44 research outputs found
Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe
Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host. To address this issue we have examined by immunohistochemistry (IHC) and Western blotting (WB) for the disease-associated form of the prion protein (PrPd), the brains of 23 sheep from five European countries, all of which were of the same ARQ/ARQ genotype. As a result of IHC examinations, sheep were distributed into five groups with different phenotypes and the groups were the same regardless of the scoring method used, ‘long’ or ‘short’ PrPd profiling. The groups made did not respond to the geographical origin of the cases and did not correlate with the vacuolar lesion profiles, which showed a high individual variability. Discriminatory IHC and WB methods coincided to detect a ‘CH1641-like’ case but otherwise correlated poorly in the classification of disease phenotypes. No other polymorphisms of the PRNP gene were found that could account for the pathological differences, except perhaps for a sheep from Spain with a mutation at codon 103 and a unique pathological phenotype. Preliminary evidence indicates that those different IHC phenotypes correlate with distinct biological properties on bioassay, suggesting that they are indicative of strain diversity. We therefore conclude that natural scrapie strains exist and that they can be revealed by detailed pathological examinations, which can be harmonized between laboratories to produce comparable results
Interacciones genotóxicas de mutágenos en mezclas binarias mediante ensayo cometa alcalino en linfocitos humanos
Introduction. Mutagens contained in complex mixtures can present synergistic interactions, eitheradditive or antagonistic. Therefore, development of experimental approaches is necessary to elucidatewhich is the responsible agent for the effect in the mixtures.Objective. An experimental design was developed that allowed an understanding of the processesbetween the compounds of complex mixtures.Materials and methods. Human lymphocytes were exposed to binary mixtures of the mutagens B[a]P,DMBA, Trp-P-1 and MX for 1 hour with or without S9. Viability was assessed with trypan blue dye andthe genotoxicity by the comet assay.Results. All of the hydrocarbon showed an effect with furanone. With and without S9, the most toxicinteractions were observed between hydrocarbons. Synergistic interaction was observed without S9between B [a] P and Trp-P-1 and between DMBA and Trp-P-1 with metabolic activity. Without S9antagonistic interaction was observed only between Trp-P-1+DMBA, and with S9 between Trp-P-1+MX and MX+DMBA. It observed an increase dose dependent in tail length. Half the cultures showedgenotoxic damage and increased cell damage. For each mixture, minimum concentrations weredetermined at which adverse effects are observed; for some only the maximum concentration wasdetermined at which no adverse effects are observed.Conclusion. The processes between mutagens present in a mixture have become better understood,and the results validated an analytical model that determined which component had an effect onanother. The results also showed that the type of compounds in the mixture determined whether or nota risk threshold was present.doi: http://dx.doi.org/10.7705/biomedica.v32i3.739Introducción. Los mutágenos contenidos en mezclas complejas presentan interacciones desinergismo, aditivas o antagónicas. Se han desarrollado enfoques experimentales que permitandilucidar el responsable de las interacciones en la mezcla.Objetivo. Desarrollar un diseño experimental para comprender los procesos que se llevan a caboentre los compuestos presentes en las mezclas complejas.Materiales y métodos. Se expusieron linfocitos humanos a mezclas binarias de mutágenos B[a]P,DMBA, Trp-P-1 y MX durante una hora, con activación metabólica y sin ella. La viabilidad se evaluócon azul de tripano y, la genotoxicidad, con cometa alcalino.Resultados. Ningún hidrocarburo tuvo efecto con furanona. Con S9 y sin él, se observó que sepresentaban interacciones tóxicas entre hidrocarburos. Se observó sinergismo sin S9 entre B[a]P yTrp-P-1 y, con actividad metabólica, entre DMBA y Trp-P-1. Sin S9 se observó interacción antagónicaentre Trp-P-1 y DMBA y, con S9, entre Trp-P-1 y MX y entre MX y DMBA. Se observó un incrementodependiente de la dosis en la longitud de la cola. Hubo daño genotóxico medio y aumento de lascélulas dañadas. Para todas las mezclas se pudo determinar la concentración mínima en la que seobservaban efectos adversos y solo para algunas se determinó la concentración máxima en la cual nose observaron efectos adversos.Conclusión. Se hace un aporte para comprender los procesos que ocurren cuando en una mezclahay presentes, al menos, dos mutágenos y se valida un modelo de análisis que permite dilucidar elcompuesto que tiene efecto sobre otro. También, se demostró que según el tipo de compuestos en lamezcla, se tendrá o no un umbral de riesgo. doi: http://dx.doi.org/10.7705/biomedica.v32i3.739
The QUIJOTE experiment: project overview and first results
QUIJOTE (Q-U-I JOint TEnerife) is a new polarimeter aimed to characterize the
polarization of the Cosmic Microwave Background and other Galactic and
extragalactic signals at medium and large angular scales in the frequency range
10-40 GHz. The multi-frequency (10-20~GHz) instrument, mounted on the first
QUIJOTE telescope, saw first light on November 2012 from the Teide Observatory
(2400~m a.s.l). During 2014 the second telescope has been installed at this
observatory. A second instrument at 30~GHz will be ready for commissioning at
this telescope during summer 2015, and a third additional instrument at 40~GHz
is now being developed. These instruments will have nominal sensitivities to
detect the B-mode polarization due to the primordial gravitational-wave
component if the tensor-to-scalar ratio is larger than r=0.05.Comment: To appear in "Highlights of Spanish Astrophysics VIII", Proceedings
of the XI Scientific Meeting of the Spanish Astronomical Society, Teruel,
Spain (2014
Can Geographical Factors Determine the Choices of Farmers in the Ethiopian Highlands to Trade in Livestock Markets?
Proximity and affiliation to the local market appear to be two of the most relevant factors to explain farmer's choices to select a particular trading point. Physical barriers may limit the options , especially in developing countries. A network of villages linked by traders/farmer-traders sharing livestock markets was built with field data collected in 75 villages from 8 kebelles in the Wassona Werna wereda of the Ethiopian Highlands. Two exponential random graph models were fitted with various geographical and demographic attributes of the nodes (dyadic independent model) and three internal network structures (dyadic dependent model). Several diagnostic methods were applied to assess the goodness of fit of the models. The odds of an edge where the distance to the main market Debre Behran and the difference in altitude between two connected villages are both large increases significantly so that villages far away from the main market and at different altitude are more likely to be linked in the network than randomly. The odds of forming an edge between two villages in Abamote or Gudoberet kebelles are approximately 75% lower than an edge between villages in any other kebelles (p<0.05). The conditional log-odds of two villages forming a tie that is not included in a triangle, a 2-star or a 3-star is extremely low, increasing the odds significantly (p<0.05) each time a node is in a 2-star structure and decreasing it when a node is in a 3-star (p<0.05) or in a triangle formation (p<0.05)), conditional on the rest of the network. Two major constraining factors, namely distance and altitude, are not deterrent for the potential contact of susceptible small ruminant populations in the Highlands of Ethiopia
QUIJOTE Experiment: status of telescopes and instrumentation
The QUIJOTE Experiment (Q-U-I JOint TEnerife) is a combined operation of two telescopes and three instruments working in the microwave band to measure the polarization of the Cosmic Microwave Background (CMB) from the northern hemisphere, at medium and large angular scales. The experiment is located at the Teide Observatory in Tenerife, one of the seven Canary Islands (Spain). The project is a consortium maintained by several institutions: the Instituto de Astrofísica de Canarias (IAC), the Instituto de Física de Cantabria (IFCA), the Communications Engineering Department (DICOM) at Universidad de Cantabria, and the Universities of Manchester and Cambridge. The consortium is led by the IAC
A home and ambulatory artificial nutrition (NADYA) group report, home parenteral nutrition in Spain, 2013
Aim: to communicate the results of the Spanish Home Parenteral Nutrition (HPN) registry of the NADYA-SENPE group for the year 2013.
Material and methods: data was recorded online by NADYA group collaborators that were responsible of the HPN follow-up from 1st January to 31st December 2013.
