46 research outputs found
Genetic variability studies for yield and its contributing traits in okra [Abelmoschus esculentus (L.) Moench]
The experiment comprising 30 okra (Abelmoschus esculentus) genotypes were grown and analysed for yield and its attributing traits at the Department of Vegetable science, Kumarganj, Faizabad during Zaid (2011) period. All the characters studied showed a wide range of variation. The variability for yield among the accessionsevaluated was also remarkable. The magnitude phenotypic coefficient of variation was higher than genotypic coefficient of variation for all traits. Both phenotypic coefficient of variation (PCV) and genotypic coefficient of variation (GCV) were high for plant height (11.10 and 10.60, respectively). Fruit weight exhibited low value of GCV (2.31) and PCV (4.74) and likely to show less response under selection. High heritability (91.3) with high genetic advance (26.74) was recorded for plant height, whereas, ridges per fruit had high heritability (97.0) with moderate genetic advance (18.45). This study aimed to evaluate okra genotypes for variability with a view to providing information on the development of high yielding genotypes to meet the growing food demand of the populace
Viscosity in cosmic fluids
The effective theory of large-scale structure formation based on CDM
paradigm predicts finite dissipative effects in the resulting fluid equations.
In this work, we study how viscous effect that could arise if one includes
self-interaction among the dark-matter particles combines with the effective
theory. It is shown that these two possible sources of dissipation can operate
together in a cosmic fluid and the interplay between them can play an important
role in determining dynamics of the cosmic fluid. In particular, we demonstrate
that the viscosity coefficient due to self-interaction is added inversely with
the viscosity calculated using effective theory of CDM model. Thus the
larger viscosity has less significant contribution in the effective viscosity.
Using the known bounds on for self-interacting dark-matter, where
and are the cross-section and mass of the dark-matter
particles respectively, we discuss role of the effective viscosity in various
cosmological scenarios.Comment: 7 pages, Updated to match with the published versio
Simultaneous estimation of etodolac and thiocolchicoside in bulk and in tablet formulation by UV-spectrophotometry
Two simple, rapid and reproducible simultaneous equation and Q-Analysis
UV-Spectrophotometric methods have been developed for simultaneous
estimation of Etodolac (ETO) and Thiocolchicoside (THC) in combined tablet
dosage form. The methods involved solving simultaneous equations and Q-value
Analysis based on measurement of absorbance at wavelengths, 223 (λmax of
ETO), 259.4 nm (λmax of THC) and 236 nm (Iso-absorptive point). Linearity
was found in the concentration range of 1-6 μg/mL and 4 - 24 μg/mL for ETO &
THC respectively with coefficient correlation 0.9998 & 0.9992. The amount of
drugs estimated by proposed methods are in excellent agreement with label
claimed. Further-more, the methods were applied for the determination of ETO
and THC in spiked human urine. The degradation behavior of ETO and THC was
investigated under acid hydrolysis, alkali hydrolysis, photo and oxidative
degradation. The samples subsequently generated were used for degradation
studies using the developed method. Thiocolchicoside was found to degrade
extensively under alkali hydrolysis and unaffected by other stress
conditions while ETO was found to be stable in all stress conditions. The
methods were validated according to ICH guidelines. The method, suitable for
routine quality control, has been successfully applied to the determination
of both drugs in commercial brands of tablets
Analysis of heterotic potential for yield and its attributing traits in okra (Abelmoschus esculentus L. Moench)
The present investigation was conducted on okra (Abelmoschus esculentus) to determine the extent of heterosis for 12 traits, including fruit yield and its attributing traits. A total of 28 F1s produced by crossing seven lines with four testers of okra in Line x Tester fashion were evaluated along with standard check during late Kharif 2022 season. The cross C20-HRB-55 x Varsha Uphar recorded best heterobeltiosis and the cross C10-VRO-4 x Azad Ganga recorded best standard heterosis for yield plant-1. The cross C10- VRO-4 x Azad Ganga showed negative heterosis over better parent and standard check for the traits days to 50% flowering and days to first picking. The F1 hybrid C10- VRO-4 x Azad Ganga, which has a high potential for yield can be evaluated further for early Kharif season in Punjab
Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions
Host innate immune response follows severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and it is the driver of the acute respiratory distress syndrome (ARDS) amongst other inflammatory end-organ morbidities. Such life-threatening coronavirus disease 2019 (COVID-19) is heralded by virus-induced activation of mononuclear phagocytes (MPs; monocytes, macrophages, and dendritic cells). MPs play substantial roles in aberrant immune secretory activities affecting profound systemic inflammation and end-organ malfunctions. All follow the presence of persistent viral components and virions without evidence of viral replication. To elucidate SARS-CoV- 2-MP interactions we investigated transcriptomic and proteomic profiles of human monocyte-derived macrophages. While expression of the SARS-CoV-2 receptor, the angiotensin-converting enzyme 2, paralleled monocyte-macrophage differentiation, it failed to affect productive viral infection. In contrast, simple macrophage viral exposure led to robust pro-inflammatory cytokine and chemokine expression but attenuated type I interferon (IFN) activity. Both paralleled dysregulation of innate immune signaling pathways, specifically those linked to IFN. We conclude that the SARS-CoV-2-infected host mounts a robust innate immune response characterized by a pro-inflammatory storm heralding end-organ tissue damage
Idiopathic intracranial hypertension: the association between weight loss and the requirement for systemic treatment
<p>Abstract</p> <p>Background</p> <p>To determine whether weight loss is significantly associated with a discontinuation of treatment for idiopathic intracranial hypertension</p> <p>Methods</p> <p>The notes of 36 patients with idiopathic intracranial hypertension under regular review for at least 12 months by a single neuro-ophthalmologist were retrospectively reviewed. Weight was recorded at each assessment and weight loss recommended. Treatment was adjusted according to symptoms, visual function including visual fields and optic disc appearance only. Patients were divided according to duration of continuous follow-up, and then sub-divided as to whether they were on or not on treatment at most recent review and whether weight loss had been achieved compared to presentation. Survival analysis was performed to assess the probability of remaining on treatment having lost weight.</p> <p>Results</p> <p>Considering the patients as 3 groups, those with at least 12 months follow-up (n = 36), those with at least 18 months follow-up (n = 24) and those with 24 months or more follow-up (n = 19), only the group with 24 months or more follow-up demonstrated a significant association between weight loss and stopping systemic treatment (Fisher's exact test, p = 0.04). Survival analysis demonstrated that the probability of being on treatment at 5 years having gained weight was 0.63 and having lost weight was 0.38 (log rank test, p = 0.04). The results suggest that final absolute body mass index is more important than the change in body mass index for patients who stop treatment (Mann Whitney U, p = 0.05).</p> <p>Conclusion</p> <p>This is the first study to demonstrate that weight loss is associated with discontinuation of treatment. Unlike previous studies, our results suggest that final absolute body mass index is more important for stopping treatment than a proportional reduction in weight.</p
Unzipping flood vulnerability and functionality loss:tale of struggle for existence of riparian buildings
Floods pose significant risk to riparian buildings as evidenced during many historical events. Although structural resilience to tsunami flooding is well studied in the literature, high-velocity and debris-laden floods in steep terrains are not considered adequately so far. Historical floods in steep terrains necessitate the need for flood vulnerability analysis of buildings. To this end, we report vulnerability of riparian-reinforced concrete buildings using forensic damage interpretations and empirical/analytical vulnerability analyses. Furthermore, we propose the concept and implications of functionality loss due to flooding in residential reinforced concrete (RC) buildings using empirical data. Fragility functions using inundation depth and momentum flux are presented for RC buildings considering a recent flooding event in Nepal. The results show that flow velocity and sediment load, rather than hydrostatic load, govern the damages in riparian RC buildings. However, at larger inundation depth, hydrostatic force alone may collapse some of the RC buildings
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries