195 research outputs found
Tsallis entropy approach to radiotherapy treatments
The biological effect of one single radiation dose on a living tissue has
been described by several radiobiological models. However, the fractionated
radiotherapy requires to account for a new magnitude: time. In this paper we
explore the biological consequences posed by the mathematical prolongation of a
model to fractionated treatment. Nonextensive composition rules are introduced
to obtain the survival fraction and equivalent physical dose in terms of a time
dependent factor describing the tissue trend towards recovering its
radioresistance (a kind of repair coefficient). Interesting (known and new)
behaviors are described regarding the effectiveness of the treatment which is
shown to be fundamentally bound to this factor. The continuous limit,
applicable to brachytherapy, is also analyzed in the framework of nonextensive
calculus. Also here a coefficient arises that rules the time behavior. All the
results are discussed in terms of the clinical evidence and their major
implications are highlighted.Comment: 6 figures, accepted for publication to Physica
Shocks in supersonic sand
We measure time-averaged velocity, density, and temperature fields for steady
granular flow past a wedge and calculate a speed of granular pressure
disturbances (sound speed) equal to 10% of the flow speed. The flow is
supersonic, forming shocks nearly identical to those in a supersonic gas.
Molecular dynamics simulations of Newton's laws and Monte Carlo simulations of
the Boltzmann equation yield fields in quantitative agreement with experiment.
A numerical solution of Navier-Stokes-like equations agrees with a molecular
dynamics simulation for experimental conditions excluding wall friction.Comment: 4 pages, 5 figure
Competing Patterns of Signaling Activity in Dictyostelium discoideum
Quantitative experiments are described on spatio-temporal patterns of
coherent chemical signaling activity in populations of {\it Dictyostelium
discoideum} amoebae. We observe competition between spontaneously firing
centers and rotating spiral waves that depends strongly on the overall cell
density. At low densities, no complete spirals appear and chemotactic
aggregation is driven by periodic concentric waves, whereas at high densities
the firing centers seen at early times nucleate and are apparently entrained by
spiral waves whose cores ultimately serve as aggregation centers. Possible
mechanisms for these observations are discussed.Comment: 10 pages, RevTeX, 4 ps figures, accepted in PR
Onset of fluidization in vertically shaken granular material
When granular material is shaken vertically one observes convection, surface
fluidization, spontaneous heap formation and other effects. There is a
controversial discussion in literature whether there exists a threshold for the
Froude number below which these effects cannot be
observed anymore. By means of theoretical analysis and computer simulation we
find that there is no such single threshold. Instead we propose a modified
criterion which coincides with critical Froude number for small
driving frequency .Comment: 7 pages, 5 figure
Spin fluctuations in CuGeO probed by light scattering
We have measured temperature dependence of low-frequency Raman spectra in
CuGeO, and have observed the quasi-elastic scattering in the
polarization above the spin-Peierls transition temperature. We attribute it to
the fluctuations of energy density in the spin system. The magnetic specific
heat and an inverse of the magnetic correlation length can be derived from the
quasi-elastic scattering. The inverse of the magnetic correlation length is
proportional to at high temperatures. We compare the
specific heat with a competing- model. This model cannot explain
quantitatively both the specific heat and the magnetic susceptibility with the
same parameters. The origin of this discrepancy is discussed.Comment: 17 pages, REVTeX, 5 Postscript figures; in press in PR
Transport Coefficients for Granular Media from Molecular Dynamics Simulations
Under many conditions, macroscopic grains flow like a fluid; kinetic theory
pred icts continuum equations of motion for this granular fluid. In order to
test the theory, we perform event driven molecular simulations of a
two-dimensional gas of inelastic hard disks, driven by contact with a heat
bath. Even for strong dissipation, high densities, and small numbers of
particles, we find that continuum theory describes the system well. With a bath
that heats the gas homogeneously, strong velocity correlations produce a
slightly smaller energy loss due to inelastic collisions than that predicted by
kinetic theory. With an inhomogeneous heat bath, thermal or velocity gradients
are induced. Determination of the resulting fluxes allows calculation of the
thermal conductivity and shear viscosity, which are compared to the predictions
of granular kinetic theory, and which can be used in continuum modeling of
granular flows. The shear viscosity is close to the prediction of kinetic
theory, while the thermal conductivity can be overestimated by a factor of 2;
in each case, transport is lowered with increasing inelasticity.Comment: 14 pages, 17 figures, 39 references, submitted to PRE feb 199
Designing Irreversible InhibitorsâWorth the Effort?
This is the peer-reviewed version of the following article: GonzĂĄlez-Bello, C. (2016). Designing Irreversible Inhibitors-Worth the Effort?. Chemmedchem, 11(1), 22-30, which has been published in final form at https://doi.org/10.1002/cmdc.201500469. This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-ArchivingDespite the unquestionable success of numerous irreversible drugs that are currently in clinical use, such as acetylsalicylic acid (Aspirin) and penicillin, the number of such approved drugs is much lower than that of noncovalent drugs. Over the years, the potential offâtarget effects of these types of compounds have been the primary concern that has hampered their development. However, their remarkable advantages over noncovalent drugs and a better analysis of the risks have decreased the widespread skepticism surrounding them. The design of irreversible inhibitors is a challenge, particularly considering that in some cases their efficacy is due to complex and unexpected mechanisms of action. In this review the main advantages of irreversible inhibition are summarized, and the complexity of certain covalent modification mechanisms is highlighted with selected examplesSpanish Ministry of Economy and Competitiveness. Grant Number: SAF2013-42899-R
Xunta de Galicia. Grant Number: GRC2013-041
European Regional Development Fund (ERDF)S
Catchability of pelagic trawls for sampling deep-living nekton in the mid-North Atlantic
Material collected in summer 2004 from the Mid-Atlantic Ridge between Iceland and the Azores with three pelagic trawls was used to estimate relative catchabilities of common fish, cephalopod, decapod, and jellyfish species. Catchability is defined as the ratio of numbers caught between two trawls, standardized for towed distance. Taxon-specific catchability coefficients were estimated for two large pelagic trawls with graded meshes, using a smaller pelagic trawl with a uniform mesh size as the reference trawl. Two of the trawls were equipped with multiple openingâclosing codends that allowed sampling of different depth layers. Generalized linear and mixed models suggest that most of the taxa have catchabilities much lower than expected from the area of opening alone, indicating that only a few species are herded by the large mesh at the mouth of larger trawls. Catchability coefficients across taxa show a very large spread, indicating that the sampled volume for the larger trawls with graded meshes was highly
taxon-specific. Part of this variability can be explained by body size and taxonomic group, the latter probably reflecting differences in body form and behaviour. The catchability estimates presented here form the basis for combining data for quantitative analyses of community structure
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