418 research outputs found
Solitary magnetic perturbations at the ELM onset
Edge localised modes (ELMs) allow maintaining sufficient purity of tokamak
H-mode plasmas and thus enable stationary H-mode. On the other hand in a future
device ELMs may cause divertor power flux densities far in excess of tolerable
material limits. The size of the energy loss per ELM is determined by
saturation effects in the non-linear phase of the ELM, which at present is
hardly understood. Solitary magnetic perturbations (SMPs) are identified as
dominant features in the radial magnetic fluctuations below 100kHz. They are
typically observed close (+-0.1ms) to the onset of pedestal erosion. SMPs are
field aligned structures rotating in the electron diamagnetic drift direction
with perpendicular velocities of about 10km/s. A comparison of perpendicular
velocities suggests that the perturbation evoking SMPs is located at or inside
the separatrix. Analysis of very pronounced examples showed that the number of
peaks per toroidal turn is 1 or 2, which is clearly lower than corresponding
numbers in linear stability calculations. In combination with strong peaking of
the magnetic signals this results in a solitary appearance resembling modes
like palm tree modes, edge snakes or outer modes. This behavior has been
quantified as solitariness and correlated to main plasma parameters. SMPs may
be considered as a signature of the non-linear ELM-phase originating at the
separatrix or further inside. Thus they provide a handle to investigate the
transition from linear to non-linear ELM phase. By comparison with data from
gas puff imaging processes in the non-linear phase at or inside the separatrix
and in the scrape-off-layer (SOL) can be correlated. A connection between the
passing of an SMP and the onset of radial filament propagation has been found.
Eventually the findings related to SMPs may contribute to a future quantitative
understanding of the non-linear ELM evolution.Comment: submitted to Nuclear Fusio
Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures.
Human induced pluripotent stem cells (iPSC) have the potential to produce desired target cell types in vitro and allow for the high-throughput screening of drugs/chemicals at population level thereby minimising the cost of drug discovery and drug withdrawals after clinical trials. There is a substantial need for the characterisation of the iPSC derived models to better understand and utilise them for toxicological relevant applications. In our study, iPSC (SBAD2 or SBAD3 lines obtained from StemBANCC project) were differentiated towards toxicologically relevant cell types: alveolar macrophages, brain capillary endothelial cells, brain cells, endothelial cells, hepatocytes, lung airway epithelium, monocytes, podocytes and renal proximal tubular cells. A targeted transcriptomic approach was employed to understand the effects of differentiation protocols on these cell types. Pearson correlation and principal component analysis (PCA) separated most of the intended target cell types and undifferentiated iPSC models as distinct groups with a high correlation among replicates from the same model. Based on PCA, the intended target cell types could also be separated into the three germ layer groups (ectoderm, endoderm and mesoderm). Differential expression analysis (DESeq2) presented the upregulated genes in each intended target cell types that allowed the evaluation of the differentiation to certain degree and the selection of key differentiation markers. In conclusion, these data confirm the versatile use of iPSC differentiated cell types as standardizable and relevant model systems for in vitro toxicology
Azimuthal asymmetries of charged hadrons produced by high-energy muons scattered off longitudinally polarised deuterons
Azimuthal asymmetries in semi-inclusive production of positive (h^+) and
negative hadrons (h^-) have been measured by scattering 160 GeV muons off
longitudinally polarised deuterons at CERN. The asymmetries were decomposed in
several terms according to their expected modulation in the azimuthal angle phi
of the outgoing hadron. Each term receives contributions from one or several
spin and transverse-momentum-dependent parton distribution and fragmentation
functions. The amplitudes of all phi-modulation terms of the hadron asymmetries
integrated over the kinematic variables are found to be consistent with zero
within statistical errors, while the constant terms are nonzero and equal for
h^+ and h^- within the statistical errors. The dependencies of the
phi-modulated terms versus the Bjorken momentum fraction x, the hadron
fractional momentum z, and the hadron transverse momentum p_h^T were studied.
The x dependence of the constant terms for both positive and negative hadrons
is in agreement with the longitudinal double-spin hadron asymmetries, measured
in semi-inclusive deep-inelastic scattering. The x dependence of the sin
phi-modulation term is less pronounced than that in the corresponding HERMES
data. All other dependencies of the phi-modulation amplitudes are consistent
with zero within the statistical errors.Comment: 12 pages, 11 Figures; revision 1 signs in Eq 5 corrected, polishe
Exclusive rho^0 muoproduction on transversely polarised protons and deuterons
The transverse target spin azimuthal asymmetry A_UT in hard exclusive
production of rho^0 mesons was measured at COMPASS by scattering 160 GeV/c
muons off transversely polarised protons and deuterons. The measured asymmetry
is sensitive to the nucleon helicity-flip generalised parton distributions E^q,
which are related to the orbital angular momentum of quarks in the nucleon. The
Q^2, x_B and p_t^2 dependence of A_UT is presented in a wide kinematic range.
Results for deuterons are obtained for the first time. The measured asymmetry
is small in the whole kinematic range for both protons and deuterons, which is
consistent with the theoretical interpretation that contributions from GPDs E^u
and E^d approximately cancel.Comment: 20 pages, 9 figures and 4 tables, updated author lis
Experimental investigation of transverse spin asymmetries in muon-p SIDIS processes: Collins asymmetries
The COMPASS Collaboration at CERN has measured the transverse spin azimuthal
asymmetry of charged hadrons produced in semi-inclusive deep inelastic
scattering using a 160 GeV positive muon beam and a transversely polarised NH_3
target. The Collins asymmetry of the proton was extracted in the Bjorken x
range 0.003<x<0.7. These new measurements confirm with higher accuracy previous
measurements from the COMPASS and HERMES collaborations, which exhibit a
definite effect in the valence quark region. The asymmetries for negative and
positive hadrons are similar in magnitude and opposite in sign. They are
compatible with model calculations in which the u-quark transversity is
opposite in sign and somewhat larger than the d-quark transversity distribution
function. The asymmetry is extracted as a function of Bjorken , the relative
hadron energy and the hadron transverse momentum p_T^h. The high statistics
and quality of the data also allow for more detailed investigations of the
dependence on the kinematic variables. These studies confirm the leading-twist
nature of the Collins asymmetry.Comment: 11 pages, 5 figure
Measurement of the Collins and Sivers asymmetries on transversely polarised protons
The Collins and Sivers asymmetries for charged hadrons produced in deeply
inelastic scattering on transversely polarised protons have been extracted from
the data collected in 2007 with the CERN SPS muon beam tuned at 160 GeV/c. At
large values of the Bjorken x variable non-zero Collins asymmetries are
observed both for positive and negative hadrons while the Sivers asymmetry for
positive hadrons is slightly positive over almost all the measured x range.
These results nicely support the present theoretical interpretation of these
asymmetries, in terms of leading-twist quark distribution and fragmentation
functions.Comment: 9 Pages, 5 figure
The Spin-dependent Structure Function of the Proton g_1^p and a Test of the Bjorken Sum Rule
The inclusive double-spin asymmetry, A_1^p, has been measured at COMPASS in
deepinelastic polarised muon scattering off a large polarised NH3 target. The
data, collected in the year 2007, cover the range Q2 > 1 (GeV/c)^2, 0.004 < x <
0.7 and improve the statistical precision of g_1^p(x) by a factor of two in the
region x < 0.02. The new proton asymmetries are combined with those previously
published for the deuteron to extract the non-singlet spin-dependent structure
function g_1^NS(x,Q2). The isovector quark density, Delta_q_3(x,Q2), is
evaluated from a NLO QCD fit of g_1^NS. The first moment of Delta_q3 is in good
agreement with the value predicted by the Bjorken sum rule and corresponds to a
ratio of the axial and vector coupling constants g_A/g_V =
1.28+-0.07(stat)+-0.10(syst).Comment: 12 pages, 5 figure
Quark helicity distributions from longitudinal spin asymmetries in muon-proton and muon-deuteron scattering
Double-spin asymmetries for production of charged pions and kaons in
semi-inclusive deep-inelastic muon scattering have been measured by the COMPASS
experiment at CERN. The data, obtained by scattering a 160 GeV muon beam off a
longitudinally polarised NH_3 target, cover a range of the Bjorken variable x
between 0.004 and 0.7. A leading order evaluation of the helicity distributions
for the three lightest quarks and antiquark flavours derived from these
asymmetries and from our previous deuteron data is presented. The resulting
values of the sea quark distributions are small and do not show any sizable
dependence on x in the range of the measurements. No significant difference is
observed between the strange and antistrange helicity distributions, both
compatible with zero. The integrated value of the flavour asymmetry of the
helicity distribution of the light-quark sea, \Delta u-bar - \Delta d-bar, is
found to be slightly positive, about 1.5 standard deviations away from zero.Comment: 13 pages, 5 figure
Transverse spin effects in hadron-pair production from semi-inclusive deep inelastic scattering
First measurements of azimuthal asymmetries in hadron-pair production in
deep-inelastic scattering of muons on transversely polarised ^6LiD (deuteron)
and NH_3 (proton) targets are presented. The data were taken in the years
2002-2004 and 2007 with the COMPASS spectrometer using a muon beam of 160 GeV/c
at the CERN SPS. The asymmetries provide access to the transversity
distribution functions, without involving the Collins effect as in single
hadron production. The sizeable asymmetries measured on the NH_ target indicate
non-vanishing u-quark transversity and two-hadron interference fragmentation
functions. The small asymmetries measured on the ^6LiD target can be
interpreted as indication for a cancellation of u- and d-quark transversities.Comment: 13 pages, 4 figures, updated to the published versio
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