A library of high resolution synthetic stellar spectra from 300nm to 1.8 micron with solar and alpha-enhanced composition

Libraries of stellar spectra are fundamental tools for the study of stellar populations and both empirical and synthetic libraries have been used for this purpose. In this paper, a new library of high resolution synthetic spectra is presented, ranging from the near-ultraviolet (300nm) to the near-infrared (1.8${\rm \mu}$m). The library spans all the stellar types that are relevant to the integrated light of old and intermediate-age stellar populations in the involved spectral region (spectral types F through M and all luminosity classes). The grid was computed for metallicities ranging from [Fe/H] = --2.5 to +0.5, including both solar and $\alpha$-enhanced ([$\alpha$/Fe] = 0.4) chemical compositions. The synthetic spectra are a good match to observations of stars throughout the stellar parameter space encompassed by the library and over the whole spectral region covered by the computations.Comment: A&A, accepted (revised version

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

ESARDA Bulletin n. 59

ESARDA is an association initially formed to advance and harmonize research and development for nuclear safeguards whose scope has in recent year expanded as the number and type of its working groups’ activities below indicates. Esarda is currently composed of about 30 laboratories, private and governmental institutions worldwide. Within Esarda (http://esarda.jrc.ec.europa.eu/), a number working groups have been over the years established and active namely: Techniques and Standards for Destructive Analysis, Techniques and Standards for Non-Destructive Analysis, Containment and Surveillance, Novel Approaches / Novel Technologies, Implementation of Safeguards, Verification Technologies and Methodologies, Training and Knowledge Management, Editorial Committee. ESARDA publishes a Bulletin containing peer reviewed scientific related to nuclear Safeguards, verification and non-proliferation. This publication appears generally twice a year. In addition, thematic special issues are published as proposed by the ESARDA community. The Bulletin Editorial Board is composed of about 10 experts in the various technical and scientific fields related to safeguards. They are all actively engaged in safeguards R&D or in safeguards implementation and other fields. The Editorial Board decides the contents of the Bulletin, selects the papers to be published and reviews them before publication. All ESARDA editorial activities are carried out at JRC in Ispra. Scientific papers submitted for publication are reviewed by independent authors and by members of the Editorial Committee. The Bulletin is currently submitted to Scopus for evaluation in view of citation. ESARDA Bulletin is published jointly by ESARDA and the Joint Research Centre of the European Commission and distributed free of charge to over 1000 registered members, libraries and institutions worldwide.JRC.G.II.7-Nuclear securit

Genome-wide association study identifies a possible susceptibility locus for endometrial cancer

Background: Genome-wide association studies (GWAS) have identified more than 100 genetic loci for various cancers. However, only one is for endometrial cancer. Methods: We conducted a three-stage GWAS including 8,492 endometrial cancer cases and 16,596 controls. After analyzing 585,963 single-nucleotide polymorphisms (SNP) in 832 cases and 2,682 controls (stage I) from the Shanghai Endometrial Cancer Genetics Study, we selected the top 106 SNPs for in silico replication among 1,265 cases and 5,190 controls from the Australian/British Endometrial Cancer GWAS (stage II). Nine SNPs showed results consistent in direction with stage I with P < 0.1. These nine SNPs were investigated among 459 cases and 558 controls (stage IIIa) and six SNPs showed a direction of association consistent with stages I and II. These six SNPs, plus two additional SNPs selected on the basis of linkage disequilibrium and P values in stage II, were investigated among 5,936 cases and 8,166 controls from an additional 11 studies (stage IIIb). Results: SNP rs1202524, near the CAPN9 gene on chromosome 1q42.2, showed a consistent association with endometrial cancer risk across all three stages, with ORs of 1.09 [95% confidence interval (CI), 1.03–1.16] for the A/G genotype and 1.17 (95% CI, 1.05–1.30) for the G/G genotype (P = 1.6 × 10−4 in combined analyses of all samples). The association was stronger when limited to the endometrioid subtype, with ORs (95% CI) of 1.11 (1.04–1.18) and 1.21 (1.08–1.35), respectively (P = 2.4 × 10−5). Conclusions: Chromosome 1q42.2 may host an endometrial cancer susceptibility locus. Impact: This study identified a potential genetic locus for endometrial cancer ris