Results: a total of 197 patients and 202 episodes of HPN were registered from 35 hospitals that represents a rate of 4,22 patients/million habitants/year 2013. The median age was 53 years (IQR 40 – 64) for 189 adult patients and 7 months (IQR 6 – 35,5) for children. The most frequent disease in adults was neoplasm (30,7%) followed by other diseases (20,1%) and mesenteric ischemia (12,7%). Short bowel syndrome and intestinal obstruction (25,9%) were in 35.7% cases the indications for HPN
Tendencias de la investigación en Ingeniería Ambiental
Esta obra incluye las memorias del Simposio “Tendencias de la Investigación en Ingeniería Ambiental”, organizado por el Grupo de Investigaciones y Mediciones Ambientales (GEMA), realizado en la Universidad de Medellín en agosto de 2007. El texto está conformado por 14 capítulos agrupados en cuatro partes. En la primera se agrupan los trabajos relacionados con la calidad y alternativas de tratamiento del agua e hidráulica ambiental (capítulos 1 al 4). La segunda trata temas relacionados con la contaminación atmosférica y calidad del aire (capítulos 5 al 6). La tercera está relacionada con las tecnologías ambientales para la recuperación y conservación de suelos (capítulos 7 al 10) y la cuarta y última comprende las temáticas asociadas con la sostenibilidad ambiental del territorio (capítulos 11 al 14). En este sentido, estamos convencidos del valioso aporte que el libro dará a la comunidad científica, por ser este un documento de divulgación de resultados de investigación en ingeniería ambiental.PRÓLOGO............13
PRESENTACIÓN.............15
PRIMERA PARTE
CALIDAD Y ALTERNATIVAS DE TRATAMIENTO DEL AGUA HIDRÁULICA AMBIENTAL
Capítulo 1
PRETRATAMIENTO DE AGUAS RESIDUALES INDUSTRIALES MEDIANTE FOTO-FENTON SOLAR A ESCALA INDUSTRIAL ACOPLADO A BIOTRATAMIENTO CON FANGOS ACTIVOS INMOVILIZADOS
Manuel Ignacio Maldonado, Isabel Oller, Wolfgang Gernjak, Sixto Malato
1.1 INTRODUCCIÓN............19
1.2 MATERIALES Y MÉTODOS.............21
1.2.1 Reactivos............21
1.2.2 Determinaciones analíticas.............22
1.2.3 Dispositivo experimental.............23
1.3 R ESULTADOS Y DISCUSIÓN............ 27
1.3.1 Tratamiento foto-Fenton solar............27
1.3.2 Biotratamiento mediante fangos activos inmovilizados.............33
1.3.3 Sistema combinado foto-Fenton solar-biológico aeróbico............35
1.4 CONCLUSIONES............. 42
Capítulo 2
DEGRADACIÓN DE LA ATRAZINA EN SOLUCIÓN ACUOSA USANDO RADIACIÓN UV Y PROCESOS DE OXIDACIÓN AVANZADA
Margarita Hincapié, Gustavo Peñuela, Manuel I. Maldonado, Sixto Malato
2.1 INTRODUCCIÓN..............47
2.2 SECCIÓN EXPERIMENTAL..............53
2.2.1 Materiales.............53
2.2.2 Metodología...............53
2.2.3 Determinación analítica..............55
2.2.4 Determinación de la toxicidad...............55
2.3 R ESULTADOS Y DISCUSIÓN...............56
2.3.1 Hidrólisis..............56
2.3.2 Fotólisis y fotocatálisis con TiO2 Degussa P25.............56
2.3.3 Efecto de los agentes oxidantes peróxido de hidrógeno y persulfato de sodio en la fotocatálisis..............59
2.3.4 Proceso foto Fenton..............63
2.3.5 Evaluación de los aniones inorgánicos durante los dos tratamientos.............66
2.3.6 Cuantificación e identificación de los productos de degradación...............68
2.3.7 Evaluación de la toxicidad...............71
2.4 CONCLUSIONES...............74
Capítulo 3
HUMEDALES ARTIFICIALES PARA EL TRATAMIENTO DE AGUAS RESIDUALES
Nazly E. Sánchez P., Gustavo A. Peñuela M., Juan C. Casas Z.
