Nutritional status, lifestyle and knowledge of predisposing factors on hyperlipedemia among outpatients in Enugu State University Teaching Hospital (ESUTH), Nigeria

The growing trend of hyperlipidemia in most developing countries has resulted largely from changes in lifestyle, diet and lack of adequate exercise which have led to decreased life expectancy and burden of cardiovascular diseases. A purposive sample size of 206 out patients was selected for this study after obtaining their due consents. Out of these, 108 (52.84%) were female and 98 (47.6%) males. Validated structured questionnaires were administered to collect basic socio-economic data from the respondents. Information obtained include drinking habits, medical history, and dietary habits. Data were presented by using descriptive statistics: frequencies and percentages. The anthropometric variables (weight and height) were analysed by using mean and standard deviation tools. Body mass index (BMI) was determined using the weight and height measurements. About 39.8% of respondents were within the age bracket (29-39 years), 25.7% had family history of diabetes mellitus, 25.2% hypertension and 11.7% had hypercholesterolemia. More than half (66.5%) of the respondents consumed alcoholic drinks. About 65.1% of the alcoholics, drink 1-3 times weekly and 46.1% took alcohol 4-6 times weekly while 14.5% drink daily. Some respondents who consumed groundnut, banana with groundnut, biscuit, buns, bread, meat pies, cakes or chicken pies with malt, juice or soft drink were 63.5%. Less than half (40.2%) of the respondents were overweight and about 37.4% of them were obese. About 45.6% of the respondents had a fair knowledge of hyperlipidemia, 40.3% had poor knowledge while 14.1% had a good knowledge. This study showed a strong evidence of poor knowledge of hyperlipidemia among out-patients attending Enugu State University Teaching Hospital (ESUTH), which may have influenced their lifestyle, dietary habit and subsequently their nutritional/health status.Keywords: Hyperlipidemia, nutritional status, diet, diabetes, cardiovascular disease

Effect of Moringa Oleifera Aqueous Leaf Extract on Some Haematological Indices in Wistar Rats

The use of Moringa oleifera leaf extract in the treatment of virtually all ailments calls for further research to support the claim for its ability to boost blood. Thirty six albino rats of the Wistar strain weighing 200-230g were sorted into groups according to their weights and sex. The animals were divided into two groups, male and female. Three (3) test groups (1%, 5%, and 10% w/w) for the males containing five (5) animals each and a control group, for the females, three (3) test groups (1%, 5%, and 10% w/w) and control group with four (4) animals each. The result of haematological indices in female Wistar rats administered aqueous extract of M. oleifera shows that Hb count generally increased significantly in all the groups compared with their control group. Similarly, PCV and WBC generally increased in all the groups, this increase was significant for WBC in all the groups. RBC values showed a non-significant (p>0.05) value at 1% treated group but a significant increases (p<0.05) were obtained in the 5% and 10% treated groups. In the male animals, the result showed that hemoglobin count (Hb) was significantly higher (p<0.05) in the group that was given 1% M. oleifera compared with the control group while there was a non-significant (p>0.05) increase Hb count in the 5% treated group. Generally, PCV count shows a dose dependent increase with 10% having the highest PCV count when compared with the control. Similarly, the WBC count also shows a dose dependent increase when compared with the control. RBC count showed a general decrease in all the exposed groups compared with their relative control. In conclusion, M. oleifera may increase PCV, HB and RBC counts, its use must be well regulated because of the fact that it increases WBC count, a possible toxicological response. Key words: haematology, Moringa oleifera, toxicological response, haemoglobin

An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology

© 2017 Elsevier B.V. All rights reserved.Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary healthcare. The aim of this review was to collect and present the scientific evidence for the use of medicinal plants that are in currect by Gabonese traditional healers to manage diabetes or hyperglycaemia based here on the pharmacological and toxicological profiles of plants with anti-diabetic activity. There are presented in order to promote their therapeutic value, ensure a safer use by population and provide some bases for further study on high potential plants reviewed. Materials and methods: Ethnobotanical studies were sourced using databases such as Online Wiley library, Pubmed, Google Scholar, PROTA, books and unpublished data including Ph.D. and Master thesis, African and Asian journals. Keywords including ‘Diabetes’ ‘Gabon’ ‘Toxicity’ ‘Constituents’ ‘hyperglycaemia’ were used. Results: A total of 69 plants currently used in Gabon with potential anti-diabetic activity have been identified in the literature, all of which have been used in in vivo or in vitro studies. Most of the plants have been studied in human or animal models for their ability to reduce blood glucose, stimulate insulin secretion or inhibit carbohydrates enzymes. Active substances have been identified in 12 out of 69 plants outlined in this review, these include Allium cepa and Tabernanthe iboga. Only eight plants have their active substances tested for anti-diabetic activity and are suitables for further investigation. Toxicological data is scarce and is dose-related to the functional parameters of major organs such as kidney and liver. Conclusion: An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments. With further research, the use of Gabonese anti-diabetic plants is important to ensure the safety of the diabetic patients in Gabon.Peer reviewedFinal Accepted Versio

Glycaemic response of four mango fruits consumed in Enugu State

Background: Mango fruit is a delicious juicy drupe, commonly consumed in Nigeria. It is a seasonal fruits that is consumed by all. However, diabetic patients sometimes are afraid of spike in their blood sugar after consuming fruits of which mango is one of them. Evidenced based dietary counselling and nutrition eduction of the public requires such an empirical study to establish evidence. Objectives: This study examined the glycemic response, glycemic index and glycemic load of four mango fruits consumed in Nsukka, Enugu state. Methodology: Samples of four mango varieties (Opioro, Alphonso, Haden, and Sweet) were randomly selected from different markets in Nsukka, Enugu state, Nigeria. These samples were thoroughly washed in warm water to remove gums. The edible portion of the mango (alphonso, haden and sweet mango was consumed with the peels, while the peel of opioro mango was remove before consumption). The weight of each variety that will give about 25g available carbohydrate was used as the test meal. Voluntary human subjects who were informed about the research were used and withdrawal at any stage was allowed. Ethical approval given by Research Ethics Committee University of Nigeria Teaching Hospital Ituku-Ozalla. Available carbohydrate was determined using standard method. The glycemic response was done using the FAO protocols. Descriptive statistics (mean and standard deviation) was used to present the data obtained while analysis of variance (ANOVA) was used to compare the means and turkey HSD test was used to separate the means. Results: Available carbohydrate was highest in Sweet mango (6.18g). Alphonso mango significantly (p<0.05) had the least effect on blood glucose levels. The glycemic index of the samples was 33 for Opioro, 4 for Alphonso, 15 for Haden and 39 for Sweet mangoes. The glycemic load ranged from 5.18 in Haden mango to 6.18 in Sweet mango. Conclusion: The study revealed that Alphonso mangoes could be used in planning diets for people with metabolic diseases like diabetes mellitus

Chemical composition and anti-diabetic properties of Jatropha curcas leaves extract on alloxan induced diabetic wistar rats

This study evaluates the chemical composition and anti-diabetic properties of fresh and shade dried Jatropha curcas aqueous leaves extracts (JCLE) on alloxan induced diabetic female wistar rats. Seven (7) kg of J. curcas leaves were pulverized and aqueous extracts produced. Thirty five (35) mature female rats were grouped into seven of five animals per group according to their body weights. Blood samples were collected for baseline data before inducing diabetes. Various groups of rats were fed graded doses (100, 200 and 300 mg of JCLE, respectively. Blood glucose was tested every seven days using glucometer. The animals were treated for 21 days with JCLE, blood samples were collected for liver enzyme function test, liver and pancreas tissues collected for histopathology. The results obtained were analysed statistically using analysis of variance (ANOVA) and Duncan Multiple range student test. Result shows that proximate composition of JCLE had higher protein, fat and carbohydrate concentrations in shade dried than the fresh samples. The vitamin, mineral and phytochemical compositions varied but higher in shade dried JCLE also than the fresh. Rats treated had significant (p<0.05) reduction in blood glucose level. Liver enzymes was higher with shade dried JCLE. The current study provides some useful insight into the anti-hyperglycemic potency of JCLE in alloxan induced diabetics and seems to repair some organs damages.Key words: Blood glucose, Jatropha curcus, liver enzymes, diabetic

The Relationship between the Clinic-Based Nutrition Instruction Given to the Nursing Mothers and Their Degree of Acceptance of the Information

No Abstract

The relationship between the clinic-based nutrition instructions given to nursing mothers and their complementary feeding practices in Enugu state

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Chemical and organoleptic evaluation of soyabean-yam receipes as possible snacks and food for children

No Abstract. Bio-Research Vol. 4(1) 2006: 18-2