Materiales audiovisuales para el estudio de cuestiones de Derecho de Familia y Sucesiones a partir de la jurisprudencia de Estrasburgo

[EN] This paper presents the teaching innovation project in which we have opted for the promotion of active learning methodologies. The reverse pedagogy has been used and the students have been the ones who have assumed the elaboration of audiovisual material that will support them and their future colleagues (we want these tools to be available and can be used during several academic courses) to address the study of current issues of Family Law and Inheritance and Donations. In particular, the jurisprudence of Strasbourg has been studied since it is the main current instrument for the legal protection of human rights at the international level.[ES] En el proyecto de innovación docente que presentamos se ha optado por el impulso de las metodologías activas de aprendizaje. Se ha usado la pedagogía inversa y los alumnos han sido quienes han asumido la elaboración de material audiovisual que les servirá de apoyo a ellos y a sus compañeros futuros (pues tenemos intención de que estas herramientas tengan perdurabilidad y las podamos usar a lo largo de varios cursos académicos) para abordar el estudio de cuestiones actuales del Derecho de Familia y de Sucesiones y Donaciones. Especialmente, se ha estudiado la jurisprudencia de Estrasburgo al ser el principal instrumento actual para la tutela jurídica de los derechos humanos en el plano internacional.Comunicación realizada en el marco del Proyecto de Innovación Docente “Materiales audiovisuales para el estudio de cuestiones de Derecho de Familia y Sucesiones a partir de la jurisprudencia de Estrasburgo” (PID 171817) perteneciente a los proyectos de innovación y mejora de la calidad docente de la Universidad de las Islas Baleares (2017-2018), siendo la investigadora principal la Dra. Catalina Pons-Estel Tugores y formando parte del Proyecto el Dr. Marcos González Sánchez, el Dr. Pedro A. Munar Bernat, el Dr. Salvador Pérez Álvarez, la Dra. Beatriz Verdera y la Dra. Francisca Mª Rosselló Rubert.Pons Estel, C.; González Sánchez, M. (2018). Materiales audiovisuales para el estudio de cuestiones de Derecho de Familia y Sucesiones a partir de la jurisprudencia de Estrasburgo. En IN-RED 2018. IV Congreso Nacional de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 220-229. https://doi.org/10.4995/INRED2018.2018.8726OCS22022

El Derecho en la prensa escrita. Una propuesta metodológica para el aprendizaje

[EN] In this project, the Law students are assigned the task of creating files from newspaper articles related to the subjects of study of the Degree in Law. To this end, they have selected the journalistic information and analyzed and systematized it, completing it with the most recent national and international jurisprudence. Thus, we have managed to ensure that they have a thorough knowledge of the studied topics. Furthermore, this project provides us with a very useful written material to support our classes.[ES] En este proyecto los alumnos han realizado unas fichas a partir de las noticias que trataban sobre las materias objeto de estudio del Grado en Derecho publicadas en la prensa escrita. Para ello han enmarcado jurídicamente la información periodística y la han analizado y sistematizado, completándola con la jurisprudencia nacional e internacional más reciente. De este modo, hemos conseguido que el alumnado domine a fondo los temas trabajados y, además, tenemos un material escrito muy útil que nos sirve de apoyo en las clases.Pons Estel, C.; González Sánchez, M. (2019). El Derecho en la prensa escrita. Una propuesta metodológica para el aprendizaje. En IN-RED 2019. V Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 789-799. https://doi.org/10.4995/INRED2019.2019.10446OCS78979

