Diseño de circuitos turísticos como estrategia de innovación territorial en Amanalco, Estado de México

Tesis que para obtener el grado de Maestra en Agroindutria Rural, Desarrollo Territorial y Turismo AgroalimentarioSe elaboró un diagnóstico de Amanalco, Estado de México para determinar la factibilidad de realizar un producto turístico en la zona. Es así, que los resultados mostraron que el municipio cuenta con un patrimonio natural y cultural que podría ser aprovechado para lograr un desarrollo territorial. Sin embargo, a pesar de los esfuerzos que han hecho algunas instancias públicas no se ha logrado posicionar a Amanalco como un destino turístico. Esto se debe a la falta de un producto turístico integral en el que se articulen los diferentes recursos, atractivos, actores e instituciones todo con el fin de complementarse unos con otros y de esta manera lograr el beneficio de las comunidades receptoras incluidas.CONACY

PENGEMBANGAN KAPASITAS SUMBER DAYA APARATUR DI PROVINSI GORONTALO

ABSTRACT This research aims at analyzing and describing the existence of development of human resources capacity for local government officials in the province of Gorontalo. This research was descriptive qualitative approach. The data were collected through observation, in-depth interviews, and documentation. Data analysis follows the interactive model namely data reduction, namely the presentation of data and draw conclusions. The results showed the development of human resources capacity of civil servants (Pegawai Negeri Sipil/ PNS) in the province of Gorontalo have not had a design as a guide for each Local Government Unit (LGU) in the development of human resources capacity. Development program of human resources capacity tends to be through education and pre-service training, leadership training at the level of Echelon III and IV with a very limited number. The programs are implemented without any synergy among the leadership of LGU, coordination, monitoring, and evaluation on an ongoing basis within each implemented program. The output resulting from the training has not been able to change the ability of PNS in terms of increased knowledge and intellectual property, interests, attitudes, and values, as well as skills that are intellectually nor are motion, controlled and conducted appropriately. Coordination, monitoring, and evaluation of development of government official Board (Badan Kepegawaian dan Pengembangan Aparatur/BKPAD) and SKPD in the implementation of programs for the development of human resources capacity in the government of the province of Gorontalo have not been functioning. The factors of leadership, transparency, shared commitment, the availability of facilities and infrastructure in the implementation of basic tasks and function, as the supporting factors in the development of PNS capacity, have not been optimal. Keywords: Development, Capacity, Human Resource

Análisis de situación financiera de la entidad Banpro a través de técnicas e Indicadores financieros en el período 2019-2020

Las instituciones financieras y específicamente las bancarias requieren de un análisis financiero de forma individual por institución al igual que un análisis del sistema completo, tanto para hacer comparaciones entre las demás instituciones a lo largo de un periodo de tiempo específico como para hacer comparaciones de la misma institución en periodos distintos, con el propósito de conocer la situación financiera y medir el desempeño de la misma. Por esta razón surge la presente investigación que trata de brindar las herramientas necesarias para aplicar un análisis de la situación financiera de BANPRO en el periodo 2019-2020. Para realizar la presente investigación de tipo documental y bibliográfica fue necesario indagar en diversas fuentes de información, partiendo desde textos académicos de finanzas, mercados financieros y gestión bancaria, también se incluyó información proveniente de leyes y normas que forman parte del marco legal de las instituciones financieras en nicaragua, así como de los lineamientos obligatorios que debe cumplir la institución ante el ente supervisor (SIBOIF). Los principales resultados de la investigación se pueden ver manifestados en los diferentes apartados que se desarrollaron, pero específicamente están presentes en la aplicación de toda la teoría presentada, detallado en la aplicación de los indicadores financieros a la institución objeto de estudio (BANPRO) en el periodo de tiempo 2019-2020. A través del análisis financiero practicado al banco se determinó que BANPRO es la institución bancaria con un muy posición financiera en el mercado bancario, situándose en primer lugar en rubos como cuota de mercado en captación de depósitos y participación de mercado en la colocación de créditos, puesto que posee la cartera de créditos más grande de todo el sistema y sobre pasa en otros aspectos a sus competidores, sin embargo al comparar el mismo banco en el año 2020 versus el año 2019, pueden observarse ciertas deficiencias en sus operaciones de crédito en cuanto a la clasificación del crédito y su condición, además de niveles de mora más altos y mayores necesidades de cobertura sobre créditos, a como se presentara a continuació

Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity.

