Programmi RITA tegevuse 1 projekti „Varustuskindluse tagamine toidu, esmatarbekaupade, isikukaitsevahendite ja vee tarneahelas Eestis“ lõpparuanne

Uuring valmis Majandus- ja Kommunikatsiooniministeeriumi, Rahandusministeeriumi, Sotsiaalministeeriumi, Siseministeeriumi, Kaitseministeeriumi, Maaeluministeeriumi ja Riigikantselei eesmärkide elluviimiseks.Lõpparanne täieneb aja jooksul. Käesolev versioon on seisuga 30.03.2022.Käesolev aruanne võtab kokku uuringu „Varustuskindluse tagamine toidu, esmatarbekaupade, isikukaitsevahendite ja vee tarneahelas Eestis (VARUST)“ olulisemad järeldused. Uuringut rahastati Eesti Teadusagentuuri Euroopa Regionaalarengu Fondi programmi „Valdkondliku teadus- ja arendustegevuse tugevdamine“ (RITA) tegevusest 1 „Strateegilise TA tegevuse toetamine“ (leping nr 7.2-2/20/24). Uuring valmis Majandus- ja Kommunikatsiooniministeeriumi, Rahandusministeeriumi, Sotsiaalministeeriumi, Siseministeeriumi, Kaitseministeeriumi, Maaeluministeeriumi ja Riigikantselei eesmärkide elluviimiseks. Uuringu viis läbi kolmest organisatsioonist koosnev konsortsium, kuhu kuulusid Eesti Maaülikool (3 töögruppi), Eesti Konjunktuuriinstituut ja Eesti Taimekasvatuse Instituut. Uuringu lähteülesande kohaselt oli uuringu eesmärgiks luua ettevõtetele toimepidevuse hindamiseks universaalne lähenemine (edaspidi mudel), pakkuda välja varustuskindluse mõõdikud ja sihttasemed ning pakkuda välja soovitused, kuidas korraldada varustuskindluse lahendamine Eesti oludele sobivaimal ja riigieelarvet ning ettevõtjaid vähem koormaval viisil.Uuringu tellis ja uuringut rahastas Eesti Teadusagentuur Euroopa Regionaalarengu Fondist toetatava programmi „Valdkondliku teadus- ja arendustegevuse tugevdamine“ (RITA) tegevuse 1 „Strateegilise TA tegevuse toetamine“ kaudu

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor allele frequency (MAF) >= 5% and low-frequency variants (0.5Peer reviewe

Late Pleistocene and Holocene groundwater flow history in the Baltic Artesian Basin: a synthesis of numerical models and hydrogeochemical data

We review our current understanding of groundwater flow history in the northern part of the Baltic Artesian Basin (BAB) from the end of the Late Pleistocene to current conditions based on the hydrogeological studies carried out in 2012â2020 by the Department of Geology, Tallinn University of Technology and its partners. Hydrogeochemical data and various numerical models are combined in order to understand the link between glaciations and groundwater flow. The results of our earlier research and published literature on groundwater flow history in the BAB are also taken into account. The reconstruction of groundwater flow history is based on the database of the isotopic, chemical and dissolved gas composition of groundwater. The database contains data on 1155 groundwater samples collected during 1974â2017. We find that groundwater in the BAB is controlled by the mixing of three distinct water masses: interglacial/modern meteoric water (δ18O â â11â°), glacial meltwater (δ18O ⤠â18â°) and an older syngenetic end-member (δ18O â¥â4.5â°). The numerical modelling has suggested that the preservation of meltwater in the northern part of the BAB is controlled by confining layers and the proximity to the outcrop areas of aquifers. Aquifers containing groundwater of glacial origin are in a transient state with respect to modern topographically-driven groundwater flow conditions. The most important topics for future research that can address gaps in our current knowledge are also reviewed

Dating of glacial palaeogroundwater in the Ordovician-Cambrian aquifer system, northern Baltic Artesian Basin

The Ordovician-Cambrian aquifer system in the northern Baltic Artesian Basin contains glacial palaeogroundwater that originates from the Scandinavian Ice Sheet that covered the study area in the Pleistocene. Previously, no absolute dating of this palaeogroundwater has been attempted. In this multi-tracer study, we use H-3, C-14, He-4 and stable isotopes of water to constrain the age distribution of groundwater. We apply the geochemical modelling approach developed by van der Kemp et al. (2000) and Blaser et al. (2010) to calculate the theoretical composition of recharge waters in three hypothetical conditions: modern, glacial and interstadial for( 14)C model age calculations. In the second phase of the geochemical modelling, the calculated recharge water compositions are used to calculate the C-14 model ages using a series of inverse models developed with NETPATH. The calculated C-14 model ages show that the groundwater in the aquifer system originates from three different climatic periods: (1) the post-glacial period; (2) the Late Glacial Maximum (LGM) and (3) the pre-LGM period. A larger pre-LGM component seems to be present in the southern and north-eastern parts of the aquifer system where the radiogenic He-4 concentrations are higher (from similar to 3.0.10(-5) to 5.5.10(-4) cc.g(-1)) and the stable isotopic composition of water is heavier (delta O-18 from - 13.5 parts per thousand to -17.3 parts per thousand). Glacial palaeogroundwater from the north-western part of the aquifer system is younger and has C-14 model ages that coincide with the end of the LGM period. It is also characterized by lower radiogenic( 4)He concentrations (similar to 2.0.10(-5) cc.g(-1)) and lighter stable isotopic composition (delta O-18 from -17.7 to - 22.4 parts per thousand). Relations between radiogenic He-4 and C-14 model ages and between radiogenic He-4 and Cl(- )concentration show that groundwater in the aquifer system does not have a single well-defined age. Rather, the groundwater age distribution has been influenced by mixing between waters originating from end-members with strongly differing ages. Overall the results suggest, that in the shallower northern part of the aquifer system, significant changes in groundwater composition can be brought about by glacial meltwater intrusion during a single glaciation. However, multiple cycles of glacial advance and retreat are needed to transport glacial meltwater to the deeper parts of the aquifer system

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based Estonian Biobank using high-coverage whole-genome sequencing (WGS) in 2,284 samples and SNP genotyping in an additional 14,904 samples. Using up to 7,134 samples with available phenotype data, our analyses identified 17 associations across 14 blood cell traits. Integration of WGS-based fine-mapping and complementary epigenomic datasets provided evidence for causal mechanisms at several loci, including at a previously undiscovered basophil count-associated locus near the master hematopoietic transcription factor CEBPA The fine-mapped variant at this basophil count association near CEBPA overlapped an enhancer active in common myeloid progenitors and influenced its activity. In situ perturbation of this enhancer by CRISPR/Cas9 mutagenesis in hematopoietic stem and progenitor cells demonstrated that it is necessary for and specifically regulates CEBPA expression during basophil differentiation. We additionally identified basophil count-associated variation at another more pleiotropic myeloid enhancer near GATA2, highlighting regulatory mechanisms for ordered expression of master hematopoietic regulators during lineage specification. Our study illustrates how population-based genetic studies can provide key insights into poorly understood cell differentiation processes of considerable physiologic relevance