3.1 INTRODUCCIÓN...............81
3.2 MARCO TEÓRICO...............83
3.2.1 Humedales construidos para el tratamiento de aguas residuales..............84
3.2.2 Clasificación de los humedales.............85
3.2.3 Ventajas y desventajas de los humedales subsuperficiales..............87
3.2.4 Aspectos a considerar en los humedales subsuperficiales..............88
3.3 MATERIALES Y MÉTODOS.................89
3.3.1 Diseño y construcción de los humedales a escala piloto..............89
3.3.2 Componentes del agua residual sintética................90
3.3.3 Siembra y aclimatación de plantas............... 90
3.3.4 Muestreos............91
3.4 R ESULTADOS Y DISCUSIÓN..............91
3.4.1 pH..............91
3.4.2 Demanda bioquímica de oxígeno (DBO5)..............92
3.4.3 Carbono orgánico total (COT)................94
3.5 CONCLUSIONES................95
Capítulo 4
DESCRIPCIÓN DE LA DINÁMICA OCEANOGRÁFICA DEL GOLFO DE URABÁ UTILIZANDO MEDICIONES DE CAMPO
Luis Javier Montoya Jaramillo, Francisco Mauricio Toro Botero
4.1 INTRODUCCIÓN...............103
4.2 DATOS Y MÉTODOS................107
4.3 DISCUSIÓN..............118
4.4 CONCLUSIONES............. 120
SEGUNDA PARTE
CONTAMINACIÓN ATMOSFÉRICA Y CALIDAD DEL AIRE
Capítulo 5
IMPACTO DE LAS MOTOCICLETAS EN LA CALIDAD DEL AIRE. ESTUDIO DE CASO: MONTERÍA
Carlos Alberto Echeverri Londoño
5.1 INTRODUCCIÓN.................127
5.2 MATERIALES Y MÉTODOS...............131
5.2.1 S elección de los sitios de medición...............131
5.2.2 Período de medición................131
5.2.3 Parámetros seleccionados...............132
5.2.4 Equipos y materiales utilizados..............132
5.2.5 Índices de calidad del aire..............133
5.2.6 Legislación.............. 138
5.2.7 Inventario de emisiones..............141
5.3 RESULTADOS...............142
5.3.1 Calidad del aire y calidad acústica................142
5.3.2 Emisiones vehiculares.............150
5.3.3 Inventario de emisiones.............155
5.4 CONCLUSIONES.............. 158
5.5 RECOMENDACIONES............. 160
Capítulo 6
ROMPIMIENTO DE LA INVERSIÓN TÉRMICA EN EL VALLE DE ABURRÁ
Ángela M. Rendón, José F. Jiménez, Carlos Palacio
6.1 INTRODUCCIÓN...............163
6.2 MEDICIÓN DE VARIABLES ATMOSFÉRICAS..............164
6.3 CAMPAÑAS DE MEDICIÓN.............165
6.4 RESULTADOS..............166
6.5 CONCLUSIONES................170
TERCERA PARTE
TECNOLOGÍAS AMBIENTALES
PARA LA RECUPERACIÓN Y CONSERVACIÓN DE SUELOS
Capítulo 7
ESTRUCTURA MODELO DE LA PARTÍCULA FUNDAMENTAL DEL COMPOST
Carlos E. Arroyave M., Carlos A. Peláez J.
7.1 INTRODUCCIÓN..............177
7.2 MATERIALES Y EQUIPOS.............178
7.2.1 Materias primas y planta de compostaje............178
7.2.2 Obtención de fracciones............. 182
7.2.3 Análisis estadístico.............184
7.3 RESULTADOS Y DISCUSIÓN.............184
7.3.1 Caracterización fisicoquímica del material de RSUsf...........184
7.3.2 Tamaño de partícula.............185
7.3.3 Análisis instrumental................187
7.3.4 Modelo de partícula..............194
7.4 CONCLUSIONES..............195
Capítulo 8
DEGRADACIÓN DE HEXACLOROCICLOHEXANO (HCH) CON HONGOS DE PODREDUMBRE DE LA MADERA
Juan Carlos Quintero Díaz, Gumersindo Feijoo, Juan Manuel Lema
8.1 INTRODUCCIÓN..............199
8.2 MATERIALES Y MÉTODOS..............204
8.2.1 Microorganismos.............204
8.2.2 Ensayos de selección de los hongos de podredumbre de la madera.............204
8.2.3 Ensayos de degradación de HCH en medio líquido.............205
8.2.4 Ensayos de degradación de HCH en sobre suelo contaminado.............205
8.2.5 Extracción y análisis de los isómeros de HCH.............208
8.3 RESULTADOS Y DISCUSIÓN..............209
8.3.1 Selección de los microorganismos.............209
8.3.2 Degradación de HCH en medio líquido.............210
8.3.3 Degradación de HCH en fase sólida.............212
8.4 CONCLUSIONES.............. 220
Capítulo 9
AVANCES EN LA PROPAGACIÓN ASIMBIÓTICA IN VITRO DE ORQUÍDEAS CON ESPECIAL ÉNFASIS EN EL GÉNERO CATTLEYA
Liliana R. Botero, María A. Jaramillo, Óscar O. Ossa R., Tatiana Saldarriaga F., Estefanía Ortiz R.
