Flamingo Vol. I N 2

Exchange. Skin Tight . Prose. 1. Yale Record. Untitled. Prose. 1. Orange Peel. Untitled. Prose. 1 Judge. Untitled. Prose. 1. Jester. Untitled. Prose. 1. Virginia Reel. Untitled. Prose. 1. Punch Bowl. Untitled. Prose. 1. Octopus. Untitled. Prose. 1. Jester. For The Backward Reader . Poem. 2. Scalper. Untitled. Prose. 2. Sun Dial. Yea, Shakespeare . Prose. 2. Sun Dial. Refined . Prose. 2. Squib. Do Tell . Poem. 2. Reel, Virginia. A Hot One . Prose. 2. Reel, Virginia. Joking A Side . Prose. 2. Widow. Craughty . Poem. 2. Widow. Even His Hair Was Wavy . Poem. 2. Funk, Dorothy K. Untitled. Picture. 3. Anonymous. Untitled. Picture. 4. Anonymous. Untitled. Prose. 4. Vogel, William. The Castle Legend . Prose. 5. Anonymous. Untitled. Poem. 8. Anonymous. He Got Two Weeks . Prose. 8. Anonymous. Agitato . Poem. 8. Anonymous. A Ballad of Loga Rithm, The Trigonometric Dragon . Poem. 8. Anonymous. Zowie . Prose. 8. Anonymous. To Our Alumni . Poem. 8. Anonymous. Moving Letters . Poem. 8. Anonymous. A Curious Phenomenon . Poem. 8. Anonymous. Toward The End of The Month . Poem. 8. Steacock, Phelan. A Senseless Novel . Prose. 9. Anonymous. Some Jesne! . Poem. 9. Breeze, Dorothy. Stained Glass Windows . Prose. 10. Anonymous. Artistic Mamma! . Prose. 10. Funk, Dorothy K. Facially Speaking . Prose. 11. A.F.T. Denisonisms . Poem. 11. Anonymous. Untitled. Poem. 11. Anonymous. How Provoking . Prose. 11. Holt, Kilburn. The Upward Trend of a Hillside . Prose. 12. Funk, Dorothy K. Untitled. Picture. 13. Anonymous. Untitled. Prose. 13. Anonymous. Redbird . Poem. 14. Anonymous. Bright . Poem. 14. E.D.T. Elusion . Poem. 14. Anonymous. Untitled. Prose. 14. Anonymous. Chapin Walk . Prose. 14. Anonymous. Denison\u27s Hall of Fame . Prose. 15. Anonymous. Untitled. Prose. 16. Anonymous. Finis . Prose. 18. Anonymous. Manlet\u27s Soliloquy . Poem. 18. Anonymous. A Song . Prose. 18. Anonymous. Pity The Poor Millionaire . Prose. 18. Anonymous. Great Expectations . Prose. 18. Anonymous. A Study In Still Life . Picture. 18. Anonymous. A Vision of Creation . Prose. 19. Anonymous. 50,000 B.C. . Prose. 19. Anonymous. Now He Knows Better . Prose. 19. Anonymous. It Is The Common Belief That: . Prose. 19. Anonymous. Untitled. Prose. 19. A.M.S. Who Am I and What? Prose. 20. Orange Ade. The Fables of the Efficient K.M. . Prose. 21. Orange Ade. On Ice . Prose. 21. Orange Ade. Famous Sayings . Prose. 21. Orange Ade. Youth and Age Again . Prose. 21. Orange Ade. Oh, That\u27s Right! . Prose. 21. Orange Ade. H.C.L. . Prose. 21. Anonymous. Untitled. Prose. 22. Jack, O. A Walking Date . Poem. 22. Anonymous. Crescendo . Poem. 22. Anonymous. The College . Prose. 23. Quinn, Alonzo. Necks . Prose. 24. Anonymous. These Women . Prose. 25. Anonymous. Recommended Readings In Shakespeare . Prose. 25. Anonymous. The Saturday Line-Up . Prose. 25. Anonymous. We Know Him . Prose. 25. Anonymous. In Ye Good Old Days . Prose. 25. Anonymous. Lament . Prose. 25. Anonymous. Untitled. Prose. 25. Anonymous. Galloping Dominoes . Prose. 26. Anonymous. Left Standing . Prose. 26. Anonymous. By All Means . Prose. 26. Anonymous. Haw! Haw! Tha\u27sh A Good One . Prose. 26. Anonymous. A Definition . Prose. 28. Funk, Dorothy K. A Definition . Picture. 28. Anonymous. A Foul Plot . Prose. 28. Anonymous. Wild West Etiquette . Prose. 28. Anonymous. What A College Education Can Do . Prose. 28. Anonymous. Efficiency Plus in The Recorder\u27s Office . Prose. 29. Reel, Virginia. Untitled. Prose. 32. Judge. A Definition . Prose. 32. Jester. One Terrible Drop . Poem. 32. Voo-Doo. Strange . Prose. 32. Reel, Virginia. The Female of the Species . Prose. 32. Mugwump. Untitled. Prose. 32. Yale Record. Untitled. Prose. 32. Tiger. Untitled. Prose. 32. Yale Record. That\u27s Us . Prose. 32. Lord Jeff. In The Mist . Prose. 32. Lord Jeff. Untitled. Prose. 32. Gargoyle. Untitled. Prose. 32. McNeil, A.M. An Apology . Poem. 34. Grogan. A Case of Identity . Picture. 31. Keeler, Clyde. Untitled. Prose. 8. Keeler, Clyde. Untitled. Picture. 18. Keeler, Clyde. Untitled. Picture. 25. Shumaker, A.M. Who Am I and What? Prose. 20. Dickerman, C.H. Untitled. Prose. 14

Interobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trials

Objective: Interobserver agreement in the context of oral epithelial dysplasia (OED) grading has been notoriously unreliable and can impose barriers for developing new molecular markers and diagnostic technologies. This paper aimed to report the details of a 3-stage histopathology review and adjudication process with the goal of achieving a consensus histopathologic diagnosis of each biopsy. Study Design: Two adjacent serial histologic sections of oral lesions from 846 patients were independently scored by 2 different pathologists from a pool of 4. In instances where the original 2 pathologists disagreed, a third, independent adjudicating pathologist conducted a review of both sections. If a majority agreement was not achieved, the third stage involved a face-to-face consensus review. Results: Individual pathologist pair κ values ranged from 0.251 to 0.706 (fair-good) before the 3-stage review process. During the initial review phase, the 2 pathologists agreed on a diagnosis for 69.9% of the cases. After the adjudication review by a third pathologist, an additional 22.8% of cases were given a consensus diagnosis (agreement of 2 out of 3 pathologists). After the face-to-face review, the remaining 7.3% of cases had a consensus diagnosis. Conclusions: The use of the defined protocol resulted in a substantial increase (30%) in diagnostic agreement and has the potential to improve the level of agreement for establishing gold standards for studies based on histopathologic diagnosis

‘Cytology-on-a-chip’ based sensors for monitoring of potentially malignant oral lesions

Despite significant advances in surgical procedures and treatment, long-term prognosis for patients with oral cancer remains poor, with survival rates among the lowest of major cancers. Better methods are desperately needed to identify potential malignancies early when treatments are more effective. Objective To develop robust classification models from cytology-on-a-chip measurements that mirror diagnostic performance of gold standard approach involving tissue biopsy. Materials and methods Measurements were recorded from 714 prospectively recruited patients with suspicious lesions across 6 diagnostic categories (each confirmed by tissue biopsy -histopathology) using a powerful new ‘cytology-on-a-chip’ approach capable of executing high content analysis at a single cell level. Over 200 cellular features related to biomarker expression, nuclear parameters and cellular morphology were recorded per cell. By cataloging an average of 2000 cells per patient, these efforts resulted in nearly 13 million indexed objects. Results Binary “low-risk”/“high-risk” models yielded AUC values of 0.88 and 0.84 for training and validation models, respectively, with an accompanying difference in sensitivity + specificity of 6.2%. In terms of accuracy, this model accurately predicted the correct diagnosis approximately 70% of the time, compared to the 69% initial agreement rate of the pool of expert pathologists. Key parameters identified in these models included cell circularity, Ki67 and EGFR expression, nuclear-cytoplasmic ratio, nuclear area, and cell area. Conclusions This chip-based approach yields objective data that can be leveraged for diagnosis and management of patients with PMOL as well as uncovering new molecular-level insights behind cytological differences across the OED spectrum

Impacto da adubação orgânica sobre a incidência de tripes em cebola.