Precise cis-regulatory control of gene expression is essential for normal embryogenesis and tissue development. The BMP antagonist Gremlin1 (Grem1) is a key node in the signalling system that coordinately controls limb bud development. Here, we use mouse reverse genetics to identify the enhancers in the Grem1 genomic landscape and the underlying cis-regulatory logics that orchestrate the spatio-temporal Grem1 expression dynamics during limb bud development. We establish that transcript levels are controlled in an additive manner while spatial regulation requires synergistic interactions among multiple enhancers. Disrupting these interactions shows that altered spatial regulation rather than reduced Grem1 transcript levels prefigures digit fusions and loss. Two of the enhancers are evolutionary ancient and highly conserved from basal fishes to mammals. Analysing these enhancers from different species reveal the substantial spatial plasticity in Grem1 regulation in tetrapods and basal fishes, which provides insights into the fin-to-limb transition and evolutionary diversification of pentadactyl limbs

In situ degradability of dry matter and crude protein of pisonay (Erythrina falcata) leaves and petiole

El estudio tuvo como objetivo determinar la composición química y la degradabilidad ruminal de la materia seca (MS) y proteína cruda (PC) del pisonay (Erythrina falcata) a los 105, 120 y 135 días de rebrote. Se tomaron muestras de hojas y peciolo, se secaron y se colocaron 8 g de muestra molida por bolsa de nylon en el rumen de tres chivatos machos adultos por 0, 24, 48 y 72 horas. Los valores de MS y PC fueron 24.4 y 21.4% a los 105, 24.8 y 23.2% a los 120 y, 27.2 y 24.4% a los 135 días, respectivamente. La degradabilidad ruminal de la fracción insoluble potencialmente degradable de MS y PC fue 29.6 y 42.9% a los 105, 24.3 y 31.4% a los 120 y, 14.9 y 24.1% a los 135 días, respectivamente, y la degradabilidad efectiva de MS y PC fue 41.3 y 41.2% a los 105, 36.5 y 30.3% a los 120 y, 32.3 y 30.5% a los 135 días, respectivamente. El estudio demuestra que el follaje E. falcata a los 105 días de crecimiento posee una mayor ventaja proteica para los caprinos.The study aimed to determine the chemical composition and ruminal degradability of dry matter (DM) and crude protein (CP) of Erythrina falcata at 105, 120 and 135 days of regrowth. Leaves and petiole samples were dried and 8 g of dry grounded samples were placed in nylon bags in the rumen of three male goats during 0, 24, 48 and 72 hours. The DM and CP values were 24.4 and 21.4% at 105, 24.8 and 23.2% at 120 and, 27.2 and 24.4% at 105 days respectively. The ruminal degradability of potentially degradable insoluble fraction of DM and CP was 29.6 and 42.9% at 105, 24.3 and 31.4% at 120 and, 14.9 and 24.1% at 135 days, respectively, and the effective degradability of DM and CP was 41.3 and 41.2% at 105, 36.5 and 30.3% at 120 and, 32.3 and 30.5% at 135 days respectively. The study showed a higher protein advantage in goats at 105 days of growth of E. falcata foliage

2011-2012 UNLV McNair Journal

Journal articles based on research conducted by undergraduate students in the McNair Scholars Program Table of Contents Biography of Dr. Ronald E. McNair Statements: Dr. Neal J. Smatresk, UNLV President Dr. Juanita P. Fain, Vice President of Student Affairs Dr. William W. Sullivan, Associate Vice President for Retention and Outreach Mr. Keith Rogers, Deputy Executive Director of the Center for Academic Enrichment and Outreach McNair Scholars Institute Staf

Physical effects upon whey protein aggregation for nano-coating production

Production of edible nanostructures constitutes a major challenge in food nanotechnology, and has attracted a great deal of interest from several research fields — including (but not limited to) food packaging. Furthermore, whey proteins are increasingly used as nutritional and functional ingredients owing to their important biological, physical and chemical functionalities. Besides their technological and functional characteristics, whey proteins are generally recognized as safe (GRAS). Denaturation and aggregation kinetics behavior of such proteins are of particular relevance toward manufacture of novel nanostructures possessing a number of potential uses. When these processes are properly engineered and controlled, whey proteins may form nanostructures useful as carriers of bioactive compounds (e.g. antimicrobials, antioxidants and nutraceuticals). This review discusses the latest advances in nano-scale phenomena involved in protein thermal aggregation aiming at formation of bio-based nano-coating networks. The extent of aggregation is dependent upon a balance between molecular interactions and environmental factors; therefore, the impact of these conditions is addressed in a critical manner. A particular emphasis is given to the effect of temperature as long as being one of the most critical variables. The application of moderate electric fields (MEF), an emergent approach, as such or combined with conventional heating is considered as it may inhibit/prevent excessive denaturation and aggregation of whey proteins — thus opening new perspectives for development of innovative protein nanostructures (i.e. nano-coatings). A better understanding of the mechanism(s) involved in whey protein denaturation and aggregation is crucial as it conveys information relevant to select methods for manipulating interactions between molecules, and thus control their functional properties in tailor-made applications in the food industry.Oscar L. Ramos and Ricardo N. Pereira gratefully acknowledge Post-Doctoral grants (SFRH/BPD/80766/2011 and SFRH/BPD/81887/2011, respectively) by Fundacao para a Ciencia e Tecnologia (FCT, Portugal). All authors thank the FCT Strategic Project PEst-OE/EQB/LA0023/2013 and Project "BioEnv - Biotechnology and Bioengineering for a sustainable world", REF. NORTE-07-0124-FEDER-000048, co-funded by Programa Operacional Regional do Norte (ON.2 - O Novo Norte), QREN, FEDER

