Book Reviews

Book Review 1Book Title: Ecotoxicology. The Study of Pollutants in Ecosystems. (Second edition)Book Author: F. MoriartyAcademic Press, 1988. 289 pages.Book Review 2Book Title: Ecology of Sandy ShoresBook Authors: A.C. Brown & A. McLachlanElsevier, 1990. 328 pages.Book Review 3Book Title: Ecology and Natural History of Tropical BeesBook Author: David W. RoubikCambridge University Press, Cambridge, 1989Book Review 4Book Title: The AntsBook Authors: Bert Hölldobler & Edward O. WilsonThe Belknap Press of Harvard University Press, Cambridge, Massachusetts,1990. 732 pages.Book Review 5Book Title: Social Insects: an evolutionary approach to castes and reproductionBook Author: Edited by W. EngelsSpringer Verlag, Berlin 1990. 265 pages.Book Review 6Book Title: Mathematical BiologyBook Author: J.D. MurraySpringer-Verlag, New York, 1989. 767 pages. Volume 19 in the Biomathematics series

Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task

Decision-making requires the coordinated activity of diverse brain structures. For example, in maze-based tasks, the prefrontal cortex must integrate spatial information encoded in the hippocampus with mnemonic information concerning route and task rules in order to direct behavior appropriately. Using simultaneous tetrode recordings from CA1 of the rat hippocampus and medial prefrontal cortex, we show that correlated firing in the two structures is selectively enhanced during behavior that recruits spatial working memory, allowing the integration of hippocampal spatial information into a broader, decision-making network. The increased correlations are paralleled by enhanced coupling of the two structures in the 4- to 12-Hz theta-frequency range. Thus the coordination of theta rhythms may constitute a general mechanism through which the relative timing of disparate neural activities can be controlled, allowing specialized brain structures to both encode information independently and to interact selectively according to current behavioral demands

Book Reviews

Book Review 1Book Title: Pheromones of Social BeesBook Author: John B. FreeChapman & Hall, 1987. 218 pp.Book Review 2Book Title: Insects - PlantsBook Authors: V. Labeyrie et alDr. W. Junk Publishers, The Hague, 1987. 459 pp.Book Review 3Book Title: The Ecology of Woodland Rodents: Bank voles and wood miceBook Authors: Edited by J.R. Flowerdew, J. Gurnell & J.H.W GippsThe Zoological Society of London. Clarendon Press, Oxford, 1985. 418 pp.Book Review 4Book Title: Visual behavior in salamandersBook Author: Gerhard RothSpringer-Verlag, Berlin, 1987. 301 pp.Book Review 5Book Title: Digestive Physiology and Nutrition of MarsupialsBook Author: Ian D. HumeMonographs on Marsupial Biology. Cambridge University Press, 1982. 256 pp.Book Review 6Book Title: Neurobiology and Behavior of HoneybeesBook Authors: Edited by Randolf Menzel & Alison MercerSpringer-Verlag, 1987.334 pp.Book Review 7Book Title: Ecology and Productivity of an African Wetland SystemBook Author: G.A. EllenbroekDr W. Junk Publishers, Dordrecht, 1987. 267 pagesBook Review 8Book Title: Biological Surveys of Estuaries and Coasts Estuarine and Brackish Water Sciences Association HandbookBook Authors: Edited by J.M. Baker & W.J. WolffCambridge University Press, 1987. 449 pp.Book Review 9Book Title: Caste Differentiation in Social InsectsBook Authors: Edited by J.A.L. Watson, S.M. Okot-Kotber & C.H. NoirotPergamon Press, Oxford, 1985. 399 pp.Book Review 10Book Title: Sistematica, filogenia y biogeografia de la subfamilia Gibbiinae (Coleoptera, Ptinidae)Book Author: Xavier BellésTreballs del Museu de Zoologia, 1985, No.3, Barcelona. 94 pp.Book Review 11Book Title: A Biologist's Advanced MathematicsBook Author: D.R. CaustonAllen & Unwin, London 326 pp.Book Review 12 Book Title: Reproduction in Mammals: 5 Manipulating reproductionBook Authors: Edited by C.R. Austin & R.V. ShortCambridge University Press, London, New York, New Rochelle, Melbourne, Sydney. 235 pp.Book Review 13Book Title: Vertebrate Fetal MembranesBook Author: Harland W. MossmanMacmillan press, 1987. 383 pp.Book Review 14Book Title: Avian Physiology (Fourth edition)Book Author: Edited by P.O. SturkieSpringer-Verlag, New York, 1986. 516 pp