Analisou-se a relação entre adubação orgânica e a incidência de Thrips tabaci Lind. em cebola (Allium cepa L), na EE de Ituporanga,entre agosto e dezembro de 1998. Os tratamentos foram determinados de acordo com a necessidade de N para a cultura pela análise de solo. Empregou-se como fonte orgânica diversos adubos fornecendo 75 Kg/ha de N (esterco suíno; adubo Barriga Verde proveniente de esterco de aves; composto orgânico; esterco de peru; húmus); 37,5 Kg/ha de N (metade da dose normal com esterco de suíno); as testemunhas foram adubação mineral fornecendo 30-120-60 kg/ha de N-P2O5-K2O e o dobro da dose (60-240-120 kg/ha de N-P2O5-K2O); e testemunha sem adubação. Nenhum tratamento apresentou incidência de T. tabaci superior à testemunha sem adubo. A adubação mineral em relação à orgânica não favoreceu significativamente a incidência de T. tabaci . O processo de conversão do manejo do solo da área experimental de convencional para orgânico pode ter favorecido a infestação similar do inseto entre tratamentos. No período de maior incidência de T. tabaci, a relação com nutrientes foi descrita por um modelo envolvendo K/Zn, B e N de maneira positiva. A correlação entre nutrientes e T. tabaci não foi linear na maioria das avaliações. A adubação orgânica pode substituir a adubação mineral na cultura da cebola, pois foi possível atingir níveis de produtividade similares para ambos tratamentos

Narrative Exposure Therapy for Posttraumatic Stress Disorder associated with repeated interpersonal trauma in patients with Severe Mental Illness: a mixed methods design

Background: In the Netherlands, most patients with severe mental illness (SMI) receive flexible assertive community treatment (FACT) provided by multidisciplinary community mental health teams. SMI patients with comorbid posttraumatic stress disorder (PTSD) are sometimes offered evidence-based trauma-focused treatment like eye movement desensitization reprocessing or prolonged exposure. There is a large amount of evidence for the effectiveness of narrative exposure therapy (NET) within various vulnerable patient groups with repeated interpersonal trauma. Some FACT-teams provide NET for patients with comorbid PTSD, which is promising, but has not been specifically studied in SMI patients. Objectives: The primary aim is to evaluate NET in SMI patients with comorbid PTSD associated with repeated interpersonal trauma to get insight into whether (1) PTSD and dissociative symptoms changes and (2) changes occur in the present SMI symptoms, care needs, quality of life, global functioning, and care consumption. The second aim is to gain insight into patients’ experiences with NET and to identify influencing factors on treatment results. Methods: This study will have a mixed methods convergent design consisting of quantitative repeated measures and qualitative semi-structured in-depth interviews based on Grounded Theory. The study population will include adult SMI outpatients (n=25) with comorbid PTSD and receiving NET. The quantitative study parameters will be existence and severity of PTSD, dissociative, and SMI symptoms; care needs; quality of life; global functioning; and care consumption. In a longitudinal analysis, outcomes will be analyzed using mixed models to estimate the difference in means between baseline and repeated measurements. The qualitative study parameters will be experiences with NET and perceived factors for success or failure. Integration of quantitative and qualitative results will be focused on interpreting how qualitative results enhance the understanding of quantitative outcomes. Discussion: The results of this study will provide more insight into influencing factors for clinical changes in this population

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

BACKGROUND: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. METHOD: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/ ), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. RESULTS: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 × 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 × 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 × 10(-4)) identified in the general populations, and rs113824616 (P = 7 × 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. CONCLUSION: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.UK funding includes Cancer Research UK and NIH.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13058-016-0718-

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Introduction: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. Methods: We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and triple-negative- (TN) status; morphologic subtypes; histological grade; and nodal involvement. Results: The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC in BRCA1 carriers were more consistent with the ER-positive as

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat