Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding

Au+Au Reactions at the AGS: Experiments E866 and E917

Particle production and correlation functions from Au+Au reactions have been measured as a function of both beam energy (2-10.7AGeV) and impact parameter. These results are used to probe the dynamics of heavy-ion reactions, confront hadronic models over a wide range of conditions and to search for the onset of new phenomena.Comment: 12 pages, 14 figures, Talk presented at Quark Matter '9

Formation of dense partonic matter in relativistic nucleus-nucleus collisions at RHIC: Experimental evaluation by the PHENIX collaboration

Extensive experimental data from high-energy nucleus-nucleus collisions were recorded using the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). The comprehensive set of measurements from the first three years of RHIC operation includes charged particle multiplicities, transverse energy, yield ratios and spectra of identified hadrons in a wide range of transverse momenta (p_T), elliptic flow, two-particle correlations, non-statistical fluctuations, and suppression of particle production at high p_T. The results are examined with an emphasis on implications for the formation of a new state of dense matter. We find that the state of matter created at RHIC cannot be described in terms of ordinary color neutral hadrons.Comment: 510 authors, 127 pages text, 56 figures, 1 tables, LaTeX. Submitted to Nuclear Physics A as a regular article; v3 has minor changes in response to referee comments. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Evaluating a light-louver system for behavioural guidance of age-0 white sturgeon

Water diversions for hydropower and other applications are some of the most disruptive alterations affecting fish populations in lotic systems. Although many different strategies have been developed to reduce lethal encounters with such infrastructure, few studies have evaluated different forms of behavioural guidance concurrently. Here, we combine an LED-based light guidance device (LGD) equipped with adjustable wavelength and strobing output with a reverse-configured louver rack to assess the effectiveness of this two-part behavioural guidance system on downstream movement through a bypass by age-0 white sturgeon (Acipenser transmontanus). Several combinations of LGD and louver settings were tested under both simulated day and night (low light) conditions in a laboratory setting. In the absence of the LGD, louver slat spacings of 10 or 20 cm were most effective at achieving downstream bypasses with greater success rates (~ two-fold greater) under night conditions tha

Preferences of age-0 white sturgeon for different colours and strobe rates of LED lights may inform behavioural guidance strategies

Many populations of migratory fish species, including white sturgeon (Acipenser transmontanus Richardson), are threatened due to modification of riverine systems and may experience downstream displacement or mortality at water intake structures. Efforts to reduce the impacts of these structures are beginning to incorporate behavioural guidance, where the sensory capabilities of fishes are exploited to repel them from high-risk areas or attract them towards desirable pat

Long term biosustainability in a high energy, low diversity crustal biome

Geochemical, microbiological, and molecular analyses of alkaline saline groundwater at 2.8 kilometers depth in Archaean metabasalt revealed a microbial biome dominated by a single phylotype affiliated with thermophilic sulfate reducers belonging to Firmicutes. These sulfate reducers were sustained by geologically produced sulfate and hydrogen at concentrations sufficient to maintain activities for millions of years with no apparent reliance on photosynthetically derived substrates