9.1 INTRODUCCIÓN...............227
9.2 MATERIALES Y MÉTODOS...............231
9.2.1 Evaluación de la metodología de desinfección de cápsulas de orquídeas.............231
9.2.2 Evaluación del efecto de un abono comercial y un suplemento comercial de banano............239
9.3 R ESULTADOS Y DISCUSIÓN..............242
9.3.1 Ensayos de desinfección...............242
9.3.2 Resultados del efecto de un abono comercial y un suplemento de banano comercial....246
9.4 CONCLUSIONES..............254
Capítulo 10
MOVILIDAD DEL BRAVONIL 720 (CLOROTALONILO) A TRAVÉS DE LA ZONA NO SATURADA Y SATURADA DE UN ACUÍFERO LIBRE SIMULADO
Idalia Jacqueline López Sánchez, Gustavo Antonio Peñuela Mesa
10.1 INTRODUCCIÓN...............259
10.2 MATERIALES Y MÉTODOS...............261
10.3 RESULTADOS Y DISCUSIÓN..............269
10.4 CONCLUSIONES..............292
CUARTA PARTE
SOSTENIBILIDAD AMBIENTAL DEL TERRITORIO
Capítulo 11
LA RESPONSABILIDAD SOCIAL EMPRESARIAL COMO COMPONENTE DE SOSTENIBILIDAD AMBIENTAL
John Fredy López Pérez
11.1 INTRODUCCIÓN...............299
11.2 UNA LECTURA DE LA SOSTENIBILIDAD AMBIENTAL DESDE UN PUNTO DE VISTA SOCIAL..............300
11.3 EL CONCEPTO DE LA RESPONSABILIDAD SOCIAL EMPRESARIAL...............303
11.4 LA RESPONSABILIDAD SOCIAL COMO ESPACIO PARA L A SOSTENIBILIDAD AMBIENTAL.............309
11.5 ESBOZOS DE UN CASO: EL SECTOR ELÉCTRICO COLOMBIANO..............311
11.6 CONCLUSIONES..............319
Capítulo 12
DETERMINACIÓN ESPACIAL DE ÁREAS DE IMPORTANCIA ESTRATÉGICA
El caso de microcuencas abastecedoras de acueductos veredales del municipio de Medellín
Joaquín Hincapié, Álvaro Lema
12.1 INTRODUCCIÓN................323
12.2 LA NOCIÓN DE ÁREA DE IMPORTANCIA ESTRATÉGICA...............325
12.3 LA IDEA DE LOS SERV ICIOS AMBIENTALES..............328
12.4 ESTRATEGIA METODOLÓGICA EN LA IDENTIFICACIÓN Y DETERMINACIÓN DE LAS ÁREAS DE IMPORTANCIA ESTRATÉGICA............332
12.5 L OS RESULTADOS DEL MODELO...............359
12.6 CONCLUSIONES............. 361
Capítulo 13
LA EDUCACIÓN AMBIENTAL EN LA TRANSFORMACIÓN DE LA CULTURA
Luz Ángela Peña Marín, Alba Miriam Vergara Vargas
13.1 INTRODUCCIÓN..............369
13.2 APROXIMACIÓN CONCEPTUAL...............370
13.2.1 La reflexividad...............372
13.2.2 La construcción del otro...............374
13.2.3 El discurso.............. 372
13.2.4 La autonomía y la participación..............375
13.2.5 La educación ambiental y el desarrollo humano..............378
13.2.6 Base conceptual de la educación ambiental..............380
13.2.7 Contexto sociocultural..............382
13.2.8 Diagnóstico de la educación ambiental y la administración de los recursos naturales..............392
13.2.9 Criterios corporativos de educación ambiental.............394
13.3 CONCLUSIONES...............398
Capítulo 14
ENFOQUE CONCEPTUAL DE UN SISTEMA DE INDICADORES AMBIENTALES PARA LA EVALUACIÓN DE LOS POT: municipios del Valle de San Nicolás Oriente Antioqueño
Carolina Arias Muñoz, Diana Elizabeth Valencia Londoño, Boris Puerto López
14.1 INTRODUCCIÓN...............401
14.2 ENFOQUE CONCEPTUAL DEL SISTEMA DE INDICADORES..............406
14.2.1 Primera aproximación: el enfoque de impacto ambiental..............406
14.2.2 Enfoque sistémico: de la sostenibilidad ambiental..............408
14.3 PROPUESTA FINAL DE INDICADORES E ÌNDICE DE SOSTENIBILIDAD AMBIENTAL DEL POT ISAPOT.............424
14.4 R EFLEXIONES FINALES..............42
Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)
This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac
Role of age and comorbidities in mortality of patients with infective endocarditis
[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.
[Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk.
[Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality.
[Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group