Subcellular Min Oscillations as a Single-Cell Reporter of the Action of Polycations, Protamine, and Gentamicin on Escherichia coli

BACKGROUND: In Escherichia coli, MinD-GFP fusion proteins show rapid pole to pole oscillations. The objective was to investigate the effects of extracellular cations on the subcellular oscillation of cytoplasmic MinD within Escherichia coli. METHODOLOGY/PRINCIPAL FINDINGS: We exposed bacteria to the extracellular cations Ca(++), Mg(++), the cationic antimicrobial peptide (CAP) protamine, and the cationic aminoglycoside gentamicin. We found rapid and substantial increases in the average MinD oscillation periods in the presence of any of these polyvalent cations. For Ca(++) and Mg(++) the increases in period were transient, even with a constant extracellular concentration, while increases in period for protamine or gentamicin were apparently irreversible. We also found striking interdependence in the action of the small cations with protamine or gentamicin, distorted oscillations under the action of intermediate levels of gentamicin and Ca(++), and reversible freezing of the Min oscillation at high cationic concentrations. CONCLUSIONS/SIGNIFICANCE: Intracellular Min oscillations provide a fast single-cell reporter of bacterial response to extracellular polycations, which can be explained by the penetration of polycations into cells

Simultaneous consumption of pentose and hexose sugars: an optimal microbial phenotype for efficient fermentation of lignocellulosic biomass

Lignocellulosic biomass is an attractive carbon source for bio-based fuel and chemical production; however, its compositional heterogeneity hinders its commercial use. Since most microbes possess carbon catabolite repression (CCR), mixed sugars derived from the lignocellulose are consumed sequentially, reducing the efficacy of the overall process. To overcome this barrier, microbes that exhibit the simultaneous consumption of mixed sugars have been isolated and/or developed and evaluated for the lignocellulosic biomass utilization. Specific strains of Escherichia coli, Saccharomyces cerevisiae, and Zymomonas mobilis have been engineered for simultaneous glucose and xylose utilization via mutagenesis or introduction of a xylose metabolic pathway. Other microbes, such as Lactobacillus brevis, Lactobacillus buchneri, and Candida shehatae possess a relaxed CCR mechanism, showing simultaneous consumption of glucose and xylose. By exploiting CCR-negative phenotypes, various integrated processes have been developed that incorporate both enzyme hydrolysis of lignocellulosic material and mixed sugar fermentation, thereby enabling greater productivity and fermentation efficacy

Ibero-American Consensus on Low- and No-Calorie Sweeteners: Safety, Nutritional Aspects and Benefits in Food and Beverages

International scientific experts in food, nutrition, dietetics, endocrinology, physical activity, paediatrics, nursing, toxicology and public health met in Lisbon on 2-4 July 2017 to develop a Consensus on the use of low- and no-calorie sweeteners (LNCS) as substitutes for sugars and other caloric sweeteners. LNCS are food additives that are broadly used as sugar substitutes to sweeten foods and beverages with the addition of fewer or no calories. They are also used in medicines, health-care products, such as toothpaste, and food supplements. The goal of this Consensus was to provide a useful, evidence-based, point of reference to assist in efforts to reduce free sugars consumption in line with current international public health recommendations. Participating experts in the Lisbon Consensus analysed and evaluated the evidence in relation to the role of LNCS in food safety, their regulation and the nutritional and dietary aspects of their use in foods and beverages. The conclusions of this Consensus were: (1) LNCS are some of the most extensively evaluated dietary constituents, and their safety has been reviewed and confirmed by regulatory bodies globally including the World Health Organisation, the US Food and Drug Administration and the European Food Safety Authority; (2) Consumer education, which is based on the most robust scientific evidence and regulatory processes, on the use of products containing LNCS should be strengthened in a comprehensive and objective way; (3) The use of LNCS in weight reduction programmes that involve replacing caloric sweeteners with LNCS in the context of structured diet plans may favour sustainable weight reduction. Furthermore, their use in diabetes management programmes may contribute to a better glycaemic control in patients, albeit with modest results. LNCS also provide dental health benefits when used in place of free sugars; (4) It is proposed that foods and beverages with LNCS could be included in dietary guidelines as alternative options to products sweetened with free sugars; (5) Continued education of health professionals is required, since they are a key source of information on issues related to food and health for both the general population and patients. With this in mind, the publication of position statements and consensus documents in the academic literature are extremely desirable