Safety-efficacy balance of S-ketamine and S-norketamine in acute and chronic pain

The balance between safety and efficacy is important in pharmacotherapy. When the indication of a registered drug shifts to another disease or a different patient population, studies on safety and efficacy need to be performed. Ketamine is a relatively __old__ drug and used for almost 50 years as an anesthetic. Recently there has been a renewed interest for the treatment of therapy-resistant chronic pain with subanesthetic doses of ketamine. This thesis describes the effects of S-ketamine in patients with chronic pain (CRPS-1 and fibromyalgia patients) and healthy volunteers. In chronic pain patients (e.g. CRPS-1) pain relief can last for months after long-term intravenous ketamine infusions, but short-term S-ketamine had no long-term efficacy in fibromyalgia patients. S-ketamine can cause a wide range of side-effects which limits its use. Therefore studies were performed in healthy volunteers to expand the knowledge on S-ketamine and the main metabolite S-norketamine to further characterize side-effects (specifically neurocognitive effects). S-norketamine does not contribute to S-ketamine__s analgesic effects and can therefore not serve as an alternative.TREND (Trauma RElated Neuronal Dysfunction)UBL - phd migration 201

The role of adoption norms and perceived product attributes in the adoption of Dutch electric vehicles and smart energy systems

We studied to what extent perceived adoption norms affect the likelihood of adopting sustainable innovations, next to evaluations of the instrumental, environmental and symbolic attributes of these innovations. As hypothesised, results showed that people are more likely to adopt a sustainable innovation the more they evaluate the attributes of these sustainable innovations favourably and the more they think significant others would consider adoption (i.e., when adoption norms are strong). Moreover, we hypothesised and found that positive evaluations of the symbolic attributes are more likely to promote the adoption of sustainable innovations when people expect that few significant others would consider adoption. These findings suggest that weak adoption norms that are typical in the early adoption stage may both inhibit and promote adoption of sustainable innovations, via different routes

Interaction of consumer preferences and climate policies in the global transition to low-carbon vehicles

Burgeoning demands for mobility and private vehicle ownership undermine global efforts to reduce energy-related greenhouse gas emissions. Advanced vehicles powered by low-carbon sources of electricity or hydrogen offer an alternative to conventional fossil-fuelled technologies. Yet, despite ambitious pledges and investments by governments and automakers, it is by no means clear that these vehicles will ultimately reach mass-market consumers. Here, we develop state-of-the-art representations of consumer preferences in multiple, global energy- economy models, specifically focusing on the non-financial preferences of individuals. We employ these enhanced model formulations to analyse the potential for a low-carbon vehicle revolution up to mid-century. Our analysis shows that a diverse set of measures targeting vehicle buyers is necessary for driving widespread adoption of clean technologies. Carbon pricing alone is insufficient for bringing low-carbon vehicles to mass market, though it can certainly play a supporting role in ensuring a decarbonised energy supply

Ketamine for pain management

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The roles of users in electric, shared and automated mobility transitions

This paper synthesizes insights from 19 peer-reviewed articles published in this Special Issue on the roles of users in shared, electric and automated mobility. While many researchers and stakeholders remain inspired by the potential low costs and societal benefits of these innovations, less is known about the real-world potential for uptake and usage. To better understand the likelihood and impacts of widespread uptake, we explore the perceptions of actual and potential users, including drivers, passengers, owners, and members, as well as other stakeholders such as pedestrians, planners, and policymakers. The Special Issue examines a range of cases, including plug-in electric vehicles, car-share and bike-share programs, ride-hailing and automated vehicles. For each innovation, we organize insights on user perceptions of benefits and drawbacks into four categories. Much of the research to date focuses on the first category, private-functional perceptions, mainly total cost of ownership (e.g., $/km), time use and comfort. Our synthesis however spans the other three categories for each innovation: private-symbolic perceptions include the potential for social signaling and communicating identity; societal-functional perceptions include GHG emissions, public safety and noise; and societal-symbolic perceptions include inspiring pro-societal behavior in others, and the potential to combat or reinforce the status quo system of “automobility”. Further, our synthesis demonstrates how different theories and methods can be more or less equipped to “see” different perception categories. We also summarize findings regarding the characteristics of early users, as well as practical insights for strategies and policies seeking societally-beneficial outcomes from mass deployment of these innovations

Exploring consumer preferences towards electric vehicles: The influence of consumer innovativeness

The diffusion of electric vehicles (EVs) is regarded as an important aspect of government policy which aims to generate a transition to a low-carbon mobility system in the United Kingdom and the wider European context. This paper investigates consumer demand for EVs by examining the influence of consumer innovativeness alongside attitudes concerning the functional capabilities of EVs over EV preferences. A conceptual framework is developed and applied which includes measurements of innovativeness at both an adoptive level, through an assessment of technology ownership, and at an innate level, by measuring a cohort of psychological and sociological factors. Additionally, the framework incorporates measurements of attitudes towards the functional performance of EVs to determine their effect on preferences. Data has been collected through the application of a self-completion household survey distributed over the cities of Dundee and Newcastle upon Tyne in the United Kingdom. Results of the analysis indicate that adoptive innovativeness and attitudes concerning the functional performance of EVs significantly affect preferences for plug-in hybrid electric vehicles (PHEVs) and battery electric vehicles (BEVs)