Spatial Learning and Action Planning in a Prefrontal Cortical Network Model

The interplay between hippocampus and prefrontal cortex (PFC) is fundamental to spatial cognition. Complementing hippocampal place coding, prefrontal representations provide more abstract and hierarchically organized memories suitable for decision making. We model a prefrontal network mediating distributed information processing for spatial learning and action planning. Specific connectivity and synaptic adaptation principles shape the recurrent dynamics of the network arranged in cortical minicolumns. We show how the PFC columnar organization is suitable for learning sparse topological-metrical representations from redundant hippocampal inputs. The recurrent nature of the network supports multilevel spatial processing, allowing structural features of the environment to be encoded. An activation diffusion mechanism spreads the neural activity through the column population leading to trajectory planning. The model provides a functional framework for interpreting the activity of PFC neurons recorded during navigation tasks. We illustrate the link from single unit activity to behavioral responses. The results suggest plausible neural mechanisms subserving the cognitive “insight” capability originally attributed to rodents by Tolman & Honzik. Our time course analysis of neural responses shows how the interaction between hippocampus and PFC can yield the encoding of manifold information pertinent to spatial planning, including prospective coding and distance-to-goal correlates

3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial

Background: Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes. Methods: In this randomised, double-blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m2, or at least 27 kg/m2 with comorbidities, were randomised 2:1, using a telephone or web-based system, to once-daily subcutaneous liraglutide 3·0 mg or matched placebo, as an adjunct to a reduced-calorie diet and increased physical activity. Time to diabetes onset by 160 weeks was the primary outcome, evaluated in all randomised treated individuals with at least one post-baseline assessment. The trial was conducted at 191 clinical research sites in 27 countries and is registered with ClinicalTrials.gov, number NCT01272219. Findings: The study ran between June 1, 2011, and March 2, 2015. We randomly assigned 2254 patients to receive liraglutide (n=1505) or placebo (n=749). 1128 (50%) participants completed the study up to week 160, after withdrawal of 714 (47%) participants in the liraglutide group and 412 (55%) participants in the placebo group. By week 160, 26 (2%) of 1472 individuals in the liraglutide group versus 46 (6%) of 738 in the placebo group were diagnosed with diabetes while on treatment. The mean time from randomisation to diagnosis was 99 (SD 47) weeks for the 26 individuals in the liraglutide group versus 87 (47) weeks for the 46 individuals in the placebo group. Taking the different diagnosis frequencies between the treatment groups into account, the time to onset of diabetes over 160 weeks among all randomised individuals was 2·7 times longer with liraglutide than with placebo (95% CI 1·9 to 3·9, p<0·0001), corresponding with a hazard ratio of 0·21 (95% CI 0·13–0·34). Liraglutide induced greater weight loss than placebo at week 160 (–6·1 [SD 7·3] vs −1·9% [6·3]; estimated treatment difference −4·3%, 95% CI −4·9 to −3·7, p<0·0001). Serious adverse events were reported by 227 (15%) of 1501 randomised treated individuals in the liraglutide group versus 96 (13%) of 747 individuals in the placebo group. Interpretation: In this trial, we provide results for 3 years of treatment, with the limitation that withdrawn individuals were not followed up after discontinuation. Liraglutide 3·0 mg might provide health benefits in terms of reduced risk of diabetes in individuals with obesity and prediabetes. Funding: Novo Nordisk, Denmark