Exploration of the phase composition of activated calcined clay-slag mixtures using 27Al and 29Si MAS NMR spectroscopy

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Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects

Pregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexplored in vivo, AlloP may confer protection against the neurological dysfunction associated with human immunodeficiency virus type 1 (HIV-1). The HIV-1 regulatory protein, trans-activator of transcription (Tat), is neurotoxic and its expression in mice increases anxiety-like behavior; an effect that can be ameliorated by progesterone, but not when 5α-reduction is blocked. Given that Tat\u27s neurotoxic effects involve mitochondrial dysfunction and can be worsened with opioid exposure, we hypothesized that Tat and/or combined morphine would perturb steroidogenesis in mice, promoting neuronal death, and that exogenous AlloP would rescue these effects. Like other models of neural injury, conditionally inducing HIV-1 Tat in transgenic mice significantly increased the central synthesis of pregnenolone and progesterone\u27s 5α-reduced metabolites, including AlloP, while decreasing central deoxycorticosterone (independent of changes in plasma). Morphine significantly increased brain and plasma concentrations of several steroids (including progesterone, deoxycorticosterone, corticosterone, and their metabolites) likely via activation of the hypothalamic-pituitary-adrenal stress axis. Tat, but not morphine, caused glucocorticoid resistance in primary splenocytes. In neurons, Tat depolarized mitochondrial membrane potential and increased cell death. Physiological concentrations of AlloP (0.1, 1, or 10 nM) reversed these effects. High-concentration AlloP (100 nM) was neurotoxic in combination with morphine. Tat induction in transgenic mice potentiated the psychomotor effects of acute morphine, while exogenous AlloP (1.0 mg/kg, but not 0.5 mg/kg) was ameliorative. Data demonstrate that steroidogenesis is altered by HIV-1 Tat or morphine and that physiological AlloP attenuates resulting neurotoxic and psychomotor effects

DFT investigation of 3d transition metal NMR shielding tensors in diamagnetic systems using the gauge-including projector augmented-wave method

We present a density functional theory based method for calculating NMR shielding tensors for 3d transition metal nuclei using periodic boundary conditions. Calculations employ the gauge-including projector augmented-wave pseudopotentials method. The effects of ultrasoft pseudopotential and induced approximations on the second-order magnetic response are intensively examined. The reliability and the strength of the approach for 49Ti and 51V nuclei is shown by comparison with traditional quantum chemical methods, using benchmarks of finite organometallic systems. Application to infinite systems is validated through comparison to experimental data for the 51V nucleus in various vanadium oxide based compounds. The successful agreement obtained for isotropic chemical shifts contrasts with full estimation of the shielding tensor eigenvalues, revealing the limitation of pure exchange-correlation functionals compared to their exact-exchange corrected analogues.Comment: 56 page

Workshop to review and progress the reported lists of eu msfd descriptor 3 ( (WKD3LISTS)

info:eu-repo/semantics/publishedVersio

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

A database of the economic impacts of historical volcanic eruptions

History has shown that economic consequences of a volcanic eruption can be disastrous, and nowadays 800 million people in 86 different countries are living within 100 km of an active or a potentially active volcano. Eruptions can cause significant economic loss and damage directly (eruptive processes) or indirectly (associated non-eruptive processes like lahars, tsunamis, etc.), and through cascading effects (perturbations on transport, networks, etc.). Loss and damages can then be direct, indirect, tangible or intangible, short-term or long-term, also depending on the exposure and vulnerability of the economic activities. Existing database on historical eruptions do not provide, or too sparsely, information on these economic impacts. The aim of the project presented in this paper is to build a new database to increase our understanding in the field, to facilitate the identification of vulnerability and resilience factors to future events. We first selected a sample of 55 eruptions from 42 volcanoes located in 18 developing and developed countries, that occurred after the World War II. We documented a number of physical characteristics of these eruptions and volcanoes. Second, we identified the different damages and losses due to volcanic events through 37 qualitative and quantitative variables. We collected economic information and data on these variables, using a variety of sources (governmental and non-governmental agencies, academic institutions, volcanic observatories, press, etc.). This database will be accessible through a web interface and the community will be able to contribute to its development by recording information on the economic consequences of past and future events. A next step would consist in extrapolating the economic impacts for those historical eruptions with missing data and of those that are not included in our first sample

Deep joint demosaicking and denoising

© 2016 ACM. SA'16 Technical Papers,, December 05-08, 2016, Macao Demosaicking and denoising are the key first stages of the digital imaging pipeline but they are also a severely ill-posed problem that infers three color values per pixel from a single noisy measurement. Earlier methods rely on hand-crafted filters or priors and still exhibit disturbing visual artifacts in hard cases such as moiré or thin edges. We introduce a new data-driven approach for these challenges: we train a deep neural network on a large corpus of images instead of using hand-tuned filters. While deep learning has shown great success, its naive application using existing training datasets does not give satisfactory results for our problem because these datasets lack hard cases. To create a better training set, we present metrics to identify difficult patches and techniques for mining community photographs for such patches. Our experiments show that this network and training procedure outperform state-of-the-art both on noisy and noise-free data. Furthermore, our algorithm is an order of magnitude faster than the previous best performing techniques

Dynamique des formes et représentation (vers une biosymbolique de l'humain)

La représentation est le moyen de traduction et de création du réel commun à l'art, la science, l'esprit, la philosophie. Sa compréhension est la clé du dialogue et de la circulation entre ces champs. Elle vise ici la mise en lumière de la continuité globale, faite de discontinuités locales par changement de formes dynamique.s., entre ce qu'une tradition métaphysique a tendu à opposer: matière et vie, corps et âme, image et formalisation théorique. S'inspirant de Diderot, cette recherche explore les pratiques modernes et contemporaines de l'art, tout en interrogeant la théorie darwinienne de l'évolution, les sciences du cerveau, la psychologie et l'anthropologie. Elle se fonde sur une hypothèse de travail moniste et matérialiste. Mais elle découvre une complexité qui interdit tout réductionnisme mécaniste et toute prétention d'une représentation systématique de la totalité à constituer une ontologie. Elle tente de mettre au jour l'enracinement des représentations dans la transformation du biologique en symbolique pour construire une interprétation biosymbolique de l'humain. Dans une double perspective: la pensée individuelle et la culture. Sachant que la subjectivité elle-même.doit s'objectiver pour se représenter et se réaliser, et que la symbolicité, qu'elle soit interne ou externe, est inséparable d'une technicité. Si la représentation est l'expression plus ou moins symbolisée d'une dynamique de formes biologiques, la réflexion sur la dynamique des formes est ontologiquement et méthodologiquement unificatrice.PARIS1-BU Pierre Mendès-France (751132102) / SudocSudocFranceF