18 Cutaneous lupus

Case 1: 35-year-old Mestizo female Bernardo Pons-Estel A 35-year-old Mestizo female was diagnosed with systemic lupus erythematosus (SLE) in 2005 based on polyarthritis, malar rash, photosensitivity, mucosal ulcerations, positive ANA and anti-dsDNA, and low complement. She was treated with prednisone 20–30 mg/day and hydroxychloroquine (HCQ) 400 mg/day. In June 2010, lupus pneumonitis was diagnosed. In July 2018, she was first admitted to our hospital. She was cushingoid and had fever, fatigue, malar rash, oral ulcers, alopecia, polyarthritis, oedema, multiple purplish-red streaks, and active erythematous, palpable and painful subcutaneous indurated nodules/plaques located on her face, proximal lower extremities and abdomen; some were ulcerated. Laboratory tests RBC 3.8 (x1012/L), hemoglobin 11.8 g/dl, WBC 2,3 (x109/L), platelets 62 (x109/L), ESR 8 mm, CRP 0.8 mg/L, serum ferritin 1,487 ng/ml, ALAT 70 UI/ml, ASAT 26 UI/ml, GGT 64 U/L, BUN 43 mg/dl, serum creatinine 1.54 mg/dl, GFR 67 mL/min, cholesterol 186 mg/dL, triglycerides 149 mg/dl, proteinuria 210 mg/24 h, ANA 1/320, speckled pattern, anti-Sm (+) and anti-dsDNA, anti-U1RNP, anti-Ro and anti-La all (-). C3 75 mg/dl, C4 10, Coombs test (-), procalcitonin 0.29 ng/ml ( She was treated with IV methylprednisolone (500 mg/day/3 days), and high-dose intravenous immunoglobulin, and discharged with mycophenolate mofetil 1 g/day, HCQ 400 mg/day, prednisone 20 mg/day and TMS-SMX 860/160 BID for 5 days. A week later she was re-admitted with fever, pancytopenia, hepatosplenomegaly, lymphadenopathy and several painful, indurated erythematous lesions. Her SLEDAI was 13. A bone marrow aspiration and biopsy was interpreted as a macrophage activated syndrome in the context of SLE exacerbation and treated with IV dexamethasone, colony stimulating factor, and rituximab 1000 mg. Despite treatment, she remained severely ill with fever, asthenia, petechiae and purpura on her abdomen and thighs, and pancytopenia. Due to disease severity, treatment with etoposide was indicated. Finally, the patient presented an acute episode of respiratory distress followed by death. Discussion Points Interpreting the different skin manifestations in a patient with SLE Analyzing complications and differential diagnoses with other associated diseases Case 2: 28-year-old Caucasian female Annegret Kuhn A 28-year-old Caucasian female was diagnosed with systemic lupus erythematosus (SLE) in 1996 and presented with severe, erythematous, scarring discoid lesions on the scalp, face, and hands. She had been resistant to a high number of therapeutic agents including hydroxychloroquine, chloroquine, methotrexate, isotretinoin, and cyclophosphamide for several years and had developed various side effects. Moreover, the long-term medication for SLE had not influenced her skin lesions in the past months. In December 2009, the patient received alitretinoin, which was administered orally with a daily dose of 30 mg. The patient showed continuous improvement of the discoid skin manifestations over a period of 5 months and finally a total clearance of most lesions. No serious adverse events were recorded during treatment with alitretinoin; however, the patient experienced recurring headache, which was successfully treated with nonsteroidal anti-inflammatory drugs. Therefore, alitretinoin was reduced to a daily dose of 10 mg. The vitamin-A derivative, alitretinoin, has been approved for use in severe chronic hand eczema unresponsive to treatment with potent topical corticosteroids. This case suggests that alitretinoin could also be an effective alternative in the treatment of cutaneous manifestations in SLE; however, randomized controlled trials are needed to prove the efficacy and evaluate the safety of alitretinoin in this disease. Discussion Points Treatment of therapy-resistant cutaneous manifestations in SLE Therapeutic guidelines in cutaneous lupus erythematosus Learning Objectives Explain different possible skin manifestations in patients with SLE Discuss complications, differential diagnosis with allied diseases and treatment approaches Describe the spectrum of manifestations in cutaneous lupus, including: ACLE, CCLE, SCLE and ICLE Explain the therapeutic guidelines in cutaneous lupus Describe preventive strategies in cutaneous lupus including photoprotection Describe topical treatment options in cutaneous lupus Discuss common and experimental systemic treatment options in cutaneous lupus Reference Kuhn A, Patsinakidis N, Luger TA. Alitretinoin for cutaneous lupus erythematosus. J Am Acad Dermatol 2012;67:123–126

Avanzando hacia la equidad de género: la elaboración de una Guía como herramienta motivadora para el alumnado de Grado en Derecho

[ES] En este proyecto los alumnos han realizado unas fichas a partir de las normas, resoluciones judiciales y noticias periodísticas que tratan sobre las materias objeto de estudio del Grado en Derecho, que presentan una visión “masculina”. Para ello han debatido en clase las normas y el lenguaje de carácter sexista, completándolo con la jurisprudencia nacional e internacional más reciente y han enmarcado jurídicamente la información periodística y la han analizado y sistematizado. A partir de aquí han elaborado unas recomendaciones para avanzar hacia la equidad de género. De este modo, hemos conseguido que el alumnado domine a fondo los temas trabajados y tome conciencia de la necesidad de avanzar hacia una sociedad más igualitaria y más justa. Además, tenemos un material escrito muy útil que nos sirve de apoyo en las clases.[EN] In this project, the students have made some data sheets from the norms, judicial resolutions and journalistic news that deal with the subjects included on the syllabus of the Degree in Law, which present a “masculine” vision. To do this, they have discussed in class the norms and language of a sexist nature, completing it with the most recent national and international jurisprudence and have legally framed the journalistic information and have analyzed and systematized it. From here, they have made some recommendations to move towards gender equality. In this way, we have achieved that the students acquire a thorough mastery of the topics studied and became aware of the need to move towards a more egalitarian and fairer society. In addition, we have very useful written material that will supports us in our future classesPons-Estel Tugores, C.; González Sánchez, M. (2021). Avanzando hacia la equidad de género: la elaboración de una Guía como herramienta motivadora para el alumnado de Grado en Derecho. En IN-RED 2020: VI Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 690-699. https://doi.org/10.4995/INRED2020.2020.11989OCS69069

First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus : Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR)

Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents a significant challenge for both diagnosis and treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice guidelines for Latin American patients with lupus. Two independent teams (rheumatologists with experience in lupus management and methodologists) had an initial meeting in Panama City, Panama, in April 2016. They selected a list of questions for the clinical problems most commonly seen in Latin American patients with SLE. These were addressed with the best available evidence and summarised in a standardised format following the Grading of Recommendations Assessment, Development and Evaluation approach. All preliminary findings were discussed in a second face-to-face meeting in Washington, DC, in November 2016. As a result, nine organ/system sections are presented with the main findings; an ’overarching’ treatment approach was added. Special emphasis was made on regional implementation issues. Best pharmacologic options were examined for musculoskeletal, mucocutaneous, kidney, cardiac, pulmonary, neuropsychiatric, haematological manifestations and the antiphospholipid syndrome. The roles of main therapeutic options (ie, glucocorticoids, antimalarials, immunosuppressant agents, therapeutic plasma exchange, belimumab, rituximab, abatacept, low-dose aspirin and anticoagulants) were summarised in each section. In all cases, benefits and harms, certainty of the evidence, values and preferences, feasibility, acceptability and equity issues were considered to produce a recommendation with special focus on ethnic and socioeconomic aspects. Guidelines for Latin American patients with lupus have been developed and could be used in similar settings

Characterization of Patients With Lupus Nephritis Included in a Large Cohort From the Spanish Society of Rheumatology Registry of Patients With Systemic Lupus Erythematosus (RELESSER)

The aim of the study was to profile those patients included in the RELESSER registry with histologically proven renal involvement in order to better understand the current state of lupus nephritis (LN) in Spain. RELESSER-TRANS is a multicenter cross-sectional registry with an analytical component. Information was collected from the medical records of patients with systemic lupus erythematosus who were followed at participating rheumatology units. A total of 359 variables including demographic data, clinical manifestations, disease activity, severity, comorbidities, LN outcome, treatments, and mortality were recorded. Only patients with a histological confirmation of LN were included.We performed a descriptive analysis, chi-square or Student?s t tests according to the type of variable and its relationship with LN. Odds ratio and confidence intervals were calculated by using simple logistic regression. LN was histologically confirmed in 1092/3575 patients (30.5%). Most patients were female (85.7%), Caucasian (90.2%), and the mean age at LN diagnosis was 28.4 12.7 years. The risk for LN development was higher in men (M/F:47.85/30.91%, P<0.001), in younger individuals (P<0.001), and in Hispanics (P¼0.03). Complete response to treatment was achieved in 68.3% of patients; 10.35% developed ESRD, which required a kidney transplant in 45% of such cases. The older the patient, the greater was the likelihood of complete response (P<0.001). Recurrences were associated with persistent lupus activity at the time of the last visit (P<0.001) and with ESRD (P<0.001). Thrombotic microangiopathy was a risk factor for ESRD (P¼0.04), as for the necessity of dialysis (P¼0.01) or renal transplantation (P¼0.03). LN itself was a poor prognostic risk factor of mortality (OR 2.4 [1.81?3.22], P<0.001). Patients receiving antimalarials had a significantly lower risk of developing LN (P<0.001) and ESRD (P<0.001), and responded better to specific treatments for LN (P¼0.014). More than two-thirds of the patients with LN from a wide European cohort achieved a complete response to treatment. The presence of positive anti-Sm antibodies was associated with a higher frequency of LN and a decreased rate of complete response to treatment. The use of antimalarials reduced both the risk of developing renal disease and its severity, and contributed to attaining a complete renal response

History of autoimmunity. First Part. The immunology From where and to where?

La inmunología nace especialmente a finales del siglo XIX y en las primeras dos décadas del siglo XX, pero su expansión y desarrollo acelerado se realiza a finales del siglo XX y exponencial-mente en el siglo XXI. Se origina de la microbiología y de la bacteriología, al buscar resultados rápidos de la aplicación inmediata en la prevención y curación de las infecciones bacterianas, que para esa época eran los problemas cruciales dela medicina. Desde ese inicio, la inmunología está conectada desde el área básica con todas las ramas de la medicina, de la biología y la ingenie-ría, originando una nueva especialidad como loes la Ingeniería Biomédica.Q411-3