian; 237–228 Mya) of Brazil. Referral to Sphenodontia is supported by the combined presence of a marginal dentition ankylosed to the apex of the dentary, maxilla, and premaxilla; the presence of ‘secondary bone’ at the bases of the marginal dentition; and a ventrally directed mental process at the symphysis of the dentary. Our phylogenetic analyses recover Clevosaurus hadroprodon as a clevosaurid, either in a polytomy with the Late Triassic to Early Jurassic Clevosaurus and Brachyrhinodon (under Bayesian inference), or nested among different species of Clevosaurus (under maximum parsimony). Clevosaurus hadroprodon represents the oldest known sphenodontian from Gondwana, and its clevosaurid relationships indicates that these sphenodontians achieved a widespread biogeographic distribution much earlier than previously thought.Fil: Hsiou, Annie S.. Universidade de Sao Paulo; BrasilFil: Nydam, Randall L.. Midwestern University; Estados UnidosFil: Simões, Tiago R.. University of Alberta; Canadá. Harvard University; Estados UnidosFil: Pretto, Flávio A.. Universidade Federal de Santa Maria; BrasilFil: Onary, Silvio. Universidade de Sao Paulo; BrasilFil: Martinelli, Agustín Guillermo. Universidade Federal do Rio Grande do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Liparini, Alexandre. Universidade Federal de Sergipe; BrasilFil: Romo de Vivar Martínez, Paulo Rodrigo. Universidade Federal do Rio Grande do Sul; BrasilFil: Soares, Marina. Universidade Federal do Rio Grande do Sul; BrasilFil: Schultz, Cesar. Universidade Federal do Rio Grande do Sul; BrasilFil: Caldwell, Michael Wayne. University of Alberta; Canad

Prevalence and architecture of de novo mutations in developmental disorders.

The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important genes. Here we have sequenced the exomes of 4,293 families containing individuals with developmental disorders, and meta-analysed these data with data from another 3,287 individuals with similar disorders. We show that the most important factors influencing the diagnostic yield of DNMs are the sex of the affected individual, the relatedness of their parents, whether close relatives are affected and the parental ages. We identified 94 genes enriched in damaging DNMs, including 14 that previously lacked compelling evidence of involvement in developmental disorders. We have also characterized the phenotypic diversity among these disorders. We estimate that 42% of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function. We estimate that developmental disorders caused by DNMs have an average prevalence of 1 in 213 to 1 in 448 births, depending on parental age. Given current global demographics, this equates to almost 400,000 children born per year

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead